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Claudia Andrea Metz Baer

Docente Investigador

Universidad San Sebastián

Santiago, Chile

Tráfico intracelular del receptor del factor de crecimiento epidermal (EGFR) por mecanismos independientes de ligando. Participación de Galectina-8 en señalización en distintos tipo celulares

Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1996
Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1989

Investigador Asociado Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago, Chile

1997 - 2016
Docente Investigador Full Time

Universidad San Sebastián

Medicina y Ciencia

Santiago, Chile

2016 - A la fecha

Investigador Asociado Full Time

Pontifica Universidad Católica de Chile

Santiago, Chile

1997 - 2016
Docente Investigador Full Time

Universidad San Sebastián

Santiago, Chile

2016 - A la fecha


Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts Smith, Patricio C.; Metz, Claudia.; de la Pena, Adely; Oyanadel, Claudia; Avila, Patricio; Arancibia, Rodrigo; Vicuna, Lucas; Retamal, Claudio; Barake, Francisca; Gonzalez, Alfonso; Soza, Andrea Article ISI JOURNAL OF PERIODONTAL RESEARCH (2020)
GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies Pardo, E.; Barake F; Tapia C.; Soza A.; Gonzalez, A Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2019)
Galectin-8 induces partial epithelial-mesenchymal transition with invasive tumorigenic capabilities involving a FAK/EGFR/proteasome pathway in Madin-Darby canine kidney cells Oyanadel, Claudia; Holmes, Christopher; Pardo, Evelyn; Retamal, Claudio; Shaughnessy, Ronan; Smith, Patricio; Cortés, Priscilla; Bravo-Zehnder, Marcela; Metz, Claudia.; Feuerhake, Teo; Romero, Diego; Roa, Juan Carlos; Montecinos, Viviana; Soza, Andrea; González, Alfonso; Yamashita, Yukiko Article ISI SCOPUS MOLECULAR BIOLOGY OF THE CELL (2018)
Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimer's disease pathophysiology. Cornejo, Francisca; Vruwink, Marianne; Metz, Claudia; Muñoz, Paola; Salgado, Nicole; Poblete, Joaquín; Andrés, María Estela; Eugenín, Jaime; von Bernhardi, Rommy Article Brain, behavior, and immunity (2018)
Galectin-8 promotes migration and proliferation and prevents apoptosis in U87 glioblastoma cells. Metz, Claudia; Döger, Remziye; Riquelme, Elizabeth; Cortés, Priscilla; Holmes, Christopher; Shaughnessy, Ronan; Oyanadel, Claudia; Grabowski, Catalina; González, Alfonso; Soza, Andrea Article Biological research (2016)
Anti-Ribosomal P Protein Autoantibodies From Patients With Neuropsychiatric Lupus Impair Memory in Mice Bravo-Zehnder, M; Toledo E.M., Segovia-Miranda; F, Serrano; F.G., Benito M.J.; Metz C., Retamal C.; Alvarez A, Massardo L.; Inestrosa N.C., Gonzalez A Article ARTHRITIS & RHEUMATOLOGY (2015)
Epidermal growth factor receptor endocytic traffic perturbation by phosphatidate phosphohydrolase inhibition: new strategy against cancer Shaughnessy, Ronan; Retamal, Claudio; Oyanadel, Claudia; Norambuena, Andrs; Lpez, Alejandro; Bravo-Zehnder, Marcela; Montecino, Fabian J.; Metz, Claudia.; Soza, Andrea; Gonzlez, Alfonso Article ISI SCOPUS FEBS JOURNAL (2014)
Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients Vicuña, Lucas; Pardo, Evelyn; Curkovic, Cristóbal; Doger, Remziye; Oyanadel, Claudia; Metz, Claudia.; Massardo, Loreto; Gonzalez, Alfonso; Soza, Andrea Article ISI SCIELO SCOPUS Biological Research (2013)
Phosphatidic Acid Induces Ligand-independent Epidermal Growth Factor Receptor Endocytic Traffic through PDE4 Activation Norambuena A, Metz C.; Jung JE, Silva A; Otero C., Cancino J; Retamal C., Valenzuela JC; Soza A, Gonzalez A Article Molecular Biology of the Cell (2010)
Autoantibodies against galectin-8=> their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. Massardo, L; Metz, C; Pardo, E; Mezzano, V; Babul, M; Jarpa, E; Guzmán, A M; André, S; Kaltner, H; Gabius, H J; Jacobelli, S; González, A; Soza, A Article Lupus (2009)
Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1/2 activation supported by protein kinase A down-regulation. Norambuena, Andrés; Metz, Claudia; Vicuña, Lucas; Silva, Antonia; Pardo, Evelyn; Oyanadel, Claudia; Massardo, Loreto; González, Alfonso; Soza, Andrea Article The Journal of biological chemistry (2009)
NFkB y su importancia en Artritis e inflamación Metz, Claudia. Article Revista Chilena de Reumatología (2008)
Factor Nuclear kB (NF-kB) y autoinmunidad Metz, Claudia. Article Revista Chilena de Reumatología (2005)
Increased expression of c-rel, from the NF-kappa B/Rel family, in T cells from patients with systemic lupus erythematosus Burgos, P; Metz C., Bull; P., Pincheira R.; Massardo L., Errazuriz; C, Bono MR; Jacobelli, S Article JOURNAL OF RHEUMATOLOGY (2000)
Characterization of human peroxisomal membrane proteins Santos, M. J., Kawada, M. E., Espeel, M., Figueroa, C., Alvarez, A., Hidalgo, U., and Metz, C. Article JOURNAL OF BIOLOGICAL CHEMISTRY (1994)
Isolation of transcription promoters from Thiobacillus ferrooxidans and T. acidophilus and its introduction by conjugation to T. intermedius Metz, C., Sanchez, H., and Venegas, A. Article ARCHIVOS DE BIOLOGIA Y MEDICINA EXPERIMENTALES (1990)


Neuroinmunología Cárcamo C, Benavides E, y Metz C.; Nogales J, Donoso A, Verdugo R. BookSection (2005)


INHIBITORS OF PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAP), INCLUDING D-PROPRANOLOL AND ANALOGS THEREOF, ALONE OR IN COMBINATION WITH DESIPRAMINE, FOR THE TREATMENT OF CANCERS THAT DEPEND ON THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR), ONCOGENIC VARIANTS THEREOF AND OTHER MEMBERS OF THE ERBB/HER FAMILY Gonzalez, A.; Soza, A. and Metz, C. Patent (2012)


PKA-mediated regulation of EGFR endocytic trafficking=> Molecular mechanisms and function FONDECYT (1181907) Proyecto 2019-2023 Coinvestigador(a)
ENDOCYTIC TRAFFICKING AND SIGNALING=>REGULATION AND DRUG INTERVENTION IN CANCER FONDECYT (1141127) Proyecto 2014-2018 Coinvestigador(a)
Gal-8 as a novel regulator of proteasomal function in autoimmunity and cancer FONDEF (1131122) Proyecto 2013-2017 Coinvestigador(a)
Generación y desarrollo de nuevos fármacos para el tratamiento de cánceres dependientes del EGFR. FONDEF (D09I1104) Proyecto 2011-2014 Investigador(a)
Function of Galectin-8 in the immune system and autoinmune diseases FONDEF (1100921) Proyecto 2010-2013 Coinvestigador(a)
Centro de Regeneración y Envejecimiento. Proyecto Basal /CONICYT FONDAP (PFB12/2007) Proyecto 2008-2013 Investigador(a)
Centro de Regulación Celular y Patología FONDECYT (13980001) Proyecto 2000-2005 Investigador(a)
Millennium Institute for Fundamental and Applied Biology (MIFAB) MIDEPLAN/Millenium Proyecto 2000-2010 Investigador(a)
REGULACION DE LA FAMILIA DE FACTORES DE TRANSCRIPCION NFkB/Rel EN SISTEMAS CELULARES VINCULADOS A INFLAMACION Y AUTOINMUNIDAD FONDECYT (8000003) Proyecto 2000-2003 Coinvestigador(a)
ESTUDIOS SOBRE LOS FACTORES DE TRANSCRIPCION NF-KB/REL DEL LINFOCITO T EN PATOLOGIAS AUTOINMUNES. FONDECYT (1981026) Proyecto 1998-2000 Coinvestigador(a)
ESTUDIO DE LA FUNCION DE FACTORES DE TRANSCRIPCION DE LA FAMILIA NF-KAPPAR Y EL PROTO-ONCOGEN C-REL EN LINFOCITOS DE ENFERMEDADES AUTOINMUNES HUMANAS FONDECYT (1951170) Proyecto 1995-1998 Coinvestigador(a)
BIOGENESIS DE PEROXISOMAS EN CELULAS ANIMALES=>UN ESTUDIO EN CELULAS GAMETICAS, EN DESARROLLO EMBRIONARIO Y EN PROLIFERACION PEROXISOMAL INDUCIDA FONDECYT (1940686) Proyecto 1994-1996 Coinvestigador(a)
BIOGENESIS DE PEROXISOMAS HUMANOS => CLONAMIENTO DE GENES DE PROTEINAS DE MEMBRANA PEROXISOMAL FONDECYT (1920824) Proyecto 1992-1994 Coinvestigador(a)
ADHERENCIA DE THIOBACILLUS FERROOXIDANS A MINERALES DE COBRE. ANALISIS DEL ROL DEL LPS Y PROTEINAS DE MEMBRANA EXTERNA EN EL ANCLAJE BACTERIANO FONDECYT (1890575) Proyecto 1989-1992 Coinvestigador(a)