Man

Olga Teresa Panes Becerra

Technical Director/ Associated Research

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Primary Hemostasis Defects; Platelet Physiology and Pathophysiology; Primary Hemostasis Disorders; Functions of Neo-synthesized Proteins by Platelets; Platelet Tissue Factor; Atherogenesis and Haemostasis.

Educación

  •  Biochemistry, Professional Title. Chile, 1995
  •  Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1995

Experiencia Académica

  •   Associated Research Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    1996 - A la fecha

Experiencia Profesional

  •   Biochemistry Full Time

    Servicio Nacional de Salud V Región, Hospital San Camilo de San Felipe

    San Felipe, Chile

    1995 - 1996

  •   Biochemistry, Technical Director Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    1996 - A la fecha

Formación de Capital Humano


TRAINING AND TUTORSHIP OF STUDENTS
Factor Tisular y su localización estratégica en “Lipid raft” de plaquetas Humanas. (Pregrado) Paula Ibarra . Bioquímica 2009 Pontificia Universidad Católica de Chile. Co-tutorships

Desarrollo de un Nuevo Ensayo de actividad Fibrinolítica (Pregrado) Sandro Astudillo y José Gutierrez .Tecnología Médica 2010 Universidad Andrés Bello. Tutor

Inhibición de la actividad procoagulante dependiente de Factor Tisular (FT) por el Inhibidor de la vía extrínseca (TFPI) en plaquetas Humanas: modulación por dominios ricos en Colesterol, "Lipid Rafts (Pregrado). César González. Bioquímica, 2011 Universidad de Santiago. Co-tutorships

Actividad Fibrinolitica en pacientes con riesgo Cardiovascular en tratamiento con Aspirina (Pregrado) Carlos Barria, Marcelo Carrasco y Carolina Valenzuela. Tecnología Médica 2010 Universidad Andrés Bello. Tutor

Evaluación de la actividad fibrinolítica en pacientes que consultan por hemorragia mucocutánea. (Pregrado) Gilda Loncón y Ana López. Tecnología Médica 2010 Universidad Andrés Bello. Tutor

Sintesis de COX-1 en Plaquetas Humanas y regeneración de la producción de TXA2 después de su inhibición por Acido Acetil Salicilico.(Pre-grado) Stephanie Acuña G, Bioquímica 2012, Pontificia Universidad Católica de Chile. Co-tutorships

Influencia de los niveles de TFPI plaquetario en la actividad pro- coagulante en pacientes con Hemorragia mucocutánea de causa desconocida, (Pre-grado) Rocio Valencia, Paola Kovacs, Marianela Gutierrez.Tecnología Médica, 2012 Universidad Andrés Bello. Tutor

Factor XIII Plaquetario : Sintesis y Rol Biológico en la Hemostasia (Pre-grado)., Luz Maria Pozo Astaburuaga. Bioquímica 2013 Pontificia Universidad Católica de Chile. Co-tutorships.

Influencia de la Proteina S en la Actividad Anticoagulante de TFPI en plaquetas humanas de pacientes con sangrado de causa desconocida (SCD)(Pre-grado). David Barahona,Isaac Correa, Maricel Martinez, Marjorie Pardo.Tecnología Médica 2013 Universidad Andrés Bello. Tutor

Activación de la hemostasia en pacientes con Insuficiencia Renal crónica en tratamiento de Peritoneodialisis: papel del factor tisular plaquetario.(Pre-grado). Maria Macarena Ruiz, Camila Sandoval.Tecnología Médica 2014 Universidad Andrés Bello. Tutor

Actividad Anticoagulante de Proteina S en Plaquetas Humanas (Pre-grado),Gustavo Soto Carrasco. Bioquímica 2014. Pontificia Universidad Católica de Chile. Co-tutorships


Premios y Distinciones

  •   Prize Sociedad Chilena de Química Clínica

    Sociedad Chilena de Química Clínica

    Chile, 2014

    The Best Scientific Work in the XVIII congress of Sociedad Chilena de Quimica Clínica.

  •   Prize Germán Duchach Grinberg

    Sociedad Médica de Chile

    Chile, 2014

    Prize to the Best Publication in Clinical Hematology


 

Article (36)

International collaborative study for the calibration of proposed International Standards for thromboplastin, rabbit, plain, and for thromboplastin, recombinant, human, plain
Human platelet interaction with E-coli O111 promotes tissue-factor-dependent procoagulant activity, involving Toll like receptor 4
Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin
Evaluation of oral anticoagulation with rivaroxaban, in patients with new onset non valvular atrial fibrillation].
Inhibition of angiogenesis by platelets in systemic sclerosis patients
Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells
Atorvastatin Reduces the Proadhesive and Prothrombotic Endothelial Cell Phenotype Induced by Cocaine and Plasma From Cocaine Consumers In Vitro
Quantitative impact of using different criteria for the laboratory diagnosis of type 1 von Willebrand disease
An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families
Clot lysis time in platelet-rich plasma: Method assessment, comparison with assays in platelet-free and platelet-poor plasmas, and response to tranexamic acid
Increased number of circulating endothelial cells and plasma markers of endothelial damage in chronic cocaine users
Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children
Platelet activation in chronic cocaine users: Effect of short term abstinence
DAÑO ENDOTELIAL Y ACTIVACION DEL SISTEMA HEMOSTATICO ASOCIADO AL USO CRONICO DE COCAINA: ESTUDIOS EX VITRO E IN VITRO
Daño endotelial y activación del sistema hemostático asociado al uso crónico de cocaína: estudios ex vivo e in vitro
La atorvastatina no modifica el incremento agudo de los niveles de p-selectina y fibrinógeno inducido con esfuerzo físico máximo
Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays
Genotype-phenotype relationship for six common polymorphisms in genes affecting platelet function from 286 healthy subjects and 160 patients with mucocutaneous bleeding of unknown cause
Platelet Tissue Factor: Fast and Specific Clotting Activation Pathway Mediated by VWF-GPIba Interaction and Platelet Membrane FVII. Human Platelets Contain All the Components for Assembling the Prothrombinase Complex and Their Procoagulant Function Is Ind
Procarboxypeptidase U (TAFI) and the Thr325Ile proCPU polymorphism in patients with hereditary mucocutaneous hemorrhages
Tissue factor storage, synthesis and function in normal and activated human platelets
High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. A prospective study of 280 patients and 299 controls
Human platelets synthesize and express functional tissue factor
Circulating platelet-derived microparticles in systemic lupus erythematosus - Association with increased thrombin generation and procoagulant state
Template bleeding time and PFA-100 (R) have low sensitivity to screen patients with hereditary mucocutaneous hemorrhages: comparative study in 148 patients
Mediterranean diet, but not red wine, is associated with beneficial changes in primary haemostasis
Thrombin generation in platelet-poor plasma is normal in patients with hereditary mucoputaneous haemorrhages
Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors
Increased activation of protein C, but lower plasma levels of free, activated protein C in uraemic patients: relationship with systemic inflammation and haemostatic activation
Inflammation, not hyperhomocysteinemia, is related to oxidative stress and hemostatic and endothelial dysfunction in uremia
Cardiovascular risk factors in vegetarians: Normalization of hyperhomocysteinemia with vitamin B-12 and reduction of platelet aggregation with n-3 fatty acids
CARDIOVASCULAR RISK FACTORS IN VEGETARIANS: NORMALIZATION OF HYPERHOMOCYSTEINEMIA WITH VITAMIN B12 AND REDUCTION OF PLATELET AGGREGATION WITH N-3 FATTY ACIDS
TRANEXAMIC ACID INHIBITS FIBRINOLYSIS, SHORTENS THE BLEEDING TIME AND IMPROVES PLATELET FUNCTION IN PATIENTS WITH CHRONIC RENAL FAILURE
VEGETARIANS AND CARDIOVASCULAR RISK FACTORS: HEMOSTASIS, INFLAMMATORY MARKERS AND PLASMA HOMOCYSTEINE
Endothelial cell markers in chronic uremia: Relationship with hemostatic defects and severity of renal failure
Hemostatic disorder of uremia: The platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis

Abstract (26)

A step forward in the evaluation of platelet function testing: routine, simultaneous measurement of platelet aggregation, serotonin (5-HT) content and secretion by HPLC-electrochemical detection in hemostasis laboratories
GPIb alpha activation mediates platelet tissue factor (TF) phosphorylation, transfer to lipid rafts (LR) and activity. TFPI and protein S, released by other agonists, would assemble the inhibitory complex (TF/FVIIA/TFPI/PS) in LR, dampening FXA activity
Hemostatic disorder of uremia: patients with terminal chronic renal failure (CRF) have increased platelet tissue factor derived intravascular clotting activation with delayed clot lysis time in platelet rich plasma (CLT-PRP)
Revisiting the hemostatic disorder of uremia: patients on peritoneal dialysis (CRF-PD) have normal platelet aggregation and secretion but increased platelet tissue factor activity (TF-PCA), probably the cause of intravascular clotting activation
GPIb alpha Activation Triggers Platelet Tissue Factor/FVIIa-Dependent Procoagulant Activity, Which Is Dampened By Platelet Secreted TFPI and Protein S. Novel Platelet-Based Model of Hemostasis
Platelet interaction induces Tissue Factor and a pro-metastatic phenotype in ovarian cancer cells
HPLC-based assay to measure platelet serotonin (5-HT) secretion in specialized hemostasis laboratories: comparison with the current 'gold standard' radioisotopic test
Human platelet activation/secretion and a membrane-associated urokinase-like activity induce the activation of the latent form of platelet transforming growth factor-beta 1 (TGF-beta 1)
Increased total platelet TFPI and higher surface expression of TFPI in activated platelets may be involved in the pathogenesis of mild bleeding disorders (MBD) of undefined cause (BUC)
Inherited mild bleeding disorders (MBD) of undefined cause (BUC): platelets express decreased tissue factor-dependent FXa generation and low thrombin generation in platelet-rich plasma
NHLBI guidelines and the percentile 2.5th of plasma VWF for the diagnosis of type 1 VWD. Comparison in 4517 referred patients and 280 selected patients with conclusive bleeding history
Statins do not correct hypofibrinolysis in hypercholesterolemia. correcting LDL-cholest unveils an inverse relation of HDL-cholest and clot lysis time
EVALUATION OF CLOT LYSIS TIME WITH PLATELETS: CORRELATION WITH CARDIOVASCULAR RISK MARKERS
Is aspirin an antifibrinolytic drug? Anticoagulant effect is associated with prolonged clot lysis time in platelet-rich plasma of older
Novel loci involved on platelet function and platelet count identified by a GWAS performed in children
One daily aspirin is enough to suppress platelet secretion without inducing a complete inhibition of aggregation in patients with cardiovascular risk
Prolonged clot lysis time (CLT) in PRP and PPP in hypercholesterolemia (Hyperch): protective effect of HDL-cholesterol and partial correction by atorvastatin
Clot lysis time (CLT) of PRP and PPP in hypercholesterolemia. Effect of atorvastatin and relationships with inflammatory markers
Platelet Tissue Factor Activity In Patients with Hypercholesterolemia: Modulation of Procoagulant Activity by Statins
Platelet Tissue Factor: Fast and Specific Clotting Activation Pathway Mediated by VWF-GPIba Interaction and Platelet Membrane FVII. Human Platelets Contain All the Components for Assembling the Prothrombinase Complex and Their Procoagulant Function Is Independent of Aggregation/Secretion and GPVI Function
Evidence of Endothelial Dysfunction in Cocaine Users
Platelet Tissue Factor: Expression of Pro-Coagulant Activity depends on Gpib alpha Activation and Signaling through Lyn-Mediated Phosphorylation. A Platelet-Based Model of Hemostasis
Human platelet tissue factor is localized in lipid rafts and is associated with GPIb-IX-V complex in the membrane: Association between adhesive and procoagulant activities of platelets.
Elevated levels of cell-derived microparticles with procoagulant activity in cocaine abusers: Association with increased thrombin generation and a prothrombotic state.
Diagnostic assessment of patients with inherited mucocutaneous hemorrhages (IMCH): Opening a pandora box?
Loss of platelet membrane phospholipid asymmetry in systemic lupus erythematosus: Association with disease activity and hypercoagulable state.

Letter (1)

High plasma levels of lipoprotein(a) in uremic patients are related to markers of inflammation, and to activated, not impaired, fibrinolysis

Proyecto (3)

ENHANCED PLATELET TISSUE FACTOR-DEPENDENT PROCOAGULANT ACTIVITY IN HYPERCHOLESTEROLEMIA AND IN PREGNANCY DYSLIPIDEMIA: INHIBITION BY STATINS, HDL-CHOLESTEROL AND TISSUE FACTOR PATHWAY INHIBITOR.
CONSTITUTIVE NEO-SYNTHESIS OF PROTEINS BY HUMAN PLATELETS: SOME DISTINCTIVE PATHOPHYSIOLOGICAL FEATURES AND CLINICAL IMPLICATIONS
NOVEL PLATELET FUNCTIONS: AN INTEGRATING ROLE IN CLOTTING INITIATION, CLOT LYSIS AND
84
Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

42
Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

41
Diego Mezzano

Director

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

21
Valeria Matus

Associate Researcher

Hematology-Oncology

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

18
Eduardo Aranda

Biochemist

Hematology

P. UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

9
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Pamela Zúñiga

Profesor Asociado

Pediatria

Pontificia Universidad Católica de Chile

Santiago , Chile

5
Monica Acevedo

Associate Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

4
Patricio Downey

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE DEPARTAMENTO DE NEFROLOGIA

SANTIAGO, Chile

4
Alejandro Berkovits

MEDICO

LABORATORIO CLINICO

CLINICA ALEMANA DE SANTIAGO

SANTIAGO, Chile

3
Ada Cuevas

Médico

Nutrición Clínica

CLINICA LAS CONDES

Santiago, Chile

3
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

2
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
RENAN ORELLANA

Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

2
oscar castillo

Director Escuela

Facultad de Medicina

Universidad Finis Terrae

Santiago, Chile

2
Pablo Strobel

Prrofesional de laboratorio

Facultad Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile

1
Enrique Castellón

Profesor Titular. Director

Oncología Básico-Clínica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Dante Lindefjeld

Staff, Assistant Professor

Cardiology

Clinical Hospital of the Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rafaela Erices

Postdoctorante

Ginecología y Obstetricia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Edgard Pais

Director Médico

Nefrodiálisis San Lucas

Santiago, Chile

1
Aniela Wozniak

Coordinador de Investigación

Dept Laboratorios Clínicos

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile