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Oscar Marcelo Lazo Jerez

Académico

Universidad San Sebastián / University College London

Santiago, Chile

Neurodegeneración y resiliencia neurológica. Integración del tráfico y la señalización de receptores neurotróficos. Transporte de organelos en neuronas. Alzheimer en Síndrome de Down. Aplicaciones interdisciplinarias de la neurociencia.

Ciencias Biológicas, Fisiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011
Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
Licenciatura en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006

Investigador Postdoctoral Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biológicas

Santiago, Chile

2011 - 2013
Profesor Adjunto Other

UNIVERSIDAD ANDRES BELLO

Ciencias Sociales

Santiago, Chile

2013 - 2016
Newton International Fellow Full Time

UNIVERSITY COLLEGE LONDON

Brain Sciences

London, Reino Unido

2016 - 2018
Research Fellow Full Time

UNIVERSITY COLLEGE LONDON

Brain Sciences

London, Reino Unido

2019 - 2023
Research Fellow Part Time

UNIVERSITY COLLEGE LONDON

Brain Sciences

London, Reino Unido

2024 - A la fecha
Académico Full Time

UNIVERSIDAD SAN SEBASTIAN

Facultad de Psicología y Humanidades

Santiago, Chile

2025 - A la fecha


PLC-γ-Ca<SUP>2+</SUP> pathway regulates axonal TrkB endocytosis and is required for long-distance propagation of BDNF signaling Valero-Pena, Xavier; Lazo, Oscar M.; Bronfman, Francisca C. Article ISI Frontiers in Molecular Neuroscience (2024)
Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons Panzi, Chiara; De La-Rocque, Samantha; Lazo, Oscar Marcelo Article ISI TOXICON (2023)
Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport Lazo, Oscar Marcelo Article ISI ELIFE (2023)
Editorial: Neuronal cytoskeleton and GTPases in health and diseases Bates, Emily Anne; Garcia, Corina; Lazo, Oscar M. Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
The Rab5-Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons Gonzalez-Gutierrez, Andres; Lazo, Oscar M.; Bronfman, Francisca C. Article ISI JOURNAL OF NEUROSCIENCE (2020)
Venlafaxine treatment after endothelin-1-induced cortical stroke modulates growth factor expression and reduces tissue damage in rats Zepeda, R.; Contreras, V; Pissani C.; Stack K.; Vargas, M.; Owen, G. I.; Lazo O.M. Article ISI SCOPUS NEUROPHARMACOLOGY (2016)
Spatiotemporal intracellular dynamics of neurotrophin and its receptors. Implications for neurotrophin signaling and neuronal function Lazo O.M.; Flores C.; Escudero, C. A. Article SCOPUS Handbook of Experimental Pharmacology (2015)
The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release. Escudero, Claudia A; Lazo, Oscal M; Galleguillos, Carolina; Parraguez, Jose I; Lopez-Verrilli, Maria A; Cabeza, Carolina; Leon, Luisa; Saeed, Uzma; Retamal, Claudio; Gonzalez, Alfonso; Marzolo, Maria-Paz; Carter, Bruce D; Court, Felipe A; Bronfman, Francisca C Article Journal of cell science (2014)
The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release. Escudero CE, Lazo OM; Galleguillos C, Parraguez JI; Lopez-Verrilli MA, Cabeza C; Leon L, Saeed U; Retamal C, Gonzalez A; Marzolo MP, Carter BD; Court FA, Bronfman FC Article Journal of Cell Science (2014)
BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching. Lazo, Oscar M; Gonzalez, Andrés; Ascaño, Maria; Kuruvilla, Rejji; Couve, Andrés; Bronfman, Francisca C Article The Journal of neuroscience => the official journal of the Society for Neuroscience (2013)
Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease Cabeza, C; Figueroa, A; Lazo O.M.; Galleguillos, C; Pissani C.; Klein, A.; Gonzalez-Billault, C; Inestrosa, N. C.; Zanlungo S. Article ISI SCOPUS Molecular Neurodegeneration (2012)
An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot and interactions with p75 coreceptors. Guillemard, Veronique; Ivanisevic, Ljubica; Garcia, Alba Galan; Scholten, Vicki; Lazo, Oscar M; Bronfman, Francisca C; Saragovi, H Uri Article Developmental neurobiology (2010)
Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Lazo, Oscar M; Mauna, Jocelyn C; Pissani, Claudia A; Inestrosa, Nibaldo C; Bronfman, Francisca C Article Molecular neurodegeneration (2010)


Neurotrophins and the balance between retrograde signalling and autophagic flux in the axon. The Royal Society (NF160681) Proyecto 2016-2018 Postdoctorado
Regulation of neurotrophin receptor retrograde transport and signalling by Rab10 PFCHA (2015/74160) Proyecto 2016-2018 Postdoctorado
ROLE OF ENDOCYTIC RAB GTPASES IN NEUROTROPHIN SIGNALING AND NEURONAL RESPONSES FONDECYT (1120146) Proyecto 2012-2016 Personal técnico y/o de apoyo
NUCLEO MILENIO EN BIOLOGIA REGENERATIVA Iniciativa Científica Milenio (P07-011- F) Proyecto 2009-2017 Postdoctorado
CENTRO DE ENVEJECIMIENTO Y REGENERACIÓN FONDAP (PFB12/2007) Proyecto 2008-2020 Postdoctorado
CONTRIBUCION DE LA ENDOCITOSIS Y EL PROCESAMIENTO PROTEOLITICO A LA SENALIZACION NEUROTROFICA=> CONVERSACION CRUZADA CON EL SISTEMA REELINA/APOER2 FONDECYT (1085273) Proyecto 2008-2012 Tesista
MECANISMOS DE SENALIZACION, TRAFICO Y COMPARTIMENTALIZACION CELULAR DE LA SENAL MEDIADA POR EL RECEPTOR DE NEUROTROFINAS p75. FONDECYT (1040799) Proyecto 2004-2008 Personal técnico y/o de apoyo


The evolution of the axonal transport toolkit Surana, Sunaina; Villarroel-Campos, David; Lazo, Oscar M.; Moretto, Edoardo; Tosolini, Andrew P.; Rhymes, Elena R.; Richter, Sandy; Sleigh, James N. Review ISI TRAFFIC (2020)
The many disguises of the signalling endosome Villarroel-Campos, David; Lazo, Oscar Marcelo Review ISI FEBS LETTERS (2018)