Man

Katia Cecilia Gysling Caselli

Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Anatomical substrates and mechanisms determining stress-induced relapse to drug seeking behavior. Role of the lateral septum in addicitve behavior. Neuropeptides, stress and addiction.

Educación

  •  Pharmacology, ST. LOUIS UNIVERSITY. Estados Unidos, 1985
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 1975

Experiencia Académica

  •   Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    1976 - A la fecha

Experiencia Profesional

  •   Departamental chairman Full Time

    Pontificia Universidad Catolica de Chile

    Chile

    2009 - 2015

Formación de Capital Humano


Undergraduate thesis (2011-2014)
María de la Luz Perry: Biochemist, 2014.
Cristian Bastías: Biochemist, 2014.
Cledi Cerda: Biochemist, 2014.
Francisca Martinez: Biochemist, 2013.
Guillermo Parada: Biochemist, 2012.
Javier Fuenzalida: Biochemist, 2012.
Sergio Pozo: Biochemist and Pharmacy, 2012.
Hector Yarur: Biochemist, 2011.
Paulina Galaz: Biochemist, 2011.
Roberto Munita: Biochemist, 2011.
Katherine Araya: Master in Biochemistry, 2011.

Graduate thesis (2011-2017)
Paula Slater: “Interaction of CRH-BP and CRH-R2". January 2016.
Macarena Vergara: “Role of the D4 dopamine receptor of prelimbic cortex in innate fear". May 2017
Roberto Munita: “Study of the biogenesis and expression of mirrorRNAs in the mammalian transcriptome". September 2014.
Verónica Noches: “Role of glutamatergic neurons of the lateral hypothalamus in stress-induced relapse to cocaine seeking behavior. October 2013.
Katherine Araya: “Role of CRH type 2 and dopamine D1 receptors in the sensitization of glutamate release in the rat ventral tegmental area induced by the repeated exposure to cocaine". September 2013.
María Raquel Ibáñez: “Protein kinase Mzeta activity in the rat ventral tegmental area is required for the execution of motivated behavior”. August 2013.
Elías Blanco: The precursor of CART neuropeptide has a sorting signal to the regulated secretion pathway". June 2011.

On-going graduate thesis
Hector Yarur: “Role of the heteromerization of CRH-R2 and D1 receptors in addiction to cocaine”.


Difusión y Transferencia


Through the Center for Addiction Studies of PUC and SENDA I have taught the neurobiological basis of drug addiction in several courses of continuing education for professionals (physicians, nurse, social workers, psychologists and others) working with patients.
Seminars and workshops with the staff of SENDA in Rancagua.


Premios y Distinciones

  •   Excellence in Teaching

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2009

    Award given by the University to professors that obtain best evaluations in their undergraduate teaching.

  •   Corresponding member

    Chilean Academy of Science

    Chile, 2016

    I was appointed corresponding member of the academy


 

Article (76)

Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors
Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression
Differential effect of amphetamine over the corticotropin-releasing factor CRF 2 receptor, the orexin OX 1 receptor and the CRF 2 -OX 1 heteroreceptor complex
Molecular Modeling of Structures and Interaction of Human Corticotropin-Releasing Factor (CRF) Binding Protein and CRF Type-2 Receptor
Activation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior
Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats
The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels
Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease
Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences
Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein coexist in rat ventral tegmental area nerve terminals originated in the lateral hypothalamic area
CRF binding protein facilitates the presence of CRF type 2? receptor on the cell surface
Opposite effects of acute and chronic amphetamine on Nurr1 and NF-?B p65 in the rat ventral tegmental area
A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature
Exposure to repeated immobilization stress inhibits cocaine-induced increase in dopamine extracellular levels in the rat ventral tegmental area
Reduced dopamine and glutamate neurotransmission in the nucleus accumbens of quinpirole-sensitized rats hints at inhibitory D2 autoreceptor function
A comprehensive survey of non-canonical splice sites in the human transcriptome
Dopamine D-1 and corticotrophin-releasing hormone type-2 alpha receptors assemble into functionally interacting complexes in living cells
EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-beta Oligomers
Improving Amphetamine Therapeutic Selectivity: N,N-dimethyl-MTA has Dopaminergic Effects and does not Produce Aortic Contraction
Withdrawal from chronic amphetamine reduces dopamine transmission in the rat lateral septum
An Amphipathic Alpha-Helix in the Prodomain of Cocaine and Amphetamine Regulated Transcript Peptide Precursor Serves as Its Sorting Signal to the Regulated Secretory Pathway
Long-term loss of dopamine release mediated by CRF-1 receptors in the rat lateral septum after repeated cocaine administration
Nur transcription factors in stress and addiction.
Varenicline and cytisine: two nicotinic acetylcholine receptor ligands reduce ethanol intake in University of Chile bibulous rats
4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo
Environmental influences that alter the stress circuitry.
Relevance of both type-1 and type-2 corticotropin releasing factor receptors in stress-induced relapse to cocaine seeking behaviour
Strengthening efforts to integrate mental health into primary health care in Chile: Lessons from an international collaboration process
Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons
Repeated Immobilization Stress Increases Nur77 Expression in the Bed Nucleus of the Stria Terminalis
Activation of GABA-B receptors induced by systemic amphetamine abolishes dopamine release in the rat lateral septum
Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain
Repeated Treatment With the kappa-Opioid Agonist U-69593 Increases K+-Stimulated Dopamine Release in the Rat Medial Prefrontal Cortex
N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents
Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593
Desipramine prevents the sustained increase in corticotropin-releasing hormone-like immunoreactivity induced by repeated immobilization stress in the rat central extended amygdala
Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene.
Intron retention as an alternative splice variant of the rat urocortin 1 gene
Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases stimulated dopamine extracellular levels in the rat nucleus accumbens.
8-oxoguanine DNA glycosylase, but not Kin17 protein, is translocated and differentially regulated by estrogens in rat brain cells
Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area
Adrenalectomy decreases corticotropin-releasing hormone gene expression and increases noradrenaline and dopamine extracellular levels in the rat lateral bed nucleus of the stria terminalis
Natural expression of immature Ucn antisense RNA in the rat brain. Evidence favoring bidirectional transcription of the Ucn gene locus
Corticotropin-releasing hormone and urocortin: redundant or distinctive functions?
Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis
Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra
Chronic morphine treatment and withdrawal increase extracellular levels of norepinephrine in the rat bed nucleus of the stria terminalis
Medullary noradrenergic neurons projecting to the bed nucleus of the stria terminalis express mRNA for the NMDA-NR1 receptor
NORADRENALINE INHIBITS GLUTAMATE RELEASE IN THE RAT BED NUCLEUS OF THE STRIA TERMINALIS: IN VIVO MICRODIALYSIS STUDIES
Noradrenaline inhibits glutamate release in the rat bed nucleus of the stria terminalis=> in vivo microdialysis studies.
Raphe serotonergic neurons projecting to the olfactory bulb contain galanin or somatostatin but not neurotensin
Differential regulation of dopamine release by N-methyl-D-aspartate receptors in rat striatum after partial and extreme lesions of the nigro-striatal pathway.
REGULATION OF NOREPINEPHRINE RELEASE FROM THE RAT BED NUCLEUS OF THE STRIA TERMINALIS: IN VIVO MICRODIALYSIS STUDIES
Regulation of norepinephrine release from the rat bed nucleus of the stria terminalis=> in vivo microdialysis studies.
NMDA-NR1 receptor subunit mRNA expression in rat brain after 6-OH-dopamine induced lesions=> a non-isotopic in situ hybridization study.
Changes in extracellular levels of glutamate and aspartate in rat substantia nigra induced by dopamine receptor ligands=> in vivo microdialysis studies.
Effects of in vitro ethanol and chronic ethanol consumption on the release of excitatory amino acids in the rat hippocampus.
Regulation of endogenous noradrenaline release from the bed nucleus of stria terminalis.
Release of endogenous catecholamines from the striatum and bed nucleus of stria terminalis evoked by potassium and N-methyl-D-aspartate=> in vitro microdialysis studies.
Some noradrenergic neurons of locus ceruleus-olfactory pathways contain neuropeptide-Y.
Differential effects of haloperidol on negative symptoms in drug-naive schizophrenic patients=> effects on plasma homovanillic acid.
Regulation of [3H]norepinephrine release by N-methyl-D-aspartate receptors in minislices from the dentate gyrus and the CA1-CA3 area of the rat hippocampus.
Studies of cholecystokinin in the rat bed nucleus of stria terminalis.
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum=> in vivo microdialysis studies.
N-Methyl-D-aspartate receptors and release of newly-synthesized [3H]dopamine in nucleus accumbens slices and its relationship with neocortical afferences.
Effect of dopamine depletion upon the K(+)-evoked release of CCK from superfused striatal slices.
Lithium preincubation stimulates the potassium-induced release of cholecystokinin from slices of cerebral cortex and caudate-putamen incubated in vitro.
The regulation of cholecystokinin release from rat caudatoputamen in vitro.
The subcellular distribution of peptide histidine isoleucine amide-27-like peptides in rat brain and their release from rat cerebral cortical slices in vitro.
Failure of chronic haloperidol treatment to alter levels of cholecystokinin in the rat brain striatum and olfactory tuberclenucleus accumbens area.
Morphine-induced activation of A10 dopamine neurons in the rat.
Regulation of transmitter synthesis and release in mesolimbic dopaminergic nerve terminals. Effect of ethanol.
Uptake and release of manganese by rat striatal slices.
Intraneuronal site of action for imipramine in rat striatal slices.
Effect of ethanol on dibutyryl cyclic adenosine monophosphate- and theophylline-induced stimulation of dopamine biosynthesis by rat striatal slices.
Effect of ethanol on dopamine synthesis and release from rat corpus striatum.

Abstract (4)

Chronic morphine treatment increases extracellular levels of noradrenaline but not glutamate in the rat bed nucleus of the stria terminalis
Distribution and modulation of urocortin mRNA in the brain of female rats
Modulation of corticotropin-releasing factor mRNA expression in the bed nucleus of the stria terminalis of female rats
Modulation of GABA efflux by endocrine factors in the corpus striatum of the rat

Review (2)

Nur transcription factors in stress and addiction
Environmental Influences that Alter the Stress Circuitry
77
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

22
Maria Andres

Full Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

19
Maria Forray

PROFESOR ASOCIADO

FARMACIA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

18
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

7
José Fuentealba

Associate professor

Farmacy

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

5
Paula Slater

Postdoctoral researcher

Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Roberto Munita

Postdoctoral Researcher

Lund Stem Cell Center

Lund University

Lund, Suecia

3
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

3
PAOLA HAEGER

Associated professor

Ciencias Biomedicas

Universidad Catolica del Norte

COQUIMBO, Chile

2
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

2
Pablo Moya

Full Professor

Physiology

Universidad de Valparaiso

Valparaiso, Chile

2
Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
lisbell estrada

Decana Facultad Ciencias de la Salud

Facultad de Ciencias de la Salud

Universidad Bernardo O Higgins

santiago, Chile

1
Lina Vargas

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

1
Montserrat Olivares

Candidata a doctor

Biología celular y molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jaime Sapag

Associate Professor

Division of Public Health and Family Medicine

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Maria Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

1
Francisca Cornejo

Assistant professor

Universidad Mayor

Santiago, Chile

1
Alberto Minoletti

Académico

Facultad de Medicina

Universidad de Chile

Santiago, Chile

1
Fernando Poblete

Académico

Salud Pública

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Patricia Muñoz

Co-investigador

Universidad de Chile

SANTIAGO, Chile

1
ADRIAN GONZALEZ

Postdoc

Biologia celular

Pontificia Universidad Católica de Chile

Santiago de Chile, Chile

1
Andrea Gómez

Investigador Postdoctoral

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Sebastián Gutiérrez

Investigador postdoctoral

Fundación Ciencia & Vida

Santiago, Chile

1
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile