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Fabian Ignacio Tempio Sepulveda

Asistente de Investigación

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Inmunoterapia contra el Cáncer Inmunología del Vitiligo Inmunolgía de enfermedades Obstetricas

Educación

  •  Biólogo , PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2012

Experiencia Académica

  •   Profesional de laboratorio Part Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2015 - A la fecha

Experiencia Profesional

  •   Profesional de laboratorio Part Time

    Universidad de Chile

    Santiago, Chile

    2015 - A la fecha

  •   Asistente de Investigación Part Time

    Oncobiomed

    Santiago, Chile

    2010 - 2013


 

Article (13)

A heat shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells inhibiting tumor growth
Inverse Relationship Between Alzheimer’s Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases
Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
Dendritic Cells Loaded with Heat Shock-Conditioned Ovarian Epithelial Carcinoma Cell Lysates Elicit T Cell-Dependent Antitumor Immune Responses In Vitro
Dexamethasone turns tumor antigen-presenting cells into tolerogenic dendritic cells with T cell inhibitory functions
The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis.
Pure platelet-rich plasma and supernatant of calcium-activated P-PRP induce different phenotypes of human macrophages
The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis
Overexpression of connexin 43 reduces melanoma proliferative and metastatic capacity
Melanocytes and melanin represent a first line of innate immunity against Candida albicans
Neisseria gonorrhoeae Induces a Tolerogenic Phenotype in Macrophages to Modulate Host Immunity
The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses
mTORC inhibitor Sirolimus deprograms monocytes in "cytokine storm" in SARS-CoV2 secondary hemophagocytic lymphohistiocytosis- like syndrome

Abstract (7)

Ovarian carcinoma cell line lysates are a potent maturation stimulus and tumoral antigen source for therapeutic dendritic cell enablement against cancer
Participation of CD103+DCs in the efficacy of a new vaccine based on conditioned melanoma lysates (TrimelVax)
Blocking of PD-L1 on therapeutic dendritic cells modulate in vitro T cells proliferation and differentiation to Th1 and Th17 subpopulations
Dexamethasone inhibits tumor cell lysate induction of a pro-inflammatory dendritic cell phenotype and function modulating T cell cytokine profiles
Role of Melanization in the Innate Immune Response of Melanocytes Against C. Albicans
In Vitro Generated Human Dendritic Cells Exposed to a Potent Maturation Melanoma Cell Lines Lysate Show a Tolerogenic-like Phenotype and Functionality When Exposed to Dexamethasone Prior to the Maturation Stimuli
Th1 and Th17 Profiles Induction and Treg Profiles Repression Are Associated With Immunological Responses and Long-term Patient Survival on Melanoma Patients Treated With Dentritic Cells Based Immunotherapy

Patent (1)

IMMUNOGENIC FORMULATIONS FOR TREATING CANCER

Proyecto (6)

Proyecto FONDEF IDEA Desarrollo de una vacuna terapéutica Thermovax, contra el cáncer de piel
Role of immune and inflammatory markers as sceening test for preeclampsia during the first trimester of pregnacy
Gap Juntion intercellular connection (GJIC) in the Anti- Tunor immune response
Studies on the Phenotypic Characteristics of Dendritic Cells that Determine the Reprogramming Capacity of Memory Anti-Tumor T
Búsqueda de marcadores moleculares de respuesta y progresión clínica en sangre de pacientes tratados con inmunoterapia
Identificación y caracterización de nuevos componentes moleculares en la interacción celular entre tumores y células del sistema inmunológico
22
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

11
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

5
Andrés Tittarelli

Investigador

Universidad Tecnológica Metropolitana

Santiago, Chile

4
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

3
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Felipe Falcón

Médico Cirujano

Pediatría

Hospital Clínico San Borja Arriarán

Santiago, Chile

3
Cristian Falcón

Urólogo

Hospital San Juan de Dios

Santiago, Chile

2
Claudio Alburquenque

Profesor asociado

Universidad Mayor

Santiago, Chile

2
Fermín González

Profesor Asociado

universidad de chile

Santiago, Chile

2
Iván Flores

Post Doc

Progama de Inmunología

Universidad de Chile

Santiago, Chile

1
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ethel Velásquez

investigador

Departamento de Tecnologías Nucleares

Comisión Chilena de Energía Nuclear

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

1
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
SERGIO BUCAREY

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

1
Raquel Aguilera

PROFESOR ASISTENTE

INMUNOLOGÍA CLÍNICA Y REUMATOLOGÍA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Kevin Maisey

Profesor Asistente

Centro de Biotecnología Acuícola

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Cecilia Tapia

Médico Asesor en Microbiología y Biología Molecular

Laboratorio

Clínica Dávila

SANTIAGO, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Diego Catalán

Profesor Asistente

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

1
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile