Man

Mario Andrés Sanhueza Cubillos

Assistant professor

Universidad Mayor

Santiago, Chile

Líneas de Investigación


Genetic modifiers of neurodegeneration and aging Lipid metabolism in the nervous system Epigenetic regulation of mitochondrial activity

Educación

  •  Engineering in Molecular Biotechnology, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Microbiology, UNIVERSIDAD DE CHILE. Chile, 2008
  •  Biomedical Sciences, UNIVERSITY OF EDINBURGH. Reino Unido, 2015
  •  Engineering in Molecular Biotechnology, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD MAYOR

    Sciences

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Research assistant Full Time

    University of Edinburgh

    Edinburgh, Reino Unido

    2014 - 2015

  •   Research assistant Full Time

    Baylor College of Medicine

    Houston, Estados Unidos

    2009 - 2010

  •   Project Coordinator (INNOVA-CORFO) Full Time

    Universidad de Chile

    Santiago, Chile

    2007 - 2008

  •   Demonstrator - Dynamic Cell 2 Part Time

    University of Edinburgh

    Edimburgo, Reino Unido

    2014 - 2014

  •   Demonstrator Part Time

    Universidad de Chile

    Santiago, Chile

    2005 - 2007

  •   Lecturer - Summer school for high-school students Part Time

    Universidad de Chile

    Santiago, Chile

    2007 - 2008

  •   Postdoctoral fellow Full Time

    Universidad Mayor

    Santiago, Chile

    2016 - 2018

Formación de Capital Humano


• 2020: Thesis Supervisor, Guilherme Gischkow. PhD in Neurobiology, Universidad Mayor.
• 2020: Thesis Supervisor, Sebastián Oyarce. Biotechnology, Universidad Mayor.
• 2020: Thesis Supervisor, Lesley Pow Hing. Biotechnology, Universidad Mayor.
• 2019: Thesis Supervisor, Andrea Lucero & Valeria Santander. Medical technology, Universidad Mayor.
• 2019: Thesis Co-supervisor, Francisco Muñoz. PhD in Neurobiology, Universidad Mayor.
• 2017: Thesis Co-supervisor, Francisco Muñoz. Biotechnology, Universidad Mayor.


Difusión y Transferencia


- "Experimenta, Ciencias con niños”. (CNTV Infantil - TV Educa). Scientific TV Show for kids. 2020.
- Coordinador and organizer of the CIB Seminar series, Universidad Mayor. 2018-2020.
- Professor y coordinator of the course “Animal models in Neurobiology” for High school students. Universidad Mayor. 2017-2018.
- Scientific mentor at “HUB Innovación”, Municipalidad de Providencia, Santiago, Chile. 2018.


Premios y Distinciones

  •   Young Neuroscientist 2017

    Sociedad Chilena de Neurociencias

    Chile, 2017

    Young Neuroscientists of the year 2017. Invited talk at the Annual meeting of Sociedad Chilena de Neurociencias. Recognition at this symposium

  •   PhD Fellowship

    Motor Neurone Disease Association

    Reino Unido, 2011

    Doctoral fellowship from the Motor neurone disease association, United Kingdom.


 

Article (11)

The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging
Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction.
Network analyses reveal novel aspects of ALS pathogenesis.
Gain-of-function mutations in the ALS8 causative gene VAPB have detrimental effects on neurons and muscles.
Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis.
A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.
Molecular characterization of totiviruses in Xanthophyllomyces dendrorhous.
Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.
Polymorphism of viral dsRNA in Xanthophyllomyces dendrorhous strains isolated from different geographic areas.
Occurrence of killer yeast strains in industrial and clinical yeast isolates.

Proyecto (6)

Fortalecimiento de la investigación en neurodegeneración y envejecimiento
Combinación de modelos de pez cebra y Drosophila para resolver la función biológica del gen mab21l2 durante la formación del ojo
The Role Of Axonal Degeneration On The Pathomechanism Of Neurodegenerative Diseases
Geroscience Center for Brain Health and Metabolism
Drosophila as a model system to elucidate the molecular mechanisms underlying amyotrophic lateral sclerosis
IDENTIFICACION Y CARACTERIZACION ESTRUCTURAL Y FUNCIONAL DE VIRUS DEL TIPO dsRNA EN XANTHOPHYLLOMYCES DENDRORORHOUS.

Review (1)

Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
3
Mario Sanhueza

Assistant professor

Universidad Mayor

Santiago, Chile

2
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Natalia Salvadores

investigador postdoctoral

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile