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Patricio Cristian Smith Ferrer

Profesor Asociado

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Enfermedades Periodontales; Reparación de heridas, Regeneración tisular, Inflamación

Biomedicina, UNIVERSIDAD DE CHILE. Chile, 2005
Cirujano Dentista, UNIVERSIDAD DE CHILE. Chile, 1992
Especialidad Odontológica, UNIVERSIDAD DE CHILE. Chile, 1992

Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Odontología

Santiago, Chile

1996 - 2006
Profesor Asociado Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago, Chile

2007 - A la fecha


Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts Article Antiviral Research (2020)
Diabetes alters the involvement of myofibroblasts during periodontal wound healing Retamal, Ignacio; Velarde, Victoria; Smith, Patricio C Article ISI SCOPUS ORAL DISEASES (2020)
Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts Metz, Claudia.; de la Pena, Adely; Oyanadel, Claudia; Avila, Patricio; Arancibia, Rodrigo; Retamal, Claudio; Soza, Andrea Article ISI JOURNAL OF PERIODONTAL RESEARCH (2020)
Uncoupled inflammatory, proliferative, and cytoskeletal responses in senescent human gingival fibroblasts Article ISI SCOPUS JOURNAL OF PERIODONTAL RESEARCH (2020)
Comparative effect of platelet-rich plasma, platelet-poor plasma, and fetal bovine serum on the proliferative response of periodontal ligament cell subpopulations Article ISI CLINICAL ORAL INVESTIGATIONS (2019)
Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts Pavez, L.; Tobar, N.; Chacon, C.; Pastor, A.; Smith, P. C. Article ISI SCOPUS JOURNAL OF PERIODONTAL RESEARCH (2018)
Galectin-8 induces partial epithelial-mesenchymal transition with invasive tumorigenic capabilities involving a FAK/EGFR/proteasome pathway in Madin-Darby canine kidney cells Oyanadel, Claudia; Holmes, Christopher; Pardo, Evelyn; Retamal, Claudio; Shaughnessy, Ronan; Smith, Patricio; Bravo-Zehnder, Marcela; Metz, Claudia.; Romero, Diego; Roa, Juan Carlos; et al. Article ISI SCOPUS MOLECULAR BIOLOGY OF THE CELL (2018)
Role of myofibroblasts in normal and pathological periodontal wound healing Smith, PC Article ISI SCOPUS ORAL DISEASES (2018)
Aged blood factors decrease cellular responses associated with delayed gingival wound repair Article ISI SCOPUS PLOS ONE (2017)
Ageing, dental caries and periodontal diseases Göstemeyer G.; Schwendicke F. Article ISI SCOPUS JOURNAL OF CLINICAL PERIODONTOLOGY (2017)
Glucose Promotes a Pro-Oxidant and Pro-Inflammatory Stromal Microenvironment Which Favors Motile Properties in Breast Tumor Cells Kallens V. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Glycated Collagen Stimulates Differentiation of Gingival Myofibroblasts Zapata, Paulina Article ISI SCOPUS JOURNAL OF PERIODONTOLOGY (2017)
Modulation of Mammary Stromal Cell Lactate Dynamics by Ambient Glucose and Epithelial Factors Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells González-Rivas C. Article ISI SCOPUS JOURNAL OF PERIODONTAL RESEARCH (2016)
Platelet-Poor and Platelet-Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells Palma, V; Smith, PC Article ISI SCOPUS JOURNAL OF PERIODONTOLOGY (2016)
Cigarette smoke condensate inhibits collagen gel contraction and prostaglandin E-2 production in human gingival fibroblasts Romero A.; Cáceres M.; Arancibia, R.; Silva D.; Couve, E.; Martínez C; Martinez, J.; Smith, PC Article ISI SCOPUS JOURNAL OF PERIODONTAL RESEARCH (2015)
Gingival wound healing: an essential response disturbed by aging? Smith, P C; Cáceres, M; Martínez, C; Oyarzún, A; Martínez, J Article Journal of dental research (2015)
Research on growth factors in periodontology. Smith, Patricio C; Martínez, Constanza; Cáceres, Mónica; Martínez, Jorge Article Periodontology 2000 (2015)
The influence of platelet-derived products on angiogenesis and tissue repair: a concise update. Martínez, Constanza E; Smith, Patricio C; Palma Alvarado, Verónica A Article Frontiers in physiology (2015)
Defective Wound-healing in Aging Gingival Tissue. Cáceres, M; Oyarzun, A; Smith, P C Article Journal of dental research (2014)
Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells. Tobar, Nicolás; Avalos, M Celeste; Méndez, Nicolás; Smith, Patricio C; Bernabeu, Carmelo; Quintanilla, Miguel; Martínez, Jorge Article Carcinogenesis (2014)
Synthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties Inzunza D.; Covarrubias, C; Von Marttens, A; Leighton Y.; Carvajal, JC; Valenzuela F; Diaz-Dosque, M; Mendez, N.; Martínez C; Pino, AM.; et al. Article ISI SCOPUS JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)
Chitosan and platelet-derived growth factor synergistically stimulate cell proliferation in gingival fibroblasts Silva D.; Arancibia, R; Tapia C.; Acuna-Rougier, C; Diaz-Dosque, M; Cáceres M.; Martinez J.; Smith, PC Article JOURNAL OF PERIODONTAL RESEARCH (2013)
Effects of Chitosan Particles in Periodontal Pathogens and Gingival Fibroblasts Arancibia, R; Maturana C.; Silva D.; Tobar, N; Tapia C.; Salazar, JC; Martinez J.; Smith, PC Article JOURNAL OF DENTAL RESEARCH (2013)
Tumor Necrosis Factor-alpha Inhibits Transforming Growth Factor-beta-Stimulated Myofibroblastic Differentiation and Extracellular Matrix Production in Human Gingival Fibroblasts Arancibia, R; Oyarzun A, Silva D; Tobar, N; Martinez J., Smith PC Article Journal of Periodontology (2013)
Effects of cigarette smoke and nicotine on cell viability, migration and myofibroblastic differentiation Silva D.; Cáceres M.; Arancibia, R; Martinez C.; Martinez J.; Smith P.C. Article JOURNAL OF PERIODONTAL RESEARCH (2012)
Effects of platelet-rich and -poor plasma on the reparative response of gingival fibroblasts Cáceres M.; Martinez C.; Martinez J.; Smith P.C. Article CLINICAL ORAL IMPLANTS RESEARCH (2012)
Simvastatin alters fibroblastic cell responses involved in tissue repair. Cáceres, M; Romero, A; Copaja, M; Díaz-Araya, G; Martínez, J; Smith, P C Article Journal of periodontal research (2011)
Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells Martinez C.; Smith, PC; Rodriguez, JP; Palma V. Article JOURNAL OF DENTAL RESEARCH (2011)
Involvement of MT1-MMP and TIMP-2 in human periodontal disease Oyarzun A, Arancibia; R, Hidalgo R.; Penafiel, C; Cáceres M., Gonzalez MJ; Martinez J., Smith PC Article Oral Diseases (2010)
NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration. Tobar, N; Guerrero, J; Smith, P C; Martínez, J Article British journal of cancer (2010)
Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-beta1 and TNF-alpha. Guerrero, Javier; Tobar, Nicolás; Cáceres, Mónica; Espinoza, Lorena; Escobar, Paula; Dotor, Javier; Smith, Patricio C; Martínez, Jorge Article Breast cancer research and treatment (2010)
Cigarette smoke condensate stimulates urokinase production through the generation of reactive oxygen species and activation of the mitogen activated protein kinase pathways in human gingival fibroblasts Gonzalez R.; Arancibia, R; Cáceres M.; Martinez J.; Smith, PC Article JOURNAL OF PERIODONTAL RESEARCH (2009)
Triclosan inhibits tumor necrosis factor-alpha-stimulated urokinase production in human gingival fibroblasts Arancibia, R; Cáceres M.; Martinez J.; Smith, PC Article JOURNAL OF PERIODONTAL RESEARCH (2009)
c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway Cáceres M., Tobar; N, Guerrero J; Smith PC, Martinez J. Article Journal of Cellular Biochemistry (2008)
Effect of platelet-rich plasma on cell adhesion, cell migration, and myofibroblastic differentiation in human gingival fibroblasts Cáceres M.; Hidalgo R.; Sanz, A; Martinez J.; Riera P.; Smith, PC Article JOURNAL OF PERIODONTOLOGY (2008)
RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFkappaB-dependent mechanism. Tobar, Nicolás; Cáceres, Mónica; Santibáñez, Juan F; Smith, Patricio C; Martínez, Jorge Article Cancer letters (2008)
Differential uPA expression by TGF-beta 1 in gingival fibroblasts Smith, PC; Martinez J. Article JOURNAL OF DENTAL RESEARCH (2006)
Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-beta 1: role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways Smith, PC; Cáceres M.; Martinez J. Article JOURNAL OF PERIODONTAL RESEARCH (2006)
Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin Smith PC, Santibanez JF; Morales, JP Article Journal of Periodontal Research (2004)
In situ detection of matrix metalloproteinase-9 (MMP-9) in gingival epithelium in human periodontal disease Smith, PC; Munoz, VC; Collados, L; Oyarzun, AD Article JOURNAL OF PERIODONTAL RESEARCH (2004)
Higher risk of preterm birth and low birth weight in women with periodontal disease Lopez, NJ; Smith PC, Gutierrez J Article Journal of Dental Research (2002)
Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease=> A randomized controlled trial Lopez, NJ; Smith PC, Gutierrez J Article Journal of Periodontology (2002)


Wound healing in the oral mucosa Martinez, Constanza E.; Bergmeier, Lesley BookSection (2018)


Gingival wound healing and aging=> Role of cellular senescence and the transcription factor FOXO1 FONDECYT (1170555) Proyecto 2017-2020 Inv. Responsable
DIABETES AS A MODULATOR OF FIBROBLASTIC CELL RESPONSES DURING PERIODONTAL WOUND HEALING FONDECYT (1130618) Proyecto 2013-2017 Inv. Responsable
ROLE OF HPV-16 E6 AND E7 ONCOPROTEINS IN TOBACCO-SMOKE ASSOCIATED CARCINOGENESIS=> INTERACTION BETWEEN CIGARETTE SMOKE COMPONENTS (CSC) AND HPV16 E6/E7 ONCOPROTEINS IN ORAL AND BRONCHIAL EPITHELIAL CELLS AND CLINICAL SPECIMENS FONDECYT (1120248) Proyecto 2012-2016 Coinvestigador(a)
EL ENVEJECIMIENTO COMO MODULADOR DE LA REGENERACION E INFLAMACION PERIODONTAL. FONDECYT (3120041) Proyecto 2011-2014 Inv. Patrocinante
Desarrollo de un prototipo de producto dental para la prevención y tratamiento de la enfermedad periodontal FONDEF (DO8I1141) Proyecto 2010-2012 Director(a)
REPARACION TISULAR EN LOS TEJIDOS PERIODONTALES HUMANOS=> MODULACION POR TABAQUISMO Y FACTORES DE CRECIMIENTO. FONDECYT (1090142) Proyecto 2009-2013 Inv. Responsable
MECANISMOS REGULADORES DE LA REMODELACION TISULAR EN LA ENFERMEDAD PERIODONTAL HUMANA. FONDECYT (1061065) Proyecto 2006-2009 Inv. Responsable
ENFERMEDAD PERIODONTAL COMO POSIBLE FACTOR DE RIESGO DE PARTO PREMATURO Y DE PESO AL NACER FONDECYT (1981094) Proyecto 1998-2001 Coinvestigador(a)
LESIONES BUCALES EN RELACION A LA ACCION TOPICA Y SISTEMICA DEL ALCOHOL FONDECYT (1920689) Proyecto 1992-1995 Coinvestigador(a)


Gingival Wound Healing: An Essential Response Disturbed by Aging? Smith, PC; Cáceres M.; Martínez C; Oyarzun A.; Martinez, J. Review ISI SCOPUS JOURNAL OF DENTAL RESEARCH (2015)
Research on growth factors in periodontology Smith, PC; Martínez C; Cáceres M.; Martinez, J. Review ISI PERIODONTOLOGY 2000 (2015)
The influence of platelet-derived products on angiogenesis and tissue repair: a concise update Smith, PC; Alvarado, VAP Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2015)

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Verónica Palma

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

CRISTIAN COVARRUBIAS

PROFESOR ASOCIADO

INSTITUTO DE INVESTIGACIÓN EN CIENCIAS ODONTOLÓGICAS

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

Mario Diaz

Profesor asistente

Instituto Ciencias odontológicas

UNIVERSIDAD DE CHILE FACULTAD DE ODONTOLOGIA

Santiago, Chile

Constanza Martinez

Profesor asociado

Facultad de Odontología

Universidad de Los Andes

Santiago de Chile, Chile

Jorge Martinez

Profesor Titular

Laboratorio de Biología Celular

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE ALIMENTOS (INTA), UNIVERSIDAD DE CHILE

Santiago, Chile

Patricio Smith

Profesor Asociado

Odontología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Eduardo Couve

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Claudia Oyanadel

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

Omar Porras

Associate professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

Alfredo von Marttens

DIRECTOR DE ESPECIALIDAD IMPLANTOLOGÍA BUCO MAXILO FACIAL

PRÓTESIS

ESCUELA GRADUADOS, FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

Nicolas Tobar

Assistan Professor

Cellular and molecular Biology Laboratory

Institute of nutrition and food technology

Santiago, Chile

Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

Francisco Melo

FULL PROFESSOR

FISICA

UNIVERSIDAD DE SANTIAGO DE CHILE

SANTIAGO, Chile

Ignacio Retamal

Assistant Professor

Centro de Oncología de Precisión

Universidad Mayor de Chile

Santiago, Chile

Christopher Holmes

Estudiante de doctorado

Ingeniería Biomédica

Pontificia Universidad Catolica de Chile

Santiago, Chile

Patricio Smith

Associate Professor

Medicine / Dentistry

Pontificia Universidad Católica de Chile

Santiago, Chile

Carolina Gonzalez

Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

Carlos Chacon

Asistente de Investigación

Impact

Universidad de Los Andes

Santiago, Chile

Patricio Cristian Smith Ferrer

Líneas de Investigación

Educación

Biomedicina, UNIVERSIDAD DE CHILE. Chile, 2005

Cirujano Dentista, UNIVERSIDAD DE CHILE. Chile, 1992

Especialidad Odontológica, UNIVERSIDAD DE CHILE. Chile, 1992

Experiencia Académica

Profesor Asistente Full Time

Profesor Asociado Full Time

Article (43)

BookSection (1)

Proyecto (9)

Gingival wound healing and aging=> Role of cellular senescence and the transcription factor FOXO1

DIABETES AS A MODULATOR OF FIBROBLASTIC CELL RESPONSES DURING PERIODONTAL WOUND HEALING

ROLE OF HPV-16 E6 AND E7 ONCOPROTEINS IN TOBACCO-SMOKE ASSOCIATED CARCINOGENESIS=> INTERACTION BETWEEN CIGARETTE SMOKE COMPONENTS (CSC) AND HPV16 E6/E7 ONCOPROTEINS IN ORAL AND BRONCHIAL EPITHELIAL CELLS AND CLINICAL SPECIMENS

EL ENVEJECIMIENTO COMO MODULADOR DE LA REGENERACION E INFLAMACION PERIODONTAL.

Desarrollo de un prototipo de producto dental para la prevención y tratamiento de la enfermedad periodontal

REPARACION TISULAR EN LOS TEJIDOS PERIODONTALES HUMANOS=> MODULACION POR TABAQUISMO Y FACTORES DE CRECIMIENTO.

MECANISMOS REGULADORES DE LA REMODELACION TISULAR EN LA ENFERMEDAD PERIODONTAL HUMANA.

ENFERMEDAD PERIODONTAL COMO POSIBLE FACTOR DE RIESGO DE PARTO PREMATURO Y DE PESO AL NACER

LESIONES BUCALES EN RELACION A LA ACCION TOPICA Y SISTEMICA DEL ALCOHOL

Review (3)