Man

Patricia Muñoz Salvatierra

Co-investigador

Universidad de Chile

SANTIAGO, Chile

Líneas de Investigación


ESTUDIOS DE MECANISMO MOLECULAR DE LA EP. POSIBLE ROL NEUROPROTECTIVO DE DT-DIAFORASA.; Generación de animales Knock-out como modelo pre-clínico para EP Desarrollo de organoides como modelos para EP

Educación

  •  MAGISTER EN BIOQUIMICA, UNIVERSIDAD ANDRES BELLO. Chile, 2009
  •  Doctorado en Farmacologia, UNIVERSIDAD DE CHILE. Chile, 2015
  •  Bioquímica, UNIVERSIDAD ANDRES BELLO. Chile, 2009

Experiencia Académica

  •   Personal de colaboración en proyectos de investigacion Part Time

    UNIVERSIDAD DE CHILE

    Chile

    2015 - 2017

  •   Profesor Part Time

    UNIVERSIDAD DE CHILE

    Medicina

    santiago, Chile

    2017 - 2017

Experiencia Profesional

  •   Encargada de Validacion de metodos Full Time

    Labser

    Rancagua, Chile

    2010 - 2010

  •   Profesional de colaboracion Part Time

    Universidad de Chile

    Santiago, Chile

    2015 - 2017

  •   Profesor cátedra de fisiologia Part Time

    CFT La Araucana

    Santiago, Chile

    2009 - 2009

  •   Academico Part Time

    Universidad de Chile

    Santiago, Chile

    2014 - 2017


 

Article (27)

DT-Diaphorase Prevents Aminochrome-Induced Lysosome Dysfunction in SH-SY5Y Cells
Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic
Protective Effects of Crude Plant Extracts Against Aminochrome-induced Toxicity in Human Astrocytoma Cells: Implications for Parkinson's Disease
Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease?
Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite)
DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers
On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo
On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo.
On the Role of Mining Exposure in Epigenetic Effects in Parkinson's Disease
The Importance of Mitophagy in Maintaining Mitochondrial Function in U373MG Cells. Bafilomycin A1 Restores Aminochrome-Induced Mitochondrial Damage..
The Importance of Mitophagy in Maintaining Mitochondrial Function in U373MG Cells. Bafilomycin A1 Restores Aminochrome-lnduced Mitochondrial Damage
Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson's Disease
Aminochrome as new preclinical model to find new pharmacological treatment that stop the development of parkinsons disease
Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease
Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin
DT-diaphorase protects astrocytes from aminochrome-induced toxicity
Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases
DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity
Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity.
Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction
One-Electron Reduction of 6-Hydroxydopamine Quinone is Essential in 6-Hydroxydopamine Neurotoxicity
Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity
Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson's Disease
Autophagy Protects Against Aminochrome-Induced Cell Death in Substantia Nigra-Derived Cell Line
Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line
Stable Expression of Short Interfering RNA for DT-Diaphorase Induces Neurotoxicity
Molecular and Neurochemical Mechanisms in PD Pathogenesis

BookWhole (1)

Molecular and neurochemical mechanisms dopamine oxidation to O-Quinones in parkinson’s disease pathogenesis

EditorialMaterial (1)

Aminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinsons Disease

Errata (3)

Commentary: Evaluation of Models of Parkinson's Disease (vol 10, 161, 2016)
Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson's Disease (vol 22, pg 177, 2012)
Erratum to: Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line (Neurotoxicity Research DOI: 10.1007/s12640-009-9148-4)

Letter (1)

The need of a new and more physiological preclinical model for Parkinson's disease

Note (1)

Commentary: Evaluation of models of Parkinson's disease

Proyecto (8)

Development of disease-relevant brain organoids for Parkinson´s disease research
Studies on the role of ectosomes on astrocytes secretion of GSTM2 to extracellular medium and its internalization into dopaminergic neurons
IMPLANTAÇÃO DO MODELO EXPERIMENTAL PRÉ-CLÍNICO DE DOENÇA DE PARKINSON INDUZIDA POR AMINOCROMO=> PROSPECÇÃO FARMACOLÓGICA DE POTENCIAL NEUROPROTETOR DE FLAVONÓIDES EXTRAÍDOS DE PLANTAS DO ESTADO DA BAHIA
ESTUDIOS SOBRE EL EFECTO DEL COBRE EN LA FUSION DE AGRESOMAS CON LISOSOMAS MEDIADO POR LA AGREGACION DE TUBULINA EN CELULAS SH-SY5Y
ESTUDIOS EN EL ROL DE LA ENERGIA Y AMINOCROMO EN LA FUSION DE AUTOFAGOSOMAS Y AGRESOMAS CON LISOSOMAS MEDIADOS POR LA INTERACCION DE TUBULINA CON DINEINA/DINACTINA EN CELULAS IPS DERIVADAS DESDE PACIENTES CON LA ENFERMEDAD DE PARKINSON EN CHILE.
ESTUDIOS DEL PAPEL DE LA DT-DIAFORASa EN LA NEUROTOXICIDAD DE AMINOCROMO EN UN MODELO ANIMAL DE LA ENFERMEDAD DE PARKINSON.
ESTUDIOS EN MECANISMOS DE DEGENERACION DE NEURONAS DOPAMINERGICAS INDUCIDO POR AMINOCROMO Y LA PREVALENCIA POLIMORFICA EN PACIENTES CON PARKINSON EN CHILE
ESTUDIOS EN EL MECANISMO MOLECULAR DE LA ENFERMEDAD DE PARKINSON. POSIBLE ROL NEUROPROTECTIVO DE DT-DIAFORASA Y GST M2-2 EN CULTIVO CELULAR Y LA COEXISTENCIA DE POLIMORFISMO DE DT-DIAFORASA Y ALFA-SINUCLEINA

Review (4)

Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease?
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
Protective and toxic roles of dopamine in Parkinson's disease
Dopamine Oxidation and Autophagy
34
Patricia Muñoz

Co-investigador

Universidad de Chile

SANTIAGO, Chile

6
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

3
Sergio Cárdenas

Coordinador de Investigación e investigador

Centro de Ingeniería y desarrollo sostenible

Universidad Central de Chile

Santiago, Chile

1
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

1
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile