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Alenka Lovy

Assistant Professor

Universidad Mayor de Chile

Santiago, Chile

Líneas de Investigación


I have been studying mitochondrial involvement in metabolism and cancer, specializing in calcium communication between the ER and mitochondria. I am developing new work studying mitochondria and microbiome interactions applied in the aging field.

Educación

  •  Plant Biology, UNIVERSITY OF MASSACHUSETTS. Estados Unidos, 2006
  •  Plant Physiology, WASHINGTON STATE UNIVERSITY. Estados Unidos, 1999
  •  Plant Biology, UNIVERSITY OF MASSACHUSETTS. Estados Unidos, 1997

Experiencia Académica

  •   Research Assistant/Microscopy Instructor Part Time

    UNIVERSITY OF MASSACHUSETTS

    Amherst, Estados Unidos

    2000 - 2006

  •   Research Assistant Professor/Microscopy Facility Manager Full Time

    TUFTS UNIVERSITY

    Boston, Estados Unidos

    2006 - 2019

  •   Adjunct Research Assistant Professor Other

    TUFTS UNIVERSITY

    Boston, Estados Unidos

    2019 - A la fecha

  •   Assistant Professor Full Time

    UNIVERSIDAD MAYOR

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Research Assistant Professor/Imaging Facility Manager Full Time

    Tufts School of Medicine

    Boston, Estados Unidos

    2006 - 2019

  •   Research Assistant/Imaging Instructor Part Time

    University of Massachusetts

    Amherst, Estados Unidos

    2002 - 2006

  •   Adjunct Professor Other

    Tufts School of Medicine

    Boston, Estados Unidos

    2019 - A la fecha

  •   Assistant Professor Full Time

    Universidad Mayor

    Santiago, Chile

    2019 - A la fecha

  •   Research Assistant Full Time

    Washington State University

    Estados Unidos

    1997 - 1999

  •   Research Assistant Full Time

    University of Massachusetts

    Estados Unidos

    2000 - 2002

Premios y Distinciones

  •   Alenka Lovy

    UNIVERSITY OF MASSACHUSETTS

    Estados Unidos, 1995

    Hughes Medical Research Institute Grant to screen fungi for anticancer activity

  •   Alenka Lovy

    UNIVERSITY OF MASSACHUSETTS

    Estados Unidos, 1997

    BS awarded with Honors: Magna Cum Laude, Commonwealth Scholar, Departmental Honors

  •   Alenka Lovy

    UNIVERSITY OF MASSACHUSETTS

    Estados Unidos, 1996

    Honors Research Grant (University of Massachusetts) to screen fungi for antimalarial properties

  •   Alenka Lovy

    UNIVERSITY OF MASSACHUSETTS

    Estados Unidos, 2002

    Davis and DeLisle Research Grant Recipient for specialized electron microscopy shadowing device to visualize actin in lily pollen tubes $2,000

  •   Alenka Lovy

    UNIVERSITY OF MASSACHUSETTS

    Estados Unidos, 2003

    Davis and DeLisle Research Grant Recipient for specialized electron microscopy shadowing device to visualize actin in lily pollen tubes $2,000

  •   Alenka Lovy

    TUFTS UNIVERSITY

    Estados Unidos, 2010

    Shared Instrumentation Grant from NIH-NCRR “Acquisition of a Nikon A1R-A1 Confocal Combined with TIRF” (PI Lovy-Wheeler) $487,867

  •   Alenka Lovy

    TUFTS UNIVERSITY

    Estados Unidos, 2017

    Evaluation of mitochondrial function and mitophagy in PINK1/PARK2 knockout iPSC derivate dopaminergic neurons CNR Pilot Grant $10,000


 

Article (21)

In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes
Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells
LFA-1 and Kindlin-3 are necessary for the myosin-dependent movement of SLP-76 microclusters.
Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca(2+)Transfer to Mitochondria
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca2+ Transfer to Mitochondria
Complex I and II are required for normal mitochondrial Ca2+ homeostasis
MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells
InsP(3)R, the calcium whisperer: Maintaining mitochondrial function in cancer
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria (vol 14, pg 2313, 2016)
A Faster, High Resolution, mtPA-GFP-based Mitochondrial Fusion Assay Acquiring Kinetic Data of Multiple Cells in Parallel Using Confocal Microscopy
Pollen tube growth oscillations and intracellular calcium levels are reversibly modulated by actin polymerization
Differential organelle movement on the actin cytoskeleton in lily pollen tubes
Imaging the actin cytoskeleton in growing pollen tubes
Oscillatory increases in alkalinity anticipate growth and may regulate actin dynamics in pollen tubes of lily
Actin polymerization promotes the reversal of streaming in the apex of pollen tubes
Enhanced fixation reveals the apical cortical fringe of actin filaments as a consistent feature of the pollen tube
Taxol biosynthesis: Differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells
Activity of Edible Mushrooms Against the Growth of Human T 4 Leukemic Cancer Cells, HeLa Cervical Cancer Cells, and Plasmodium falciparum

BookSection (2)

Calcium and proton gradients and their oscillations in growing pollen tubes.
Ions and Pollen Tube Growth

Review (2)

Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target
The Mitochondrial Complex(I) ty of Cancer
25
Alenka Lovy

Assistant Professor

Science

Universidad Mayor de Chile

Santiago, Chile

5
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

2
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

1
Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

1
Carla Basualto

Jefe de Departamento - Académico

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

1
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile