Man

Patricio Cristian Smith Ferrer

Profesor Asociado

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Enfermedades Periodontales; Reparación de heridas, Regeneración tisular, Inflamación

Educación

  •  Biomedicina, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Cirujano Dentista, UNIVERSIDAD DE CHILE. Chile, 1992
  •  Especialidad Odontológica, UNIVERSIDAD DE CHILE. Chile, 1992

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Odontología

    Santiago, Chile

    1996 - 2006

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2007 - A la fecha


 

Article (43)

Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts

Alvarez, Diana M.; Duarte, Luisa F.; Corrales, Nicolas; Smith, Patricio C.; González, Pablo A.

Article
Antiviral Research  (2020)

Diabetes alters the involvement of myofibroblasts during periodontal wound healing

Retamal, Ignacio; Hernández, Romina; Velarde, Victoria; Oyarzún, Alejandro; Martínez, Constanza; González, María Julieta; Martínez, Jorge; Smith, Patricio C

Article ISI SCOPUS
ORAL DISEASES  (2020)

Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts

Smith, Patricio C.; Metz, Claudia.; de la Pena, Adely; Oyanadel, Claudia; Avila, Patricio; Arancibia, Rodrigo; Vicuna, Lucas; Retamal, Claudio; Barake, Francisca; Gonzalez, Alfonso; Soza, Andrea

Article ISI
JOURNAL OF PERIODONTAL RESEARCH  (2020)

Uncoupled inflammatory, proliferative, and cytoskeletal responses in senescent human gingival fibroblasts

Páez J.; Hernández R.; Espinoza J.; Rojas L.; Martínez C.E.; Tobar N.; Martínez J.; Smith P.C.

Article ISI SCOPUS
JOURNAL OF PERIODONTAL RESEARCH  (2020)

Comparative effect of platelet-rich plasma, platelet-poor plasma, and fetal bovine serum on the proliferative response of periodontal ligament cell subpopulations

Martinez, CE; Gomez, R; Kalergis, AM; Smith, PC

Article ISI
CLINICAL ORAL INVESTIGATIONS  (2019)

Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts

Pavez, L.; Tobar, N.; Chacon, C.; Arancibia, R.; Martinez, C.; Tapia, C.; Pastor, A.; Gonzalez, M.; Martinez, J.; Smith, P. C.

Article ISI SCOPUS
JOURNAL OF PERIODONTAL RESEARCH  (2018)

Galectin-8 induces partial epithelial-mesenchymal transition with invasive tumorigenic capabilities involving a FAK/EGFR/proteasome pathway in Madin-Darby canine kidney cells

Oyanadel, Claudia; Holmes, Christopher; Pardo, Evelyn; Retamal, Claudio; Shaughnessy, Ronan; Smith, Patricio; Cortés, Priscilla; Bravo-Zehnder, Marcela; Metz, Claudia.; Feuerhake, Teo; Romero, Diego; Roa, Juan Carlos; Montecinos, Viviana; Soza, Andrea; González, Alfonso; Yamashita, Yukiko

Article ISI SCOPUS
MOLECULAR BIOLOGY OF THE CELL  (2018)

Role of myofibroblasts in normal and pathological periodontal wound healing

Smith, PC

Article ISI SCOPUS
ORAL DISEASES  (2018)

Aged blood factors decrease cellular responses associated with delayed gingival wound repair

Saldías M.P.; Fernández C.; Morgan A.; Díaz C.; Morales D.; Jaña F.; Gómez A.; Silva A.; Briceño F.; Oyarzún A.; Maldonado F.; Cerda O.; Smith P.C.; Cáceres M.

Article ISI SCOPUS
PLOS ONE  (2017)

Ageing, dental caries and periodontal diseases

López R.; Smith P.C.; Göstemeyer G.; Schwendicke F.

Article ISI SCOPUS
JOURNAL OF CLINICAL PERIODONTOLOGY  (2017)

Glucose Promotes a Pro-Oxidant and Pro-Inflammatory Stromal Microenvironment Which Favors Motile Properties in Breast Tumor Cells

Kallens V.; Tobar N.; Molina J.; Bidegain A.; Smith P.C.; Porras O.; Martínez J.

Article ISI SCOPUS
JOURNAL OF CELLULAR BIOCHEMISTRY  (2017)

Glycated Collagen Stimulates Differentiation of Gingival Myofibroblasts

Retamal, Ignacio N.; Hernández, Romina; Melo, Francisco; Zapata, Paulina; Martínez, Constanza; Martínez, Jorge; Smith, Patricio C.

Article ISI SCOPUS
JOURNAL OF PERIODONTOLOGY  (2017)

Modulation of Mammary Stromal Cell Lactate Dynamics by Ambient Glucose and Epithelial Factors

Tobar N.; Porras O.; Smith P.C.; Barros L.F.; Martínez J.

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2017)

Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells

Retamal IN.; Hernández R.; González-Rivas C.; Cáceres M.; Arancibia R.; Romero A.; Martínez C.; Tobar N.; Martínez J.; Smith PC.

Article ISI SCOPUS
JOURNAL OF PERIODONTAL RESEARCH  (2016)

Platelet-Poor and Platelet-Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells

Martinez, CE; Gonzalez, SA; Palma, V; Smith, PC

Article ISI SCOPUS
JOURNAL OF PERIODONTOLOGY  (2016)

Cigarette smoke condensate inhibits collagen gel contraction and prostaglandin E-2 production in human gingival fibroblasts

Romero A.; Cáceres M.; Arancibia, R.; Silva D.; Couve, E.; Martínez C; Martinez, J.; Smith, PC

Article ISI SCOPUS
JOURNAL OF PERIODONTAL RESEARCH  (2015)

Gingival wound healing: an essential response disturbed by aging?

Smith, P C; Cáceres, M; Martínez, C; Oyarzún, A; Martínez, J

Article
Journal of dental research  (2015)

Research on growth factors in periodontology.

Smith, Patricio C; Martínez, Constanza; Cáceres, Mónica; Martínez, Jorge

Article
Periodontology 2000  (2015)

The influence of platelet-derived products on angiogenesis and tissue repair: a concise update.

Martínez, Constanza E; Smith, Patricio C; Palma Alvarado, Verónica A

Article
Frontiers in physiology  (2015)

Defective Wound-healing in Aging Gingival Tissue.

Cáceres, M; Oyarzun, A; Smith, P C

Article
Journal of dental research  (2014)

Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells.

Tobar, Nicolás; Avalos, M Celeste; Méndez, Nicolás; Smith, Patricio C; Bernabeu, Carmelo; Quintanilla, Miguel; Martínez, Jorge

Article
Carcinogenesis  (2014)

Synthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties

Inzunza D.; Covarrubias, C; Von Marttens, A; Leighton Y.; Carvajal, JC; Valenzuela F.; Diaz-Dosque, M; Mendez, N.; Martínez C; Pino, AM.; Rodriguez, JP; Cáceres M.; Smith P.

Article ISI SCOPUS
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A  (2014)

Chitosan and platelet-derived growth factor synergistically stimulate cell proliferation in gingival fibroblasts

Silva D.; Arancibia, R; Tapia C.; Acuna-Rougier, C; Diaz-Dosque, M; Cáceres M.; Martinez J.; Smith, PC

Article
JOURNAL OF PERIODONTAL RESEARCH  (2013)

Effects of Chitosan Particles in Periodontal Pathogens and Gingival Fibroblasts

Arancibia, R; Maturana C.; Silva D.; Tobar, N; Tapia C.; Salazar, JC; Martinez J.; Smith, PC

Article
JOURNAL OF DENTAL RESEARCH  (2013)

Tumor Necrosis Factor-alpha Inhibits Transforming Growth Factor-beta-Stimulated Myofibroblastic Differentiation and Extracellular Matrix Production in Human Gingival Fibroblasts

Arancibia, R; Oyarzun A, Silva D; Tobar, N; Martinez J., Smith PC

Article
Journal of Periodontology  (2013)

Effects of cigarette smoke and nicotine on cell viability, migration and myofibroblastic differentiation

Silva D.; Cáceres M.; Arancibia, R; Martinez C.; Martinez J.; Smith P.C.

Article
JOURNAL OF PERIODONTAL RESEARCH  (2012)

Effects of platelet-rich and -poor plasma on the reparative response of gingival fibroblasts

Cáceres M.; Martinez C.; Martinez J.; Smith P.C.

Article
CLINICAL ORAL IMPLANTS RESEARCH  (2012)

Simvastatin alters fibroblastic cell responses involved in tissue repair.

Cáceres, M; Romero, A; Copaja, M; Díaz-Araya, G; Martínez, J; Smith, P C

Article
Journal of periodontal research  (2011)

Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells

Martinez C.; Smith, PC; Rodriguez, JP; Palma V.

Article
JOURNAL OF DENTAL RESEARCH  (2011)

Involvement of MT1-MMP and TIMP-2 in human periodontal disease

Oyarzun A, Arancibia; R, Hidalgo R.; Penafiel, C; Cáceres M., Gonzalez MJ; Martinez J., Smith PC

Article
Oral Diseases  (2010)

NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration.

Tobar, N; Guerrero, J; Smith, P C; Martínez, J

Article
British journal of cancer  (2010)

Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-beta1 and TNF-alpha.

Guerrero, Javier; Tobar, Nicolás; Cáceres, Mónica; Espinoza, Lorena; Escobar, Paula; Dotor, Javier; Smith, Patricio C; Martínez, Jorge

Article
Breast cancer research and treatment  (2010)

Cigarette smoke condensate stimulates urokinase production through the generation of reactive oxygen species and activation of the mitogen activated protein kinase pathways in human gingival fibroblasts

Gonzalez R.; Arancibia, R; Cáceres M.; Martinez J.; Smith, PC

Article
JOURNAL OF PERIODONTAL RESEARCH  (2009)

Triclosan inhibits tumor necrosis factor-alpha-stimulated urokinase production in human gingival fibroblasts

Arancibia, R; Cáceres M.; Martinez J.; Smith, PC

Article
JOURNAL OF PERIODONTAL RESEARCH  (2009)

c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway

Cáceres M., Tobar; N, Guerrero J; Smith PC, Martinez J.

Article
Journal of Cellular Biochemistry  (2008)

Effect of platelet-rich plasma on cell adhesion, cell migration, and myofibroblastic differentiation in human gingival fibroblasts

Cáceres M.; Hidalgo R.; Sanz, A; Martinez J.; Riera P.; Smith, PC

Article
JOURNAL OF PERIODONTOLOGY  (2008)

RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFkappaB-dependent mechanism.

Tobar, Nicolás; Cáceres, Mónica; Santibáñez, Juan F; Smith, Patricio C; Martínez, Jorge

Article
Cancer letters  (2008)

Differential uPA expression by TGF-beta 1 in gingival fibroblasts

Smith, PC; Martinez J.

Article
JOURNAL OF DENTAL RESEARCH  (2006)

Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-beta 1: role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways

Smith, PC; Cáceres M.; Martinez J.

Article
JOURNAL OF PERIODONTAL RESEARCH  (2006)

Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin

Smith PC, Santibanez JF; Morales, JP

Article
Journal of Periodontal Research  (2004)

In situ detection of matrix metalloproteinase-9 (MMP-9) in gingival epithelium in human periodontal disease

Smith, PC; Munoz, VC; Collados, L; Oyarzun, AD

Article
JOURNAL OF PERIODONTAL RESEARCH  (2004)

Higher risk of preterm birth and low birth weight in women with periodontal disease

Lopez, NJ; Smith PC, Gutierrez J

Article
Journal of Dental Research  (2002)

Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease=> A randomized controlled trial

Lopez, NJ; Smith PC, Gutierrez J

Article
Journal of Periodontology  (2002)

BookSection (1)

Wound healing in the oral mucosa

Smith, Patricio C.; Martinez, Constanza E.; Bergmeier, Lesley

BookSection
 (2018)

Proyecto (9)

Gingival wound healing and aging=> Role of cellular senescence and the transcription factor FOXO1

FONDECYT (1170555)

Proyecto
2017-2020
Inv. Responsable

DIABETES AS A MODULATOR OF FIBROBLASTIC CELL RESPONSES DURING PERIODONTAL WOUND HEALING

FONDECYT (1130618)

Proyecto
2013-2017
Inv. Responsable

ROLE OF HPV-16 E6 AND E7 ONCOPROTEINS IN TOBACCO-SMOKE ASSOCIATED CARCINOGENESIS=> INTERACTION BETWEEN CIGARETTE SMOKE COMPONENTS (CSC) AND HPV16 E6/E7 ONCOPROTEINS IN ORAL AND BRONCHIAL EPITHELIAL CELLS AND CLINICAL SPECIMENS

FONDECYT (1120248)

Proyecto
2012-2016
Coinvestigador(a)

EL ENVEJECIMIENTO COMO MODULADOR DE LA REGENERACION E INFLAMACION PERIODONTAL.

FONDECYT (3120041)

Proyecto
2011-2014
Inv. Patrocinante

Desarrollo de un prototipo de producto dental para la prevención y tratamiento de la enfermedad periodontal

FONDEF (DO8I1141)

Proyecto
2010-2012
Director(a)

REPARACION TISULAR EN LOS TEJIDOS PERIODONTALES HUMANOS=> MODULACION POR TABAQUISMO Y FACTORES DE CRECIMIENTO.

FONDECYT (1090142)

Proyecto
2009-2013
Inv. Responsable

MECANISMOS REGULADORES DE LA REMODELACION TISULAR EN LA ENFERMEDAD PERIODONTAL HUMANA.

FONDECYT (1061065)

Proyecto
2006-2009
Inv. Responsable

ENFERMEDAD PERIODONTAL COMO POSIBLE FACTOR DE RIESGO DE PARTO PREMATURO Y DE PESO AL NACER

FONDECYT (1981094)

Proyecto
1998-2001
Coinvestigador(a)

LESIONES BUCALES EN RELACION A LA ACCION TOPICA Y SISTEMICA DEL ALCOHOL

FONDECYT (1920689)

Proyecto
1992-1995
Coinvestigador(a)

Review (3)

Gingival Wound Healing: An Essential Response Disturbed by Aging?

Smith, PC; Cáceres M.; Martínez C; Oyarzun A.; Martinez, J.

Review ISI SCOPUS
JOURNAL OF DENTAL RESEARCH  (2015)

Research on growth factors in periodontology

Smith, PC; Martínez C; Cáceres M.; Martinez, J.

Review ISI
PERIODONTOLOGY 2000  (2015)

The influence of platelet-derived products on angiogenesis and tissue repair: a concise update

Martinez, CE; Smith, PC; Alvarado, VAP

Review ISI SCOPUS
FRONTIERS IN PHYSIOLOGY  (2015)

21
Patricio Smith

Profesor Asociado

Odontología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

12
Patricio Smith

Associate Professor

Medicine / Dentistry

Pontificia Universidad Católica de Chile

Santiago, Chile

8
Constanza Martinez

Profesor asociado

Facultad de Odontología

Universidad de Los Andes

Santiago de Chile, Chile

5
Jorge Martinez

Profesor Titular

Laboratorio de Biología Celular

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE ALIMENTOS (INTA), UNIVERSIDAD DE CHILE

Santiago, Chile

5
Nicolas Tobar

Assistan Professor

Cellular and molecular Biology Laboratory

Institute of nutrition and food technology

Santiago, Chile

5
Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

3
Ignacio Retamal

Assistant Professor

Centro de Oncología de Precisión

Universidad Mayor de Chile

Santiago, Chile

2
Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

2
Omar Porras

Associate professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Claudia Oyanadel

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Francisco Melo

FULL PROFESSOR

FISICA

UNIVERSIDAD DE SANTIAGO DE CHILE

SANTIAGO, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

1
Christopher Holmes

Estudiante de doctorado

Ingeniería Biomédica

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Carolina Gonzalez

1
Verónica Palma

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Eduardo Couve

1
Mario Diaz

Profesor asistente

Instituto Ciencias odontológicas

UNIVERSIDAD DE CHILE FACULTAD DE ODONTOLOGIA

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

1
Carlos Chacon

Asistente de Investigación

Impact

Universidad de Los Andes

Santiago, Chile

1
Alfredo von Marttens

DIRECTOR DE ESPECIALIDAD IMPLANTOLOGÍA BUCO MAXILO FACIAL

PRÓTESIS

ESCUELA GRADUADOS, FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
CRISTIAN COVARRUBIAS

PROFESOR ASOCIADO

INSTITUTO DE INVESTIGACIÓN EN CIENCIAS ODONTOLÓGICAS

UNIVERSIDAD DE CHILE

SANTIAGO, Chile