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Oscar Marcelo Lazo Jerez

Research Fellow

UCL Queen Square Institute of Neurology

London, Reino Unido

Tráfico y señalización de receptores de neurotrofinas; Neuroplasticidad en el sistema nervioso adulto; Regulación de la morfología y complejidad neuronal; Regeneración en el sistema nervioso central; Enfermedades neurodegenerativas.

Ciencias Biológicas, Fisiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011
Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
Licenciatura en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006

Investigador Postdoctoral Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biológicas

Santiago, Chile

2011 - 2013
Profesor Adjunto Other

UNIVERSIDAD ANDRES BELLO

Ciencias Sociales

Santiago, Chile

2013 - 2016
Newton International Fellow Full Time

UNIVERSITY COLLEGE LONDON

Brain Sciences

London, Reino Unido

2016 - 2018
Research Fellow Full Time

UNIVERSITY COLLEGE LONDON

Brain Sciences

London, Reino Unido

2019 - A la fecha


Venlafaxine treatment after endothelin-1-induced cortical stroke modulates growth factor expression and reduces tissue damage in rats Zepeda, R.; Contreras, V; Pissani C.; Stack K.; Vargas, M.; Owen, G. I.; Lazo O.M.; Bronfman F.C. Article ISI SCOPUS Neuropharmacology (2016)
Spatiotemporal intracellular dynamics of neurotrophin and its receptors. Implications for neurotrophin signaling and neuronal function Bronfman F.C.; Lazo O.M.; Flores C.; Escudero, C. A. Article SCOPUS Handbook of Experimental Pharmacology (2015)
The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release. Escudero CE, Lazo OM; Galleguillos C, Parraguez JI; Lopez-Verrilli MA, Cabeza C; Leon L, Saeed U; Retamal C, Gonzalez A; Marzolo MP, Carter BD; Court FA, Bronfman FC Article Journal of Cell Science (2014)
BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching. Lazo OM, Gonzalez A; Ascano M, Kuruvilla R; Couve A, Bronfman FC Article The Journal of Neuroscience (2013)
Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease Cabeza, C; Figueroa, A; Lazo O.M.; Galleguillos, C; Pissani C.; Klein, A.; Gonzalez-Billault, C; Inestrosa, N. C.; Alvarez, A.R.; Zanlungo S.; Bronfman F.C. Article ISI SCOPUS Molecular Neurodegeneration (2012)
Cholinergic abnormalities, endosomal alterations and up-regulation of Nerve Growth Factor signaling in Niemann-Pick type C disease. Cabeza C, Figueroa A; Lazo OM, Galleguillos C; Pissani C, Klein A; Gonzalez-Billault C, Inestrosa NI; Alvarez A, Zanlungo S Article Molecular Neurodegeneration (2012)
An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot and interactions with p75 coreceptors. Guillemard V, Ivanisevic L; Garcia AG, Scholten V; Lazo OM, Bronfman FC Article Developmental Neurobiology (0)
Axotomy-induced neurotrophic withdrawal causes loss of phenotypic differentiation and downregulation of NGF signaling, but not death of septal cholinergic neurons. Lazo OM, Mauna J; Pissani C, Inestrosa NC Article Molecular Neurodegeneration (0)
Spatiotemporal intracellular dynamics of neurotrophin and its receptors. Implications for neurotrophin signaling and neuronal function. Bronfman FC, Lazo OM Article Handbook in Experimental Pharmacology. (0)