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Alenka Lovy

Assistant Professor

Universidad Mayor de Chile

Santiago, Chile

I have been studying mitochondrial involvement in metabolism and cancer, specializing in calcium communication between the ER and mitochondria. I am developing new work studying mitochondria and microbiome interactions applied in the aging field.

Plant Biology, UNIVERSITY OF MASSACHUSETTS. Estados Unidos, 2006
Plant Physiology, WASHINGTON STATE UNIVERSITY. Estados Unidos, 1999
Plant Biology, UNIVERSITY OF MASSACHUSETTS. Estados Unidos, 1997

Research Assistant/Microscopy Instructor Part Time

UNIVERSITY OF MASSACHUSETTS

Amherst, Estados Unidos

2000 - 2006
Research Assistant Professor/Microscopy Facility Manager Full Time

TUFTS UNIVERSITY

Boston, Estados Unidos

2006 - 2019
Adjunct Research Assistant Professor Other

TUFTS UNIVERSITY

Boston, Estados Unidos

2019 - A la fecha
Assistant Professor Full Time

UNIVERSIDAD MAYOR

Santiago, Chile

2019 - A la fecha

Research Assistant Professor/Imaging Facility Manager Full Time

Tufts School of Medicine

Boston, Estados Unidos

2006 - 2019
Research Assistant/Imaging Instructor Part Time

University of Massachusetts

Amherst, Estados Unidos

2002 - 2006
Adjunct Professor Other

Tufts School of Medicine

Boston, Estados Unidos

2019 - A la fecha
Assistant Professor Full Time

Universidad Mayor

Santiago, Chile

2019 - A la fecha
Research Assistant Full Time

Washington State University

Estados Unidos

1997 - 1999
Research Assistant Full Time

University of Massachusetts

Estados Unidos

2000 - 2002

Alenka Lovy

UNIVERSITY OF MASSACHUSETTS

Estados Unidos, 1995

Hughes Medical Research Institute Grant to screen fungi for anticancer activity
Alenka Lovy

UNIVERSITY OF MASSACHUSETTS

Estados Unidos, 1997

BS awarded with Honors: Magna Cum Laude, Commonwealth Scholar, Departmental Honors
Alenka Lovy

UNIVERSITY OF MASSACHUSETTS

Estados Unidos, 1996

Honors Research Grant (University of Massachusetts) to screen fungi for antimalarial properties
Alenka Lovy

UNIVERSITY OF MASSACHUSETTS

Estados Unidos, 2002

Davis and DeLisle Research Grant Recipient for specialized electron microscopy shadowing device to visualize actin in lily pollen tubes $2,000
Alenka Lovy

UNIVERSITY OF MASSACHUSETTS

Estados Unidos, 2003

Davis and DeLisle Research Grant Recipient for specialized electron microscopy shadowing device to visualize actin in lily pollen tubes $2,000
Alenka Lovy

TUFTS UNIVERSITY

Estados Unidos, 2010

Shared Instrumentation Grant from NIH-NCRR “Acquisition of a Nikon A1R-A1 Confocal Combined with TIRF” (PI Lovy-Wheeler) $487,867
Alenka Lovy

TUFTS UNIVERSITY

Estados Unidos, 2017

Evaluation of mitochondrial function and mitophagy in PINK1/PARK2 knockout iPSC derivate dopaminergic neurons CNR Pilot Grant $10,000


In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes Ahumada-Castro, Ulises; Bustos, Galdo; Silva-Pavez, Eduardo; Puebla-Huerta, Andrea; Lovy, Alenka; Cardenas, Cesar Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells Cruz, Pablo; Ahumada-Castro, Ulises; Bustos, Galdo; Molgo, Jordi; Sauma, Daniela; Lovy, Alenka; Cardenas, Cesar Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
LFA-1 and Kindlin-3 are necessary for the myosin-dependent movement of SLP-76 microclusters. Eidell, K., Lovy, A., Sylvain, N., Muendlein, H., Ophir, M., Nguyen, K., Seminario, MC., and Stephen C. Bunnell Article JOURNAL OF CELL SCIENCE (2021)
Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival Podunavac, Masa; Mailyan, Artur K.; Jackson, Jeffrey J.; Lovy, Alenka; Farias, Paula; Huerta, Hernan; Molgo, Jordi; Cardenas, Cesar; Zakarian, Armen Article ISI ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival Cardenas, Cesar; Lovy, Alenka; Silva-Pavez, Eduardo; Urra, Felix; Mizzoni, Craig; Ahumada-Castro, Ulises; Bustos, Galdo; Foskett, Kevin J. Article SCIENCE SIGNALING (2020)
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca(2+)Transfer to Mitochondria Lovy, Alenka; Ahumada-Castro, Ulises; Bustos, Galdo; Farias, Paula; Gonzalez-Billault, Christian; Molgo, Jordi; Cardenas, Cesar Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca2+ Transfer to Mitochondria Lovy, Alenka; Ahumada-Castro, Ulises; Bustos, Galdo; Farias, Paula; Gonzalez-Billault, Christian; Molgó, Jordi; Cardenas, Cesar Article FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Complex I and II are required for normal mitochondrial Ca2+ homeostasis Jaña, Fabian; Bustos, Galdo; Rivas, José; Cruz, Pablo; Urra, Felix; Basualto-Alarcón, Carla; Sagredo, Eduardo; Ríos, Melany; Lovy, Alenka; Dong, Zhiwei; Cerda, Oscar; Madesh, Muniswamy; Cárdenas, César Article ISI SCOPUS MITOCHONDRION (2019)
MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells Ahumada-Castro, U; Silva-Pavez, E; Lovy, A; Pardo, E; Molgo, J; Cardenas, C Article ISI SCOPUS AUTOPHAGY (2019)
InsP(3)R, the calcium whisperer: Maintaining mitochondrial function in cancer Lovy, Alenka; Foskett, J. Kevin; Cardenas, Cesar Article WOS-ESCI Molecular and Cellular Oncology (2016)
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria Cárdenas C; Müller M.; McNeal A.; Lovy, A; JaÃ±a F.; Bustos G.; Urra, F.; Smith N.; Molgó J.; Diehl J.A.; Ridky T.W.; Foskett J.K. Article ISI SCOPUS CELL REPORTS (2016)
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria (vol 14, pg 2313, 2016) Cardenas, Cesar; Mueller, Marioly; McNeal, Andrew; Lovy, Alenka; Jana, Fabian; Bustos, Galdo; Urra, Felix; Smith, Natalia; Molgo, Jordi; Diehl, J. Alan; Ridky, Todd W.; Foskett, J. Kevin Article ISI CELL REPORTS (2016)
A Faster, High Resolution, mtPA-GFP-based Mitochondrial Fusion Assay Acquiring Kinetic Data of Multiple Cells in Parallel Using Confocal Microscopy Lovy, Alenka; Molina, Anthony J. A.; Cerqueira, Fernanda M.; Trudeau, Kyle; Shirihai, Orian S. Article ISI JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2012)
Pollen tube growth oscillations and intracellular calcium levels are reversibly modulated by actin polymerization Cardenas, Luis; Lovy-Wheeler, Alenka; Kunkel, Joseph G.; Hepler, Peter K. Article ISI PLANT PHYSIOLOGY (2008)
Differential organelle movement on the actin cytoskeleton in lily pollen tubes Lovy-Wheeler, Alenka; Cardenas, Luis; Kunkel, Joseph G.; Hepler, Peter K. Article ISI CELL MOTILITY AND THE CYTOSKELETON (2007)
Imaging the actin cytoskeleton in growing pollen tubes Wilsen, KL; Lovy-Wheeler, A; Voigt, B; Menzel, D; Kunkel, JG; Hepler, PK Article ISI SEXUAL PLANT REPRODUCTION (2006)
Oscillatory increases in alkalinity anticipate growth and may regulate actin dynamics in pollen tubes of lily Lovy-Wheeler, Alenka; Kunkel, Joseph G.; Allwood, Ellen G.; Hussey, Patrick J.; Hepler, Peter K. Article ISI PLANT CELL (2006)
Actin polymerization promotes the reversal of streaming in the apex of pollen tubes Cardenas, L; Lovy-Wheeler, A; Wilsen, KL; Hepler, PK Article ISI CELL MOTILITY AND THE CYTOSKELETON (2005)
Enhanced fixation reveals the apical cortical fringe of actin filaments as a consistent feature of the pollen tube Lovy-Wheeler, A; Wilsen, KL; Baskin, TI; Hepler, PK Article ISI PLANTA (2005)
Taxol biosynthesis: Differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells Wheeler, AL; Long, RM; Ketchum, REB; Rithner, CD; Williams, RM; Croteau, R Article ISI ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2001)
Activity of Edible Mushrooms Against the Growth of Human T 4 Leukemic Cancer Cells, HeLa Cervical Cancer Cells, and Plasmodium falciparum Lovy, Alenka; Knowles, Barbara; Labbe, Ronald; Nolan, Linda Article Journal of Herbs, Spices & Medicinal Plants (2000)


Calcium and proton gradients and their oscillations in growing pollen tubes. Hepler, PK; Lovy-Wheeler, Alenka; Taiz and Zeiger BookSection (2006)
Ions and Pollen Tube Growth Hepler, Peter; Lovy-Wheeler, Alenka; McKenna, S. T.,; Kunkel, J.G.; Rui Malho BookSection (2006)


Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target Bustos G.; Cruz P.; Lovy A.; Cárdenas C. Review ISI SCOPUS FRONTIERS IN ONCOLOGY (2017)
The Mitochondrial Complex(I) ty of Cancer Urra F.A.; Muñoz F.; Lovy A.; Cárdenas C. Review ISI SCOPUS FRONTIERS IN ONCOLOGY (2017)