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Claudia Andrea Quezada Monrás

Full Professor

Universidad Austral de Chile

Valdivia, Chile

Líneas de Investigación


Cancer stem cells Glioblastoma Multidrugs resistance Adenosine and receptors Resistance mechanisms Clinical studies in cancer Cancer treatment alternatives Angiogenesis

Educación

  •   PhD in Molecular Biosciences, Universidad Andrés Bello. Chile, 2005
  •  Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997
  •  Bachelor in Biochemistry, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997

Experiencia Académica

  •   Assistant Professor Full Time

    Universidad Andrés Bello

    Science Faculty

    Santiago, Chile

    1999 - 2005

  •   Associate Professor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Science Faculty

    Valdivia, Chile

    2011 - 2018

  •   Assistant Professor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Science Faculty

    Valdivia, Chile

    2005 - 2011

  •   Full Professor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Science Faculty

    Valdivia, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Academic Secretary Baccalaureate in Science Program Other

    Universidad Andrés Bello

    Santiago, Chile

    1999 - 2005

  •   Director of Medical Technology Other

    Universidad Andrés Bello

    Santiago, Chile

    1999 - 2000

  •   Director of Dissemination of Undergraduate Careers of the Faculty of Sciences. Other

    Universidad Austral de Chile

    Valdivia, Chile

    2017 - A la fecha

  •   Member of the commission of accreditation of the PhD Program in Sciences, mention Cellular and Molecular Biology Part Time

    Universidad Austral de Chile

    Valdivia, Chile

    2016 - A la fecha

  •   Director by Valdivia of the Society of Biochemistry and Molecular Biology of Chile Part Time

    Universidad Austral de Chile

    Valdivia, Chile

    2015 - A la fecha

  •   Profesor Titular Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2018 - A la fecha

  •   Member of the Academic Council and Higher University Council Part Time

    Universidad Austral de Chile

    Valdivia, Chile

    2017 - A la fecha

Formación de Capital Humano


Human Capital Formation

Undergraduate Sponsorship (23)

-2020 Uribe A.Rol de adenosina desaminasa en el fenotipo invasivo de las glioblastoma stem-like cells bajo condiciones de hipoxia”. Bioquímica. Universidad Austral de Chile.
-2019. Toro MA. Estudio de la expresión y actividad de los transportadores de nucleósidos en glioblastoma stem-like cells” Bioquímica. Universidad Austral de Chile.
-2019. Wagner G. Participación de los receptores de adenosina A2b y A3 en la regulación de las características troncales de glioblastoma stem-like cells. Tecnología. Médica. Universidad Austral de Chile.
-2018. Delgado J. Análisis de la vía de señalización PI3K/Akt y su rol en quimioresistencia mediada por los receptores de baja afinidad de adenosina en células iniciadoras del glioblastoma multiforme humano”, Bioquímica. Universidad Austral de Chile.
-2017. Rios J. Evaluación de los genes relacionados con quimioresistencia e infiltración regulados por el receptor de Adenosina A3 en glioblastoma stem-like cells”,Química y Farmacia. Universidad Andrés Bello
-2017. Ojeda K. '' Role of adenosine on the secretion of VEGF and differentiation of glioblastoma stm-likeCells to vascular endothelial cells under conditions of hypoxia. BIOCHEMISTRY. Universidad Austral de Chile.
-2017. Delgado J. '' Analysis of the PI3K / Akt signaling pathway and its role in drug-mediated chemoresistanceAdenosine low affinity receptors on human Glioblastoma multiforme primers ".BIOCHEMISTRY. Universidad Austral de Chile.
-2017. Erices J. '' Study of the role of adenosine in the invasive capacity of glioblastoma stem-like cells underConditions of hypoxia ". BIOCHEMISTRY. Universidad Austral de Chile.
-2016. Arriagada V. '' Study of the effect of tacrolimus on multiple drug resistance of stem-like cells ofGlioblastoma multiforme human ". BIOCHEMISTRY. Universidad Austral de Chile.
-2015. Vargas Y. Study of multiple drug resistance modulators in an in vivo allogeneic model ofGlioblastoma ". BIOCHEMISTRY. Universidad Austral de Chile.
-2015. Uribe D. Study of the effect of hypoxia on multiple drug resistance in stem-like cells ofGlioblastoma ". BIOCHEMISTRY. Universidad Austral de Chile.
-2015. González C. '' Study of signaling pathways involved in the chemoresistance in GlioblastomaMediated by Adenosine ". BIOCHEMISTRY. Universidad Austral de Chile.
-2014. Dellarossa A. Role of adenosine in multiple drug resistance in glioma-starter cells ofhigh grade''. BIOCHEMISTRY. Universidad Austral de Chile.
-2014. Hueicha K. Effect of MRP1 chemosensitizers on cytotoxicity and antiproliferation of drugsAntitumor agents in human glioblastoma multiforme primer cells ". MEDICAL TECHNOLOGY. Universidad Austral de Chile.
-2014. Rocha J. Study of the MRP1 drug resistance transporter in Gliobastoma multiforme human ". BIOCHEMISTRY. Universidad Austral de Chile.
-2013. Vergara R. '' Characterization of drug resistance transporters in gynecological tumors ''.BIOCHEMISTRY. Universidad Austral de Chile.
-2013. Cid M. Effect of Sulindac on the activity of multiple drug resistance proteins inHuman multiform glioblastomas ". MEDICAL TECHNOLOGY. Universidad Austral de Chile.
-2012. Muñoz M. '' Tacrolimus modulates the expression and activity of drug resistance transporters in Brain tumors ". CHEMISTRY AND PHARMACY. Universidad Austral de Chile.
-2011. Salinas J. Effect of inhibition of the MRP1 transporter on the chemoresistance in glioblastoma Human multiforme ". CHEMISTRY AND PHARMACY. Universidad Austral de Chile.
-2010. Cabezas G. '' Quantification of the expression and determination of the location of the transporters of Drug resistance MRP-1, P-gp and ABCG2 in cell lines and primary culture of brain tumors humans''. CHEMISTRY AND PHARMACY. Universidad Austral de Chile.
-2010. Peigñan L. 'Evaluation of the inhibition of MRP1 transporter activity on cytotoxicity and Antiproliferative effect of antineoplastic drugs in the T98G cell line and primary culture of glioblastoma Human multiforme ". BIOCHEMISTRY. Universidad Austral de Chile.
-2009. Alarcón S. '' Effect of diabetic syndrome on the expression and activity of ABC proteins ''. BIOCHEMISTRY. Universidad Austral de Chile.
-2008. Garrido W. '' Regulation of the expression and activity of proteins of the ABC family and non ABC by tacrolimus and cyclosporin A in hematopoietic barrier and brain tumor cells. " BIOCHEMISTRY. Universidad Austral de Chile.

Undergraduate Co-Sponsorship (6)

-2015. Rubilar P. The variation of the expression of immunophilin 65 (FKBP65) in the diagnosis and prognosis of colon cancer. Defining a possible early marker ". MEDICAL TECHNOLOGY. Universidad Austral de Chile.
-2014. Bórquez C. '' Estimation of the incidence of genetic polymorphisms associated with the pharmacogenetics of Methotrexate and its clinical implications in pediatric patients with acute lymphoblastic leukemia. " CHEMISTRY AND PHARMACY. Universidad Austral de Chile.
-2014. Ross T. Generation of a plasmid vector for the overexpression of the adenosine A2B receptor in Renal cell lines ". Bachelor of Science in Biological Sciences. Universidad Austral de Chile.
-2014. Vidal Y. Study of the differentiation in glioblastoma-initiating cells in the presence of a new Polymer matrix ". CHEMISTRY AND PHARMACY. Universidad Austral de Chile.
-2013. Kretschmar C. '' Role of adenosine receptors on epithelial-mesenchymal transdifferentiation In HK-2 "human proximal tubule cells. BIOCHEMISTRY. Universidad Austral de Chile.
-2013. Cofré A. Effect of tacrolimus on the expression of multiple resistance proteins to MVP andRLIP76 in T lymphocytes and its relation to the secretion of interleukin-2 ". MEDICAL TECHNOLOGY. Universidad Austral de Chile.

Postgraduate Sponsorship (3)
-2019. Dellis Rocha J. Role of adenosine in the chemoresistance of stem-like glioblastoma cells under conditions of hypoxia . PhD IN SCIENCES, MENTION CELLULAR AND MOLECULAR BIOLOGY. Universidad Austral de Chile.
-2017. Torres A. '' Generation of a high-grade brain tumor model in rats. In vivo study of Multiple drug resistance chemosensitizers ". PhD IN VETERINARY SCIENCES. Universidad Austral de Chile.
-2013. Garrido W. '' Role of nucleoside adenosine in chemoresistance of human glioblastoma multiforme ''. PhD IN SCIENCES, MENTION CELLULAR AND MOLECULAR BIOLOGY. Universidad Austral de Chile.

In progress (4)

-PhD (Candidate) Daniel Uribe, Scholarship CONICYT. PhD in Sciences, Cellular and Molecular Biology, Faculty of Sciences, Universidad Austral de Chile (In progress)
-PhD (Candidate) Jose Ignacio Erices, Scholarship CONICYT PhD in Sciences, Cellular and Molecular Biology, Faculty of Sciences, Universidad Austral de Chile (In progress)
-PhD (Candidate) Liuba Peñate, Scholarship CONICYT PhD in Sciences, Cellular and Molecular Biology, Faculty of Sciences, Universidad Austral de Chile (In progress)
-PhD. (Candidate) Arnaldo Rosales, Scholarship CONICYT PhD in Sciences, Cellular and Molecular Biology, Faculty of Sciences, Universidad Austral de Chile (In progress)

Co-sponsorship

-Mr. Erwin Budinich Murúa. Magister in Sciences mention Pathology, Faculty of Medicine, Universidad Austral de Chile. Thesis topic: Role of the Kinase B1 Receptor in the Epithelial-Mesenchymal and Mesenchymal-Epithelial Transition of Breast Cancer Cells (2016).

Postdoc (3)

-Sponsor Investigator CONICYT Postdoctoral Projec "Papel de adenosina con la capacidad invasiva de las glioblastoma stell-like celIs. Evaluación de una estrategia terapéutica para disminuir la invasión" (No. 3180621). 2018-2021.
-Sponsor Investigator CONICYT Postdoctoral Project. "Characterization of glioblastoma stem cells with Differences in adenosine metabolism. Implications in the phenomenon of multiple drug resistance " (No. 3170851). 2017-2020.
-Sponsor Investigator CONICYT Postdoctoral Project. "Signaling mechanisms involved in the Cell chemoresistance induced by the adenosine A3 receptor on stem-like cells of glioblastoma multiform human". (No. 3150626). 2014-2017.
-Sponsor Investigator CONICYT Postdoctoral Project. "Role of nucleoside adenosine in the ability Angiogenic activity of human glioblastoma multiforme priming cells "(No. 3140217). 2013-2016.


Difusión y Transferencia


Technological Transfer Projects.

-Sponsor Investigator Stage II Project FONDEF VIU16P0145 "Kit for the detection of markers of stem cells Mesenchymal and proneural in samples of glioblastoma. 2017-2018.
-Sponsor Investigator Stage I Project FONDEF VIU16P0145 "Kit for the detection of markers of stem cells Mesenchymal and proneural in samples of glioblastoma. 2016-2017.
-Researcher FONDEF D08I1096. '' Adaptation and implementation of VLPS production method (virus as Particles) in insect cells and / or larvae for the development of low cost oral vaccines using a model of generation of vaccine against IPNV ''. 2009-2012.
-Project Director FIC17-19 "Biomarkers in Gallbladder Cancer". Project Regional collaborative research funds with the Hospital Base Valdivia and the Millennium Institute of Immunology and Immunotherapy

Management Projects
-Responsible Researcher Project VIII MEDIUM SCIENTIFIC TECHNOLOGICAL EQUIPMENT COMPETITION - FONDEQUIP 2019. "Update of the isolation unit and characterization of cellular subpopulations involved in human and animal pathologies". Cytometer equipment with cell sorter FACS Melody brand BD.
-Associate Researcher and Coordinator UACh Headquarters of the Millennium Institute of Immunology and Immunotherapy (IMII).2019-2020
- Principal Investigator of Research agreement "STUDENT INVESTIGATION DEVELOPMENT CENTER", International Internships Agreement UACH-University of Puerto Rico. 2015-2017.
-Investigator Responsible FONDEQUIP. I Medium Technological Scientific Equipment Contest: Unit of isolation and characterization of cellular subpopulations involved in animal and human pathologies. "Cytometer equipment with the FACSJAZZ cell sorter BD brand. .2012-2014.
- FIDECNO researcher 2010-2011. Collaborative project with the Department of Neurological Sciences of the Instituto Ascenjo Neurosurgery INCA. Prevalence of glioblastoma multiforme in Chile and studies of resistance to chemotherapy mediated by ABC transporters. 2010-2011.

Collaborative and student transfer agreements
-2019-2020 Associate Researcher and Coordinator UACh Headquarters of the Millennium Institute of Immunology and Immunotherapy (IMII).
-2015. to date. Collaboration Agreement. International Agreement. Participation in the program STUDENT RESEARCH DEVELOPMENT CENTER, Metropolitan University, San Juan, Puerto Rico for Research stays at the Laboratory of Molecular Pathology of the UACh. Responsible Investigator.
-2012. - to date. Collaboration agreement. National Convention. Scientific Research Agreement with the Valdivia Base Hospital, Chile. (Projects FONDECYT 1121121, 1160777, 1200885). Responsible Investigator.
-2012. - to date. Collaboration agreement. National Convention. Scientific Research Agreement with the Institute of Asenjo Neurosurgery, Santiago, Chile. (Projects FONDECYT 1121121, 1160777, 1200885). Responsable investigator
-2012. - to date. Collaboration agreement. International Agreement. Collaboration with the International Cooperation "Red Glial Ibero-America" (RGIA). Coordinator Dr. Bernardo Castellano, Barcelona Spain. Coinvestigator.

Extension and dissemination to the Community
-Participation in Symposium "Recent advances in metabolism and disease". "Adenosine metabolism as a therapeutic target for glioblastoma". Valdivia March 21, 2019.
-Participation and speaker in Seminars Cycle of the Department of Biomedical Sciences of the Universidad Católica del Norte “Glioblastomas and their chemosensitization to antitumor drugs”. Coquimbo October 27, 2018.
-Talk for Doctors Coquimbo Hospital "Study of drug resistance in glioblastoma". Coquimbo October 26, 2018
-Exhibitor 3rd Science Fair College Maria Auxiliadora "Cancer and drug resistance". College Maria Auxiliadora, Valdivia October 2, 2018.
-Talk for Medicos Hospital Puerto Montt "Detection of pro-neural and mesenchymal stem cells markers in glioblastoma samples". Puerto Montt, August 17, 2018.
-Exhibitor 2nd Scientific Cafeteria “El Café de Renata” Science Festival 2018 of Explora by CONICYT Los Ríos. Valdivia. October 5, 2018.
-Participation in the “Let's Open Our Laboratories Program of the PAR Explora region of Los Rios”. Topic: Effect of natural compounds on brain cancer tumor stem cells. Students third half Liceo Bicentenario de Excelencia Altamira de Panguipulli. April to December 2018
-Exhibitor Workshop of cell cultures of cold waterfish and alternatives primary cell culture (from fish to mouse and human’s methods). "Obtaining Stem-like cells from primary cultures of Glioblastoma: studies on chemoresistance and cell invasion". Austral University of Chile, Valdivia. March 2018.
- Exhibitor 1st Scientific Cafeteria “El Café de Renata” Science Festival 2017 of Explora by CONICYT Los Ríos. Valdivia. October 06, 2017.
- Talks for students Chile VA Project. Llifen Chile Boarding School. July 2016
-2017 - to date. Director of Dissemination of Undergraduate Careers of the Faculty of Sciences.Universidad Austral de Chile.
-Conference for Medical Doctors and Medical interns. Institute of Neurosurgery Dr. Asenjo "Role of hypoxia and adenosine in chemoresistance of subtypes of stem cells of Glioblastoma Multiforme: evaluation of personalized therapies". Santiago, April 2016
-Simposio for Biomedicine Association of Students of Biochemistry ANEB Universidad Austral de Chile. September 2015.
-Conferencefor for Medical Doctors and Medical Interns in the Department of Pathology Valdivia Base Hospital. Study of multiple drug resistance in human gliomas: Strategies for the optimization of the pharmacological treatment of brain tumors. Valdivia March 2014.
-Simposium for Cancer Association of Students of Biochemistry ANEB 2014. Pontificia Universidad Católica de Chile and Universidad Andrés Bello, Santiago. November 2014.
-Inaugural Conference Program Explore CONICYT Region de los ríos. "Combating drug resistance in cancer." Aula Magna Universidad Austral de Chile. Valdivia April 2014.
-Conference for school students "How to be a scientist". November 2014, San Luis de Alba College, Valdivia, Chile.
-Conference for school students "How to be a scientist". November 2013, San Luis de Alba College, Valdivia, Chile.
-Charla for Medical Doctors and Medical interns. Institute of Neurosurgery Dr. Asenjo "Latest advances in the study of multiple drug resistance in glioblastoma multiforme", Santiago. December 2012
-Responsable Professor in course "Medicine of future: Manipulate genes to cure diseases" at the Talent School (ALTA-UACH) of Universidad Austral de Chile. 2010.
-Conference "Cancer and Multiple Drug Resistance", Program CONICYT, Dissemination and Evaluation of Science and Technology, XII National Science and Technology Week "1000 scientists 1000 classrooms". October 2008, San Luis de Alba College, Chile.
-Conference "Resistance and Cancer," Program CONICYT Explore, Dissemination and Evaluation of Science and Technology, XII national science and technology week "1000 scientists 1000 classrooms". October 2007, Prince of Asturias College, Valdivia, Chile.
-Participation in National Television program of Chile (TVN) "Hunters of science" 2008. Theme: "Leptocarpina as a possible antitumor agent".

Management of national and international scientific events
-2017. Organization of Scientific Event. National. Organization symposium "Exploring the winding path of cancer". Society of Biochemistry and Microbiology 2017. Puerto Varas 26 to 29 September 2017. Organizer and Responsible for the Scientific Event.
-2016. Organization of Scientific Event. National. Organization Seminar Series of the Institute of Biochemistry. Science Faculty. Coordinator.
-2015. Organization of Scientific Event. International. Organization I Workshop in Molecular Pathology: "Cancer Stem cells biology and nucleoside metabolism in diseases. Responsible investigator.
-2013. Organization of Scientific Event. International. Organization of National Scientific Symposium. "Paper Nucleoside transporters in pathologies ". Collaborator.
-2013. Organization of Scientific Event. International. Organization International Symposium "Cancer and Inflammation: of the joints adherent to the disease ". Collaborator.
-2011. Organization of Scientific Event. National. Organizer Symposium "Role of adenosine in Pathologies". UACh. Responsible investigator.


Premios y Distinciones

  •   National University Award for Scientific Research: "Cure and Cancer Prevention"

    Santander Universidades y El Mercurio

    Chile, 2013

    National University Award for Scientific Research: "Cure and Cancer Prevention" Santander Universities and El Mercurio- Version 2013, Young Investigator. "Study of the chemoresistance of glioblastoma multiforme human". Principal investigator. Coinvestigator: Rody San Martín, Romulo Melo.

  •   Award Best Oral Presentation Society of Biochemistry and Molecular Biology of Chile

    SOCIEDAD DE BIOQUIMICA DE CHILE

    Chile, 2015

    Award Best Oral Presentation Society of Biochemistry and Molecular Biology of Chile, Puerto Varas.Chile.

  •   Best Chemistry Research Special Award. AGMUS 2015

    AGMUS

    Chile, 2015

    Best Chemistry Research Special Award. AGMUS 2015 Research Symposium. UMET’s Science Honor Program. Puerto Rico. Tanya Escalera and Claudia Quezada

  •   Award for best research work in Neurosurgery.

    SOCIEDAD CHILENA DE NEUROCIRUGIA

    Chile, 2013

    First Place Poster (LVI Congreso Chileno de Neurocirugía, Chile, 2013). Characterization of the highly chemoresistant subpopulation of glioblastoma starter cells Dra. Claudia Quezada and Dr. Rómulo Melo

  •   Honorable Mention in Oral Mode to Scientific Work

    SOCIEDAD CHILENA DE NEUROCIRUGIA

    Chile, 2012

    Honorable Mention in Oral Mode to Scientific Work (LV Congreso Chileno de Neurocirugía, Chile, 2012). "Chemo-resistance in Glioblastoma Multiforme mediated by CD73". Dra. Claudia Quezada and Dr. Rómulo Melo

  •   International Stay of investigation

    MECESUP

    Chile, 2011

    Scholarship for International Stay of investigation. Fellowship MECESUP Project AUS 0704. Stay in Center for Research and Hospital de Oncología.VHIO - Vall d'Hebron Institute of Oncology. Barcelona, Spain.

  •   Second prize in Neurosurgery to the scientific work

    SOCIEDAD DE NEUROLOGIA, PSIQUIATRIA Y NEUROCIRUGIA

    Chile, 2012

    Second prize in Neurosurgery to the scientific work (LXVII Congreso Chileno de Neurologia, Psiquiatría y Neurocirugía, Chile, 2012). Effect of inhibition of CD73 on the chemoresistance in high grade gliomas. Dra. Claudia Quezada and Dr. Rómulo Melo

  •   First place Poster in Neurosurgery Specialty

    SOCIEDAD DE NEUROLOGIA, PSIQUIATRIA Y NEUROCIRUGIA

    Chile, 2009

    First place Poster in Neurosurgery Specialty (64º Congreso Chileno de Neurología, Psiquiatría y Neurocirugía, Chile, 2009). "Study of Multiple Drug Resistance in Primary Culture of Human Glioblastoma". Dra. Claudia Quezada and Dr. Rómulo Melo

  •   Hermann Niemeyer Medal Award 2019

    Society for Biochemistry and Molecular Biology.

    Chile, 2019

    Hermann Niemeyer Medal Award 2019 Society for Biochemistry and Molecular Biology. Best PhD student 2019 Dr. Daniel Uribe (Dra. Claudia Quezada Sponsoring Thesis)

  •   Prize for the best Researcher and Postgraduate Professor

    Faculty of Sciences, Austral University of Chile

    Chile, 2017

    Prize for the best Researcher and Postgraduate Professor 2018-2019. Faculty of Sciences, Austral University of Chile.


 

Article (51)

Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B Adenosine Receptor
The TGF-β profibrotic cascade targets ecto-5'-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease
Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness
Blockade of the Adenosine A3 Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats
Current natural therapies in the treatment against glioblastoma.
Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A(3) Adenosine Receptor activation under hypoxia
Glioma progression in diabesity
Interleukin 8 from glioblastoma-cell line U87 induces microvascular hyperpermeability through S-nitrosylation of p120 and VE-cadherin.
Current natural therapies in the treatment against glioblastoma
FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells.
The Adenosine A3 Receptor Regulates Differentiation of Glioblastoma Stem-Like Cells to Endothelial Cells under Hypoxia
Adenosine contribution to normal renal physiology and chronic kidney disease
Adenosine contribution to normal renal physiology and chronic kidney disease.
Chemoresistance in glioblastoma stem-like cells: role of the hypoxic microenvironment and adenosine signaling
Chemoresistance in glioblastoma stem-like cells=> role of the hypoxic microenvironment and adenosine signaling.
Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme.
Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme.
DEFICIENT INSULIN-MEDIATED UPREGULATION OF THE EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2 CONTRIBUTES TO CHRONICALLY INCREASED ADENOSINE IN DIABETIC GLOMERULOPATHY
The Adenosine A3 Receptor regulates differentiation of Glioblastoma Stem-like Cells to Endothelial Cells under Hypoxia
Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells
Pro-apoptotic and anti-angiogenic properties of the ? /?-thujone fraction from Thuja occidentalis on glioblastoma cells
Reduced Adenosine Uptake and Its Contribution to Signaling that Mediates Profibrotic Activation in Renal Tubular Epithelial Cells: Implication in Diabetic Nephropathy
Increased levels of adenosine and ecto 5 '-nucleotidase (CD73) activity precede renal alterations in experimental diabetic rats
Chemoresistance in high-grade gliomas: Relevance of adenosine signalling in stem-like cells of glioblastoma multiforme
Chemoresistance in high-grade gliomas: Relevance of the multidrug resistance-associated protein 1 and adenosina
5 '-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells
Adenosine A(2B) receptor-mediated VEGF induction promotes diabetic glomerulopathy
Targeting Adenosine Signaling to Treatment of Diabetic Nephropathy
Herpes simplex virus type 1 induces simultaneous activation of Toll-like receptors 2 and 4 and expression of the endogenous ligand serum amyloid A in astrocytes
S-Nitrosation of beta-Catenin and p120 Catenin A Novel Regulatory Mechanism in Endothelial Hyperpermeability
Combined Use of Anticancer Drugs and an Inhibitor of Multiple Drug Resistance-Associated Protein-1 Increases Sensitivity and Decreases Survival of Glioblastoma Multiforme Cells In Vitro
Effect of emamectin benzoate on transcriptional expression of cytochromes P450 and the multidrug transporters (Pgp and MRP1) in rainbow trout (Oncorhynchus mykiss) and the sea lice Caligus rogercresseyi.
Effect of emamectin benzoate on transcriptional expression of cytochromes P450 and the multidrug transporters (Pgp and MRP1) in rainbow trout (Oncorhynchus mykiss) and the sea lice Caligus rogercresseyi.
FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1
Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC
Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium
Increased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats
Study of resistance to chemotherapy mediated by ABC transporters in biopsies of glioblastoma multiforme
Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats
Tacrolimus causes a blockage of protein secretion which reinforces its immunosuppressive activity and also explains some of its toxic side-effects
Adenosine A(2B) receptor mediates an increase on VEGF-A production in rat kidney glomeruli
Effect of tacrolimus on activity and expression of Pgp and ABCA5 proteins in hematoencephalic barrier cells
Gene structure and seasonal expression of carp fish prolactin short receptor isoforms
Genomic organization of nucleolin gene in carp fish: Evidence for several genes
Ultrastructural changes of the carp (Cyprinus carpio) hepatocyte nucleolus during seasonal acclimatization
Eurythermal fish acclimatization and nucleolar function: a review
An increased expression of nucleolin is associated with a physiological nucleolar segregation
Genomic organization of the rDNA cistron of the teleost fish Cyprinus carpio
Environmental acclimatization of the carp modulates the transcription of ?-actin
Environmental acclimatization of the carp modulates the transcription of beta-actin
Seasonal adaptation modulates the expression of the protein kinase CK2 beta subunit gene in the carp

Abstract (8)

D-glucose and insulin regulate the activity of equilibrative nucleoside transporters in renal glomerular cells
ADENOSINE A2B RECEPTOR INDUCES TRANSITION OF PODOCYTE TO A LESS DIFFERENTIATED STATE.
Adenosine affects the slit diaphragm and podocyte cytoarchitecture
Adenosine induces markers of epithelial to mesenchymal transition in renal proximal epithelial tubule cells
Study of the role of extracellular adenosine on chemoresistance in glioblastoma stem-like cells
Adenosine metabolism and physiological effects in podocytes.
Cloning and studies of the seasonal expression of carp nucleolin gene
Molecular mechanisms involved in the modulation of nucleolar gene expression during the acclimatization of the carp fish

BookSection (1)

Membrane Transporters and Receptors in Disease. Multidrug resistance proteins.

Proyecto (50)

Several mechanisms of therapeutic resistance are regulated through adenosine signaling in glioblastoma stem-like cells
Actualización de la unidad de aislamiento y caracterización de subpoblaciones celulares implicadas en patologías de humanos y animales
Biomarcadores en Cáncer de Vesícula Biliar
Instituto Milenio de Inmunología e Inmunoterapia (IMII)
Papel de adenosina con la capacidad invasiva de las glioblastoma stem-like celIs. Evaluación de una estrategia terapéutica para disminuir la invasión
Papel de adenosina en la invasión celular de Glioblastoma stem-like cells bajo condiciones de hipoxia. Evaluación de una estrategia terapéutica para disminuir la invasión celular.
Caracterización de células madre de glioblastoma con diferencias en el metabolismo de adenosina. Implicancias en el fenómeno de la resistencia múltiple a drogas
Caracterización de células madre de glioblastoma con diferencias en el metabolismo de adenosina. Implicancias en el fenómeno de la resistencia múltiple a drogas
Estudio de la regulación del transportador equilibrativo de nucléosidos-2 por insulina y señalización fibrótica de adenosina en la nefropatía diabética
Kit para la detección de marcadores stem cells mesenquimales y proneurales en muestras de glioblastoma
Study of equilibrative nucleotide transporter 2 regulation by insulin and fibrosis mediated by adenosine signaling in diabetic nephrophathy
'Kit para la detección de marcadores stem cells mesenquimales y proneurales en muestras de glioblastoma
Kit para la detección de marcadores stem cells mesenquimales y proneurales en muestras de glioblastoma
Role of hypoxia and adenosine on chemoresistance mediated by multidrug resistance-associated proteins 1 and 3 in glioblastoma stem like cells
Role of hypoxia and adenosine on chemoresistance mediated by multidrug resistance-associated proteins 1 and 3 in glioblastoma stem like cells
'Centro Interdisciplinario de Estudios del Sistema Nervioso (CISNe)
'Mecanismos de señalización involucrados en la quimioresistencia celular inducida por el receptor de adenosina A3 en stem-like cells de glioblastoma multiforme humano
Centro Interdisciplinario de Estudios del Sistema Nervioso (CISNe)
'Papel de nucleósido adenosina en la capacidad angiogénica de las células iniciadoras del glioblastoma multiforme humano
Mecanismos de señalización involucrados en la quimioresistencia celular inducida por el receptor de adenosina A3 en stem-like cells de glioblastoma multiforme humano
ESTUDIO DE LA QUIMIORESISTENCIA DEL GLIOBLASTOMA MULTIFORME
Papel del nucleósido adenosina en la capacidad angiogénica de las células iniciadoras del glioblastoma multiforme humano
Pathogenic role of adenosine in diabetic nephropathy: mechanisms and intervention
Pathogenic role of adenosine in diabetic nephropathy=> mechanisms and intervention
'Modulation of the stress sensors AMPK- and Sirtuin 1-dependent pathways during herpes simplex virus type 1 neuronal infection'
'Studies of the interaction of emamectin benzoate treatment with antibiotic treatments and its effect on the drugs biodisposition in rainbow trout grown in controlled conditions: Role of metabolizing enzymes and ABC transporters''
'Study of the role of multiple resistance associated protein 1 on chemoresitance of glioblastoma stem-like cells and evaluation of inhibitors
Centro de Investigación Sur-Austral en Enfermedades del Sistema Nervioso (CISNe)
Effect of Emamectin benzoate treatment on metabolizing enzymes and transporter proteins expression and its drug interactions
MATERIALS BASED ON NANOPARTICLES CONTAINING ACTIVE LOW MOLECULAR WEIGTH MOLECULES
Materials based on nanoparticles containing active low molecular weight molecules
MODULATION OF THE STRESS SENSORS AMPK- AND SIRTUIN 1-DEPENDENT PATHWAYS DURING HERPES SIMPLEX VIRUS TYPE 1 NEURONAL INFECTION
Papel del nucleósido adenosina en quimioresistencia y angiogénesis del glioblastoma multiforme humano.
Study of the role of multiple resistance associated protein 1 on chemoresistance of glioblastoma stem-like cells and evaluation of inhibitors
Unidad de aislamiento y caracterización de subpoblaciones celulares implicadas en patologías de humanos y animales
'Prevalencia de glioblastoma multiforme en Chile y estudios de la resistencia a la quimioterapia mediada por transportadores ABC
Characterization of the pathohysiological mechanisms, and detection of common therapeutic targets in placental dysfunction in pathologies of the human pregnancy
Prevalence of glioblastoma multiforme in Chile and studies of resistance to chemotherapy mediated by ABC transporters.
''Characterization of the pathohysiological mechanisms, and detection of 16 common therapeutic targets in placental dysfunction in pathologies of the human pregnancy
'Identification of the molecular mechanisms involved in emamectin benzoate and pyrethroids resistance in salmonid caligus infestations
Adaptación e implementación de método de producción VLPS (virus like particles) en células y/o larvas de insectos para el desarrollo de vacunas orales de bajo costo usando como modelo la generación de una vacuna contra IPNV
Identification of the molecular mechanisms involved in Emamectin benzoate and Pyrethroids resistance in salmonid caligus infestations
'Adaptación e implementación de método de producción VLPS (virus like particles) en células y/o larvas de insectos para el desarrollo de vacunas orales de bajo costo usando como modelo la generación de una vacuna contra IPNV
'Inhibition of multiple resitance protein-1 (MRP-1) by tacrolimus in glioblastoma multiforme cells''. Investigador Responsable
Inhibition of Multiple Resistance Protein-1 (MRP-1) by tacrolimus in glioblastoma multiforme cells.
'Efecto de los inmunopresores tacrolimus y ciclosporina A sobre la expresión y función de las proteínas de membrana Pgp1 y ABCA5
Efecto de los inmunosupresores tacrolimus y ciclosporina A sobre la expresión y función de las proteínas de membrana Pgp1 y ABCA5.
Caracterización funcional de proteínas de resistencia múltiple a drogas en tumores cerebrales
Moléculas naturales con propiedades antitumorales o de modulación de la resistencia múltiple a drogas.
Moléculas naturales con propiedades antitumorales o de modulación de la resistencia múltiple a drogas.

Review (1)

Role of extracellular vesicles in glioma progression
81
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

32
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

14
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

9
Carlos Oyarzún

Profesor Adjunto Asociado

Ciencias

Universidad Austral de Chile

Valdivia, Chile

9
Sebastián Alarcón

Bioquímico - COVID19

Facultad Medicina

Universidad Atacama

Copiapo, Chile

7
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

6
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

6
Rómulo Melo

Neurosurgeon

Department of Neurosurgery

Instituto de Neurocirugía Dr. Asenjo

Santiago, Chile

6
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

5
Marco Alvarez

Full Professor

Department of Biological Science

Universidad Andres Bello

Viña del Mar, Chile

4
Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

4
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

4
Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

3
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

3
José Rocha

Research Assistant

Evolutionary Biology

Centro de investigación i-mar

Puerto Montt, Chile

2
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

2
Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

2
INGRID EHRENFELD

ASSOCIATE PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

1
Constanza Salinas

Tesista de Postgrado

Centro Interdisciplinario de Estudios del Sistema Nervioso (CISNe)

Universidad Austral de Chile

Valdivia, Chile

1
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

1
Katia Fernández

Académico - Profesor Asociado

Facultad de Salud y Odontología

Universidad Diego Portales

Santiago, Chile

1
Claudio Flores

Académico

Medicina

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Lucia Podesta

Directora

Facultad de Medicina

CENTRO DE DOCENCIA DE ATENCIÓN INTEGRAL AMBULATORIA

Valdivia, Chile

1
Alejandro San Martin

Senior Reseacher

Biología

CENTRO DE ESTUDIOS CIENTIFICOS

Valdivia, Chile

1
Melina Villalba

Postdoctorante

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
Blanca Aguila

Estudiante programa Doctorado en ciencias mención en Microbiología

Ciencias

Universidad de Chile

Ñuñoa, Chile

1
Melissa Hott

Bioquímico

Biomédico

Instituto de Salud Pública

Santiago, Chile

1
Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
María Rauch

ACADEMICO

INSTITUTO DE BIOQUÍMICA Y MICROBIOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile

1
Angara Zambrano

Assistant Professor

Biochemistry and Microbiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Denisse Valladares

Assistant Professor

Universidad de O'Higgins

Rancagua, Chile

1
Cristopher Villablanca

Investigador post doctoral

Centro de Gerociencia, Salud Mental y Metabolismo (GERO)

Santiago, Chile

1
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Genesis Vega

Investigador

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Sharin Valdivia

Profesor Adjunto Adhonorem

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
Carolina Martin

Docente Auxiliar

Sede Puerto Montt

UNIVERSIDAD AUSTRAL DE CHILE

Puerto Montt, Chile

1
Erwin Krauskopf

Profesor Asociado

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
CATALINA PRIETO

Postdoctor

Biología

Universidad de Chile

Santiago, Chile