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Claudia Andrea Duran-Aniotz

Profesor Asociado

Universidad Adolfo Ibánez

Santiago, Chile

Enfermedad de Alzheimer; Enfermedades Neurodegenerativas; Modelos MurinosTransgénicos; Investigación Traslacional; Biomarcadores tempranos en demencias

Biología, UNIVERSIDAD DE CHILE. Chile, 2006
Inmunologia, UNIVERSIDAD DE CHILE. Chile, 2010
Biomedicina, UNIVERSIDAD DE LOS ANDES. Chile, 2013

Co-tutor Unidad de Investigacion Other

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2014 - 2016
Co-tutor Tesis de Pre-grado Other

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2016 - A la fecha
Co-tutor tesis de Pre-grado Other

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2017 - A la fecha
Profesor Asistente Full Time

UNIVERSIDAD ADOLFO IBANEZ

Chile

2020 - A la fecha

Investigador Fondecyt Postdoctoral Full Time

Universidad de Chile

Santiago, Chile

2013 - 2016
Director Other

COPRAD

Santiago, Chile

2015 - A la fecha
Investigador Asociado Part Time

Centro de Gerociencia, Salud Mental y Metabolismo (GERO)

Santiago, Chile

2016 - A la fecha
Investigador Asociado Other

Instituto de Neurociencias Biomédicas (BNI)

Santiago, Chile

2016 - A la fecha
Investigador Fondecyt Iniciación Full Time

Universidad de Chile

Santiago, Chile

2016 - 2019
Profesor Asistente Full Time

Universidad Adolfo Ibañez

Santiago, Chile

2020 - A la fecha

1.
Descripción: Tesis de pregrado para obtener el grado de licenciatura en ciencias farmacéuticas
Facultad de Ciencias Químicas y Farmacia, Departamento de Bioquímica y Biología Molecular.
Estudiante: Pablo Cabrera
Año: 2017-2018
Asesores: Director Dr. Claudio Hetz y Co-Director Dr. Claudia Duran-Aniotz

2.
Descripción: Tesis de pregrado para obtener el título de licenciatura en bioquímica
Facultad de Ciencias Químicas y Farmacia, Departamento de Bioquímica y Biología Molecular.
Estudiante: Javiera Acevedo
Año: 2016-2017
Asesores: Director Dr. Claudio Hetz y Co-Director Dr. Claudia Duran-Aniotz

3.
Descripción: Estancia de Investigación Corta de estudiantes de Medicina de Pregrado
Facultad de Medicina, Departamento de Biología Celular y Molecular
Estudiantes: Alfonso Warnken y Javiera Guerra
Año: 2016
Asesores: Director Dr. Claudio Hetz y Co-Director Dr. Claudia Duran-Aniotz

4.
Descripción: Estancia de investigación corta de los estudiantes de medicina de pregrado
Facultad de Medicina, Departamento de Biología Celular y Molecular
Estudiantes: Mario Ortega y César Pinilla
Año: 2015
Asesores: Director Dr. Claudio Hetz y Co-Director Dr. Claudia Duran-Aniotz

5.
Descripción: Estancia corta de investigación de estudiantes de medicina de pregrado
Facultad de Medicina, Departamento de Biología Celular y Molecular
Estudiantes: Nicolás Larraín y Camilo Cisternas.
Año 2014
Asesores: Director Dr. Claudio Hetz y Co-Director Dr. Claudia Duran-Aniotz

Difusión

1.
Descripción: Directora en la Corporación profesional Alzheimer y otras demencias (COPRAD). Difusión y extension en actividades Sociales.
Fecha: 2013 hasta la fecha
COPRAD es una agrupación multidisciplinaria de profesionales enfocada en contribuir al mejoramiento de la calidad de vida de las personas afectadas por la enfermedad de Alzheimer y otras demencias, así como de sus grupos familiares y cercanos. La finalidad esencial de COPRAD es velar por el bienestar de aquellos, mediante la disminución del impacto social y económico causado por la enfermedad de Alzheimer y otras demencias, tanto en el ámbito público como privado, a través de la organización, planificación, ejecución y seguimiento de programas, proyectos, iniciativas y acciones conducentes a la investigación, educación, prevención y el tratamiento de dichas enfermedades.

2.
Descripción: Difusión y participación activa en programa de difusión y extension Instituto de Neurociencias Biomédicas (BNI) y el programa Explora
Fecha: 2014 hasta la fecha

Propiedad Intelectual

1. Titulo: MÉTODO PARA IDENTIFICAR CANDIDATOS TERAPÉUTICOS PARA EL TRATAMIENTO DE ALZHEIMER A TRAVÉS DE IRE1
La tecnología fue evaluada en modelos preclínicos y está siendo presentada a solicitud de patente nacional por la Vicerrectoría de Investigaciones de la Universidad de Chile.
Inventores: Dr. Claudio Hetz y Dr. Claudia Duran-Aniotz
N° Solicitud: 201603402.
Fecha Presentación: 30/12/2016.
Folio Pago Electrónico: 280982.
N° Atención: 161229175528008.

Estadías en el Extranjero

1.
Universidad: Universidad de Texas, Houston, Estados Unidos.
Año: 2014.
Duración: 2 meses.
Investigador Principal: Dr. Claudio Soto.

2.
Universidad: Universidad de Amsterdam, Holanda.
Año: 2016.
Duración: 1 mes.
Investigador Principal: Dr. Jereon Hoozemans.

Beca Magister

UNIVERSIDAD DE CHILE

Chile, 2008

Beca Arancel Magíster en Ciencias con mención en Inmunología, Universidad de Chile.
Beca Ph.D.

UNIVERSIDAD DE LOS ANDES

Chile, 2010

Beca Arancel Ph.D. en Biomedicina, Universidad de los Andes.


The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis Duran-Aniotz, Claudia; Poblete, Natalia; Rivera-Krstulovic, Catalina; Ardiles, alvaro O.; Li Diaz-Hung, Mei; Tamburini, Giovanni; Sabusap, Carleen Mae P.; Gerakis, Yannis; Cabral-Miranda, Felipe; Diaz, Javier; Fuentealba, Matias; Arriagada, Diego; Munoz, Ernesto; Espinoza, Sandra; Martinez, Gabriela; Quiroz, Gabriel; Sardi, Pablo; Medinas, Danilo B.; Contreras, Darwin; Pina, Ricardo; V. Lourenco, Mychael; Ribeiro, Felipe C.; Ferreira, Sergio T.; Rozas, Carlos; Morales, Bernardo; Plate, Lars; Gonzalez-Billault, Christian; Palacios, Adrian G.; Hetz, Claudio Article ISI MOLECULAR THERAPY (2023)
A predictive coding framework of allostatic-interoceptive overload in frontotemporal dementia Migeot, Joaquin A.; Duran-Aniotz, Claudia A.; Signorelli, Camilo M.; Piguet, Olivier; Ibanez, Agustin Article ISI TRENDS IN NEUROSCIENCES (2022)
Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model Moreno-Gonzalez, Ines; Edwards, George, III; Morales, Rodrigo; Duran-Aniotz, Claudia; Escobedo Jr, Gabriel; Marquez, Mercedes; Pumarola, Marti; Soto, Claudio Article ISI FRONTIERS IN AGING NEUROSCIENCE (2022)
Biomarkers for dementia in Latin American countries: Gaps and opportunities Parra, Mario A.; Orellana, Paulina; Leon, Tomas; Victoria, Cabello G.; Henriquez, Fernando; Gomez, Rodrigo; Avalos, Constanza; Damian, Andres; Slachevsky, Andrea; Ibanez, Agustin; Zetterberg, Henrik; Tijms, Betty M.; Yokoyama, Jennifer S.; Pina-Escudero, Stefanie D.; Cochran, J. Nicholas; Matallana, Diana L.; Acosta, Daisy; Allegri, Ricardo; Arias-Suarez, Bianca P.; Barra, Bernardo; Isabel Behrens, Maria; Brucki, Sonia M. D.; Busatto, Geraldo; Caramelli, Paulo; Castro-Suarez, Sheila; Contreras, Valeria; Custodio, Nilton; Dansilio, Sergio; De la Cruz-Puebla, Myriam; de Souza, Leonardo Cruz; Diaz, Monica M.; Duque, Lissette; Farias, Gonzalo A.; Ferreira, Sergio T.; Magrath Guimet, Nahuel; Kmaid, Ana; Lira, David; Lopera, Francisco; Mar Meza, Beatriz; Miotto, Eliane C.; Nitrini, Ricardo; Nunez, Alberto; O'Neill, Santiago; Ochoa, John; Pintado-Caipa, Maritza; Franca Resende, Elisa de Paula; Risacher, Shannon; Angela Rojas, Luz; Sabaj, Valentina; Schilling, Lucas; Sellek, Allis F.; Sosa, Ana; Takada, Leonel T.; Teixeira, Antonio L.; Unaucho-Pilalumbo, Martha; Duran-Aniotz, Claudia Article ISI Alzheimer's & Dementia (2022)
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis Ogonowski, Natalia; Salcidua, Stefanny; Leon, Tomas; Chamorro-Veloso, Nayaret; Valls, Cristian; Avalos, Constanza; Bisquertt, Alejandro; Renteria, Miguel E.; Orellana, Paulina; Duran-Aniotz, Claudia Article ISI FRONTIERS IN AGING NEUROSCIENCE (2022)
Amyloid pathology arrangements in Alzheimer's disease brains modulate in vivo seeding capability Duran-Aniotz, Claudia; Moreno-Gonzalez, Ines; Gamez, Nazaret; Perez-Urrutia, Nelson; Vegas-Gomez, Laura; Soto, Claudio; Morales, Rodrigo Article ISI ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)
Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries Duran-Aniotz, Claudia; Orellana, Paulina; Leon Rodriguez, Tomas; Henriquez, Fernando; Cabello, Victoria; Aguirre-Pinto, Maria F.; Escobedo, Tamara; Takada, Leonel T.; Pina-Escudero, Stefanie D.; Lopez, Oscar; Yokoyama, Jennifer S.; Ibanez, Agustin; Parra, Mario A.; Slachevsky, Andrea Article ISI FRONTIERS IN NEUROLOGY (2021)
Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease Flores-Muñoz, Carolina; Gómez, Bárbara; Mery, Elena; Mujica, Paula; Gajardo, Ivana; Córdova, Claudio; Lopez-Espíndola, Daniela; Durán-Aniotz, Claudia; Hetz, Claudio; Muñoz, Pablo; Gonzalez-Jamett, Arlek M.; Ardiles, Álvaro O. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2020)
Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer's disease Morales, Rodrigo; Duran-Aniotz, Claudia; Bravo-Alegria, Javiera; Estrada, Lisbell D.; Shahnawaz, Mohammad; Hu, Ping-Ping; Kramm, Carlos; Morales-Scheihing, Diego; Urayama, Akihiko; Soto, Claudio Article ISI ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)
Unfolded protein response as a target in the treatment of Alzheimer's disease Rivera-Krstulovic, Catalina; Duran-Aniotz, Claudia Article ISI REVISTA MEDICA DE CHILE (2020)
Endoplasmic reticulum proteostasis impairment in aging. Martínez, Gabriela; Duran-Aniotz, Claudia; Cabral-Miranda, Felipe; Vivar, Juan P; Hetz, Claudio Article Aging cell (2017)
Gene therapy to target ER stress in brain diseases Valenzuela, V.; Martinez, G; Duran-Aniotz C.; hetz C. Article (2017)
IRE1 signaling exacerbates Alzheimer's disease pathogenesis Duran-Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Álvaro O; Medinas, Danilo B; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G; Hoozemans, Jeroen J M; Hetz, Claudio Article ACTA NEUROPATHOLOGICA (2017)
IRE1 signaling exacerbates Alzheimer's disease pathogenesis Duran-Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Álvaro O.; Medinas, Danilo B.; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J. M.; Hetz, Claudio Article ISI SCOPUS ACTA NEUROPATHOLOGICA (2017)
IRE1 signaling exacerbates Alzheimer's disease pathogenesis. Duran-Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Álvaro O; Medinas, Danilo B; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G; Hoozemans, Jeroen J M; Hetz, Claudio Article Acta neuropathologica (2017)
Commentary=> XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity. Martínez, Gabriela; Duran-Aniotz, Claudia; Cabral-Miranda, Felipe; Hetz, Claudio Article Frontiers in aging neuroscience (2016)
Gene therapy to target ER stress in brain diseases. Valenzuela, Vicente; Martínez, Gabriela; Duran-Aniotz, Claudia; Hetz, Claudio Article Brain research (2016)
Gene therapy to target ER stress in brain diseases. Valenzuela, Vicente; Martínez, Gabriela; Duran-Aniotz, Claudia; Hetz, Claudio Article Brain research (2016)
Glucose Metabolism=> A Sweet Relief of Alzheimer's Disease. Duran-Aniotz, Claudia; Hetz, Claudio Article Current biology => CB (2016)
Role of prion replication in the strain-dependent brain regional distribution of prions Hu P.P.; Morales R.; Duran-Aniotz C.; Moreno-Gonzalez I.; Khan U.; Soto C. Article ISI SCOPUS Journal of Biological Chemistry (2016)
Role of Prion Replication in the Strain-dependent Brain Regional Distribution of Prions. Hu, Ping Ping; Morales, Rodrigo; Duran-Aniotz, Claudia; Moreno-Gonzalez, Ines; Khan, Uffaf; Soto, Claudio Article The Journal of biological chemistry (2016)
Strain-dependent profile of misfolded prion protein aggregates Morales R.; Hu, PP; Duran-Aniotz, C; Moda, F; Diaz-Espinoza, R; Chen, BA; Bravo-Alegria, J; Makarava, N; Baskakov, IV; Soto, C. Article Scientific Reports (2016)
Strain-dependent profile of misfolded prion protein aggregates Morales R.; Hu PP; Duran-Aniotz C.; Moda F; Diaz-Espinoza, R.; Chen, B; Bravo-Alegria J.; Makarava N; Baskakov IV; Soto C. Article (2016)
Strain-dependent profile of misfolded prion protein aggregates. Morales, Rodrigo; Hu, Ping Ping; Duran-Aniotz, Claudia; Moda, Fabio; Diaz-Espinoza, Rodrigo; Chen, Baian; Bravo-Alegria, Javiera; Makarava, Natallia; Baskakov, Ilia V; Soto, Claudio Article Scientific reports (2016)
Strain-dependent profile of misfolded prion protein aggregates. Morales, Rodrigo; Hu, Ping Ping; Duran-Aniotz, Claudia; Moda, Fabio; Diaz-Espinoza, Rodrigo; Chen, Baian; Bravo-Alegria, Javiera; Makarava, Natallia; Baskakov, Ilia V; Soto, Claudio Article Scientific reports (2016)
Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease Duran-Aniotz C.; Cornejo, VH; hetz C. Article (2016)
Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease. Duran-Aniotz, Claudia; Cornejo, Victor Hugo; Hetz, Claudio Article Brain : a journal of neurology (2016)
Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease. Duran-Aniotz, Claudia; Cornejo, Victor Hugo; Hetz, Claudio Article Brain => a journal of neurology (2016)
ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders Torres M.; Matamala, JM; Duran-Aniotz, C; Cornejo, VH; Foley, A; Hetz C. Article Virus Research (2015)
ER stress signaling and neurodegeneration=> At the intersection between Alzheimer's disease and Prion-related disorders. Torres, Mauricio; Matamala, José Manuel; Duran-Aniotz, Claudia; Cornejo, Victor Hugo; Foley, Andrew; Hetz, Claudio Article Virus research (2015)
Titration of biologically active amyloid-beta seeds in a transgenic mouse model of Alzheimer's disease Morales R.; Bravo-Alegria, J; Duran-Aniotz, C; Soto, C. Article Scientific Reports (2015)
Titration of biologically active amyloid-Î² seeds in a transgenic mouse model of Alzheimer's disease. Morales, Rodrigo; Bravo-Alegria, Javiera; Duran-Aniotz, Claudia; Soto, Claudio Article Scientific reports (2015)
Titration of biologically active amyloid-β seeds in a transgenic mouse model of Alzheimer's disease Morales R.; Bravo-Alegria J.; Duran-Aniotz C.; Soto C. Article (2015)
Aggregate-Depleted Brain Fails to Induce A beta Deposition in a Mouse Model of Alzheimer's Disease Duran-Aniotz, C; Morales R.; Moreno-Gonzalez, I; Hu, PP; Fedynyshyn, J; Soto, C. Article PLoS ONE (2014)
Aggregate-depleted brain fails to induce AÎ² deposition in a mouse model of Alzheimer's disease. Duran-Aniotz, Claudia; Morales, Rodrigo; Moreno-Gonzalez, Ines; Hu, Ping Ping; Fedynyshyn, Joseph; Soto, Claudio Article PloS one (2014)
Brains from non-Alzheimer's individuals containing amyloid deposits accelerate A? deposition in vivo Duran-Aniotz C.; Morales R.; Moreno-Gonzalez I.; Hu P.P.; Soto C. Article ISI SCOPUS Acta Neuropathologica Communications (2014)
Memory loss in Alzheimer's disease: are the alterations in the UPR network involved in the cognitive impairment? Duran-Aniotz, Claudia; Martínez, Gabriela; Hetz, Claudio Article Frontiers in aging neuroscience (2014)
Memory loss in Alzheimer's disease=> are the alterations in the UPR network involved in the cognitive impairment? Duran-Aniotz, Claudia; Martínez, Gabriela; Hetz, Claudio Article Frontiers in aging neuroscience (2014)
[Amyloid aggregates: role in Protein Misfolding Disorders]. Duran-Aniotz, Claudia; Moreno-Gonzalez, Inés; Morales, Rodrigo Article Revista meÌ�dica de Chile (2013)
[Amyloid aggregates=> role in Protein Misfolding Disorders]. Duran-Aniotz, Claudia; Moreno-Gonzalez, Inés; Morales, Rodrigo Article Revista medica de Chile (2013)
Brains from non-Alzheimer's individuals containing amyloid deposits accelerate AÎ² deposition in vivo. Duran-Aniotz, Claudia; Morales, Rodrigo; Moreno-Gonzalez, Ines; Hu, Ping Ping; Soto, Claudio Article Acta neuropathologica communications (2013)
Brains from non-Alzheimer's individuals containing amyloid deposits accelerate AÎ² deposition in vivo. Duran-Aniotz, Claudia; Morales, Rodrigo; Moreno-Gonzalez, Ines; Hu, Ping Ping; Soto, Claudio Article Acta neuropathologica communications (2013)
Lack of prion transmission by sexual or parental routes in experimentally infected hamsters Morales R.; Pritzkow, S; Hu, PP; Duran-Aniotz, C; Soto, C. Article PRION (2013)
Lack of prion transmission by sexual or parental routes in experimentally infected hamsters Morales R.; Pritzkow, S; Hu PP; Duran-Aniotz, C; Soto C. Article ISI SCOPUS Prion (2013)
Lack of prion transmission by sexual or parental routes in experimentally infected hamsters. Morales, Rodrigo; Pritzkow, Sandra; Hu, Ping Ping; Duran-Aniotz, Claudia; Soto, Claudio Article PRION (2013)
Lack of prion transmission by sexual or parental routes in experimentally infected hamsters. Morales R.; Pritzkow, S; Hu PP; Duran-Aniotz C.; Soto C. Article (2013)
The immunological response and post treatment survival of DC-Vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine Responses Duran-Aniotz C.; Segal G; Salazar, L; Salazar-Onfray F.; Lopez M. Article (2013)
The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses Duran-Aniotz, C; Segal, G; Salazar L.; Pereda C; Falcon, C.; Tempio, F; Aguilera R; González R.; Pérez, C.; Tittarelli A; Catalan D.; Nervi B.; Larrondo, M; Salazar-Onfray, F; López MN Article CANCER IMMUNOLOGY IMMUNOTHERAPY (2013)
The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses. Durán-Aniotz, Claudia; Segal, Gabriela; Salazar, Lorena; Pereda, Cristián; Falcón, Cristián; Tempio, Fabián; Aguilera, Raquel; González, Rodrigo; Pérez, Claudio; Tittarelli, Andrés; Catalán, Diego; Nervi, Bruno; Larrondo, Milton; Salazar-Onfray, Flavio; López, Mercedes N Article Cancer immunology, immunotherapy => CII (2013)
De novo induction of amyloid-beta deposition in vivo Morales R.; Duran-Aniotz, C; Castilla, J; Estrada L.D.; Soto, C. Article MOLECULAR PSYCHIATRY (2012)
De novo induction of amyloid-Î² deposition in vivo. Morales, R; Duran-Aniotz, C; Castilla, J; Estrada, L D; Soto, C Article Molecular psychiatry (2012)
Protein Misfolding Cyclic Amplification (PMCA) of Infectious Prions Morales R.; Duran-Aniotz C.; Diaz-Espinoza, R.; Camacho M.; Soto C. Article (2012)
Protein misfolding cyclic amplification of infectious prions Morales R.; Duran-Aniotz, C; Diaz-Espinoza, R; Camacho, MV; Soto, C. Article NATURE PROTOCOLS (2012)
Protein misfolding cyclic amplification of infectious prions Morales, Rodrigo; Duran-Aniotz, Claudia; Diaz-Espinoza, Rodrigo; Camacho, Manuel V.; Soto, Claudio Article ISI NATURE PROTOCOLS (2012)
De novo induction of amyloid-β deposition in vivo Morales R.; Duran-Aniotz C.; Castilla J.; Estrada, LD; Soto C. Article (2011)
Respiratory refinements in the mygalomorph spider Grammostola rosea walckenaer 1837 (Araneae, Theraphosidae) Canals M.; Salazar MJ.; Durán C.; Figueroa D.; Veloso C. Article ISI SCOPUS JOURNAL OF ARACHNOLOGY (2007)


Th1 and Th17 Profiles Induction and Treg Profiles Repression Are Associated With Immunological Responses and Long-term Patient Survival on Melanoma Patients Treated With Dentritic Cells Based Immunotherapy Durán C.; Segal G; Salazar, L; Pereda, C; Falcon, C; Tempio F.; Pérez, C.; SALAZAR ONFRAY F; Lopez M. Abstract ISI EUROPEAN JOURNAL OF CANCER (2012)
Dendritic Cells Therapy Induces CD4+T Memory Cells with Concomitant Profile TH1-TH17 in Responding Melanoma Pati ents Salazar, L; Lopez M.; Durán C.; Segal G; SALAZAR ONFRAY F Abstract ISI CLINICAL IMMUNOLOGY (2010)


1. Amyloid-β transmissibity. In “Proteopathic seeds and neurodegenerative diseases” Duran-Aniotz C.; Morales R.; Moreno-Gonzalez I.; Soto C.; Jucker M; Christen Y BookWhole (2012)


Targeting IRE1 in the nervous system reduces Alzheimer's disease pathogenesis. Duran Aniotz C,; Espinoza S,; Medinas D,; Cornejo VH,; Foley A,; Soto C,; Ardiles A,; Palacios A,; Hoozemans J; Hetz C. ConferencePoster (2017)
The Unfolded protein response (UPR) regulates the accumulation of Amyloid beta deposits in experimental model of Alzheimer’s disease. Duran-Aniotz C,; Espinoza S,; Foley A,; Cornejo VH,; Martinez G,; Vidal R,; Hetz C. ConferencePoster (2015)
Unfolded protein response (UPR) regulates the accumulation of Amyloid beta deposits in experimental model of Alzheimer’s disease Duran-Aniotz C,; Espinoza S,; Foley A,; Cornejo VH,; Martinez G,; Vidal R,; Hetz C. ConferencePoster (2015)
In vivo induction of Aβ aggregation by exposure to pre-symptomatic or asymptomatic AD brain samples. Duran-Aniotz C.; Morales R,; Moreno-Gonzalez I.; Hu PP.; Soto C. ConferencePoster (2013)
IRE1a/XBP-1 pathway controls APP metabolism and amyloid-beta aggregation in experimental models of Alzheimer’s disease. Cornejo VH,; Duran-Aniotz C,; González A,; Barraza R,; Burgos P,; Hetz C. ConferencePoster (2013)
The ER stress factor XBP-1 controls APP metabolism and amyloid- beta aggregation in experimental models of Alzheimer’s disease. Cornejo VH,; Paula-Lima A,; Duran-Aniotz C,; González A,; Burgos P,; Hetz C. ConferencePoster (2013)
The Unfolded protein response regulates the accumulation of Amyloid beta deposits in experimental model of Alzheimer’s disease Duran-Aniotz C,; Espinoza S,; Foley A,; Cornejo VH,; Soto C,; Palacios A,; Ardiles, A; Hetz C. ConferencePoster (2013)
Unfolded protein response (UPR) controls APP metabolism in experimental models of Alzheimer’s disease. Cornejo VH,; Duran-Aniotz C,; Espinoza S,; Foley A,; González A,; Burgos P,; Paula-Lima A,; Hetz C. ConferencePoster (2013)
Unfolded protein response (UPR) regulates the accumulation of Amyloid beta deposits in experimental model of Alzheimer’s disease. Duran-Aniotz C,; Espinoza S,; Foley A,; Cornejo VH,; Martinez G,; Vidal R,; Hetz C. ConferencePoster (2013)
Induction of Amyloid Deposition and Memory Impairments in Animal Models of Alzheimer’s disease by Blood Transfusion. Duran-Aniotz C.; Morales M.; Estrada L.; Urayama A.; Morales-Scheihing D.; Soto C. ConferencePoster (2012)
Induction of Aβ amyloidogenesis in vivo by blood transfusion. Morales M.; Duran-Aniotz C.; Urayama A.; Estrada L.; Morales-Scheihing D.; Soto C. ConferencePoster (2010)
Induction of TH1/TH17 and inhibition of TH3 Cellular Profile by DC-based Immunotherapy is Associated with Immunological and Clinical anti-Tumor Responses in Melanoma Patients. Duran-Aniotz C.; Segal G.; Salazar L.; Pereda C.; Tempio F.; Salazar-Onfray F.; Lopez M.N. ConferencePoster (2010)
TH1 and TH17 profiles induction and regulatory T cells decrement are associated with immunological responses and long-term patient survival on melanoma patients treated with dentritic cells based immunotherapy. Duran-Aniotz C.; Segal G.; Salazar L.; Pereda C.; Salazar-Onfray F.; López M.N. ConferencePoster (2010)
TH1 and TH17 profiles induction are associated with immunological responses and long-term patient survival on advanced melanoma patients treated with Dentritic Cells based immunotherapy. Falcón C.; Duran-Aniotz C.; Segal G.; Salazar L.; Pereda C.; Salazar-Onfray F.; López M.N. ConferencePoster (2010)
TH1 and TH17 profiles induction are associated with immunological responses and long-term patient survival on melanoma patients treated with Dentritic Cells based immunotherapy. Falcón C.; Duran-Aniotz C.; Segal G.; Salazar L.; Pereda C.; Salazar-Onfray F.; López M.N. ConferencePoster (2010)
Evaluation of cellular and soluble factors in malignant melanoma patients treated with cellular immunotherapy. Duran-Aniotz C.; Segal Wasserman G.; Salazar L.; Salazar-Onfray F.; Lopez M.N. ConferencePoster (2009)
Induction of immunoregulatory T lymphocytes populations by different human dendritic cells. Segal Wasserman G.; Duran-Aniotz C.; Salazar L.; Tempio F.; Salazar-Onfray F.; Lopez M.N. ConferencePoster (2009)
TH1 and TH17 Induction Assessment, mediated by human Dendritic Cells. Duran-Aniotz C.; Segal Wasserman G.; Salazar Aravena L.; Salazar-Onfray F.; Lopez M.N. ConferencePoster (2009)
Activation of NK cells in vivo by vaccination with DCs in melanoma patients. Kurte, M.; Toledo, P.; Duran-Aniotz C.; Pereda C.; López M.N.; Salazar-Onfray F. ConferencePoster (2008)
Evaluation of soluble levels of TGF-β1 and TH17 profile in melanoma patients with immunotherapy-based dendritic cells. Duran-Aniotz C.; Salazar L.; Serrano C.; Salazar-Onfray F.; Lopez M.N. ConferencePoster (2008)
Intercellular interaction between DC and NK cell mediated by Gap junctions. Farías M.; Salazar L.; Mendoza-Naranjo A.; Pereda C.; Duran-Aniotz C.; Segal G.; Sáez JC.; Salazar-Onfray F. ConferencePoster (2008)
Dendritic cells induce the activation of NK cells in melanoma patients. Kurte M.; Duran-Aniotz C.; Pereda C.; Segal G.; López M.N.; Salazar-Onfray F. ConferencePoster (2007)
Fauna malacológica del Archipiélago Juan Fernández (33º37'S; 78º51'O) presente en la colección de moluscos del Museo Nacional de Historia Natural (MNHNCL). Letelier S,; Duran-Aniotz C.; Salazar MJ.; Jaramillo P. ConferencePoster (2006)
Human NK activation mediated by melanoma lysate pulsed DC. Kurte M.; Pereda C.; Segal G.; Duran-Aniotz C.; Salazar-Onfray F. ConferencePoster (2006)
Pulmonary refinements for a good oxygen delivery in the migalomorfae spider Grammostola rosea. Canals, M.; Salazar M.J.; Duran-Aniotz C.; Figueroa D. P.; Veloso C. ConferencePoster (2006)


ER proteostasis impairment in aging Martínez G; Duran-Aniotz C.; Cabral-Miranda F.; Vivar JP; hetz C. JournalWhole (2017)


An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populations IbaÑez, Agustin Mariano; Claudia Duran-Aniotz Proyecto (2023)
Circadian disturbance and dementia in Latin America IbaÑez, Agustin Mariano; Claudia Duran-Aniotz Proyecto (2023)
Blood-borne components from pregnant females as a novel therapeutic avenue against Alzheimer’s disease Claudia Duran-Aniotz Proyecto (2022)
Contribution of peripheral Tau aggregates to Alzheimer´s disease pathogenesis Claudia, Duran-Aniotz Proyecto (2021)
Latin American Brain Health Institute (Brainlat). Universidad Adolfo Ibañez Claudia Duran-Aniotz Proyecto (2021)
Machine Learning for Mental Health: New Developments and Applications Using Multimodal Data de la Cruz, Rolando; Claudia, Duran-Aniotz Proyecto (2021)
Contribution of the Unfolded Protein Response Signaling to Retinal Neural circuits Function during Aging and Neurodegeneration Palacios A.G.; Duran-Aniotz C. Proyecto (2020)
Cancer leaves a trait of diminished immune tolerance that protects from Alzheimer’s disease Beherens, Maria I.; Duran-Aniotz C. Proyecto (2019)
Targeting the UPR stress sensor IRE1 to treat Alzheimer´s disease Alzheimer's Association (2018-AARG-591107) Proyecto 2019-2021 Inv. Responsable
Investigación traslacional en enfermedades neurodegenerativas y envejecimiento=> estudio de factores de riesgo y biomarcadores inflamatorios PCI (REDI170583) Proyecto 2017-2019 Inv. Responsable
Disrupted Proteostasis as a shared mechanism of cognitive decline in normal aging and Alzheimer’s Disease Hetz, C.; Duran-Aniotz, C. Proyecto (2016)
Proteostaser-1: una terapia génica enfocada a disminuir la neurodegeneración y aumentar la función cognitiva en la enfermedad de Alzheimer Hetz, C.; Duran-Aniotz, C. Proyecto (2016)
Proteostaser-1=> una terapia génica enfocada a disminuir la neurodegeneración y aumentar la función cognitiva en la enfermedad de Alzheimer FONDEF (ID16I10223) Proyecto 2016-2019 Subdirector(a)
TARGETING THE ER STRESS SENSOR IRE1 TO TREAT ALZHEIMER'S DISEASE FONDECYT (11160760) Proyecto 2016-2019 Inv. Responsable
Targeting the ER stress sensor IRE1 to treat Alzheimer’s disease Duran-Aniotz C.; Duran-Aniotz C. Proyecto (2016)
REGULATION OF AN AD-LIKE PROCESS BY THE UPR TRANSCRIPTION FACTOR XBP1 IN VIVO FONDECYT (3140466) Proyecto 2013-2016 Inv. Responsable
Absorption, Metabolism and Biodistribution of Prion after Oral Ingestion NIH/NINDS (1R01 NS340526-01) Proyecto 2012-2017 Personal técnico y/o de apoyo
Novartis Research Project Novartis Inc. Proyecto 2011-2012 Personal técnico y/o de apoyo
BUSQUEDA DE MARCADORES MOLECULARES DE RESPUESTA Y PROGRESION CLINICA EN SANGRE DE PACIENTES TRATADOS CON INMUNOTERAPIA CELULAR. FONDECYT (1090243) Proyecto 2009-2013 Personal técnico y/o de apoyo
Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases NIH/NIAID (5P01 AI077774-03) Proyecto 2008-2013 Personal técnico y/o de apoyo
CARACTERIZACION DE UN LISADO DE MELANOMA (TRIMEL) Y SU EFECTO SOBRE LA MADURACION Y DIFERENCIACION DE CELULAS DENDRITICAS DERIVADAS DE MONOCITOS DE PACIENTES CON CANCER PARA INMUNOTERAPIA CELULAR. FONDECYT (1070559) Proyecto 2007-2009 Personal técnico y/o de apoyo
Cyclic Amplification of Prion Protein Misfolding NIH/NINDS (5R01 NS49173-07) Proyecto 2004-2015 Personal técnico y/o de apoyo


La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer Rivera-Krstulovi?, Catalina; Duran-Aniotz, Claudia Review SCIELO REVISTA MEDICA DE CHILE (2020)
Endoplasmic reticulum proteostasis impairment in aging Martínez G.; Duran-Aniotz C.; Cabral-Miranda F.; Vivar J.P.; Hetz C. Review ISI SCOPUS AGING CELL (2017)

Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

Rodrigo Morales

Assistant Professor

Neurology

The University of Texas Health Science Center at Houston

Houston, Estados Unidos

Agustin Ibanez

Profesor Titular

Psicologia

Universidad Adolfo Ibánez

Santiago, Chile

Fernando Henriquez

Investigador Asociado

Departamento de Fisiopatologia, Facultad de Medicina

Universidad de Chile

Santiago , Chile

Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Daniela López

Profesora Adjunta

UNIVERSIDAD DE VALPARAISO

Viña de Mar, Chile

Arlek Gonzalez

INVESTIGADOR POST-DOCTORAL

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA, UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Gabriela Martinez

Instructor Adjunto

medicina

Universidad de Chile

santiago, Chile

Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Carolina Flores

Investigador Postdoctoral

Neurociencias

Universidad de Valparaíso

Valparaíso, Chile

Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Felipe Cabral

ASSISTENTE DE INVESTIGACIONES

UNIVERSIDADE FEDERAL DO RIO DE JANEIRO

Niterói, Chile

Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

lisbell estrada

Decana Facultad Ciencias de la Salud

Facultad de Ciencias de la Salud

Universidad Bernardo O Higgins

santiago, Chile

Víctor Cornejo

Associate Research Scientist

Biological Sciences

Columbia University

New York, Estados Unidos

Daniela Figueroa

Presidenta

Fundación Educación y Ciencia

Santiago, Chile

Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

Claudio Cordova

Investigador asistente

Medicina

Universidad de Valparaíso

Valparaíso, Chile

Claudio Veloso

Profesor Asociado

Departamento de Ciencias Ecológicas

UNIVERSIDAD DE CHILE. FACULTAD DE CIENCIAS

Santiago, Chile

Mauricio Canals

PROFESOR TITULAR

MEDICINA

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

SANTIAGO, Chile

Claudia Andrea Duran-Aniotz

Líneas de Investigación

Educación

Biología, UNIVERSIDAD DE CHILE. Chile, 2006

Inmunologia, UNIVERSIDAD DE CHILE. Chile, 2010

Biomedicina, UNIVERSIDAD DE LOS ANDES. Chile, 2013

Experiencia Académica

Co-tutor Unidad de Investigacion Other

Co-tutor Tesis de Pre-grado Other

Co-tutor tesis de Pre-grado Other

Profesor Asistente Full Time

Experiencia Profesional

Investigador Fondecyt Postdoctoral Full Time

Director Other

Investigador Asociado Part Time

Investigador Asociado Other

Investigador Fondecyt Iniciación Full Time

Profesor Asistente Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Beca Magister

Beca Ph.D.

Article (56)

Abstract (2)

BookWhole (1)

ConferencePoster (25)

JournalWhole (1)

Proyecto (22)

Targeting the UPR stress sensor IRE1 to treat Alzheimer´s disease

Investigación traslacional en enfermedades neurodegenerativas y envejecimiento=> estudio de factores de riesgo y biomarcadores inflamatorios

Proteostaser-1=> una terapia génica enfocada a disminuir la neurodegeneración y aumentar la función cognitiva en la enfermedad de Alzheimer

TARGETING THE ER STRESS SENSOR IRE1 TO TREAT ALZHEIMER'S DISEASE

REGULATION OF AN AD-LIKE PROCESS BY THE UPR TRANSCRIPTION FACTOR XBP1 IN VIVO

Absorption, Metabolism and Biodistribution of Prion after Oral Ingestion

Novartis Research Project

BUSQUEDA DE MARCADORES MOLECULARES DE RESPUESTA Y PROGRESION CLINICA EN SANGRE DE PACIENTES TRATADOS CON INMUNOTERAPIA CELULAR.

Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases

CARACTERIZACION DE UN LISADO DE MELANOMA (TRIMEL) Y SU EFECTO SOBRE LA MADURACION Y DIFERENCIACION DE CELULAS DENDRITICAS DERIVADAS DE MONOCITOS DE PACIENTES CON CANCER PARA INMUNOTERAPIA CELULAR.

Cyclic Amplification of Prion Protein Misfolding

Review (2)