Man

Maria Isabel Behrens Pellegrino

Profesor Titular

Hospital Clínico Universidad de Chile

Santiago, Chile

Líneas de Investigación


Biological Mechanisms relating the inverse association between Alzheimer Dementia and cancer. Cell death and cell proliferation. Immune system and neurodegeneration

Educación

  •  Ciencias Biológicas, mención Biologia Celular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1986
  •  Post doc on Central Nervous System Injury, Postdoctoral fellow. Estados Unidos, 1995
  •  Geriatric Dementia, WASHINGTON UNIVERSITY IN ST. LOUIS. Chile, 2004
  •  Médico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1978

Experiencia Académica

  •   Neurologist Part Time

    Hospital Clínico Universidad de Chile

    Medicina

    Santiago, Chile

    2001 - A la fecha

  •   Researcher Full Time

    Centro de Estudios Científicos de Santiago

    Santiago, Chile

    1986 - 1993

  •   Neuróloga Part Time

    Hospital Clínico Universidad de Chile

    Santiago, Chile

    2000 - A la fecha

Experiencia Profesional

  •   MD PhD Full Professor Neurology Part Time

    Hospital Clínico Universidad de Chile

    Santiago, Chile

    2001 - A la fecha

  •   MD PhD, Full Professor researcher Part Time

    Universidad de Chile, Departamento de Neurociencias

    Santiago, Chile

    2013 - A la fecha

  •   Neuróloga Part Time

    Clínica Alemana

    Santiago, Chile

    2000 - A la fecha

Formación de Capital Humano


Dirección de Tesis
a. Magíster en Ciencias Biológicas Mención Neurociencias y Tratornos de la conducta (Neurociencias)

2010-2013 finalizada: Título Tesis: “Validación del instrumento Montreal Cognitive Assessment, versión en español (mMoCA-S) en adultos mayores de Santiago de Chile” Estudiante: Alex Araneda Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte.

2010-2013. finalizada: Astrid Schmied. Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte.Título Tesis: “Caracterización del Tipo de Muerte Celular de Linfocitos de Pacientes con Enfermedad de Alzheimer y Cáncer de Piel”

Co-directora de tesis:
2008-2010 finalizada: Teresa Parrao Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte. En codirección con Dra Marilú Aylwin. Título Tesis: “Sensibilidad olfatoria en pacientes con Parkinson”.

2010- en curso: Sandra Echeverry Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte. En codirección con Dra Marilú Aylwin. Título Tesis: “Prueba de tamizaje: memoria, orientacion y fluidez (mefo), como herramienta diagnóstica para la detección del deterioro cognitivo leve amnésico y no amnésico en la práctica médica”

2013-en curso: Rodrigo Cisneros Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte

b. Doctorado:
Codirectora de tesis:
2011- en curso: Título de la tesis: “Rol de klotho en la Regulación de la Neurogénesis Hipocampal del Adulto” Estudiante: Dr Felipe Salech, estudiante de doctorado en Ciencias Médicas con especialidad en Medicina Interna.Facultad de Medicina Universidad de Chile Sede Norte. En codirección con Dr Andrés Couve.

Docencia Tutorial becados de Neurología y de otras disciplinas en rotación por Unidad de Demencias en el Hospital Clínico Universidad de Chile desde 2001 a la fecha (aprox 3-4 por año).


Premios y Distinciones

  •   Academic Excellence Prize 2006

    FACULTAD MEDICINA U CHILE

    Chile, 2006

    To the best publication at the Hospital Clínico Universidad de Chile

  •   “Rodolfo Rencoret Award”

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1978

    to the most outstanding medical student of Universidad Católica de Chile

  •   Academic Excellence

    FACULTAD MEDICINA U CHILE

    Chile, 2006

    To the best published paper of the year in Hospital Clínico Universidad de Chile


 

Article (70)

Inverse relationship between Alzheimer’s disease and cancer: how immune checkpoints might explain the mechanisms underlying age-related diseases
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus
Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimers Disease
Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimers disease
Vitamin D Increases A beta 140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients
Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease
On the Role of Mining Exposure in Epigenetic Effects in Parkinson's Disease
PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients
Frizzled-1 receptor regulates adult hippocampal neurogenesis
Validation of the Spanish-language version of the Montreal Cognitive Assessment test in adults older than 60 years
Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia Severity
Memory, fluency, and orientation: A five-minute screening test for cognitive decline
Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer
Motor pathway excitability in ATP13A2 mutation carriers: A transcranial magnetic stimulation study
Olfactory Deficits and Cognitive Dysfunction in Parkinson's Disease
Age-Dependent Increases in Apoptosis/Necrosis Ratios in Human Lymphocytes Exposed to Oxidative Stress
Association of Parkinson disease to PARK16 in a Chilean cohort
Cancer Inversely Linked to Alzheimer’s Disease but not Vascular Dementia: The Cardiovascular Health Study.
Cancer linked to Alzheimer disease but not vascular dementia
Clinical and genetic analysis of a Chilean family with early-onset autosomal dominant Alzheimer Disease
Clinical Spectrum of Kufor-Rakeb Syndrome in the Chilean Kindred with ATP13A2 Mutations
Frequency and Determinants of Poststroke Cognitive Impairment at Three and Twelve Months in Chile
Impaired Sense of Smell and Color Discrimination in Monogenic and Idiopathic Parkinson's Disease
Non-motor symptoms in genetic Parkinson disease.
Recessively Inherited Parkinsonism Effect of ATP13A2 Mutations on the Clinical and Neuroimaging Phenotype
Structural imaging in the presymptomatic stage of genetically determined parkinsonism
Utilidad de un cuestionario breve dirigido al informante para el diagnóstico temprano de casos de demencia: La versión Chilena del AD8 (AD8-Ch).
A COMMON BIOLOGICAL MECHANISM IN CANCER AND ALZHEIMERS DISEASE?
ATP13A2 Variants in Early-Onset Parkinson's Disease Patients and Controls
Demencia frontotemporal: experiencia clinica.
Ischemia enhances activation by Ca2+ and redox modification of ryanodine receptor channels from rat brain cortex
Rendimiento cognitivo en pacientes chilenos con cardiopatía coronaria y factores de riesgo cardiovascular
Afasia progresiva fluente: ¿una forma de presentación inicial de demencia semántica? Fluent progressive aphasia: a form of inicial presentation of semantic dementia?
Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex
Neuropathologic heterogeneity in HDDD1: A familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation
HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
Migraña con aura: Una mirada molecular a un problema hereditario.
Alzheimer’s Disease and Cancer.
Síndrome de Capgras en enfermedad de Alzheimer: presentación de 2 casos.
Variabilidad y variantes en la enfermedad de Alzheimer.
Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
Demencia por carencia de vitamina B12, un caso clínico.
Mild cognitive impairment: Follow-up of ten patients Deterioro cognitivo leve: Seguimiento de 10 casos
SH oxidation coordinates subunits of rat brain ryanodine receptor channels activated by calcium and ATP
No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischemia in vivo.
Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation.
E280A PS-1 mutation causes Alzheimer’s disease but age of onset is not modified by ApoE alleles.
Susceptibility to apoptosis is enhanced in immature cortical neurons.
NADPH-diaphorase-containing striatal or cortical neurons are resistant to apoptosis
Neural control of the expression of a Ca2+-activated K+ channel involved in the induction of myotonic-like characteristics
The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-beta peptide but not aggregated, cytotoxic amyloid-beta peptideThe sec receptor recognizes soluble non-toxic amyloid but not aggregated, cytotoxic amyloid ß peptide
3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons.
The structure of Presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families.
Possible role of apamin-sensitive K+ channels in myotonic dystrophy.
COLCHICINE ALTERS APAMIN RECEPTORS, ELECTRICAL-ACTIVITY, AND SKELETAL-MUSCLE RELAXATION
Increase of apamin sensitive K+ channels in rat skeletal muscle induced by colchicine. Possible role in myotonia.
Potassium channels in developing excitable cells.
Effect of pyridine nucleotides on ATP synthesis and hydrolysis by the mitochondrial ATPase.
Batrachotoxin modified sodium channels from squid optic nerve in planar lipid bilayers. Ion conduction and gating properties.
Calcium activated potassium channels of large unitary conductance.
Orthophosphate-pyrophosphate exchange catalyzed by soluble and membrane-bound inorganic pyrophosphatases. Role of H+-gradient.
Contribution of water to free energy of hydrolysis of pyrophosphate
Synthesis of pyrophosphate by chromatophores of Rhodospirillum Rubrum in the light and by soluble yeast inorganic pyrophosphatase in water-organic solvent mixtures.
Axonal transport dysfunction in Dystrophia Myotonica.
Increase of muscle peroxisomal enzymes and myotonia induced by Nafenopin, a hypolipidemic drug.
Neural 16 S acetylcholinesterase is solubilized by heparin.
[New concepts on homeostasis)].
Modification of the Rosenblueth phenomenon by blockage of axonal flow. Behrens MI, Fernandez O, Luco JV. Brain Res. 1980 Aug 4;194(2):521-4.
The Rosenblueth Phenomenon.

CaseReport (1)

Demencia por déficit de vitamina B12: Caso clínico

Editorial (2)

Is there a link between dementia and cancer?
Guías Clínicas de Diagnóstico y Tratamiento de las Demencias

EditorialMaterial (1)

AD and cancer Epidemiology makes for strange bedfellows

Letter (2)

Eye Movement Disorders in ATP13A2 Mutation Carriers (PARK9)
Utilidad de un cuestionario breve dirigido al informante para el diagnóstico temprano de casos de demencia: La versión Chilena del AD8 (AD8-Ch)

Review (2)

Red neural por defecto y enfermedad de Alzheimer
Cien años de la enfermedad de Alzheimer: La inmunoterapia ¿una esperanza?
82
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

7
Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

5
CAROLINA DELGADO

ASSOCIATE PROFESSOR

NEUROLOGÍA y neurocirugía

HOSPITAL CLINICO UNIVERSIDAD DE CHILE

SANTIAGO, Chile

5
Daniela Ponce

Coordinadora de investigación

Universidad de Chile

Santiago, Chile

3
Nicole Rogers

Instructora

Universidad de Chile

Santiago, Chile

3
Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

2
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

2
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

2
TERESA PARRAO

Instructor

Facultad de Psicologia

Universidad Alberto Hurtado

Santiago, Chile

2
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

2
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Pedro Chana

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

2
Mónica Silva

Lab Manager

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

1
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mariana Sinning

Medico Staff

Neurología Psiquiatria y Oncología

Clinica Alemana Santiago

Santiago, Chile

1
Maria Aylwin

Associate Professor

Universidad de Talca

Talca, Chile

1
Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

1
Patricia Muñoz

Co-investigador

Universidad de Chile

SANTIAGO, Chile

1
ALEXIS HUMERES

DIRECTOR

MORFOFUNCIÓN

Universidad Diego Portales

SANTIAGO, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Hachi Manzur

Neurólogo de Adultos

Red de Salud UC Christus

Santiago, Chile

1
Cristian Garrido

Coordinador Resonancia Magnetica

Radiologia

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE - CENTRO DE IMAGENOLOGÍA

Santiago, Chile

1
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile