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Nicolas Andres Tobar Bachler

Assistan Professor

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS, INTA-UCHILE

Santiago, Chile

Líneas de Investigación


Our main line of research is to determine which are the molecular mechanisms that allow us to link the inflammatory states derived from the intake of hypercaloric diets and the acquisition of tumor malignancy.

Educación

  •  Exact and Natural Sciences , UNIVERSIDAD DE CHILE. Chile, 1999
  •   Food and Nutrition, UNIVERSIDAD DE CHILE. Chile, 2015
  •  Molecular Biotechnology, UNIVERSIDAD DE CHILE. Chile, 2006
  •  Molecular Biotechnology Engineer, UNIVERSIDAD DE CHILE. Chile, 2008
  •  Innovación Tecnológica, UNIVERSIDAD DE TALCA. Chile, 2007

Experiencia Académica

  •   Postdoctoral researcher Full Time

    UNIVERSIDAD DE CHILE

    INTA

    Santiago, Chile

    2015 - 2018

  •   Laboratory Teacher Part Time

    UNIVERSIDAD DE CHILE

    INTA

    Santiago, Chile

    2011 - 2011

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    INTA

    Santiago, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Asistente de Investigacion Part Time

    INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS

    santiago, Chile

    2008 - 2012

  •   Perito en patentes biotecnologicas y farmaceuticas Part Time

    ESTUDIO DE ABOGADOS JUVENAL HERNANDEZ S.

    Santiago, Chile

    2002 - 2007

  •   Asistente de Investigacion Part Time

    Universidad de Chile

    Santiago, Chile

    2010 - 2012

  •   Asistente de investigacion Part Time

    Universidad de Chile

    Santiago, Chile

    2007 - 2009

  •   Investigador Part Time

    INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS

    Santiago, Chile

    2014 - 2016

  •   INVESTIGADOR Part Time

    INSTITUTO DE NUTRICION Y ALIMENTOS

    Santiago, Chile

    2016 - 2018

  •   ASISTENTE DE INVESTIGACION Part Time

    INSTITUTO DE NUTRICION Y ALIMENTOS

    SANTIAGO, Chile

    2012 - 2016

Formación de Capital Humano


Tesisi.
2020 Aldo Leyva Soto (co-tutoría).
Doctorado en Ciencias e Ingeniería. Facultad de Ciencias Químicas e Ingeniería. Universidad Autónoma de Baja California, México. En curso.

2020 Daniela Salgado Canales (co-tutoría).
Magister en Nutrición y Alimentos, mención Nutrición Humana, INTA - Universidad de Chile. En curso.

2020 Isidora Villagrán Varas (co-tutoría).
Licenciatura en Bioquímica. Pontificia Universidad Católica de Chile. En curso.

2019 Elizabeth Trejo González (co-tutoría).
Magister en Nutrición y Alimentos, mención Nutrición Humana, INTA - Universidad de Chile. En curso.


Difusión y Transferencia


My relationship with society is based on my firm intention to collaborate in the generation of a population composed of critical individuals, in which science has a fundamental role. This conviction has been expressed mainly in my participation as a volunteer in the school science club program of the Explora program, in which I have participated as a tutor for last three years. My training in biotechnology and my studies in nutrition and food allow me to advise on topics of interest to young people and society, guiding their research under a public interest perspective but with a solid scientific base. Also, I have carried out some scientific dissemination activities in "science week" for schoolchildren at the San Agustín de Ñuñoa school. On the other hand, since 2021, I have participated in the INTA extension council, which advises the Extension Directorate on society and the environment. Finally, through this project, I also hope to generate educational material on breast cancer and the impact of a healthy diet in the prevention of non-communicable chronic diseases such as obesity, diabetes and cancer. My training with a multidisciplinary and collaborative approach allows me to offer a broad view of breast cancer and obesity, which I hope will be a contribution both in the generation of relevant basic knowledge and in education for the general population.


Premios y Distinciones

  •   Beca Dr. Abraham stekel

    NESTLE CHILE S.A.

    Chile, 2011

    Young researcher

  •   BECA DOCTORADO

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    scholarship for doctoral program


 

Article (21)

Domeless receptor loss in fat body tissue reverts insulin resistance induced by a high-sugar diet in Drosophila melanogaster
Lampaya Medicinalis Phil. decreases lipid-induced triglyceride accumulation and proinflammatory markers in human hepatocytes and fat body of Drosophila melanogaster
Uncoupled inflammatory, proliferative, and cytoskeletal responses in senescent human gingival fibroblasts
Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes
Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts
Insights into the HyPer biosensor as molecular tool for monitoring cellular antioxidant capacity
Glucose Promotes a Pro-Oxidant and Pro-Inflammatory Stromal Microenvironment Which Favors Motile Properties in Breast Tumor Cells
Modulation of Mammary Stromal Cell Lactate Dynamics by Ambient Glucose and Epithelial Factors
Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells.
c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells
Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells
Adipogenic effect of calcium sensing receptor activation
Effects of Chitosan Particles in Periodontal Pathogens and Gingival Fibroblasts
Tumor Necrosis Factor-alpha Inhibits Transforming Growth Factor-beta-Stimulated Myofibroblastic Differentiation and Extracellular Matrix Production in Human Gingival Fibroblasts
Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and adipose tissue
NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration
Obesity-associated proinflammatory cytokines increase calcium sensing receptor (CaSR) protein expression in primary human adipocytes and LS14 human adipose cell line
ROS-NF kappa I' mediates TGF-beta 1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion
Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts
c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway
RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NF kappa B-dependent mechanism

Abstract (2)

Antioxidant and Anti-Inflammatory Effects of Dietary Polyphenols on a Cellular Model for Intestinal Epithelia
Soluble MMP-14 Produced by Bone Marrow-derived Cells Sheds Epithelial Endoglin Modulating the Migratory Properties of Human Breast Cancer Cells

ConferencePoster (19)

High sugar diet stimulates the pro-inflammatory response mediated by hemocytes and fatty body, which favors the metastatic capacity of tumors generated in larvae of Drosophila melanogaster
Drosophila melanogaster un modelo para entender la relación dieta e inflamación: una historia no tan dulce.
High glucose generates a pro-inflammatory stromal microenvironment which favors the expression of malignancy traits in breast tumor cells
Matrix stiffness and glucose availability as determinants of metabolic reprogramming in mammary stromal cells
The crosstalk between haemocytes and fat body throught Upd3/Dome pathway mediate the pro-inflammatory response in high-sugar-fed larvae in Drosophila melanogaster
Antioxidant capacity of different molecules in human cell-lines using the Hidrogen peroxide biosensor HyPer
Is the antioxidant capacity of mammalian cells connected with motility and viability?
In human mammary fibroblast long-term glucose exposure favors myo-differentiation and the expression of the IL-1β receptor
Production and transport of stromal lactate, a mediator of epithelial malignancy
Glucose generates a pro-inflammatory stromal microenvironment which favors the expression of malignancy traits in breast tumor cells
Tumor epithelial factors and glucose modulate lactate transport in normal mammary stromal cells
Active/latent TGF-beta ratio correlates with invasive grade in human mammary tumors
Efecto de la activación del receptor sensor de calcio sobre la adipogénesis en Adipocitos humanos
Effect of tumor epithelial and normal stroma mammary cells on CD4+ T lymphocyte differentiation
In stromal mammary cells, TGF-β1 and Glucose availability stimulate lactate production and expression of Glucose and monocarboxylates transporters
Anti-inflammatory effects of chitosan nanoparticles in human gingival fibroblasts
Connective Tissue Growth Factor modulates TGF-beta-dependent mammary fibroblast differentiation by a non-Smads-dependent mechanism
Efecto Antiinflamatorio de Nanopartículas de Quitosano en Fibroblastos Gingivales Humanos
Stromal NOX determines mammary epithelial migration potential through the activation of CXCL12-CXCR4 axis

Letter (1)

Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-beta 1 and TNF-alpha

Proyecto (12)

Empaquetamiento y puesta en marcha de Redoxcell, un servicio para evaluar el impacto antioxidante de matrices alimentarias en células vivas
Desarrollo de un modelo animal para el estudio del efecto de la dieta sobre la respuesta inflamatoria promotora de la malignidad tumoral
Desarrollo de un modelo animal para el estudio del efecto de la dieta sobre la respuesta inflamatoria promotora de la malignidad tumoral
Redoxcell: una plataforma para el registro del impacto antioxidante en células vivas
Redoxcell=> una plataforma para el registro del impacto antioxidante en células vivas
EFECTO DE UNA DIETA ALTA EN GLUCOSA SOBRE LA CONDUCTA METASTÁSICA DE TUMORES DEL DISCO IMAGINAL DE LA LARVA DE DROSOPHILA MELANOGASTER.
Efecto de una dieta alta en glucosa sobre la conducta metastásica de tumores del disco imaginal de la larva de Drosophila Melanogaster
Uso de células que expresan un biosensor REDOX para evaluar la capacidad antioxidante de moléculas de interés nutricional y terapéutico
Uso de células que expresan un biosensor REDOX para evaluar la capacidad antioxidante de moléculas de interés nutricional y terapéutico.
TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA) FAVOURS TUMOUR GROWTH BY MODULATING INVASIVE, FIBROTIC AND IMMUNE RESPONSES IN HUMAN BREAST CANCER
ESTUDIOS DEL PAPEL INSTRUCTIVO DEL ESTROMA CELULAR EN LA TUMORIGENESIS MAMARIA HUMANA. IDENTIFICACION DE MARCADORES TEMPRANOS DE MALIGNIDAD.
LA ASOCIACION FUNCIONAL ENTRE LOS RECEPTORES DE EGF Y uPA Y LA MODULACION DE CADHERINA-E POR GTPasas DE LA FAMILIA Rho, SON FACTORES DETERMINANTES EN LA EXPRESION Y MANTENCION DEL FENOTIPO INVASIVO.
51
Nicolas Tobar

Assistan Professor

Cellular and molecular Biology Laboratory

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS, INTA-UCHILE

Santiago, Chile

17
Jorge Martinez

Profesor Titular

Laboratorio de Biología Celular

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE ALIMENTOS (INTA), UNIVERSIDAD DE CHILE

Santiago, Chile

5
Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

5
Patricio Smith

Profesor Asociado

Odontología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

5
Patricio Smith

Associate Professor

Medicine / Dentistry

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

4
Monica Caceres

Profesor asistente

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

2
Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

2
Marcela Reyes

Profesor Asistente

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE LOS ALIMENTOS (INTA)

Santiago, Chile

1
cristian tapia

profesor asociado

ciencia de los alimentos y tecnologia quimica

University of Chile

santiago, Chile

1
Juan Salazar

Profesor Asociado

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

1
Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pia Villarroel

Docente investigador

UNIVERSIDAD MAYOR

Santiago, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Ignacio Retamal

Docente

Universidad de Los Andes

Santiago, Chile