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Mario Andrés Sanhueza Cubillos

Regional Director of Research

Universidad Mayor

Temuco, Chile

Genetic modifiers of neurodegeneration and aging Lipid metabolism in the nervous system Epigenetic regulation of mitochondrial activity

Engineering in Molecular Biotechnology, UNIVERSIDAD DE CHILE. Chile, 2005
Microbiology, UNIVERSIDAD DE CHILE. Chile, 2008
Biomedical Sciences, UNIVERSITY OF EDINBURGH. Reino Unido, 2015
Engineering in Molecular Biotechnology, UNIVERSIDAD DE CHILE. Chile, 2007

Assistant Professor Full Time

UNIVERSIDAD MAYOR

Sciences

Santiago, Chile

2019 - 2021
Regional Director of Research Full Time

UNIVERSIDAD MAYOR

Sciences

Temuco, Chile

2022 - A la fecha

Research assistant Full Time

University of Edinburgh

Edinburgh, Reino Unido

2014 - 2015
Research assistant Full Time

Baylor College of Medicine

Houston, Estados Unidos

2009 - 2010
Project Coordinator (INNOVA-CORFO) Full Time

Universidad de Chile

Santiago, Chile

2007 - 2008
Demonstrator - Dynamic Cell 2 Part Time

University of Edinburgh

Edimburgo, Reino Unido

2014 - 2014
Demonstrator Part Time

Universidad de Chile

Santiago, Chile

2005 - 2007
Lecturer - Summer school for high-school students Part Time

Universidad de Chile

Santiago, Chile

2007 - 2008
Postdoctoral fellow Full Time

Universidad Mayor

Santiago, Chile

2016 - 2018

• 2021: Thesis Supervisor, Catalina Gomez. Biotechnology, Universidad Mayor.
• 2021: Thesis Supervisor, Pablo Jimenez. Biotechnology, Universidad Mayor.
• 2020: Thesis Supervisor, Guilherme Gischkow. PhD in Neurobiology, Universidad Mayor.
• 2020: Thesis Supervisor, Sebastián Oyarce. Biotechnology, Universidad Mayor.
• 2020: Thesis Supervisor, Lesley Pow Hing. Biotechnology, Universidad Mayor.
• 2019: Thesis Supervisor, Andrea Lucero & Valeria Santander. Medical technology, Universidad Mayor.
• 2019: Thesis Co-supervisor, Francisco Muñoz. PhD in Neurobiology, Universidad Mayor.
• 2017: Thesis Co-supervisor, Francisco Muñoz. Biotechnology, Universidad Mayor.

- "Experimenta, Ciencias con niños”. (CNTV Infantil - TV Educa). Scientific TV Show for kids. 2020.
- Coordinador and organizer of the CIB Seminar series, Universidad Mayor. 2018-2020.
- Professor y coordinator of the course “Animal models in Neurobiology” for High school students. Universidad Mayor. 2017-2018.
- Scientific mentor at “HUB Innovación”, Municipalidad de Providencia, Santiago, Chile. 2018.

Young Neuroscientist 2017

Sociedad Chilena de Neurociencias

Chile, 2017

Young Neuroscientists of the year 2017. Invited talk at the Annual meeting of Sociedad Chilena de Neurociencias. Recognition at this symposium
PhD Fellowship

Motor Neurone Disease Association

Reino Unido, 2011

Doctoral fellowship from the Motor neurone disease association, United Kingdom.


The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging Munoz-Carvajal, Francisco; Sanhueza, Mario Article ISI FRONTIERS IN AGING NEUROSCIENCE (2020)
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging Mueller, Marioly; Ahumada-Castro, Ulises; Sanhueza, Mario; Gonzalez-Billault, Christian; Court, Felipe A.; Cardenas, Cesar Article ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2018)
Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction. Sanhueza, Mario; Kubasik-Thayil, Anisha; Pennetta, Giuseppa Article Journal of visualized experiments : JoVE (2016)
Network analyses reveal novel aspects of ALS pathogenesis. Sanhueza, Mario; Chai, Andrea; Smith, Colin; McCray, Brett A; Simpson, T Ian; Taylor, J Paul; Pennetta, Giuseppa Article PLoS genetics (2015)
Gain-of-function mutations in the ALS8 causative gene VAPB have detrimental effects on neurons and muscles. Sanhueza, Mario; Zechini, Luigi; Gillespie, Trudy; Pennetta, Giuseppa Article Biology open (2014)
Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis. Forrest, Stuart; Chai, Andrea; Sanhueza, Mario; Marescotti, Manuela; Parry, Katherine; Georgiev, Atanas; Sahota, Virender; Mendez-Castro, Raquel; Pennetta, Giuseppa Article Human molecular genetics (2013)
A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. Miller, John P; Yates, Bridget E; Al-Ramahi, Ismael; Berman, Ari E; Sanhueza, Mario; Kim, Eugene; de Haro, Maria; DeGiacomo, Francesco; Torcassi, Cameron; Holcomb, Jennifer; Gafni, Juliette; Mooney, Sean D; Botas, Juan; Ellerby, Lisa M; Hughes, Robert E Article PLoS genetics (2012)
Molecular characterization of totiviruses in Xanthophyllomyces dendrorhous. Baeza, Marcelo; Bravo, Natalia; Sanhueza, Mario; Flores, Oriana; Villarreal, Pablo; Cifuentes, Victor Article Virology journal (2012)
Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Miller, John P; Holcomb, Jennifer; Al-Ramahi, Ismael; de Haro, Maria; Gafni, Juliette; Zhang, Ningzhe; Kim, Eugene; Sanhueza, Mario; Torcassi, Cameron; Kwak, Seung; Botas, Juan; Hughes, Robert E; Ellerby, Lisa M Article Neuron (2010)
Polymorphism of viral dsRNA in Xanthophyllomyces dendrorhous strains isolated from different geographic areas. Baeza, Marcelo; Sanhueza, Mario; Flores, Oriana; Oviedo, Vicente; Libkind, Diego; Cifuentes, Víctor Article Virology journal (2009)
Occurrence of killer yeast strains in industrial and clinical yeast isolates. Baeza, Marcelo E; Sanhueza, Mario A; Cifuentes, Víctor H Article Biological research (2008)


Fortalecimiento de la investigación en neurodegeneración y envejecimiento PAI (PAI7718005) Proyecto 2019-2021 Inv. Responsable
Combinación de modelos de pez cebra y Drosophila para resolver la función biológica del gen mab21l2 durante la formación del ojo PCI (14092523-3) Proyecto 2017-2018 Coinvestigador(a)
The Role Of Axonal Degeneration On The Pathomechanism Of Neurodegenerative Diseases FONDECYT (3170577) Proyecto 2017-2018 Inv. Responsable
Geroscience Center for Brain Health and Metabolism FONDAP (15150012) Proyecto 2016-2020 Postdoctorado
Drosophila as a model system to elucidate the molecular mechanisms underlying amyotrophic lateral sclerosis Motor Neurone Disease Association (6231) Proyecto 2011-2014 Tesista
IDENTIFICACION Y CARACTERIZACION ESTRUCTURAL Y FUNCIONAL DE VIRUS DEL TIPO dsRNA EN XANTHOPHYLLOMYCES DENDRORORHOUS. FONDECYT (11060157) Proyecto 2006-2009 Tesista


Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders Salvadores N.; Sanhueza M.; Manque P.; Court F.A. Review ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2017)