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Maria Isabel Behrens Pellegrino

Profesor Titular

Hospital Clínico Universidad de Chile

Santiago, Chile

Biological Mechanisms relating the inverse association between Alzheimer Dementia and cancer. Cell death and cell proliferation. Immune system and neurodegeneration

Ciencias Biológicas, mención Biologia Celular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1986
Post doc on Central Nervous System Injury, Postdoctoral fellow. Estados Unidos, 1995
Geriatric Dementia, WASHINGTON UNIVERSITY IN ST. LOUIS. Chile, 2004
Médico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1978

Neurologist Part Time

Hospital Clínico Universidad de Chile

Medicina

Santiago, Chile

2001 - A la fecha
Researcher Full Time

Centro de Estudios Científicos de Santiago

Santiago, Chile

1986 - 1993
Neuróloga Part Time

Hospital Clínico Universidad de Chile

Santiago, Chile

2000 - A la fecha

MD PhD Full Professor Neurology Part Time

Hospital Clínico Universidad de Chile

Santiago, Chile

2001 - A la fecha
MD PhD, Full Professor researcher Part Time

Universidad de Chile, Departamento de Neurociencias

Santiago, Chile

2013 - A la fecha
Neuróloga Part Time

Clínica Alemana

Santiago, Chile

2000 - A la fecha

Dirección de Tesis
a. Magíster en Ciencias Biológicas Mención Neurociencias y Tratornos de la conducta (Neurociencias)

2010-2013 finalizada: Título Tesis: “Validación del instrumento Montreal Cognitive Assessment, versión en español (mMoCA-S) en adultos mayores de Santiago de Chile” Estudiante: Alex Araneda Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte.

2010-2013. finalizada: Astrid Schmied. Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte.Título Tesis: “Caracterización del Tipo de Muerte Celular de Linfocitos de Pacientes con Enfermedad de Alzheimer y Cáncer de Piel”

Co-directora de tesis:
2008-2010 finalizada: Teresa Parrao Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte. En codirección con Dra Marilú Aylwin. Título Tesis: “Sensibilidad olfatoria en pacientes con Parkinson”.

2010- en curso: Sandra Echeverry Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte. En codirección con Dra Marilú Aylwin. Título Tesis: “Prueba de tamizaje: memoria, orientacion y fluidez (mefo), como herramienta diagnóstica para la detección del deterioro cognitivo leve amnésico y no amnésico en la práctica médica”

2013-en curso: Rodrigo Cisneros Magíster Neurociencias Facultad de Medicina Universidad de Chile Sede Norte

b. Doctorado:
Codirectora de tesis:
2011- en curso: Título de la tesis: “Rol de klotho en la Regulación de la Neurogénesis Hipocampal del Adulto” Estudiante: Dr Felipe Salech, estudiante de doctorado en Ciencias Médicas con especialidad en Medicina Interna.Facultad de Medicina Universidad de Chile Sede Norte. En codirección con Dr Andrés Couve.

Docencia Tutorial becados de Neurología y de otras disciplinas en rotación por Unidad de Demencias en el Hospital Clínico Universidad de Chile desde 2001 a la fecha (aprox 3-4 por año).

Academic Excellence Prize 2006

FACULTAD MEDICINA U CHILE

Chile, 2006

To the best publication at the Hospital Clínico Universidad de Chile
“Rodolfo Rencoret Award”

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 1978

to the most outstanding medical student of Universidad Católica de Chile
Academic Excellence

FACULTAD MEDICINA U CHILE

Chile, 2006

To the best published paper of the year in Hospital Clínico Universidad de Chile


Inverse relationship between Alzheimer’s disease and cancer: how immune checkpoints might explain the mechanisms underlying age-related diseases Rogers, Nicole K.; Romero, Cesar; SanMartin Carol D.; Ponce, Daniela P; Salech, Felipe; Gleisner, Alejandra; Tempio, Fabian I.; Behrens, Maria I. Article ISI JOURNAL OF ALZHEIMERS DISEASE (2019)
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus Salech, Felipe; Varela-Nallar, Lorena; Arredondo, Sebastian B.; Bustamante, Daniel B.; Andaur, Gabriela A.; Cisneros, Rodrigo; Ponce, Daniela P.; Ayala, Patricia; Inestrosa, Nibaldo C.; Valdes, Jose L.; Behrens, Maria I.; Couve, Andres Article ISI SCOPUS JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)
Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimers Disease Behrens, Maria I.; Rogers, Nicole K.; Salech, Felipe; Henriquez, Mauricio; SanMartin, Carol D.; Ponce, Daniela P. Article ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2018)
Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimers disease Jose Perez, Maria; Ponce, Daniela P.; Aranguiz, Alejandra; Behrens, Maria I.; Quintanilla, Rodrigo A. Article ISI SCOPUS REDOX BIOLOGY (2018)
Vitamin D Increases A beta 140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients SanMartin, CD; Henriquez, M; Chacon, C; Ponce, DP; Salech, F; Rogers, NK; Behrens, MI Article ISI SCOPUS CURRENT ALZHEIMER RESEARCH (2018)
Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease Pérez, María J.; Ponce, Daniela P.; Osorio-Fuentealba, Cesar; Behrens, Maria I.; Quintanilla, Rodrigo A. Article ISI SCOPUS Frontiers in Neuroscience (2017)
On the Role of Mining Exposure in Epigenetic Effects in Parkinson's Disease Castillo, Sebastian; Muñoz, Patricia; Behrens, María Isabel; Diaz-Grez, Fernando; Segura-Aguilar, Juan Article ISI SCOPUS NEUROTOXICITY RESEARCH (2017)
PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients Salech, F; Ponce, DP; SanMartin, CD; Rogers, NK; Chacon, C; Henriquez, M; Behrens, MI Article ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2017)
Frizzled-1 receptor regulates adult hippocampal neurogenesis Mardones M.D.; Andaur G.A.; Varas-Godoy, M; Henriquez J.F.; Salech, F; Behrens, M. I.; couve, a; Inestrosa, N. C.; Varela-Nallar L. Article ISI SCOPUS MOLECULAR BRAIN (2016)
Validation of the Spanish-language version of the Montreal Cognitive Assessment test in adults older than 60 years Delgado C.; Araneda A.; Behrens M.I. Article ISI SCOPUS NEUROLOGIA (2016)
Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia Severity Ponce, Daniela P.; Salech, Felipe; Silva, Mónica; Xiong, C.; Roe, Catherine M.; Henriquez, Mauricio; Quest, A.F.G.; Behrens MI. Article CURRENT ALZHEIMER RESEARCH (2014)
Memory, fluency, and orientation: A five-minute screening test for cognitive decline Derio, CD; Bonnet, SG; Ponce, MT; Yanez, AA; Chonchol, AS; Pellegrino, MIB Article ISI SCOPUS Neurologia (2013)
Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer Behrens, M. I.; Silva M.; Salech, F; Ponce D.P.; Merino D.; Sinning, M; Xiong, C.; Roe C.M.; Quest, A.F.G. Article ISI SCOPUS Journals of Gerontology - Series A Biological Sciences and Medical Sciences (2012)
Motor pathway excitability in ATP13A2 mutation carriers: A transcranial magnetic stimulation study Zittel S.; Kroeger J.; van der Vegt J.P.M.; Siebner, H.R.; Bruggemann, N; Ramirez A.; Behrens, M. I.; Gerloff C.; Baumer T.; Klein, C.; Munchau, A Article ISI SCOPUS Parkinsonism and Related Disorders (2012)
Olfactory Deficits and Cognitive Dysfunction in Parkinson's Disease Parrao T, Chana P, Venegas P, Behrens MI, Aylwin ML. Article ISI SCOPUS Neurodegenerative Diseases (2012)
Age-Dependent Increases in Apoptosis/Necrosis Ratios in Human Lymphocytes Exposed to Oxidative Stress Behrens, MI; Silva M.; Schmied, A.; Salech, F; Manzur, H.; Rebolledo R.; Bull, R; Torres V.; Henríquez M; Quest, AFG Article ISI SCOPUS Journals of Gerontology - Series A Biological Sciences and Medical Sciences (2011)
Association of Parkinson disease to PARK16 in a Chilean cohort Ramirez A.; Ziegler A.; Winkler, S; Kottwitz, J.; Giesen R.; Diaz-Grez, F; Miranda M.; Venegas, P.; Trujillo-Godoy, O; Rodrigo Avello, R.; Behrens M.I.; Klein, C; Segura-Aguilar, J; Lohmann, K Article ISI Parkinsonism Relat Disord (2011)
Cancer Inversely Linked to Alzheimer’s Disease but not Vascular Dementia: The Cardiovascular Health Study. Roe C.M.; Fitzpatrick, A.L.; Xiong, C.; Sieh, W; Kuller, L; Miller, J.P.; Williams, M.M.; Kopan, R; Behrens, M. I.; Morris J.C. Article ISI NEUROLOGY (2010)
Cancer linked to Alzheimer disease but not vascular dementia Roe, CM; Fitzpatrick, AL; Xiong, C.; Sieh, W; Kuller, L; Miller, JP; Williams, MM; Kopan, R; Behrens, MI; Morris, JC Article ISI SCOPUS Neurology (2010)
Clinical and genetic analysis of a Chilean family with early-onset autosomal dominant Alzheimer Disease Sinning, M; van Rooyan, J.P.; Venegas-Francke P.; Vásquez C.; Behrens, M. I.; Ramirez A. Article ISI J Alzheimers Dis (2010)
Clinical Spectrum of Kufor-Rakeb Syndrome in the Chilean Kindred with ATP13A2 Mutations Behrens, MI; Bruggemann, N; Chana, P; Venegas P.; Kagi, M; Parrao T.; Orellana P.; Garrido, C.; Rojas, CV; Hauke, J; Hahnen, E; González R.; Seleme, N; Fernández V.; Schmidt, A; Binkofski, F; Kompf, D; Kubisch, C; Hagenah, J; Klein, C.; Ramirez A. Article ISI SCOPUS Movement Disorders (2010)
Frequency and Determinants of Poststroke Cognitive Impairment at Three and Twelve Months in Chile Delgado C.; Donoso, A.; Orellana P.; Vásquez C.; Díaz V.; Behrens, MI Article ISI SCOPUS Dementia and Geriatric Cognitive Disorders (2010)
Impaired Sense of Smell and Color Discrimination in Monogenic and Idiopathic Parkinson's Disease Kertelge, L; Bruggemann, N; Schmidt, A; Tadic, V; Wisse, C; Dankert, S; Drude, L; van der Vegt, J; Siebner, H; Pawlack, H; Pramstaller, PP; Behrens, MI; Ramirez A.; Reichel, D; Buhmann, C; Hagenah, J; Klein, C.; Lohmann, K; Kasten, M Article ISI SCOPUS Movement Disorders (2010)
Non-motor symptoms in genetic Parkinson disease. Kasten, M; Kertelge, L; Brüggemann, N.; van der Vegt, J; Schmidt, A; Tadic, V; Buhmann, C; Steinlechner S.; Behrens, M. I.; Ramirez A.; Binkofski, F; Siebner, H; Raspe, H; Hagenah, J; Lencer, R; Klein, C. Article SCOPUS Archives of Neurology (2010)
Recessively Inherited Parkinsonism Effect of ATP13A2 Mutations on the Clinical and Neuroimaging Phenotype Bruggemann, N; Hagenah, J; Reetz, K; Schmidt, A; Kasten, M; Buchmann, I; Eckerle, S; Bahre, M; Munchau, A; Djarmati, A; van der Vegt, J; Siebner, H; Binkofski, F; Ramirez A.; Behrens, MI; Klein, C. Article ISI SCOPUS Archives of Neurology (2010)
Structural imaging in the presymptomatic stage of genetically determined parkinsonism Reetz, K; Tadic, V; Kasten, M; Bruggemann, N; Schmidt, A; Hagenah, J; Pramstaller, PP; Ramirez A.; Behrens, MI; Siebner, HR; Klein, C.; Binkofski, F Article ISI SCOPUS Neurobiology of Disease (2010)
Utilidad de un cuestionario breve dirigido al informante para el diagnóstico temprano de casos de demencia: La versión Chilena del AD8 (AD8-Ch). Munoz, C; Núñez, J.; Flores P.; Behrens, M. I.; Slachevsky, A Article ISI REVISTA MEDICA DE CHILE (2010)
A COMMON BIOLOGICAL MECHANISM IN CANCER AND ALZHEIMERS DISEASE? Behrens, Maria; Lendon, Corinne; Roe, Catherine Article CURRENT ALZHEIMER RESEARCH (2009)
ATP13A2 Variants in Early-Onset Parkinson's Disease Patients and Controls Djarmati, A; Hagenah, J; Reetz, K; Winkler, S; Behrens, MI; Pawlack, H; Lohmann, K; Ramirez A.; Tadic, V; Bruggemann, N; Berg, D; Siebner, HR; Lang, AE; Pramstaller, PP; Binkofski, F; Kostic, VS; Volkmann, J; Gasser, T; Klein, C. Article ISI SCOPUS MOVEMENT DISORDERS (2009)
Demencia frontotemporal: experiencia clinica. Donoso, A.; Figueroa C.; Gomez, R; Behrens, M. I. Article ISI REVISTA MEDICA DE CHILE (2009)
Ischemia enhances activation by Ca2+ and redox modification of ryanodine receptor channels from rat brain cortex Bull, R; Finkelstein, JP; Galvez, J; Sánchez G; Donoso P.; Behrens, MI; Hidalgo C. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2008)
Rendimiento cognitivo en pacientes chilenos con cardiopatía coronaria y factores de riesgo cardiovascular Delgado-Derio C.; Vasquez-Vivar, C; Orellana-Pineda, P; Reccius-Meza, A; Donoso-Sepulveda, A; Behrens-Pellegrino, M.I. Article WOS Core Collection ISI REVISTA DE NEUROLOGIA (2008)
Afasia progresiva fluente: ¿una forma de presentación inicial de demencia semántica? Fluent progressive aphasia: a form of inicial presentation of semantic dementia? González, R.V.; Vásquez, C.V,; Venegas, V.F.; Behrens, M. I.; Donoso, A.S.; Massardo, T.V. Article Scielo Revista Chilena de Neuro-Psiquiatria (2007)
Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex Bull, R; Finkelstein, JP; Humeres, A; Behrens, MI; Hidalgo C. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Neuropathologic heterogeneity in HDDD1: A familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation Behrens, MI; Mukherjee, O; Tu, PH; Liscic, RM; Grinberg, LT; Carter D.; Paulsmeyer, K; Taylor-Reinwald, L; Gitcho, M; Norton, JB; Chakraverty, S; Goate, AM; Morris, JC; Cairns, NJ Article ISI SCOPUS ALZHEIMER DISEASE ASSOCIATED DISORDERS (2007)
HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin Mukherjee, O; Pastor P; Cairns, NJ; Chakraverty, S; Kauwe, JSK; Shears, S; Behrens, MI; Budde, J; Hinrichs, AL; NORTON, J; Levitch, D; Taylor-Reinwald, L; Gitcho, M; Tu, PH; Grinberg, LT; Liscic, RM; Armendariz J.; Morris, JC; Goate, AM Article ISI SCOPUS ANNALS OF NEUROLOGY (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase Ramirez A.; Heimbach, A; Gruendemann, J; Stiller, B; Hampshire, D; Cid, LP; Goebel, I; Mubaidin, AF; Wriekat, AL; Roeper, J; Al-Din, A; Hillmer, AM; Karsak, M; Liss, B; Woods, CG; Behrens, MI; Kubisch, C Article ISI SCOPUS NATURE GENETICS (2006)
Migraña con aura: Una mirada molecular a un problema hereditario. Ramírez, Alfredo Z.; Díaz, Violeta T.; Rojas, Cecilia B.V.; Behrens, M. I.; Kubisch, C Article Scielo Revista Chilena de Neuro-Psiquiatria (2006)
Alzheimer’s Disease and Cancer. Roe C.M.; Behrens, M. I.; Xiong, C.; Miller, J.P.; Morris J.C. Article ISI NEUROLOGY (2005)
Síndrome de Capgras en enfermedad de Alzheimer: presentación de 2 casos. Donoso, A.; Behrens, M. I. Article Scielo Revista Chilena de Neuro-Psiquiatria (2005)
Variabilidad y variantes en la enfermedad de Alzheimer. Donoso, A.; Behrens, M. I. Article ISI REVISTA MEDICA DE CHILE (2005)
Redox regulation of RyR-mediated Ca2+ release in muscle and neurons Hidalgo, Cecilia; Bull, Ricardo; BEHRENS, M. ISABEL; Donoso, Paulina Article SCIELO BIOLOGICAL RESEARCH (2004)
Demencia por carencia de vitamina B12, un caso clínico. Behrens, M. I.; Díaz V.; Vásquez C.; Donoso, A. Article ISI REVISTA MEDICA DE CHILE (2003)
Mild cognitive impairment: Follow-up of ten patients Deterioro cognitivo leve: Seguimiento de 10 casos Donoso, A.; Behrens, M. I.; Venegas P. Article SCOPUS Revista Chilena de Neuro-Psiquiatria (2003)
SH oxidation coordinates subunits of rat brain ryanodine receptor channels activated by calcium and ATP Bull, R; Marengo, JJ; Finkelstein, JP; Behrens, MI; Alvarez, O Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)
No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischemia in vivo. Lendon, C.L.; Han, B.H.; Salimi, K; Fagan, A.M.; Behrens, M. I.; Muller, M.C.; Holtzman, D.M. Article ISI The European Journal of Neuroscience (2000)
Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation. LOPERA, F; Ardilla, A; Martínez A; MADRIGAL, L; Arango Viana, J.C.; Lemere, C; Arango-Lasprilla, J.C.; Hincapie, L.; Arcos-Burgos, M; Ossa, J.E.; Behrens, M. I.; NORTON, J; LENDON, C; GOATE, A; Ruiz-Linares, A; Roselli, M.; Kosik, K.S. Article ISI JAMA (1997)
E280A PS-1 mutation causes Alzheimer’s disease but age of onset is not modified by ApoE alleles. Lendon, C.L.; Martínez A; Behrens, I.M.; Kosik, K.S.; MADRIGAL, L; NORTON, J; Neuman, R.; MYERS, A; BUSFIELD, F; WRAGG, M; ARCOS, M; Arango Viana, J.C.; Ossa, J; Ruiz A.; Goate, A.M.; LOPERA, F Article ISI HUMAN MUTATION (1997)
Susceptibility to apoptosis is enhanced in immature cortical neurons. McDonald, J.W.; Behrens, M. I.; Chung, C; Bhattacharyya, T; Choi, DW Article ISI BRAIN RESEARCH (1997)
NADPH-diaphorase-containing striatal or cortical neurons are resistant to apoptosis Behrens, M. I.; Koh, J; Muller, M.; Choi D.W. Article ISI NEUROBIOLOGY OF DISEASE (1996)
Neural control of the expression of a Ca2+-activated K+ channel involved in the induction of myotonic-like characteristics Ramírez, B.U.; Behrens, M. I.; Vergara C. Article CELLULAR AND MOLECULAR NEUROBIOLOGY (1996)
The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-beta peptide but not aggregated, cytotoxic amyloid-beta peptideThe sec receptor recognizes soluble non-toxic amyloid but not aggregated, cytotoxic amyloid ß peptide Boland, K.; Behrens, M.; Choi D.W.; Manias, K.; Perlmutter, D.H. Article ISI The Journal of Biological Chemistry (1996)
3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons. Behrens, M. I.; Koh, J; Canzoniero, L.M.T.; Sensi, S.L.; Cernansky, C.; Choi D.W. Article ISI NEUROREPORT (1995)
The structure of Presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Clark, R.F.; HUTTON, M; Fuldner, R.A.; FROELICH, S; KARRAN, E; TALBOT, C; CROOK, R; LENDON, C; Pribar, G.; HE, C; KORENBLAT, K; Martínez A; WRAGG, M; BUSFIELD, F; Behrens, M. I.; MYERS, A; NORTON, J; MORRIS, J; MEHTA, N; Pearson, C; LINCOLN, S; Baker M.; DUFF, K; ZEHR, C; Perez-Tur, J.; HOULDEN, H; Ruiz A.; Ossa, J; LOPERA, F; ARCOS, M; MADRIGAL, L; COLLINGE, J; HUMPHREYS, C; Ashworth, T.; SARNER, S; Pox, N.; HARVEY, R; KENNEDY, A; ROQUES, P; Cline, R.T.; Philips, C.A.; Venter, J.C.; FORSELL, L; AXELMAN, K; LILIUS, L; JOHNSTON J.; Coeburn, R.; Vritanen, M.; WINBLAD, B; Kosik, K.S.; HALTIA, M; POYHONEN, M; DICKSON, D; Marin D.; NEARY, D; SNOWDEN, J; LANTOS, P; LANNFELT, L; ROSSOR, M; Roberts, G.W.; Adams, M.D.; HARDY, J; GOATE, A Article ISI NATURE GENETICS (1995)
Possible role of apamin-sensitive K+ channels in myotonic dystrophy. Behrens, M. I.; Jalil, P.; Serani, A; Vergara, F.; Alvarez, 0. Article ISI MUSCLE NERVE (1994)
COLCHICINE ALTERS APAMIN RECEPTORS, ELECTRICAL-ACTIVITY, AND SKELETAL-MUSCLE RELAXATION VERGARA, C; RAMIREZ, B; BEHRENS, MI Article ISI MUSCLE NERVE (1993)
Increase of apamin sensitive K+ channels in rat skeletal muscle induced by colchicine. Possible role in myotonia. Behrens, M. I.; Vergara C. Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (1992)
Potassium channels in developing excitable cells. Behrens, M. I.; Latorre R. Article ISI Current topics in membranes (1991)
Effect of pyridine nucleotides on ATP synthesis and hydrolysis by the mitochondrial ATPase. Baizabal-Aguirre, V.M.; Behrens, M. I.; Gómez-Puyou, A.; Tuena de Gómez-Puyou, M. Article ISI Biochemistry International (1990)
Batrachotoxin modified sodium channels from squid optic nerve in planar lipid bilayers. Ion conduction and gating properties. Behrens, M. I.; Oberhauser, A.; Bezanilla, F; Latorre R. Article ISI The Journal of General Physiology (1989)
Calcium activated potassium channels of large unitary conductance. Behrens, M. I.; Vergara C.; Latorre R. Article ISI BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (1988)
Orthophosphate-pyrophosphate exchange catalyzed by soluble and membrane-bound inorganic pyrophosphatases. Role of H+-gradient. de Meis, L.; Behrens, M. I.; Celis, H.; Romero, I.; Tuena de Gómez-Puyou, M.; Gómez-Puyou, A. Article ISI European Journal of Biochemistry/FEBS (1986)
Contribution of water to free energy of hydrolysis of pyrophosphate de Meis, L.; Behrens, M. I.; Petretski, J.H.; Politi, M.J. Article ISI Biochemistry International (1985)
Synthesis of pyrophosphate by chromatophores of Rhodospirillum Rubrum in the light and by soluble yeast inorganic pyrophosphatase in water-organic solvent mixtures. Behrens, M. I.; de Meis, L. Article ISI European Journal of Biochemistry/FEBS (1985)
Axonal transport dysfunction in Dystrophia Myotonica. Behrens, M. I.; Torrealba G.; COURT, J; Soza, M.A.; Ramírez, B.U. Article ISI ACTA NEUROPATHOLOGICA (1983)
Increase of muscle peroxisomal enzymes and myotonia induced by Nafenopin, a hypolipidemic drug. Behrens, M. I.; Soza, M.A.; Inestrosa, N. C. Article ISI MUSCLE NERVE (1983)
Neural 16 S acetylcholinesterase is solubilized by heparin. Torres, J.C.; Behrens, M. I.; Inestrosa, N. C. Article ISI The biochemical journal (1983)
[New concepts on homeostasis)]. Luco, J.; Behrens, M. I. Article ISI ARCHIVOS DE BIOLOGIA Y MEDICINA EXPERIMENTALES (1980)
Modification of the Rosenblueth phenomenon by blockage of axonal flow. Behrens MI, Fernandez O, Luco JV. Brain Res. 1980 Aug 4;194(2):521-4. Behrens, M. I.; Fernandez, O; Luco, J.V. Article ISI BRAIN RESEARCH (1980)
The Rosenblueth Phenomenon. Behrens, M. I.; Lorenzo, D.; Fernandez, O; Luco, J.V. Article ISI BRAIN RESEARCH (1979)


Demencia por déficit de vitamina B12: Caso clínico Behrens P, María Isabel; Díaz T, Violeta; Vásquez V, Carolina; Donoso S, Archibaldo CaseReport ISI SCIELO REVISTA MEDICA DE CHILE (2003)


Is there a link between dementia and cancer? Behrens, M. I.; Quest A.F.; Roe C.M.; Morris J.C. Editorial Aging Health (2010)
Guías Clínicas de Diagnóstico y Tratamiento de las Demencias Behrens, María Isabel; Slachevsky, Andrea Editorial SCIELO REVISTA CHILENA DE NEUROPSIQUIATRÍA. (Rev. Chil Neuro-Psiquiat 2024; 62 (2); 177-183.) (2007)


AD and cancer Epidemiology makes for strange bedfellows Roe, C.M.; Behrens, M.I. EditorialMaterial ISI SCOPUS Neurology (2013)


Eye Movement Disorders in ATP13A2 Mutation Carriers (PARK9) Machner, B; Sprenger, A; Behrens, MI; Ramirez A.; Bruggemann, N; Klein, C.; Helmchen, C Letter ISI SCOPUS Movement Disorders (2010)
Utilidad de un cuestionario breve dirigido al informante para el diagnóstico temprano de casos de demencia: La versión Chilena del AD8 (AD8-Ch) Muñoz, Carlos; Nuñez, Javier; Flores, Patricia; Behrens P, María Isabel; Slachevsky, Andrea Letter SCIELO REVISTA MEDICA DE CHILE (2010)


Red neural por defecto y enfermedad de Alzheimer Vergara E, Fernando; Behrens, María Isabel Review SCIELO SCOPUS REVISTA MEDICA DE CHILE (2013)
Cien años de la enfermedad de Alzheimer: La inmunoterapia ¿una esperanza? Behrens P, María Isabel; Vergara E, Fernando Review SCIELO REVISTA MEDICA DE CHILE (2007)

Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

CAROLINA DELGADO

ASSOCIATE PROFESSOR

NEUROLOGÍA y neurocirugía

HOSPITAL CLINICO UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Daniela Ponce

Coordinadora de investigación

Universidad de Chile

Santiago, Chile

Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

Nicole Rogers

Instructora

Universidad de Chile

Santiago, Chile

Mónica Silva

Lab Manager

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

TERESA PARRAO

Instructor

Facultad de Psicologia

Universidad Alberto Hurtado

Santiago, Chile

Pedro Chana Cuevas

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

Carlos Chacon

Asistente de Investigación

Impact

Universidad de Los Andes

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Mariana Sinning

Medico Staff

Neurología Psiquiatria y Oncología

Clinica Alemana Santiago

Santiago, Chile

Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Felix Diaz

Patricia Muñoz

Co-investigador

Universidad de Chile

SANTIAGO, Chile

Maria Aylwin

Associate Professor

Universidad de Talca

Talca, Chile

Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

ALEXIS HUMERES

DIRECTOR

MORFOFUNCIÓN

Universidad Diego Portales

SANTIAGO, Chile

Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

Hachi Manzur

Neurólogo de Adultos

Red de Salud UC Christus

Santiago, Chile

Rolando Rebolledo

Cirujano

Servicio de Cirugía

Hospital Dr. Sótero del Río

Santiago, Chile

Cristian Garrido

Coordinador Resonancia Magnetica

Radiologia

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE - CENTRO DE IMAGENOLOGÍA

Santiago, Chile

Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

Maria Isabel Behrens Pellegrino

Líneas de Investigación

Educación

Ciencias Biológicas, mención Biologia Celular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1986

Post doc on Central Nervous System Injury, Postdoctoral fellow. Estados Unidos, 1995

Geriatric Dementia, WASHINGTON UNIVERSITY IN ST. LOUIS. Chile, 2004

Médico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1978

Experiencia Académica

Neurologist Part Time

Researcher Full Time

Neuróloga Part Time

Experiencia Profesional

MD PhD Full Professor Neurology Part Time

MD PhD, Full Professor researcher Part Time

Neuróloga Part Time

Formación de Capital Humano

Premios y Distinciones

Academic Excellence Prize 2006

“Rodolfo Rencoret Award”

Academic Excellence

Article (70)

CaseReport (1)

Editorial (2)

EditorialMaterial (1)

Letter (2)

Review (2)