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Decana Facultad Ciencias de la Salud

Universidad Bernardo O Higgins

santiago, Chile

Líneas de Investigación


Alzheimer disease; Protein misfolding; Molecular and cell Biology

Educación

  •  Ciencias mención Biología, UNIVERSIDAD DE CHILE. Chile, 2010
  •  Ingeniero en Biotecnologia Molecular, UNIVERSIDAD DE CHILE. Chile, 2005

Experiencia Académica

  •   Directora de Investigacion y Doctorados Full Time

    UNIVERSIDAD BERNARDO O'HIGGINS

    Salud

    santiago, Chile

    2015 - 2019

  •   Investigador Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Santiago, Chile

    2010 - 2015

  •   Decana Full Time

    UNIVERSIDAD BERNARDO O'HIGGINS

    Ciencias de la Salud

    Santiago, Chile

    2020 - A la fecha

Experiencia Profesional

  •   research associate Full Time

    University of texas medical branch

    Galveston, Estados Unidos

    2003 - 2008

Formación de Capital Humano


2016-Tesista de Pregrado Universidad Bernardo O Higgins. Srta. Nicole Mundaca. Fondecyt 11130561.
2017-Tesista de Pregrado Universidad Bernardo O Higgins. Sr. Pablo Ahumada. Fondecyt 11130561.
2017-Tesista de Postgrado Programa Magister en Ciencias Químico-Biológicas Universidad Bernardo O Higgins. Srta. Elizabeth Durán. Fondecyt 11130561.
2018-Tesista de Postgrado Programa Magister en Ciencias Químico-Biológicas Universidad Bernardo O Higgins. Srta. Elena Castañeda. Fondecyt 11130561.
2019-Tesista de Postgrado Programa Magister en Ciencias Químico-Biológicas Universidad Bernardo O Higgins. Sr. Pablo Ahumada Fondecyt 11130561.
2019-Tesista de Postgrado (en curso) Programa Magister en Ciencias Químico-Biológicas Universidad Bernardo O Higgins. Sr. Luis Astete.
2019-Tesista de Postgrado (en curso) Programa Magister en Ciencias Químico-Biológicas Universidad Bernardo O Higgins. Srta. María Celis.



 

Article (24)

Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer's disease
Liver Dysfunction as a Novel Player in Alzheimer’s Progression: Looking Outside the Brain
Functionalization of stable fluorescent nanodiamonds towards reliable detection of biomarkers for Alzheimers disease
Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia.
The cluster [ReSeI] penetrates biological membranes=> drug-like properties for CNS tumor treatment and diagnosis.
Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer´s Disease.
c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease
Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1.
Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition.
c-Abl Stabilizes HDAC2 Levels by Tyrosine Phosphorylation Repressing Neuronal Gene Expression in Alzheimer's Disease
EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-beta Oligomers
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer´s disease.
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease
De novo induction of amyloid-beta deposition in vivo
Induction of amyloid deposition and memory impairments in animal models of Alzheimer disease by blood transfusion
C-Abl Tyrosine Kinase Signaling: A New Player in AD Tau Pathology
Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases
Protein misfolding and neurodegeneration
Disrupting beta-amyloid aggregation for Alzheimer disease treatment.
Amyloids, prions and the inherent infectious nature of misfolded protein aggregates.
Inhibition of protein misfolding and aggregation by small rationally-designed peptides.
Protein misfolding disorders and rational design of antimisfolding agents.
Amyloid formation modulates the biological activity of a bacterial protein
Amyloid inhibitors and beta-sheet breakers

Abstract (6)

A beta oligomers affects Blood-brain-barrier integrity in Alzheimers disease.
Induction of amyloid deposition and memory impairments in animal models of Alzheimer disease by blood transfusion
Regulation of HDAC2 by of the tyrosine kinase c-Abl, a new mechanism of regulation of the gene expression.
c-Abl inhibition decreases the levels of Amyloid beta peptide in plasma of Alzheimer transgenic mice.
Induction of A beta Amyloidogenesis In Vivo by Blood Transfusion
Transmission of Alzheimer Disease and Type 2 Diabetes by a Prion Mechanism

EditorialMaterial (1)

Oxidative Stress in Disease and Aging: Mechanisms and Therapies 2018

Proyecto (8)

BLOOD BRAIN BARRIER INSIGHTS=> PATHOLOGICAL BREAKDOWN AND MODULATION AS A THERAPEUTIC APPROACH FOR ALZHEIMER´S DISEASE
Centro de envejecimiento y regeneracion CARE
Identification of c-Abl inhibitors for the potential treatment of Alzheimer disease
Uncovering the mechanisms of Amyloid clearence induced by STI571-treatment in Alzheimers disease=> the role of the Abl kinase
Development of Blood biomarkers for early diagnosis and to track progression of Alzheimers disease
Detection of misfolded Aß oligomers for early diagnosis of Alzheimer’s diseases
Small molecule ß-sheet breaker peptidemimetics for Alzheimer’s therapy
Smoking and amyloid formation in Alzheimer’s disease

Review (3)

Liver Dysfunction as a Novel Player in Alzheimer's Progression: Looking Outside the Brain
TGF-? and hepatocellular carcinoma: When a friend becomes an enemy
Protein misfolding and neurodegeneration
19
lisbell estrada

Decana Facultad Ciencias de la Salud

Facultad de Ciencias de la Salud

Universidad Bernardo O Higgins

santiago, Chile

3
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

2
Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

2
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Rodrigo Morales

Assistant Professor

Neurology

The University of Texas Health Science Center at Houston

Houston, Estados Unidos

2
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Francisco Morales

Posdoctoral

Universidad de Chile. Centro FONDAP ACCDiS

Santiago, Chile

1
Nathalie Casanova

profesor asociado

artes liberales

Universidad Adolfo Ibañez

Santiago, Chile

1
Jeronimo Maze

Associate Professor

Physics

FACULTAD DE FISICA, PONTIFICIA UNIVERSIDAD CATOLICA

Santiago, Chile

1
Fanny Guzman

Investigador Senior

Núcleo de Biotecnología Curauma

Pontificia Universidad Católica de Valparaiso

Valparaiso, Chile

1
Mario Favre

Profesor Titular

Instituto de Física, Pontificia Universidad Católica de Chile

Santiago, Chile

1
Lina Vargas

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
ADRIAN GONZALEZ

Postdoc

Biologia celular

Pontificia Universidad Católica de Chile

Santiago de Chile, Chile

1
Marcelo Baeza

Profesor Titular

Ciencias Ecologicas

Universidad de Chile

Santiago, Chile

1
Rosalba Lagos

Professor

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

1
Simon Guerrero

Investigador

Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK

Universidad SEK

Santiago, Chile