Man

Christian Enrique Gonzalez Billault

Full Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


1.- The role of MAP1B in axon formation 2.- The role of MAP1B in neurotransmission 3.- Participation of NADPH oxidase and ROS in axon formation 4.- Neuronal and glial mechanisms of aging 5.- Neurodegeneration

Educación

  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 1994
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 1996
  •  Cell Molecular Biology, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

  •   Full Professor Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2012 - A la fecha

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2007 - Sin Información

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2003 - Sin Información

  •   Profesor Titular Part Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2019 - A la fecha

  •   Adjunct Professor Other

    BUCK INSTITUTE

    Estados Unidos

    2016 - A la fecha

Experiencia Profesional

  •   Full Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2012 - A la fecha

Formación de Capital Humano


Postdoctoral
Daniel Henriquez
Pablo Muñoz-Llancao

Graduate Students
Erick Contreras-Vallejos
Felipe Bodaleo
Carlos Wilson, co-mentored with Prof. Tulio Nuñez
Pamela Urrutia, co-mentored with Prof. Tulio Nuñez
Carlos Carrasco, co-mentored with Prof. tulio Nuñez

Magister Students
Sebastian Alvarez
Pablo Lazcano, co-mentored with Dr. Elias Utreras

Undergraduate Students
Mauro Canaval


Premios y Distinciones

  •   Member of the Science in the Frontier Program

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2007

    Awardee as member of the Science in the Frontier Program from the Chilean Academy of Sciences for talented young academics

  •   EMBO Associate Member

    European Molecular Biology Organization (EMBO)

    Alemania, 2020

    First Chilean awarded EMBO Associate Member


 

Article (99)

Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia? Review of Key Points Toward an Accurate Clinical and Neuropsychological Diagnosis
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca(2+)Transfer to Mitochondria
Geroscience in the Age of COVID-19
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates
Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease
Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons
Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders
Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
Crosstalk between Rac1-mediated actin regulation and ROS production.
Editorial=> From Ecology to Brain Development=> Bridging Separate Evolutionary Paradigms.
From birth to death=> A role for reactive oxygen species in neuronal development.
IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A.
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging
TNF-alpha Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons
Aging and Health Policies in Chile: New Agendas for Research
CDK5 downregulation enhances synaptic plasticity.
Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth
Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372
Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia
Identity of the Purkinje Cell Cytoplasmic Antibody Type 2 Autoantibody Antigen Is Finally Revealed
Microtubule-regulating proteins and cAMP-dependent signaling in neuroblastoma differentiation
A feed-forward mechanism involving the NOX complex and RyR-mediated Ca2+release during axonal specification
Actin filaments - a target for redox regulation.
Actin filaments-A target for redox regulation.
CDK5 downregulation enhances synaptic plasticity
Corrigendum=> Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
Corrigendum=> Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
Dissecting the role of redox signaling in neuronal development
Dissecting the role of redox signaling in neuronal development.
Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth
Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth.
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease.
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease.
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease.
Rab GTPase signaling in neurite outgrowth and axon specification.
Rab GTPase signaling in neurite outgrowth and axon specification.
Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B
Targeted overexpression of tumor necrosis factor-? increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons
Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons.
The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic Paraplegias
Contribution of NADPH oxidase to the establishment of hippocampal neuronal polarity in culture
Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B
Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP plus /MPTP-Lesioned Dopaminergic Neurons
p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing
Prenatal Stress Down-Regulates Reelin Expression by Methylation of Its Promoter and Induces Adult Behavioral Impairments in Rats
Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking.
Regulation of neuronal cav3.1 channels by cyclin-dependent kinase 5 (Cdk5).
Regulation of neuronal cav3.1 channels by cyclin-dependent kinase 5 (Cdk5).
A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases
CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation
Emerging concepts on neuronal cytoskeleton
Rab-mediated trafficking role in neurite formation.
Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5(-/-) Mice
The MAP1B Case: An Old MAP That is New Again
Actin filaments and microtubules in dendritic spines.
Bioinformatic survey for new physiological substrates of Cyclin-dependent kinase 5
Ca2+-Activated Cl- Channels of the ClCa Family Express in the Cilia of a Subset of Rat Olfactory Sensory Neurons
Cdk5 regulates Rap1 activity
Frizzled-5 Receptor Is Involved in Neuronal Polarity and Morphogenesis of Hippocampal Neurons
Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
MAP1B-dependent Rac activation is required for AMPA receptor endocytosis during long-term depression
A gathering of neuronal cytoskeletal scientists in South America.
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1 alpha
Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease
Fibrillar Amyloid-beta(1-42) Modifies Actin Organization Affecting the Cofilin Phosphorylation State: A Role for Rac1/cdc42 Effector Proteins and the Slingshot Phosphatase
Fibrillar amyloid-β1-42 modifies actin organization affecting the cofilin phosphorylation state: a role for Rac1/cdc42 effector proteins and the slingshot phosphatase.
Frizzled Receptors in Neurons: From Growth Cones to the Synapse
Going out of the brain: non-nervous system physiological and pathological functions of Cdk5.
The amyloid precursor protein intracellular domain-Fe65 multiprotein complexes: A challenge to the amyloid hypothesis for Alzheimer's disease?
The Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B) Is Responsible for Tiam1 Binding and Rac1 Activation in Neuronal Cells
The role of small GTPases in neuronal morphogenesis and polarity.
Iron mediates neuritic tree collapse in mesencephalic neurons treated with 1-methyl-4-phenylpyridinium (MPP+)
Microtubule-associated Protein 1B (MAP1B) Is Required for Dendritic Spine Development and Synaptic Maturation
Regulation of cell polarity by controlled proteolytic systems
MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity
CYCLIN-DEPENDENT KINASE 5 ACTIVATOR p35 OVER-EXPRESSION AND AMYLOID BETA SYNERGISM INCREASE APOPTOSIS IN CULTURED NEURONAL CELLS
Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination
A beta(1-42) stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases
Role of MAP1B in axonal retrograde transport of mitochondria.
A role of MAP1B in reelin-dependent neuronal migration
Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1
End binding protein-1 (EB1) complements microtubule-associated protein-1B during axonogenesis
Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
MAP1B is required for netrin 1 signaling in neuronal migration and axonal guidance
Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system.
Oxidative stress promotes T dephosphorylation in neuronal cells: The roles of cdk5 and pp1
Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures
AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.
Microtubule-associated protein 1B is involved in the initial stages of axonogenesis in peripheral nervous system cultured neurons.
Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity
Evidence for the role of MAP1B in axon formation
Molecular genetic approaches to microtubule-associated proteins.
Perinatal lethality of microtubule-associated protein 1B deficient mice expressing alternative isoforms of the protein at low levels.
Modifications of tau to an Alzheimer’s type protein interferes with its association with microtubules.
Immunological characterization of epitopes on tau of Alzheimer's type and chemically modified tau

Abstract (13)

Contribution of NADPH oxidase (NOX) to the establishment of hippocampal neuronal polarity
Contribution of Reactive Oxygen Species to the Establishment of Hippocampal Neuronal Polarity.
Rab35-dependent axon elongation is negatively regulated by p53-related protein kinase (PRPK).
Inflammatory stimuli and iron accumulation in neurons: two processes linked by hepcidin
Microtubule-associated protein 1B (MAP1B) regulates synaptic functions in mature neurons
Microtubule-associated protein 1B in axon elongation and neurotransmission
Regulation of kinesin-5, a brake on neuronal microtubules
Microtubule associated protein (MAP1B) is involved in dendritic spine development and neurotransmission
N-type Ca2+ channel regulation by the light chain 1 (LC1) of the microtubule associated protein B (MAP1B)
A beta PP transgenic mice Tg2576 induces Cdk5-dependent tau hyperphosphorylation
Interleukin-6 induces Alzheimer's type phosphorylation of tau protein by the cdk5/p35 pathway
MAP1B regulates axon formation by stimulation of Rac1 activity
Regulation of brain tau phosphorylation by the CDK5/P35 system under oxidative stress and iron overload conditions

EditorialMaterial (4)

Emerging concepts on neuronal cytoskeleton
A Gathering of Neuronal Cytoskeletal Scientists in South America
Contributions by researchers of "Ciencia de Frontera" of the Chilean Academy of Sciences
Regulation of brain tau phosphorylation by the CDK5/P35 complex under oxidative stress conditions

Errata (3)

Publisher Correction: Non-canonical function of IRE1? determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics (Nature Cell Biology, (2019), 21, 6, (755-767), 10.1038/s41556-019-0329-y)
Erratum to: IRE1? governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A (Nature Cell Biology, (2018), 20, 8, (942-953), 10.1038/s41556-018-0141-0)
Going out of the brain: Non-nervous system physiological pathological functions of Cdk5 (vol 24, pg 44, 2012)

Review (8)

Microtubule-Asssociated Proteins: Structuring the Cytoskeleton
Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models
Crosstalk between Rac1-mediated actin regulation and ROS production
Rab-mediated trafficking role in neurite formation
Actin filaments and microtubules in dendritic spines
Going out of the brain: Non-nervous system physiological and pathological functions of Cdk5
The role of small GTPases in neuronal morphogenesis and polarity
Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system
98
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

12
Ricardo Maccioni

DIRECTOR

RESEARCH AND DEVELOPMENT

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

SANTIAGO, Chile

12
Daniel Henriquez

Director Ciencia Transversal

Fundación Centro MERI

Santiago, Chile

11
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

7
Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

6
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

5
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

5
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Felipe Bodaleo

Postdoctoral Researcher

Universidad de Chile

Santiago, Chile

4
Pabla Aguirre

Asistente de investigación

Biología

Universidad de Chile

Santiago, Chile

3
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

3
Pamela Urrutia

Investigador

Biología

Universidad de Chile

Santiago, Chile

3
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

2
Daniel Bórquez

Profesor asistente

Centro de Investigación Biomédica

Universidad Diego Portales

Santiago, Chile

2
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

2
CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile

2
Alex Di Genova

Assistant professor

Engineering sciences

Universidad de O'Higgins

Rancagua, Chile

2
Cristopher Villablanca

Investigador post doctoral

Centro de Gerociencia, Salud Mental y Metabolismo (GERO)

Santiago, Chile

2
Daniel Bórquez

Profesor asociado

Facultad de Medicina

Universidad Diego Portales

Santiago, Chile

2
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

2
Jose Egana

Profesor asistente

Instituto de Ingeniería Biológica y Médica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

2
Alejandro Maass

Director

Center for Mathematical Modeling

Universidad de Chile

Santiago, Chile

2
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

2
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Maria Yolanda Espinosa

Associate Professor

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

1
Juan Montiel

Profesor Titular

FACULTAD DE MEDICINA

UNIVERSIDAD DIEGO PORTALES

Santiago, Chile

1
Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

1
Emiliano Molina

Estudiante de doctorado

Biología

Universidad de Chile

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

1
Maricarmen Andrade

Coordinadora Geriatría

Medicina Interna

Cínica Universidad de los Andes

Santiago, Chile

1
Mario Sanhueza

Assistant professor

Universidad Mayor

Santiago, Chile

1
Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

1
Alvaro Glavic

Associate Professor

Departamento de Biología

Universidad de Chile

Santiago, Chile

1
Agustin Ibanez

Profesor Titular

Psicologia

Universidad Adolfo Ibánez

Santiago, Chile

1
Pedro Zitko

Jefe de Unidad

Dirección

Hospital Barros Luco Trudeau

Santiago, Chile

1
Carolina Mendez

Assistant Professor

Health Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

1
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

1
Daniela Thumala

Profesora Asociada - área Psicología Clínica

Departamento de Psicología

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Esteban Calvo

Director and Full Professor

Universidad Mayor de Chile

Santiago, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Hery Urra

Postdoctorado

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Lisbona

Postdoctorado

Biología

Universidad de Chile

Santiago, Chile

1
Gada Musa

Investigador

Neurología

Hospital Clínico de la Universidad de Chile

Santiago, Chile

1
Christian Cea

Profesor Asistente

Escuela de Medicina

Universidad de Santiago de Chile

Santiago, Chile

1
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
María Pertusa

Profesor Asistente

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE. FACULTAD QUÍMICA Y BIOLOGÍA

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Alexia Núñez

Profesora Asistente

Departamento de Biología

Universidad de Chile

Santiago, Chile

1
Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

1
Angara Zambrano

Assistant Professor

Biochemistry and Microbiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
ignacio jausoro

POSTDOC

BIOLOGIA CELULAR Y MOLECULAR

PONTIFICIA UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Hans Richter

Profesor Titular

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Alenka Lovy

Assistant Professor

Science

Universidad Mayor de Chile

Santiago, Chile

1
Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
Philippe Pihán

Posdoctorado

Fisiología

Universidad de Chile

Santiago, Chile

1
Pablo Rozas

Asistente de Investigación

Instituto de Neurociencia Biomédica

Universidad de Chile

Santiago, Chile

1
Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

1
Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Cristian De Gregorio

Postdoctoral fellow

medicine

Universidad del Desarrollo

Lo Barnechea, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Oscar Lazo

Research Fellow

UK Dementia Research Institute and Department of Neuromuscular diseases

UCL Queen Square Institute of Neurology

London, Reino Unido

1
Pedro Chana

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

1
Patricio Pérez

Asistant Project Scientist

Botany and Plant Science

University of California, Riverside

Riverside, Estados Unidos

1
Paulina Troncoso

Inserción PhD

Investigación y Desarrollo

Neurognos SpA

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Celia Limia

N/A

N/A

Santiago, Chile