Man

Fabiola Alejandra Sánchez Vásquez

Associate Profesor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Líneas de Investigación


Inflammation, endothelial cell biology, S-nitrosylation

Educación

  •  Molecular and Cell Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
  •  Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1996

Experiencia Académica

  •   Associate Profesor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Chile

    2014 - A la fecha

  •   Assistant Profesor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Chile

    2009 - 2014

Experiencia Profesional

  •   Research Associate Other

    University of Medicine and Dentistry of New Jersey

    Estados Unidos

    2007 - 2008

Formación de Capital Humano


THESIS DIRECTION (Tutor):

Finished Under-graduate:
-Roshniben J. Rana. Functional significance of cytosol, plasma membrane and Golgi-targeted endothelial nitric oxide synthase in ECV-304 cells. Master in Sciences. Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey. 2009.

-Rodrigo Carrasco. Modifications mediated by nitric oxide in proteins from the adherens junction during the increase in microvascular permeability. UACh. Biochemist. 2011.

-Natalie Marín. Nitric oxide modifies ß-Catenin and VASP through S-nitrosation dependen ton te subcellular location of eNOS. UACh. Medical Technician. 2012.

-Anita Guequén A. ''Rol del óxido nítrico sobre permeabilidad microvascular mediada por interleuquina 8''. BIOQUÍMICA. Universidad Austral de Chile. 2013.

-Francisco Córdova. Modificaciones en ELAM-1 e ICAM-1 por agonistas proinflamatorios que estimulan la producción de Óxido Nítrico en el comienzo de la respuesta inflamatoria. UACh. Medical Technician.

-Lorena Rebolledo. ROL DE LA S-NITROSILACIÓN DE VE-CADERINA EN EL CONTEXTO DE LA PERMEABILIDAD MICROVASCULAR ASOCIADA A CÁNCER DE MAMA” UACh. Medical Technician.

-Nicolás Nahuel. Mechanisms of regulation of VE-cadherin by S-nitrosylation. UACh. Medical Technician. 2018

-Tania Koning. Rol de la s-nitrosilación de VCAM-1 sobre la adhesión de leucocitos inducido por IL-8 y medio condicionado de células de cáncer de mama MDA-MB- 231.UACh. Biochemist. 2018

Finished Gaduate:
-Alejandra Aguilar. Mechanisms of regulation of ICAM-1 involved eNOS activation at the onset of the inflammatory response. Doctorate Program in Veterinary Sciences. 2019

In course Graduate:
-Patricia Zamorano. Galectin-8 induces increase in endothelial permeability through eNOs-S-nitrosylation signalling.
- Tania Koning. VCAM-1 Y S-NITROSILACIÓN DE PROTEÍNAS EN LA METÁSTASIS PULMONAR DE CÁNCER DE MAMA EN UN MODELO MURINO

THESIS DIRECTION (Co-Tutor):

2013. Andrade Y. ''Efecto de la Activación del Receptor b1 de Cininas vía Transactivación del EGFR en la Fosforilación de MAPKs, JNK, p38, Akt y mTOR en Células de Cáncer de Mama''. TECNOLOGÍA MÉDICA. Universidad Austral de Chile.

In course:
Beatriz Teuber. El RB1 modula los niveles de expresión de UPA y COX-2 en células de cáncer de mama. Master in Phatology. UACh.


Difusión y Transferencia


2018. Organización 3rd International Symposium Cancer and Inflammation: from cell biology to therapy. Universidad Austral de Chile, Campus Isla Teja, Valdivia, Chile.
2017. Organización Curso sobre cuidado y uso de roedores de laboratorio, Valdivia,
2015. Organización 2nd International Symposium on Cancer and Inflammation: from adherens junctions to disease. CHILE, Valdivia.
2013. Organización International Symposium: Cancer and Inflammation: From Adherens Junctions to Disease. Valdivia, Chile.


Premios y Distinciones

  •   August Krogh Postdoctoral Fellow Award

    The Microcirculatory Society

    Estados Unidos, 2008

    Award to Post-Doctoral work

  •   Recognition Award for Meritorious Research by a Young Investigator

    The American Physiological Society, Cardiovascular Section

    Chile, 2007

    Award to young investigators


 

Article (19)

Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A(3) Adenosine Receptor activation under hypoxia
Galectin-8 induces endothelial hyperpermeability through the eNOS pathway involving S-nitrosylation-mediated adherens junction disassembly
Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells
S-nitrosylation and its role in breast cancer angiogenesis and metastasis.
Endothelial cAMP deactivates ischemia-reperfusion-induced microvascular hyperpermeability via Rap1-mediated mechanisms
S-nitrosylation of VASP at cysteine 64 mediates the inflammation-stimulated increase in microvascular permeability
New Member of Endothelial Arsenal Against Inflammation
S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability
S-nitrosation of proteins: An emergent regulatory mechanism in microvascular permeability and vascular function
S-Nitrosation of beta-Catenin and p120 Catenin A Novel Regulatory Mechanism in Endothelial Hyperpermeability
Functional Significance of Cytosolic Endothelial Nitric-oxide Synthase (eNOS) REGULATION OF HYPERPERMEABILITY
Independent Regulation of Periarteriolar and Perivenular Nitric Oxide Mechanisms in the In Vivo Hamster Cheek Pouch Microvasculature
Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability
Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules
Endothelial nitric oxide synthase is a molecular vascular target for the Chinese herb Danshen in hypertension
. Endothelial nitric oxide synthase-derived NO signals regulate microvascular permeability
Functional significance of differential eNOS translocation
Evaluation of the internalization process of the fish pathogen Renibacterium salmoninarum in cultured fish cells

Abstract (4)

S-nitrosylation of beta-catenin and p-120 catenin: a novel regulatory mechanism in endothelial hyperpermeability.
Platelet activating factor (PAF) induces s-nitrosylation of signalling proteins in an endothelial cell line
Inhibition of eNOS internalization dissociates PAF-induced
Opioid receptor are apically segregated in transfected MDCK cells

Proyecto (4)

Unveiling the functional role, signaling and biomarker utility of KLK4 and KLK12 in breast cancer
Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process
eNOS-derived NO signaling mechanisms in the regulation of endothelial paracellular permeability
Signaling Mechanisms Regulated by eNOS-S-nitrosation at the Onset of the Inflammatory Process.

Review (4)

S-nitrosylation and its role in breast cancer angiogenesis and metastasis
Nitric Oxide, S-Nitrosation, and Endothelial Permeability
The NO cascade, eNOS location, and microvascular permeability
MECHANISMS OF ACUPUNCTURE AND HERBAL MEDICINE IN HYPERTENSION
37
Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

4
INGRID EHRENFELD

ASSOCIATE PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

3
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

2
Anita Guequen

Asistente de investigación

Biología

Centro Estudios Científicos (CECs)

Valdivia, Chile

2
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

2
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

2
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

1
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Ethel Velásquez

investigador

Departamento de Tecnologías Nucleares

Comisión Chilena de Energía Nuclear

Santiago, Chile

1
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
José Rocha

Research Assistant

Evolutionary Biology

Centro de investigación i-mar

Puerto Montt, Chile

1
GONZALO MARDONES

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile