Man

Maria Loreto Massardo Vega

Docente Investigador

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Estudio de la patogenia de autoanticuerpos en enfermedades autoinmunes

Educación

  •  Médico-Cirujano, UNIVERSIDAD DE CHILE. Chile, 1979
  •  Reumatología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1982
  •  Rheumatology, University of Bristol. Reino Unido, 1988

Experiencia Académica

  •   Profesor titular Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Chile

    1985 - 2017

  •   Docente Investigador Full Time

    Universidad San Sebastián

    Medicina y Ciencia

    Santiago, Chile

    2017 - A la fecha

Formación de Capital Humano


Participación en la formación de médicos en su etapa formativa en medicina en reumatologia y en la especialidad de reumatologia y apoyo en la formación de tesistas y magisteres de pre y pos titulo en biologia celular


Difusión y Transferencia


Difusion
En los media:
Sitio web educativo para pacientes con artritis reumatoide de PANLAR: www.artritisreumatoide.cl. Fan page 2017
SItio web educativo y face book: Hablemos de Lupus
Vinculación con el medio
Charlas a los pacientes y familiares de la Agrupación Lupus Chile 10 Agosto 2019: Lupus y Memoria y 2017 Qué es el lupus


Premios y Distinciones

  •   PANLAR-Merck Rheumatology Prize for LatinAmerican Rheumatologists 2002

    Pan American Associations for Rheumatology PANLAR

    Estados Unidos, 2002

    PANLAR-Merck Rheumatology Prize for LatinAmerican Rheumatologists 2002

  •   Premio Academia de Medicina 2012

    Instituto de Chile. Academia de Medicina

    Chile, 2012

    Premio Academia de Medicina 2012 en reconocimiento a la calidad de su investigación científica

  •   Premio Conferencia Sociedad Médica de Santiago

    SOCIEDAD MEDICA DE SANTIAGO

    Chile, 2017

    Premio Conferencia Sociedad Médica de Santiago "El compromiso cognitivo en el Lupus Neuro-Psiquiatrico"


 

Article (52)

Applying the 2019 EULAR/ACR lupus criteria to patients from an established cohort: A Latin American perspective
Clinical features, damage accrual, and survival in patients with familial systemic lupus erythematosus: data from a multi-ethnic, multinational Latin American lupus cohort
Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale – Depression subscale scores: An individual participant data meta-analysis of 73 primary studies
A Consensus Position Paper From REAL-PANLAR Group About the Methodological Approach for the Accreditation Process of Centers of Excellence in Rheumatoid Arthritis in Latin America
Factors predictive of serious infections over time in systemic lupus erythematosus patients: data from a multi-ethnic, multi-national, Latin American lupus cohort
GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies.
Predictors of damage accrual in systemic lupus erythematosus: a longitudinal observational study with focus on neuropsychological factors and anti-neuronal antibodies
Antibodies and the brain: antiribosomal P protein antibody and the clinical effects in patients with systemic lupus erythematosus
First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus=> Latin American Group for the Study of Lupus (GLADEL, )-Pan-American League of Associations of Rheumatology (PANLAR).
Predictive factors of flares in systemic lupus erythematosus patients: data from a multiethnic Latin American cohort
Renal involvement in antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides. Recommendations of the Chilean Societies of Nephrology and Rheumatology
Therapeutic Guidelines for Latin American Lupus Patients Methodology
Impact of cognitive impairment, depression, disease activity, and disease damage on quality of life in women with systemic lupus erythematosus.
Remission and Low Disease Activity Status (LDAS) protect lupus patients from damage occurrence=> data from a multiethnic, multinational Latin American Lupus Cohort (GLADEL).
Features associated with hematologic abnormalities and their impact in patients with systemic lupus erythematosus: Data from a multiethnic Latin American cohort
Anti-N-methyl-D-aspartate receptor and anti-ribosomal-P autoantibodies contribute to cognitive dysfunction in systemic lupus erythematosus.
Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice.
Beginning to Explore the High Rate of Work Limitation in Patients With Rheumatoid Arthritis in Chile
Late-onset systemic lupus erythematosus in Latin Americans: a distinct subgroup?
Pathogenicity of lupus anti-ribosomal P antibodies=> role of cross-reacting neuronal surface P antigen in glutamatergic transmission and plasticity in a mouse model.
REAL-PANLAR Project for the Implementation and Accreditation of Centers of Excellence in Rheumatoid Arthritis Throughout Latin America A Consensus Position Paper From REAL-PANLAR Group on Improvement of Rheumatoid Arthritis Care in Latin America Establishing Centers of Excellence
Recomendaciones sobre el manejo del compromiso renal del lupus eritematoso sistémico: Documento de Consenso de las Sociedades Chilenas de Nefrología y Reumatología
The number of flares patients experience impacts on damage accrual in systemic lupus erythematosus=> data from a multiethnic Latin American cohort.
Primary cardiac disease in systemic lupus erythematosus patients: protective and risk factors-data from a multi-ethnic Latin American cohort
Primary cardiac disease in systemic lupus erythematosus patients=> protective and risk factors--data from a multi-ethnic Latin American cohort.
Systemic lupus erythematosus impairs memory cognitive tests not affected by depression
Systemic lupus erythematosus impairs memory cognitive tests not affected by depression.
Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients
Mestizos with systemic lupus erythematosus develop renal disease early while antimalarials retard its appearance: Data from a Latin American cohort
Early Rheumatoid Arthritis in Latin America: Low Socioeconomic Status Related to High Disease Activity at Baseline
Treatment of Early Rheumatoid Arthritis in a Multinational Inception Cohort of Latin American Patients The GLADAR Experience
Common mental disorders and psychological distress in systemic lupus erythematosus are not associated with disease activity
Antimalarial Treatment May Have a Time-Dependent Effect on Lupus Survival
Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation
Management of Patients With Rheumatoid Arthritis in Latin America A Consensus Position Paper From Pan-American League of Associations of Rheumatology and Grupo Latino Americano De Estudio de Artritis Reumatoide
Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis
Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus - An international meta-analysis
Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico
Circulating Platelet-Derived Microparticles in Systemic Lupus Erythematosus. Association With Increased Thrombin Generation and Procoagulant State
Galectin-8 binds specific beta 1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells
Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort
Outcome of Chilean Patients with Lupus Nephritis and Response to Intravenous Cyclophosphamide
A population based assessment of the use of orthopedic surgery in patients with rheumatoid arthritis
Antiribosomal P protein antibodies in Chilean SLE patients: no association with renal disease
Prevalence and isotype distribution of antiphospholipid antibodies in Chilean patients with systemic lupus erythematosus (SLE)
Influence of the HLA-DRbeta shared epitope on susceptibility to and clinical expression of rheumatoid arthritis in Chilean patients
Occasional Series: Lupus Around the World The Chilean experience of systemic lupus erythematosus
High-Dose Intravenous Methylprednisolone Therapy Associated with Osteonecrosis in Patients with Systemic Lupus Erythematosus
Novel genetic markers of rheumatoid arthritis in chilean patients, by dr serotyping and restriction fragment length polymorphism analysis
Weak association between HLA-DR4 and rheumatoid arthritis in Chilean patients.
Osteoarthritis of the knee joint: an eight year prospective study.
Inspiratory muscle dysfunction and unexplained dyspnea in systemic lupus erythematosus

BookSection (3)

Lupus eritematoso sistémico y psiquiatría
Síndrome metabólico en Lupus eritematoso sistémico.
Rheumatoid Arthritis.

CaseReport (2)

Trombosis de senos venosos encefálicos como posible primera manifestación de enfermedad de Behçet: Caso clínico
Eficacia del infliximab en pacientes con síndrome de Behçet portadores de úveo-retinitis grave

Errata (1)

Clinical predictors of remission and low disease activity in Latin American early rheumatoid arthritis: data from the GLADAR cohort (vol 38, pg 2737, 2019)

Proyecto (15)

PATHOGENIC MECHANISMS OF ANTI-RIBOSOMAL P AND CROSS-REACTING ANTI-DOUBLE STRANDED DNA ANTIBODIES IN LUPUS NEPHRITIS=> ROLE OF NEURONAL-SURFACE-P-ANTIGEN (NSPA)
GAL-8 AS A NOVEL REGULATOR OF PROTEOSOMAL FUNCTION IN AUTOIMMUNITY AND CANCER
ROLE OF AUTOANTIBODIES IN COGNITIVE IMPAIRMENT IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
FUNCTION OF GALECTIN-8 IN THE IMMUNE SYSTEM AND AUTOIMMUNE DISEASES
POTENCIAL PATOGENICO DE AUTOANTICUERPOS EN LAS MANIFESTACIONES DIFUSAS DEL SISTEMA NERVIOSO CENTRAL DE PACIENTES CON LUPUS ERITEMATOSO SISTEMICO.
FUNCION DE LA GAL-8 Y LOS AUTOANTICUERPOS ANTI-GAL8 EN LINFOCITOS Y SU RELACION CON AUTOINMUNIDAD.
IDENTIFICACION Y CARACTERIZACION DE AUTOANTIGENOS DE LA SUPERFICIE CELULAR ASOCIADOS A LA PATOGENIA DEL LUPUS ERITEMATOSO GENERALIZADO
PAPEL DE LAS PLAQUETAS EN LA PATOGENIA DE ESTADOS DE HIPERCOAGULABILIDAD ADQUIRIDOS=> ESTUDIOS EN PACIENTES PORTADORES DE LUPUS ERITEMATOSO SISTEMICO Y SINDROME ANTIFOSFOLIPIDO.
ESTUDIOS SOBRE LOS FACTORES DE TRANSCRIPCION NF-KB/REL DEL LINFOCITO T EN PATOLOGIAS AUTOINMUNES.
ESTUDIO DE AUTOANTIGENOS EN ENFERMEDADES AUTOINMUNES
ESTUDIO DE LA FUNCION DE FACTORES DE TRANSCRIPCION DE LA FAMILIA NF-KAPPAR Y EL PROTO-ONCOGEN C-REL EN LINFOCITOS DE ENFERMEDADES AUTOINMUNES HUMANAS
ESTUDIO DE SECUENCIA DE GENOMA HUMANO Y DE LA EXPRESION DEL PROTO-ONCOGEN C-REL EN ARTRITIS REUMATOIDEA
EFECTOS DE LA SUPRESION DE PROLACTINA SOBRE LA FUNCION INMUNE CELULAR Y LA EVOLUCION CLINICA DE LA ENFERMEDAD EN ARTRITIS REUMATOIDEA ACTIVA
SECUENCIAS EN EL GENOMA HUMANO DETERMINANTES DE SUSCEPTIBILIDAD A LA ARTRITIS REUMATOIDEA. ESTUDIO MEDIANTE AMPLIFICACION GENICA (PCR)
ESTUDIO DE NUEVOS MARCADORES PARA ARTRITIS REUMATOIDEA MEDIANTE ANALISIS DEL DNA GENOMICO.

Review (4)

Education for patients with rheumatoid arthritis in Latin America and the Caribbean
Lupus in Latin-American patients: lessons from the GLADEL cohort
Actualización en lupus neuro-psiquiátrico con énfasis en déficit cognitivo
Artritis reumatoide temprana
52
Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

9
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

4
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

3
Andrea Soza

Profesor Asociado

Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

2
CLAUDIA CARCAMO

Profesor Asistente

neurology

PONTIFICIA UNIVERSIDADA CATÓLICA DE CHILE. DEPARTAMENTO DE NEUROLOGÍA

Santiago, Chile

2
Jorge Martinez

Profesor Titular

Laboratorio de Biología Celular

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE ALIMENTOS (INTA), UNIVERSIDAD DE CHILE

Santiago, Chile

2
PATRICIA BURGOS

Associate Professor & Sub-Director CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

2
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Oscar Neira

Medico internista y reumatólogo

Medicina oriente

Hospital del Salvador

Santiago, Chile

1
Leopoldo Ardiles

Profesor Titular

Medicina

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Monica Caceres

Profesor asistente

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
Miguel Gutierrez

jefe servicio medicina

medicina

hospital naval almirante nef

viña del mar, Chile

1
Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

1
MARIO CALVO

Director de Instituto

Instituto de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

1
Jaime Leppe

Coordinador de Investigación Carrera de Kinesiología

Universidad del Desarrollo

Santiago, Chile