Man

Susana de las Mercedes Contreras Duarte

Assistant Professor

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Metabolismo lipídico; Funcionalidad de las Lipoproteinas de alta densidad (HDL) en patologías metabólicas; Antioxidantes sobre el metabolismo del colesterol y aterosclerósis; diabetes gestacional, dislipidemias postparto y embarazo, leche materna

Educación

  •  Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2016
  •  Licenciado en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010

Experiencia Académica

  •   PhD student (ANID) Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago, Chile

    2012 - 2016

  •   Postdoctor (ANID) Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago, Chile

    2018 - 2021

  •   Assistant Professor Full Time

    Universidad San Sebastián

    Health Care Sciences

    Santiago, Chile

    2021 - A la fecha

Experiencia Profesional

  •   Research assistant Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2010 - 2011

  •   Research assistant Part Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2008 - 2009

  •   Research assistant Other

    Universidad de Chile

    Santiago, Chile

    2009 - 2009

  •   Postdoctor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2017 - 2017

Premios y Distinciones

  •   Extension PhD Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2016

    6 month extension PhD funding

  •   PhD Fellowship 2012-2016

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    Funding for the development of the Medical Science PhD program

  •   Internship PhD Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2015

    Funding to develop one goal of the PhD thesis abroad (Austria)

  •   Congresses and short courses abroad PhD Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    Attendance to Lyon, to the European Atherosclerosis Society congress


 

Article (19)

High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies
Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia
Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function
Interferon-gamma and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage
Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice
Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function
Foetoplacental epigenetic changes associated with maternal metabolic dysfunction.
High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation
Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature
Role of extracellular vesicles in glioma progression.
Adenosine receptors=> Modulators of lipid availability that are controlled by lipid levels
Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice.
Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin
[ANTIOXIDANT DYSFUNCTIONALITY OF HIGH-DENSITY LIPOPROTEINS (HDL) IN DECOMPENSATED DIABETIC PATIENTS].
[Protective role of high density lipoproteins in sepsis=> basic issues and clinical implications].
Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI.
Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels.
Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions
Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones

Review (1)

Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation
11
Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

5
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

4
Claudette Cantin

Investigador Postdoctoral

Universidad San Sebastián

Santiago, Chile

4
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

2
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

2
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

2
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

2
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

2
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

1
Bastian Sobrevia

Médico en etapa de Destinación y Formación

Servicio de Salud del Reloncaví

Puerto Montt, Chile

1
Pablo Irarrazaval

Professor

Electrical Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Trinidad Montero

postdoctorate

Medicine

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

Santiago, Chile

1
Nicolás Santander

Assistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1
Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

1
MONICA ACEVEDO

Titular Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile