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Maria Isabel Behrens Pellegrino

Profesor Titular

Hospital Clínico Universidad de Chile

Santiago, Chile

Biological Mechanisms relating the inverse association between Alzheimer Dementia and cancer. Cell death and cell proliferation. Immune system and neurodegeneration

Doctorado en Ciencias Biológicas, mención Biología Celular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1986
Post doc on Central Nervous System Injury, Postdoctoral fellow. Estados Unidos, 1995
Geriatric Dementia, WASHINGTON UNIVERSITY IN ST. LOUIS. Chile, 2004
Médico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1978

Neurologist Part Time

Hospital Clínico Universidad de Chile

Medicina

Santiago, Chile

2001 - A la fecha
Researcher Full Time

Centro de Estudios Científicos de Santiago

Santiago, Chile

1986 - 1993
Neuróloga Part Time

Hospital Clínico Universidad de Chile

Santiago, Chile

2000 - A la fecha

MD PhD Full Professor Neurology Part Time

Hospital Clínico Universidad de Chile

Santiago, Chile

2001 - A la fecha
MD PhD, Full Professor researcher Part Time

Universidad de Chile, Departamento de Neurociencias

Santiago, Chile

2013 - A la fecha
Neuróloga Part Time

Clínica Alemana

Santiago, Chile

2000 - A la fecha

Dirección de Tesis
a. Magíster en Ciencias Biológicas Mención Neurociencias y Tratornos de la conducta (Neurociencias)

2010-2013 finalizada: Título Tesis: “Validación del instrumento Montreal Cognitive Assessment, versión en español (mMoCA-S) en adultos mayores de Santiago de Chile” Estudiante: Alex Araneda Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte.

2010-2013. finalizada: Astrid Schmied. Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte.Título Tesis: “Caracterización del Tipo de Muerte Celular de Linfocitos de Pacientes con Enfermedad de Alzheimer y Cáncer de Piel”

Co-directora de tesis:
2008-2010 finalizada: Teresa Parrao Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte. En codirección con Dra Marilú Aylwin. Título Tesis: “Sensibilidad olfatoria en pacientes con Parkinson”.

2010- en curso: Sandra Echeverry Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte. En codirección con Dra Marilú Aylwin. Título Tesis: “Prueba de tamizaje: memoria, orientacion y fluidez (mefo), como herramienta diagnóstica para la detección del deterioro cognitivo leve amnésico y no amnésico en la práctica médica”

2013-en curso: Rodrigo Cisneros Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte

b. Doctorado:
Codirectora de tesis:
2011- en curso: Título de la tesis: “Rol de klotho en la Regulación de la Neurogénesis Hipocampal del Adulto” Estudiante: Dr Felipe Salech, estudiante de doctorado en Ciencias Médicas con especialidad en Medicina Interna.Facultad de Medicina Universidad de Chile Sede Norte. En codirección con Dr Andrés Couve.

Docencia Tutorial becados de Neurología y de otras disciplinas en rotación por Unidad de Demencias en el Hospital Clínico Universidad de Chile desde 2001 a la fecha (aprox 3-4 por año).

Academic Excellence Prize 2006

FACULTAD MEDICINA U CHILE

Chile, 2006

To the best publication at the Hospital Clínico Universidad de Chile
“Rodolfo Rencoret Award”

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 1978

to the most outstanding medical student of Universidad Católica de Chile
Academic Excellence

FACULTAD MEDICINA U CHILE

Chile, 2006

To the best published paper of the year in Hospital Clínico Universidad de Chile
Miembro correspondiente de la Academia Chilena de Medicina

ACADEMIA CHILENA DE MEDICINA

Chile, 2021

Participación en las actividades regulares de la Academia Chilena de Medicina, miembro del Comité de Educación Médica y del Comité de selección del Premio Anual de la Investigación Médica.
Premio a la Investigación Médica

ACADEMIA CHILENA DE MEDICINA

Chile, 2019

Premio a la trayectoria de investigación médica


Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations Baez, Sandra; Farina, Francesca R.; Altschuler, Florencia; Ochoa-Gomez, John Fredy; Hernandez, Alfredis Gonzalez; Manfrinati, Luis E. d'Almeida; Olivares, Daniela; Yirikogullari, Harun; Lucas, Alberto Fernandez; Huepe, David; et al. Article ISI NATURE MEDICINE (2024)
Educational disparities in brain health and dementia across Latin America and the United States Baez, Sandra; Cocchi, Rafael; Coronel-Olivero, Carlos; Santamaria Garcia, Hernando; Slachevsky, Andrea; Ibáñez, Agustín Article ISI ALZHEIMERS & DEMENTIA (2024)
Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas Legaz, A., Altschuler. F., Gonzalez-Gomez, R., Hernández, H., Baez, S., Migeot, J., Fittipaldi, S., Medel, V., Maito, MA., Godoy, ME., Moguilner, S., Cruzat, J., Coronel-Oliveros, C., Tagliazuchi, E,, Santamaria Garcia, H., Farina, FR., Reyes, P., Javande Article (2024)
A call for clinical trial globalization in Alzheimer's disease and related dementia Heavener, Anika; Diaz Marante, Juan Pablo; Chen, Yaohua; Admirall-Sanchez, Arianna; Dorsman, Karen A.; Rodriguez-Salgado, Ana M.; Solorzano, Joel; Diversity Disparity Professional I Article ISI ALZHEIMERS & DEMENTIA (2023)
Cancer History Avoids the Increase of Senescence Markers in Peripheral Cells of Amnestic Mild Cognitive Impaired Patients Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study Maito, Marcelo Adrian; Slachevsky, Andrea; Ortiz, Ana L. Sosa; Tagliazuchi, Enzo; Ibáñez, Agustín Article ISI LANCET REGIONAL HEALTH-AMERICAS (2023)
The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing <i>Drosophila</i> brains Rucatti, Guilherme Gischkow; Sanhueza, Mario Article ISI Scientific Reports (2023)
The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds Slachevsky, Andrea; Beherens, Maria Isabel; Funes, Alberto avila; Ibáñez, Agustín Article ISI SCIENTIFIC DATA (2023)
Visual-spatial processing impairment in the occipital-frontal connectivity network at early stages of Alzheimer's disease Brunetti, Enzo; Hafelin, Rodrigo Article ISI FRONTIERS IN AGING NEUROSCIENCE (2023)
Biomarkers for dementia in Latin American countries: Gaps and opportunities Henriquez, Fernando; Slachevsky, Andrea; Ibáñez, Agustín; Ferreira, Sergio T.; Ochoa, John Article ISI ALZHEIMERS & DEMENTIA (2022)
Cancer History Is Associated with Slower Speed of Cognitive Decline in Patients with Amnestic Cognitive Impairment Castillo-Passi, Rolando, I Article ISI JOURNAL OF ALZHEIMERS DISEASE (2022)
Impact of social isolation and coping strategies in older adults with mild cognitive impairment during the covid-19 pandemic: A qualitative study Castillo, Eduardo; Mosquera Amar, Sandra; Rojas, Graciela Article ISI AGING & MENTAL HEALTH (2022)
Neuronal Rubicon Represses Extracellular APP/Amyloid beta Deposition in Alzheimer's Disease Oyarce-Pezoa, Sebastian; Fernanda Hernandez, Maria; Uhrig, Markus; Cornejo, Victor H.; Manque, Patricio A. Article ISI CELLS (2022)
Senescence Markers in Peripheral Blood Mononuclear Cells in Amnestic Mild Cognitive Impairment and Alzheimer's Disease Concha-Cerda, Jorge; Romero-Hernandez, Esteban; Liabeuf, Gianella Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
The Impact of a Yoga-Based Mindfulness Intervention versus Psycho-Educational Session for Older Adults with Mild Cognitive Impairment: The Protocol of a Randomized Controlled Trial Rojas, Graciela; Martinez, Pablo Article ISI International #Journal of Environmental Research and Public Health (2022)
Analyzing Olfactory Neuron Precursors Non-Invasively Isolated through NADH FLIM as a Potential Tool to Study Oxidative Stress in Alzheimer's Disease Gomez-Virgilio, Laura Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Association of Vitamin D Receptor Polymorphisms with Amyloid-β Transporters Expression and Risk of Mild Cognitive Impairment in a Chilean Cohort Delgado, Carolina; Henriquez, Mauricio; Herrera, Luisa Article ISI JOURNAL OF ALZHEIMERS DISEASE (2021)
DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease Matias Benitez, Jose; Isabel Behrens, Maria Article ISI JOURNAL OF ALZHEIMERS DISEASE (2021)
Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes Mendez, Patricio Chrem; Surace, Ezequiel I.; Alaez-Verson, Carmen; Longoria, Erika-Mariana; Tellez, Alberto; Carrillo-Sanchez, Karol; Flores-Lagunes, Luis Leonardo; Sanchez, Victor; Ferreira-Frota, Norberto Anizio; Benevides-Lima, Joyce; et al. Article ISI ALZHEIMERS & DEMENTIA (2021)
The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science Ibáñez, Agustín; Possin, Katherine L.; Sosa Ortiz, Ana Luisa; Avila-Funes, Jose Alberto; Slachevsky, Andrea; Myers, Richard M.; Cochran, J. Nicholas; Brusco, Luis Ignacio; Bruno, Martin A.; Pina-Escudero, Stefanie Danielle; et al. Article ISI FRONTIERS IN NEUROLOGY (2021)
Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease Article ISI FRONTIERS IN AGING NEUROSCIENCE (2020)
The impact of SARS-CoV-2 in dementia across Latin America: A call for an urgent regional plan and coordinated response Ibáñez, Agustín; Kornhuber, Alexander; Slachevsky, Andrea; Lucio Teixeira, Antonio; Mar Meza, Beatriz Marcela; Cano, Carlos; Arias Gonzalez, Carolina; Acosta, Daisy; Matallana, Diana L.; Franca Resende, Elisa De Paula; et al. Article ISI (2020)
Inverse relationship between Alzheimer’s disease and cancer: how immune checkpoints might explain the mechanisms underlying age-related diseases Romero, Cesar Article ISI JOURNAL OF ALZHEIMERS DISEASE (2019)
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus Couve, Andres Article ISI SCOPUS JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)
Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimers Disease Rogers, Nicole K.; Ponce, Daniela P. Article ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2018)
Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimers disease Jose Perez, Maria; Quintanilla, Rodrigo A. Article ISI SCOPUS REDOX BIOLOGY (2018)
Vitamin D Increases A beta 140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients Ponce, DP; Salech, F; Behrens, MI Article ISI SCOPUS CURRENT ALZHEIMER RESEARCH (2018)
Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease Pérez, María J.; Ponce, Daniela P.; Osorio-Fuentealba, Cesar Article ISI SCOPUS Frontiers in Neuroscience (2017)
On the Role of Mining Exposure in Epigenetic Effects in Parkinson's Disease Castillo, Sebastian; Diaz-Grez, Fernando Article ISI SCOPUS NEUROTOXICITY RESEARCH (2017)
PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients Rogers, NK Article ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2017)
Virtual spatial navigation correlates with the moca score in amnestic mild cognitive impairment patients SanMartin, C.; Behrens, M. I. Article ISI JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)
Frizzled-1 receptor regulates adult hippocampal neurogenesis Mardones M.D.; Andaur G.A.; Henriquez J.F.; Salech, F; Behrens, M. I.; couve, a; Inestrosa, N. C. Article ISI SCOPUS MOLECULAR BRAIN (2016)
Validation of the Spanish-language version of the Montreal Cognitive Assessment test in adults older than 60 years Article ISI SCOPUS NEUROLOGIA (2016)
Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia Severity Ponce, DP; Salech, F; Silva, M; Xiong, C.; Roe, CM; Henriquez, M.; Behrens, MI Article ISI SCOPUS CURRENT ALZHEIMER RESEARCH (2014)
Memory, fluency, and orientation: A five-minute screening test for cognitive decline Derio, CD; Bonnet, SG; Ponce, MT; Yanez, AA; Chonchol, AS; Pellegrino, MIB Article ISI SCOPUS Neurologia (2013)
Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer Behrens, M. I.; Silva, M; Salech, F; Merino D.; Sinning, M; Xiong, C. Article ISI SCOPUS Journals of Gerontology - Series A Biological Sciences and Medical Sciences (2012)
Motor pathway excitability in ATP13A2 mutation carriers: A transcranial magnetic stimulation study Zittel S.; Kroeger J.; Bruggemann, N; Ramirez A.; Behrens, M. I.; Gerloff C.; Baumer T.; Klein, C.; Munchau, A Article ISI SCOPUS Parkinsonism and Related Disorders (2012)
Olfactory Deficits and Cognitive Dysfunction in Parkinson's Disease Parrao T, Chana P, Venegas P, Behrens MI, Aylwin ML. Article ISI SCOPUS Neurodegenerative Diseases (2012)
Age-Dependent Increases in Apoptosis/Necrosis Ratios in Human Lymphocytes Exposed to Oxidative Stress Behrens, MI; Silva, M; Schmied, A.; Salech, F; Manzur, H.; Rebolledo R.; Bull, R; Torres V.; Henriquez, M.; Quest, AFG Article ISI SCOPUS Journals of Gerontology - Series A Biological Sciences and Medical Sciences (2011)
Association of Parkinson disease to PARK16 in a Chilean sample. Ramirez, Alfredo; Ziegler, Andreas; Winkler, Susen; Kottwitz, Jan; Giesen, Roland; Díaz-Grez, Fernando; Miranda, Marcelo; Venegas, Pablo; Godoy, Osvaldo Trujillo; Avello, Rodrigo; Behrens, Maria Isabel; Klein, Christine; Segura-Aguilar, Juan; Lohmann, Katja Article Parkinsonism & related disorders (2011)
Cancer linked to Alzheimer disease but not vascular dementia Roe, CM; Fitzpatrick, AL; Xiong, C.; Sieh, W; Kuller, L; Miller, JP; Williams, MM; Kopan, R; Behrens, MI; Morris, JC Article ISI SCOPUS Neurology (2010)
Clinical and Genetic Analysis of a Chilean Family with Early-Onset Autosomal Dominant Alzheimer's Disease Sinning, M; van Rooyen, JP; Venegas-Francke P.; Vasquez, C.; Behrens, MI; Ramirez A. Article ISI SCOPUS Journal of Alzheimer's Disease (2010)
Clinical Spectrum of Kufor-Rakeb Syndrome in the Chilean Kindred with ATP13A2 Mutations Behrens, MI; Bruggemann, N; Chana, P; Venegas P.; Kagi, M; Parrao T.; Orellana P.; Garrido, C.; Hauke, J; Hahnen, E; et al. Article ISI SCOPUS Movement Disorders (2010)
Frequency and Determinants of Poststroke Cognitive Impairment at Three and Twelve Months in Chile Delgado C.; Donoso, A.; Orellana P.; Vasquez, C.; Díaz V.; Behrens, MI Article ISI SCOPUS Dementia and Geriatric Cognitive Disorders (2010)
Impaired Sense of Smell and Color Discrimination in Monogenic and Idiopathic Parkinson's Disease Kertelge, L; Bruggemann, N; Schmidt, A; Tadic, V; Wisse, C; Dankert, S; Drude, L; van der Vegt, J; Siebner, H; Pawlack, H; et al. Article ISI SCOPUS Movement Disorders (2010)
Non-motor symptoms in genetic Parkinson disease. Kasten, M; Kertelge, L; van der Vegt, J; Schmidt, A; Tadic, V; Buhmann, C; Steinlechner S.; Behrens, M. I.; Ramirez A.; Binkofski, F; et al. Article SCOPUS Archives of Neurology (2010)
Recessively Inherited Parkinsonism Effect of ATP13A2 Mutations on the Clinical and Neuroimaging Phenotype Bruggemann, N; Hagenah, J; Reetz, K; Schmidt, A; Kasten, M; Buchmann, I; Eckerle, S; Bahre, M; Munchau, A; Djarmati, A; et al. Article ISI SCOPUS Archives of Neurology (2010)
Structural imaging in the presymptomatic stage of genetically determined parkinsonism Reetz, K; Tadic, V; Kasten, M; Bruggemann, N; Schmidt, A; Hagenah, J; Pramstaller, PP; Ramirez A.; Behrens, MI; Siebner, HR; et al. Article ISI SCOPUS Neurobiology of Disease (2010)
Utilidad de un cuestionario breve dirigido al informante para el diagnóstico temprano de casos de demencia: La versión Chilena del AD8 (AD8-Ch). Munoz, C; Núñez, J.; Flores P.; Behrens, M. I.; Slachevsky, A Article ISI REVISTA MEDICA DE CHILE (2010)
A COMMON BIOLOGICAL MECHANISM IN CANCER AND ALZHEIMERS DISEASE? Behrens, Maria; Lendon, Corinne; Roe, Catherine Article CURRENT ALZHEIMER RESEARCH (2009)
ATP13A2 Variants in Early-Onset Parkinson's Disease Patients and Controls Djarmati, A; Hagenah, J; Reetz, K; Winkler, S; Behrens, MI; Pawlack, H; Lohmann, K; Ramirez A.; Tadic, V; Bruggemann, N; et al. Article ISI SCOPUS MOVEMENT DISORDERS (2009)
Frontotemporal dementia. Review of 63 cases Donoso S, Archibaldo; Figueroa, Cristian, V; Isabel Behrens P, M. Article ISI REVISTA MEDICA DE CHILE (2009)
Ischemia enhances activation by Ca2+ and redox modification of ryanodine receptor channels from rat brain cortex Bull, R; Galvez, J; Sánchez G; Donoso P.; Behrens, MI; Hidalgo C. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2008)
Rendimiento cognitivo en pacientes chilenos con cardiopatía coronaria y factores de riesgo cardiovascular Delgado-Derio C.; Vasquez-Vivar, C; Orellana-Pineda, P; Reccius-Meza, A; Donoso-Sepulveda, A Article WOS Core Collection ISI REVISTA DE NEUROLOGIA (2008)
Afasia progresiva fluente: ¿Una forma de presentación inicial de demencia semántica? González V, Rafael; Vásquez V, Carolina; Venegas F, Pablo; Behrens P, María Isabel; Donoso S, Archibaldo; Massardo V, Teresa Article ISI SCIELO Revista chilena de neuro-psiquiatrï¿½a (2007)
Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex Bull, R; Humeres, A; Behrens, MI; Hidalgo C. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Neuropathologic heterogeneity in HDDD1: A familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation Behrens, MI; Mukherjee, O; Tu, PH; Liscic, RM; Grinberg, LT; Carter D.; Paulsmeyer, K; Taylor-Reinwald, L; Gitcho, M; Norton, JB; et al. Article ISI SCOPUS ALZHEIMER DISEASE ASSOCIATED DISORDERS (2007)
HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin Mukherjee, O; Pastor P; Cairns, NJ; Chakraverty, S; Kauwe, JSK; Shears, S; Behrens, MI; Budde, J; Hinrichs, AL; NORTON, J; et al. Article ISI SCOPUS ANNALS OF NEUROLOGY (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase Ramirez A.; Heimbach, A; Gruendemann, J; Stiller, B; Hampshire, D; Cid, LP; Goebel, I; Mubaidin, AF; Wriekat, AL; Roeper, J; et al. Article ISI SCOPUS NATURE GENETICS (2006)
Migraña con aura: Una mirada molecular a un problema hereditario Ramírez Z, Alfredo; Díaz T, Violeta; Rojas B, Cecilia V; Behrens P, María Isabel; Kubisch, Christian Article ISI SCIELO Revista chilena de neuro-psiquiatrï¿½a (2006)
Alzheimer disease and cancer Roe, CM; Behrens, MI; Xiong, C.; Miller, JP; Morris, JC Article ISI SCOPUS NEUROLOGY (2005)
Clinical variants of Alzheimer disease Donoso, A.; Behrens, MI Article ISI REVISTA MEDICA DE CHILE (2005)
Síndrome de Capgras en enfermedad de Alzheimer: Presentación de 2 casos Donoso S, Archibaldo; Behrens P, María Isabel Article ISI SCIELO Revista chilena de neuro-psiquiatrï¿½a (2005)
Redox regulation of RyR-mediated Ca2+ release in muscle and neurons Hidalgo, Cecilia; Bull, Ricardo; BEHRENS, M. ISABEL; Donoso, Paulina Article SCIELO BIOLOGICAL RESEARCH (2004)
Demencia por carencia de vitamina B12, un caso clínico. Behrens, M. I.; Díaz V.; Vasquez, C.; Donoso, A. Article ISI REVISTA MEDICA DE CHILE (2003)
Deterioro cognitivo leve: seguimiento de 10 casos ARCHIBALDO DONOSO; Mar Behrens; Pablo Venegas Article ISI SCIELO Revista chilena de neuro-psiquiatrï¿½a (2003)
SH oxidation coordinates subunits of rat brain ryanodine receptor channels activated by calcium and ATP Bull, R; Behrens, MI; Alvarez, O Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)
No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo Lendon, CL; Han, BH; Salimi, K; Fagan, AM; Behrens, MI; Muller, MC; Holtzman, DM Article ISI SCOPUS EUROPEAN JOURNAL OF NEUROSCIENCE (2000)
Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation. LOPERA, F; Ardilla, A; Martínez, A.; MADRIGAL, L; Arango Viana, J.C.; Lemere, C; Arango-Lasprilla, J.C.; Hincapie, L.; Arcos-Burgos, M; Ossa, J.E.; et al. Article ISI JAMA (1997)
E280A PS-1 mutation causes Alzheimer’s disease but age of onset is not modified by ApoE alleles. Martínez, A.; Behrens, I.M.; MADRIGAL, L; NORTON, J; Neuman, R.; MYERS, A; BUSFIELD, F; WRAGG, M; ARCOS, M; Arango Viana, J.C.; et al. Article ISI HUMAN MUTATION (1997)
Susceptibility to apoptosis is enhanced in immature cortical neurons Chung, C; Bhattacharyya, T; Choi, DW Article ISI BRAIN RESEARCH (1997)
NADPH-diaphorase-containing striatal or cortical neurons are resistant to apoptosis Behrens, M. I.; Koh, J Article ISI NEUROBIOLOGY OF DISEASE (1996)
Neural control of the expression of a Ca2+-activated K+ channel involved in the induction of myotonic-like characteristics Behrens, M. I.; Vergara C. Article CELLULAR AND MOLECULAR NEUROBIOLOGY (1996)
The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-beta peptide but not aggregated, cytotoxic amyloid-beta peptideThe sec receptor recognizes soluble non-toxic amyloid but not aggregated, cytotoxic amyloid ß peptide Boland, K.; Behrens, M.; Manias, K.; Perlmutter, D.H. Article ISI The Journal of Biological Chemistry (1996)
3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons. Koh, J; Canzoniero, L.M.T.; Sensi, S.L.; Cernansky, C. Article ISI NEUROREPORT (1995)
THE STRUCTURE OF THE PRESENILIN-1 (S182) GENE AND IDENTIFICATION OF 6 NOVEL MUTATIONS IN EARLY-ONSET AD FAMILIES HUTTON, M; FROELICH, S; KARRAN, E; TALBOT, C; CROOK, R; LENDON, C; PRIHAR, G; HE, C; KORENBLAT, K; WRAGG, M; et al. Article ISI NATURE GENETICS (1995)
Possible role of apamin-sensitive K+ channels in myotonic dystrophy. Behrens, M. I.; Jalil, P.; Serani, A; Vergara, F.; Alvarez, 0. Article ISI MUSCLE NERVE (1994)
COLCHICINE ALTERS APAMIN RECEPTORS, ELECTRICAL-ACTIVITY, AND SKELETAL-MUSCLE RELAXATION RAMIREZ, B Article ISI MUSCLE NERVE (1993)
Increase of apamin sensitive K+ channels in rat skeletal muscle induced by colchicine. Possible role in myotonia. Behrens, M. I.; Vergara C. Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (1992)
Potassium channels in developing excitable cells. Behrens, M. I.; Latorre R. Article ISI Current topics in membranes (1991)
Effect of pyridine nucleotides on ATP synthesis and hydrolysis by the mitochondrial ATPase. Baizabal-Aguirre, V.M.; Behrens, M. I.; Gómez-Puyou, A.; Tuena de Gómez-Puyou, M. Article ISI Biochemistry International (1990)
Batrachotoxin modified sodium channels from squid optic nerve in planar lipid bilayers. Ion conduction and gating properties. Behrens, M. I.; Oberhauser, A.; Bezanilla, F; Latorre R. Article ISI The Journal of General Physiology (1989)
Calcium activated potassium channels of large unitary conductance. Behrens, M. I.; Vergara C.; Latorre R. Article ISI BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (1988)
Orthophosphate-pyrophosphate exchange catalyzed by soluble and membrane-bound inorganic pyrophosphatases. Role of H+-gradient. de Meis, L.; Behrens, M. I.; Celis, H.; Romero, I.; Tuena de Gómez-Puyou, M.; Gómez-Puyou, A. Article ISI European Journal of Biochemistry/FEBS (1986)
Contribution of water to free energy of hydrolysis of pyrophosphate de Meis, L.; Behrens, M. I.; Petretski, J.H.; Politi, M.J. Article ISI Biochemistry International (1985)
Synthesis of pyrophosphate by chromatophores of Rhodospirillum Rubrum in the light and by soluble yeast inorganic pyrophosphatase in water-organic solvent mixtures. Behrens, M. I.; de Meis, L. Article ISI European Journal of Biochemistry/FEBS (1985)
AXONAL-TRANSPORT DYSFUNCTION IN DYSTROPHIA MYOTONICA COURT, J; SOZA, MA; RAMIREZ, BU Article ISI ACTA NEUROPATHOLOGICA (1983)
Increase of muscle peroxisomal enzymes and myotonia induced by Nafenopin, a hypolipidemic drug. Behrens, M. I.; Inestrosa, N. C. Article ISI MUSCLE NERVE (1983)
Neural 16 S acetylcholinesterase is solubilized by heparin. Behrens, M. I.; Inestrosa, N. C. Article ISI The biochemical journal (1983)
[New concepts on homeostasis)]. Luco, J.; Behrens, M. I. Article ISI ARCHIVOS DE BIOLOGIA Y MEDICINA EXPERIMENTALES (1980)
Modification of the Rosenblueth phenomenon by blockage of axonal flow. Behrens MI, Fernandez O, Luco JV. Brain Res. 1980 Aug 4;194(2):521-4. Behrens, M. I.; Fernandez, O; Luco, J.V. Article ISI BRAIN RESEARCH (1980)
The Rosenblueth Phenomenon. Behrens, M. I.; Lorenzo, D.; Fernandez, O; Luco, J.V. Article ISI BRAIN RESEARCH (1979)


HDDD with Alzheimer's disease as common comorbidity: A clinicopathologic case report Liscic, RM; Behrens, MI; Morris, JC; Cairns, NJ Abstract ISI JOURNAL OF THE NEUROLOGICAL SCIENCES (2009)
Nigrostriatal impairment in heterozygous ATP13A2 mutation carriers Bruggemann, N; Schmidt, A; Behrens, MI; Ramirez A.; van der Vegt, J; Djarmati, A; Siebner, H; Binkofski, F; Bahre, M; Hagenah, J; et al. Abstract ISI JOURNAL OF NEURAL TRANSMISSION (2009)
Frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation in two kindreds Liscic, RM; Behrens, MI; Mukherjee, O; Tu, PH; Chakraverty, S; Norton, JB; GOATE, A; Morris, JC; Cairns, NJ Abstract ISI EUROPEAN JOURNAL OF NEUROLOGY (2007)
Regulation of single RyR channels from brain by endogenous modulators Bull, R; Finkelstein, J; Maass, R.; Behrens, MI; Hidalgo C. Abstract ISI PLACENTA (2006)
Functional evaluation of Stroke patients in Chile: Three years follow up Díaz V.; Rodriguez, C; Behrens, MI Abstract ISI JOURNAL OF THE NEUROLOGICAL SCIENCES (2005)
Obesity as a stroke risk factor in Chile: a case-control study Díaz V.; Pastene, J; Behrens, MI Abstract ISI JOURNAL OF THE NEUROLOGICAL SCIENCES (2005)
Co-occurrence of dementia of the Alzheimer's type and cancer Roe, CM; Behrens, MI; Xiong, CJ; Miller, JP; Morris, JC Abstract ISI NEUROBIOLOGY OF AGING (2004)


Demencia por déficit de vitamina B12: Caso clínico Behrens P, María Isabel; Díaz T, Violeta; Vásquez V, Carolina; Donoso S, Archibaldo CaseReport ISI SCIELO REVISTA MEDICA DE CHILE (2003)


Modulation of ryanodine receptor channels from rat brain cortex in lipid bilayers Behrens, MI; Bull, R ConferencePaper ISI PUMPS, TRANSPORTERS, AND ION CHANNELS: STUDIES ON THEIR STRUCTURE, FUNCTION, AND CELL BIOLOGY (2005)


Is there a link between dementia and cancer? Behrens, M. I.; Quest A.F. Editorial SCOPUS Aging Health (2010)
Guías Clínicas de Diagnóstico y Tratamiento de las Demencias Behrens, Maria Isabel; Slachevsky, Andrea Editorial SCIELO Revista chilena de neuro-psiquiatrï¿½a (2007)


AD and cancer Epidemiology makes for strange bedfellows Roe, C.M.; Behrens, M.I. EditorialMaterial ISI SCOPUS Neurology (2013)


Association of Parkinson disease to PARK16 in a Chilean sample Ramirez A.; Ziegler, A; Winkler, S; Kottwitz, J.; Giesen R.; Diaz-Grez, F; Miranda, M; Venegas P.; Godoy, OT; Avello R.; et al. Letter ISI SCOPUS Parkinsonism and Related Disorders (2011)
Eye Movement Disorders in ATP13A2 Mutation Carriers (PARK9) Machner, B; Sprenger, A; Behrens, MI; Ramirez A.; Bruggemann, N; Klein, C.; Helmchen, C Letter ISI SCOPUS Movement Disorders (2010)
Utilidad de un cuestionario breve dirigido al informante para el diagnóstico temprano de casos de demencia: La versión Chilena del AD8 (AD8-Ch) Muñoz, Carlos; Núñez, Javier; Flores, Patricia; Behrens P, María Isabel; Slachevsky, Andrea Letter SCIELO REVISTA MEDICA DE CHILE (2010)


Genetics of Alzheimer's Disease and Related Dementias in Latin America Jennifer S. Yokoyama Proyecto (2022)
Analizador HD-X SIMOA®️: fortalecimiento de la investigación traslacional mediante la detección de biomarcadores utilizando tecnología ultrasensible y automatizada" Proyecto Fondequip. (2021)
Multi-partner Consortium for Dementia Research in Latin America Victor Valcour Proyecto (2020)
Red de investigación traslacional en envejecimiento saludable=> Estudio de biomarcadores en “súper ancianos” Vicerrectoría de Investigación y Desarrollo (VID) Universidad de Chile (N° URC-036/17) Proyecto 2017-2019 Inv. Responsable
Cellular senescence and senescence-associated secretion phenotype (SASP) involvement in the inverse association between Alzheimer disease and cancer FONDECYT (1151297) Proyecto 2015-2019 Inv. Responsable
Defective calcium/redox signaling and anomalous electrical brain activity in rats injected with amyloid beta oligomers=> functional and behavioral correlates with Alzheimer ́s patients FONDECYT (1150736) Proyecto 2015-2019 Coinvestigador(a)
ESTUDIO DE UN NUEVO BIOMARCADOR PLASMATICO PARA LA DETECCION DE DETERIORO COGNITIVO LEVE. FONDECYT (3140467) Proyecto 2013-2017 Inv. Patrocinante
Asociación Inversa entre cáncer y Alzheimer. Un mecanismo biológico común Oficina Apoyo a la Investigación Clínica (OAIC) (No 119-05) Proyecto 2005-2007 Inv. Principal


Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research Montero, Lucia; Torralva, Teresa; Longoria-Ibarrola, Erika Mariana; Giraldo-Chica, Margarita; Hardi, Angela; Maestre, Gladys E.; Doldan, Celeste; Santana-Trinidad, Dhara Angelina; Lopez-Contreras, Ricardo Review ISI FRONTIERS IN NEUROLOGY (2021)
Default mode network and Alzheimer's disease Vergara, F.; Behrens, MI Review ISI REVISTA MEDICA DE CHILE (2013)
Red neural por defecto y enfermedad de Alzheimer Vergara E, Fernando; Behrens, Maria Isabel Review SCIELO SCOPUS REVISTA MEDICA DE CHILE (2013)
Nonmotor Symptoms in Genetic Parkinson Disease Kasten, M; Kertelge, L; Braggemann, N; van der Vegt, J; Schmidt, A; Tadic, V; Buhmann, C; Steinlechner S.; Behrens, MI; Ramirez A.; et al. Review ISI ARCHIVES OF NEUROLOGY (2010)
Cien años de la enfermedad de Alzheimer: La inmunoterapia ¿una esperanza? Behrens P, María Isabel; Vergara E, Fernando Review SCIELO REVISTA MEDICA DE CHILE (2007)
One hundred years of Alzheimer's disease. Immunotherapy a hope? Behrens, MI; Vergara, F. Review ISI REVISTA MEDICA DE CHILE (2007)
Redox regulation of RyR-mediated Ca2+ release in muscle neurons Hidalgo C.; Bull, R; Behrens, MI; Donoso P. Review ISI BIOLOGICAL RESEARCH (2004)

Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

CAROLINA DELGADO

ASSOCIATE PROFESSOR

NEUROLOGÍA y neurocirugía

HOSPITAL CLINICO UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

Agustin Ibanez

Profesor Titular

Psicologia

Universidad Adolfo Ibánez

Santiago, Chile

Cristian Garrido

Coordinador Resonancia Magnetica

Radiologia

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE - CENTRO DE IMAGENOLOGÍA

Santiago, Chile

René Vidal

Profesor Asociado

Universidad Mayor

Santiago, Chile

Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Paola Murgas

Profesor Investigador Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Puerto Montt, Chile

Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

Gorka Navarrete

Adjunct Professor

Psychology

Universidad Adolfo Ibánez

Santiago, Chile

Maria Aylwin

Associate Professor

Universidad de Talca

Talca, Chile

120

Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

Christian Gonzalez

Full Professor

Biologia

Universidad de Chile

Santiago, Chile

Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Álvaro Langer

Investigador

Instituto Milenio para la Investigación en Depresión y Personalidad (MIDAP)

Rodrigo Vergara

Investigador

Psicología

Universidad San Sebastián

Valdivia, Chile

Patricia Muñoz

Co-investigador

Universidad de Chile

SANTIAGO, Chile

Melissa Calegaro

Principal Investigator, head lab

Research Vice Presidency

Universidad Mayor

Santiago, Chile

Rodrigo Montefusco

Profesor Auxiliar

Instituto de Aparato Locomotor y Rehabilitación

Universidad Austral de Chile

Valdivia, Chile

Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

Natalia Salvadores

Profesora Asistente

Centro de Resiliencia, Adaptación y Mitigación

Universidad Mayor de Chile

Temuco, Chile

Maryam Farhang

FONDECYT POSTDOCTORADO 2019, N Proyeto 3190275

ENFERMERIA

Universidad de Las Américas

Santiago, Chile

Alejandro Luarte

Profesor Investigador

Neurociencias

Universidad de Los Andes

santiago, Chile

Carol San Martín

Profesora Asistente

Neurología y Neurocirugía

Universidad de Chile

Santiago, Chile

Pedro Chana Cuevas

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

Marcelo Miranda

Neurólogo

Neurología

CLINICA LAS CONDES

Santiago, Chile

Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Iván Plaza

Assistant Professor

Medical Technology

Universidad de Chile

Santiago, Chile

Daniela Ponce

Coordinadora de investigación

Universidad de Chile

Santiago, Chile

Nicole Rogers

Instructora

Universidad de Chile

Santiago, Chile

Rodrigo Santibáñez

Behavioral Neurologist

Neurology

Pontificia Universidad Católica de Chile

Santiago, Chile

Pavel Prado

Lead Researcher

Universidad Adolfo Ibáñez

Latin American Brain Health Institute (BrainLat)

Santiago de Chile, Chile

Fernando Henriquez

Investigador Asociado

Departamento de Fisiopatologia, Facultad de Medicina

Universidad de Chile

Santiago , Chile

Mariana Sinning

Medico Staff

Neurología Psiquiatria y Oncología

Clinica Alemana Santiago

Santiago, Chile

Mónica Silva

Lab Manager

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

Felix Diaz

TERESA PARRAO

Instructor

Facultad de Psicologia

Universidad Alberto Hurtado

Santiago, Chile

Barbara Bruna

Postdoctoral Researcher

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

Adolfo García

Investigador Asociado

Facultad de Humanidades

Universidad de Santiago de Chile

Santiago de Chile, Chile

ALEXIS HUMERES

DIRECTOR

MORFOFUNCIÓN

Universidad Diego Portales

SANTIAGO, Chile

Wileidy Gómez

Postdoctorado

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Hachi Manzur

Neurólogo de Adultos

Neurología

Hospital Clínico de la Universidad de Chile

Independencia, Chile

Felipe Grunenwald

Postdoctoral Researcher

CIIB

Universidad de Los Andes

santiago, Chile

Carlos Chacon

Asistente de Investigación

Impact

Universidad de Los Andes

Santiago, Chile

Rolando Rebolledo

Cirujano

Servicio de Cirugía

Hospital Dr. Sótero del Río

Santiago, Chile

Daniela Castillo

Estudiante de doctorado en Biotecnología

Biológicas

Universidad Andrés Bello

Santiago , Chile

sandra espinoza

asistente de investigacion

Laboratorio Neuroinmunologia

Fundacion Ciencias para la Vida/Universidad San Sebastian

Santiago, Chile

Maria Isabel Behrens Pellegrino

Líneas de Investigación

Educación

Doctorado en Ciencias Biológicas, mención Biología Celular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1986

Post doc on Central Nervous System Injury, Postdoctoral fellow. Estados Unidos, 1995

Geriatric Dementia, WASHINGTON UNIVERSITY IN ST. LOUIS. Chile, 2004

Médico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1978

Experiencia Académica

Neurologist Part Time

Researcher Full Time

Neuróloga Part Time

Experiencia Profesional

MD PhD Full Professor Neurology Part Time

MD PhD, Full Professor researcher Part Time

Neuróloga Part Time

Formación de Capital Humano

Premios y Distinciones

Academic Excellence Prize 2006

“Rodolfo Rencoret Award”

Academic Excellence

Miembro correspondiente de la Academia Chilena de Medicina

Premio a la Investigación Médica

Article (92)

Abstract (7)

CaseReport (1)

ConferencePaper (1)

Editorial (2)

EditorialMaterial (1)

Letter (3)

Proyecto (8)

Red de investigación traslacional en envejecimiento saludable=> Estudio de biomarcadores en “súper ancianos”

Cellular senescence and senescence-associated secretion phenotype (SASP) involvement in the inverse association between Alzheimer disease and cancer

Defective calcium/redox signaling and anomalous electrical brain activity in rats injected with amyloid beta oligomers=> functional and behavioral correlates with Alzheimer &#769;s patients

ESTUDIO DE UN NUEVO BIOMARCADOR PLASMATICO PARA LA DETECCION DE DETERIORO COGNITIVO LEVE.

Asociación Inversa entre cáncer y Alzheimer. Un mecanismo biológico común

Review (7)

Defective calcium/redox signaling and anomalous electrical brain activity in rats injected with amyloid beta oligomers=> functional and behavioral correlates with Alzheimer ́s patients