Man

Claudia Andrea Duran-Aniotz

Profesor Asociado

Universidad Adolfo Ibánez

Santiago, Chile

Líneas de Investigación


Enfermedad de Alzheimer; Enfermedades Neurodegenerativas; Modelos MurinosTransgénicos; Investigación Traslacional; Biomarcadores tempranos en demencias

Educación

  •  Biología, UNIVERSIDAD DE CHILE. Chile, 2006
  •  Inmunologia, UNIVERSIDAD DE CHILE. Chile, 2010
  •  Biomedicina, UNIVERSIDAD DE LOS ANDES. Chile, 2013
  •  Neuroscience, UNIVERSIDAD DE CHILE. Chile, 2016

Experiencia Académica

  •   Co-tutor Unidad de Investigacion Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2014 - 2016

  •   Co-tutor Tesis de Pre-grado Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2016 - A la fecha

  •   Co-tutor tesis de Pre-grado Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2017 - A la fecha

  •   Profesor Asistente Full Time

    UNIVERSIDAD ADOLFO IBANEZ

    Chile

    2020 - 2022

  •   Profesor Asociado Full Time

    UNIVERSIDAD ADOLFO IBANEZ

    Chile

    2022 - A la fecha

Experiencia Profesional

  •   Investigador Fondecyt Postdoctoral Full Time

    Universidad de Chile

    Santiago, Chile

    2013 - 2016

  •   Director Other

    COPRAD

    Santiago, Chile

    2015 - 2021

  •   Investigador Asociado Part Time

    Centro de Gerociencia, Salud Mental y Metabolismo (GERO)

    Santiago, Chile

    2016 - A la fecha

  •   Investigador postdoctoral Other

    Instituto de Neurociencias Biomédicas (BNI)

    Santiago, Chile

    2013 - 2016

  •   Investigador Fondecyt Iniciación Full Time

    Universidad de Chile

    Santiago, Chile

    2016 - 2019

  •   Profesor Asistente Full Time

    Universidad Adolfo Ibañez

    Santiago, Chile

    2020 - 2022

  •   Miembro Científico Other

    COPRAD

    Chile

    2021 - A la fecha

  •   Miembro, Comité de Ética Other

    Escuela de Psicología, Universidad Adolfo Ibáñez

    Chile

    2020 - 2024

  •   Miembro Científico Part Time

    Universidad de Chile

    Chile

    2016 - 2019

Formación de Capital Humano


1.
Descripción: Tesis de pregrado para obtener el grado de licenciatura en ciencias farmacéuticas
Facultad de Ciencias Químicas y Farmacia, Departamento de Bioquímica y Biología Molecular.
Estudiante: Pablo Cabrera
Año: 2017-2018
Asesores: Director Dr. Claudio Hetz y Co-Director Dr. Claudia Duran-Aniotz

2.
Descripción: Tesis de pregrado para obtener el título de licenciatura en bioquímica
Facultad de Ciencias Químicas y Farmacia, Departamento de Bioquímica y Biología Molecular.
Estudiante: Javiera Acevedo
Año: 2016-2017
Asesores: Director Dr. Claudio Hetz y Co-Director Dr. Claudia Duran-Aniotz

3.
Descripción: Estancia de Investigación Corta de estudiantes de Medicina de Pregrado
Facultad de Medicina, Departamento de Biología Celular y Molecular
Estudiantes: Alfonso Warnken y Javiera Guerra
Año: 2016
Asesores: Director Dr. Claudio Hetz y Co-Director Dr. Claudia Duran-Aniotz

4.
Descripción: Estancia de investigación corta de los estudiantes de medicina de pregrado
Facultad de Medicina, Departamento de Biología Celular y Molecular
Estudiantes: Mario Ortega y César Pinilla
Año: 2015
Asesores: Director Dr. Claudio Hetz y Co-Director Dr. Claudia Duran-Aniotz

5.
Descripción: Estancia corta de investigación de estudiantes de medicina de pregrado
Facultad de Medicina, Departamento de Biología Celular y Molecular
Estudiantes: Nicolás Larraín y Camilo Cisternas.
Año 2014
Asesores: Director Dr. Claudio Hetz y Co-Director Dr. Claudia Duran-Aniotz


Difusión y Transferencia


Difusión

1.
Descripción: Directora en la Corporación profesional Alzheimer y otras demencias (COPRAD). Difusión y extension en actividades Sociales.
Fecha: 2013 hasta la fecha
COPRAD es una agrupación multidisciplinaria de profesionales enfocada en contribuir al mejoramiento de la calidad de vida de las personas afectadas por la enfermedad de Alzheimer y otras demencias, así como de sus grupos familiares y cercanos. La finalidad esencial de COPRAD es velar por el bienestar de aquellos, mediante la disminución del impacto social y económico causado por la enfermedad de Alzheimer y otras demencias, tanto en el ámbito público como privado, a través de la organización, planificación, ejecución y seguimiento de programas, proyectos, iniciativas y acciones conducentes a la investigación, educación, prevención y el tratamiento de dichas enfermedades.

2.
Descripción: Difusión y participación activa en programa de difusión y extension Instituto de Neurociencias Biomédicas (BNI) y el programa Explora
Fecha: 2014 hasta la fecha

Propiedad Intelectual

1. Titulo: MÉTODO PARA IDENTIFICAR CANDIDATOS TERAPÉUTICOS PARA EL TRATAMIENTO DE ALZHEIMER A TRAVÉS DE IRE1
La tecnología fue evaluada en modelos preclínicos y está siendo presentada a solicitud de patente nacional por la Vicerrectoría de Investigaciones de la Universidad de Chile.
Inventores: Dr. Claudio Hetz y Dr. Claudia Duran-Aniotz
N° Solicitud: 201603402.
Fecha Presentación: 30/12/2016.
Folio Pago Electrónico: 280982.
N° Atención: 161229175528008.

Estadías en el Extranjero

1.
Universidad: Universidad de Texas, Houston, Estados Unidos.
Año: 2014.
Duración: 2 meses.
Investigador Principal: Dr. Claudio Soto.

2.
Universidad: Universidad de Amsterdam, Holanda.
Año: 2016.
Duración: 1 mes.
Investigador Principal: Dr. Jereon Hoozemans.


Premios y Distinciones

  •   Beca Magister

    UNIVERSIDAD DE CHILE

    Chile, 2008

    Beca Arancel Magíster en Ciencias con mención en Inmunología, Universidad de Chile.

  •   Beca Ph.D.

    UNIVERSIDAD DE LOS ANDES

    Chile, 2010

    Beca Arancel Ph.D. en Biomedicina, Universidad de los Andes.


 

Article (47)

Allostasis, health, and development in Latin America
Long-Term Survival and Immune Response Dynamics in Melanoma Patients Undergoing TAPCells-Based Vaccination Therapy
Neuroecological links of the exposome and One Health
Genetic overlap between cortical brain morphometry and frontotemporal dementia risk
Latin American women in dementia research: outstanding contributions, barriers, and opportunities from Argentinian, Chilean, and Colombian colleagues
Promoting diversity and overcoming publication barriers in Latin American neuroscience and Alzheimer's disease research: A call to action
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis
A predictive coding framework of allostatic-interoceptive overload in frontotemporal dementia
Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model
Allostatic-Interoceptive Overload in Frontotemporal Dementia
Associations of body mass index and sarcopenia with screen-detected mild cognitive impairment in older adults in Colombia
Biomarkers for dementia in Latin American countries: Gaps and opportunities
Editorial: Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches
Multiscale entropy analysis of retinal signals reveals reduced complexity in a mouse model of Alzheimer's disease
Neuronal Rubicon Represses Extracellular APP/Amyloid beta Deposition in Alzheimer's Disease
Risk factors for loneliness in family caregivers of people with dementia and enduring mental health conditions during the COVID-19 pandemic in Latin America
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis
The burden of mild cognitive impairment attributable to physical inactivity in Colombia
The Latin American Brain Health Institute, a regional initiative to reduce the scale and impact of dementia
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging
Amyloid pathology arrangements in Alzheimer's disease brains modulate in vivo seeding capability
DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease
Retinal Ganglion Cells Functional Changes in a Mouse Model of Alzheimer's Disease Are Linked with Neurotransmitter Alterations
Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries
The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science
Transmission of cerebral amyloid pathology by peripheral administration of misfolded Aβ aggregates
Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease
GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly
Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer's disease
The impact of SARS-CoV-2 in dementia across Latin America: A call for an urgent regional plan and coordinated response
Unfolded protein response as a target in the treatment of Alzheimer's disease
IRE1 signaling exacerbates Alzheimer's disease pathogenesis
Commentary=> XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity.
Gene therapy to target ER stress in brain diseases
Glucose Metabolism=> A Sweet Relief of Alzheimer's Disease.
Role of prion replication in the strain-dependent brain regional distribution of prions
Strain-dependent profile of misfolded prion protein aggregates
ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders
Titration of biologically active amyloid-beta seeds in a transgenic mouse model of Alzheimer's disease
Aggregate-Depleted Brain Fails to Induce A beta Deposition in a Mouse Model of Alzheimer's Disease
Brains from non-Alzheimer's individuals containing amyloid deposits accelerate A? deposition in vivo
Agregados amiloides: rol en desórdenes de conformación proteica
Lack of prion transmission by sexual or parental routes in experimentally infected hamsters
The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses
De novo induction of amyloid-beta deposition in vivo
Protein misfolding cyclic amplification of infectious prions
Respiratory refinements in the mygalomorph spider Grammostola rosea walckenaer 1837 (Araneae, Theraphosidae)

Abstract (2)

Th1 and Th17 Profiles Induction and Treg Profiles Repression Are Associated With Immunological Responses and Long-term Patient Survival on Melanoma Patients Treated With Dentritic Cells Based Immunotherapy
Dendritic Cells Therapy Induces CD4+T Memory Cells with Concomitant Profile TH1-TH17 in Responding Melanoma Pati ents

BookWhole (2)

1. Amyloid-β transmissibity. In “Proteopathic seeds and neurodegenerative diseases”
Role of prion protein oligomers in the pathogenesis of transmissible spongiform encephalopathies

ConferencePaper (1)

Reconsideración de los aportes de Humberto Maturana para los desafíos actuales de las neurociencias cognitivas

ConferencePoster (25)

Targeting IRE1 in the nervous system reduces Alzheimer's disease pathogenesis.
The Unfolded protein response (UPR) regulates the accumulation of Amyloid beta deposits in experimental model of Alzheimer’s disease.
Unfolded protein response (UPR) regulates the accumulation of Amyloid beta deposits in experimental model of Alzheimer’s disease
In vivo induction of Aβ aggregation by exposure to pre-symptomatic or asymptomatic AD brain samples.
IRE1a/XBP-1 pathway controls APP metabolism and amyloid-beta aggregation in experimental models of Alzheimer’s disease.
The ER stress factor XBP-1 controls APP metabolism and amyloid- beta aggregation in experimental models of Alzheimer’s disease.
The Unfolded protein response regulates the accumulation of Amyloid beta deposits in experimental model of Alzheimer’s disease
Unfolded protein response (UPR) controls APP metabolism in experimental models of Alzheimer’s disease.
Unfolded protein response (UPR) regulates the accumulation of Amyloid beta deposits in experimental model of Alzheimer’s disease.
Induction of Amyloid Deposition and Memory Impairments in Animal Models of Alzheimer’s disease by Blood Transfusion.
Induction of Aβ amyloidogenesis in vivo by blood transfusion.
Induction of TH1/TH17 and inhibition of TH3 Cellular Profile by DC-based Immunotherapy is Associated with Immunological and Clinical anti-Tumor Responses in Melanoma Patients.
TH1 and TH17 profiles induction and regulatory T cells decrement are associated with immunological responses and long-term patient survival on melanoma patients treated with dentritic cells based immunotherapy.
TH1 and TH17 profiles induction are associated with immunological responses and long-term patient survival on advanced melanoma patients treated with Dentritic Cells based immunotherapy.
TH1 and TH17 profiles induction are associated with immunological responses and long-term patient survival on melanoma patients treated with Dentritic Cells based immunotherapy.
Evaluation of cellular and soluble factors in malignant melanoma patients treated with cellular immunotherapy.
Induction of immunoregulatory T lymphocytes populations by different human dendritic cells.
TH1 and TH17 Induction Assessment, mediated by human Dendritic Cells.
Activation of NK cells in vivo by vaccination with DCs in melanoma patients.
Evaluation of soluble levels of TGF-β1 and TH17 profile in melanoma patients with immunotherapy-based dendritic cells.
Intercellular interaction between DC and NK cell mediated by Gap junctions.
Dendritic cells induce the activation of NK cells in melanoma patients.
Fauna malacológica del Archipiélago Juan Fernández (33º37'S; 78º51'O) presente en la colección de moluscos del Museo Nacional de Historia Natural (MNHNCL).
Human NK activation mediated by melanoma lysate pulsed DC.
Pulmonary refinements for a good oxygen delivery in the migalomorfae spider Grammostola rosea.

EditorialMaterial (2)

Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease
Memory loss in Alzheimer's disease: are the alterations in the UPR network involved in the cognitive impairment?

Proyecto (25)

An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populations
Circadian disturbance and dementia in Latin America
Identification and validation of novel cell-free DNA methylation-based biomarkers for diagnosis of Alzheimer’s disease and frontotemporal dementia progression in blood
Peripheral Tau Aggregates in Alzheimer´s Disease pathogenesis
Blood-borne components from pregnant females as a novel therapeutic avenue against Alzheimer’s disease
Genetics of Alzheimer's Disease and Related Dementias in Latin America
Contribution of peripheral Tau aggregates to Alzheimer´s disease pathogenesis
Latin American Brain Health Institute (Brainlat). Universidad Adolfo Ibañez
Machine Learning for Mental Health: New Developments and Applications Using Multimodal Data
Contribution of the Unfolded Protein Response Signaling to Retinal Neural circuits Function during Aging and Neurodegeneration
Cancer leaves a trait of diminished immune tolerance that protects from Alzheimer’s disease
Targeting the UPR stress sensor IRE1 to treat Alzheimer´s disease
Investigación traslacional en enfermedades neurodegenerativas y envejecimiento=> estudio de factores de riesgo y biomarcadores inflamatorios
Disrupted Proteostasis as a shared mechanism of cognitive decline in normal aging and Alzheimer’s Disease
Proteostaser-1: una terapia génica enfocada a disminuir la neurodegeneración y aumentar la función cognitiva en la enfermedad de Alzheimer
Proteostaser-1=> una terapia génica enfocada a disminuir la neurodegeneración y aumentar la función cognitiva en la enfermedad de Alzheimer
TARGETING THE ER STRESS SENSOR IRE1 TO TREAT ALZHEIMER'S DISEASE
Targeting the ER stress sensor IRE1 to treat Alzheimer’s disease
REGULATION OF AN AD-LIKE PROCESS BY THE UPR TRANSCRIPTION FACTOR XBP1 IN VIVO
Absorption, Metabolism and Biodistribution of Prion after Oral Ingestion
Novartis Research Project
BUSQUEDA DE MARCADORES MOLECULARES DE RESPUESTA Y PROGRESION CLINICA EN SANGRE DE PACIENTES TRATADOS CON INMUNOTERAPIA CELULAR.
Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases
CARACTERIZACION DE UN LISADO DE MELANOMA (TRIMEL) Y SU EFECTO SOBRE LA MADURACION Y DIFERENCIACION DE CELULAS DENDRITICAS DERIVADAS DE MONOCITOS DE PACIENTES CON CANCER PARA INMUNOTERAPIA CELULAR.
Cyclic Amplification of Prion Protein Misfolding

Review (4)

Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City
Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer's disease
La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer
Endoplasmic reticulum proteostasis impairment in aging
97
Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

11
Agustin Ibanez

Profesor Titular

Psicologia

Universidad Adolfo Ibánez

Santiago, Chile

9
Rodrigo Morales

Assistant Professor

Neurology

The University of Texas Health Science Center at Houston

Houston, Estados Unidos

5
Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

4
Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

3
Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

2
Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

2
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

2
Wileidy Gómez

Postdoctorado

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Joaquìn Araya

Profesor Asistente

Facultad de Salud

Universidad Santo Tomás

Santiago, Chile

2
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

2
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

2
Fernando Henriquez

Investigador Asociado

Departamento de Fisiopatologia, Facultad de Medicina

Universidad de Chile

Santiago , Chile

2
Rodrigo Santibáñez

Behavioral Neurologist

Neurology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
lisbell estrada

Decana Facultad Ciencias de la Salud

Facultad de Ciencias de la Salud

Universidad Bernardo O Higgins

santiago, Chile

2
Víctor Cornejo

Profesor Asistente

Facultad de Ciencias Biológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pedro Zitko

Jefe de Unidad

Dirección

Hospital Barros Luco Trudeau

Santiago, Chile

1
Diego Catalán

Associate Professor

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

1
Carolina Toledo

Jefa de Departamento

Dirección de Atención Primaria

Servicio de Salud Metropolitano Occidente

Santiago, Chile

1
Daniela Thumala

Profesora Asociada - área Psicología Clínica

Departamento de Psicología

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Melissa Calegaro

Principal Investigator, head lab

Research Vice Presidency

Universidad Mayor

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Adolfo García

Investigador Asociado

Facultad de Humanidades

Universidad de Santiago de Chile

Santiago de Chile, Chile

1
Gorka Navarrete

Adjunct Professor

Psychology

Universidad Adolfo Ibánez

Santiago, Chile

1
Carolina Flores

Investigador Postdoctoral

Neurociencias

Universidad de Valparaíso

Valparaíso, Chile

1
Raquel Aguilera

PROFESOR ASISTENTE

INMUNOLOGÍA CLÍNICA Y REUMATOLOGÍA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Arlek Gonzalez

INVESTIGADOR POST-DOCTORAL

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA, UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Cristian Falcón

Urólogo

Hospital San Juan de Dios

Santiago, Chile

1
Gabriela Martinez

Instructor Adjunto

medicina

Universidad de Chile

santiago, Chile

1
Max Chacón

Profesor Titular

Ingeniería Informática

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Vicente Valenzuela

Investigador postdoctoral

Instituto de Neurociencia Biomédica

Santiago, Chile

1
Carol San Martín

Profesora Asistente

Neurología y Neurocirugía

Universidad de Chile

Santiago, Chile

1
Felipe Grunenwald

Postdoctoral Researcher

CIIB

Universidad de Los Andes

santiago, Chile

1
Felipe Cabral

ASSISTENTE DE INVESTIGACIONES

UNIVERSIDADE FEDERAL DO RIO DE JANEIRO

Niterói, Chile

1
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Claudio Cordova

Investigador asistente

Medicina

Universidad de Valparaíso

Valparaíso, Chile

1
Daniela Figueroa

Presidenta

Fundación Educación y Ciencia

Santiago, Chile

1
Andrés Tittarelli

Profesor Asociado

Instituto Universitario de Investigación y Desarrollo Tecnológico (IDT)

Universidad Tecnológica Metropolitana

Santiago, Chile

1
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Daniela López

Profesora Adjunta

UNIVERSIDAD DE VALPARAISO

Viña de Mar, Chile

1
Josefina Cruzat

Profesor Asistente

Psicología

Universidad Adolfo Ibánez

Santiago, Chile

1
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Rolando de la Cruz

Associate Professor

Faculty of Engineering and Sciences

Universidad Adolfo Ibáñez

Peñalolén, Santiago, Chile

1
Claudio Veloso

Profesor Asociado

Departamento de Ciencias Ecológicas

UNIVERSIDAD DE CHILE. FACULTAD DE CIENCIAS

Santiago, Chile

1
Mauricio Canals

PROFESOR TITULAR

MEDICINA

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

SANTIAGO, Chile