Man

Maria Carolina Otero Acuña

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Líneas de Investigación


Propiedades biológicas de Plantas Nativas Tráfico intracelular de nanopartículas

Educación

  •  Inmunología, UNIVERSITY OF KONSTANZ. Alemania, 2006

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD ANDRES BELLO

    Medicina

    Chile

    2012 - A la fecha

Experiencia Profesional

  •   Postdoctorado Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2009 - 2011

  •   Postdoctorado Full Time

    Universidad de Goettingen

    Goettingen, Alemania

    2007 - 2008

Formación de Capital Humano


Tesis Magister en Bioquímica
"Activación del receptor Nod1 mediante encapsulación de su agonista en nanopartículas"
Alumno: Mauricio Cabaña
Año: 2015

Tesis Magister en Bioquímica
"Caracterización de la incorporación de nanopartículas de poli(3-hidroxibutirato-co-3-hidroxivalerato) en células epiteliales"
Alumno: Juan Pablo Peñaloza
Año: 2016

Tesis Magister en Bioquímica
"Caracterización biológica de un derivado de benzoimidazol (B2) como ligando ancilar de un núcleo tricarbonilo de Renio (I) y su potencial como
biomarcador en células eucariontes"
Alumno: Felipe Marchant
Año: 2017

Tesis Doctorado en Biotecnología
“Rational design of synthetic proteins based on dendrimers as transfection reagents”
Alumno: Valeria Marquez
Año: 2016


Premios y Distinciones

  •   Carolina Otero

    MINISTERIO DE EDUCACION

    Chile, 2019

    Primer Lugar Concurso audiovisual científicas chilenas

  •   Carolina Otero

    UNIVERSITY OF KONSTANZ

    Alemania, 2006

    Summa Cum Laude


 

Article (30)

"One for All": Functional Transfer of OMV-Mediated Polymyxin B Resistance From Salmonella enterica sv. Typhi Delta tolR and Delta degS to Susceptible Bacteria
Biochemical characterization of Peumus boldus fruits: Insights of its antioxidant properties through a theoretical approach
Development of a PHBV nanoparticle as a peptide vehicle for NOD1 activation
Phytochemical profile and antioxidant activity of extracts of the peruvian peppertree Schinus areira L. from Chile
Penicillium spp. mycotoxins found in food and feed and their health effects
Structural Characterization, DFT Calculation, NCI, Scan-Rate Analysis and Antifungal Activity againstBotrytis cinereaof (E)-2-{[(2-Aminopyridin-2-yl)imino]-methyl}-4,6-di-tert-butylphenol (Pyridine Schiff Base)
TRPM Channels in Human Diseases
Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction
Confocal microscopy studies of living fungal hyphae and conidia using rhenium (I) tricarbonyl complexes as fluorescent dyes
Identification of Genes Involved in Biogenesis of Outer Membrane Vesicles (OMVs) in Salmonella enterica Serovar Typhi
Prototypical cis-ruthenium(II) complexes present differential fluorescent staining in walled-cell models (yeasts)
Antimicrobial activity of gunnera tinctoria (mol.) mirb. against porphyromonas gingivalis in periodontal disease.
New Properties of a Bioinspired Pyridine Benzimidazole Compound as a Novel Differential Staining Agent for Endoplasmic Reticulum and Golgi Apparatus in Fluorescence Live Cell Imaging
Study of the structure-bioactivity relationship of three new pyridine Schiff bases: synthesis, spectral characterization, DFT calculations and biological assays
The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium
Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines
Substituted bidentate and ancillary ligands modulate the bioimaging properties of the classical Re(I) tricarbonyl core with yeasts and bacteria
Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake
Fluorescence probes for both prokaryotic and eukaryotic cells using new Rhenium (I) tricarbonyl complexes with an electron withdrawing ancillary ligand
The NarE protein of Neisseria gonorrhoeae catalyzes ADP-ribosylation of several ADP-ribose acceptors despite an N-terminus deletion
Theoretical and experimental characterization of a novel pyridine benzimidazole: Suitability for fluorescence staining in cells and antimicrobial properties
Advances in Nanomedicine Towards Clinical Application in Oncology and Immunology
Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases
Propranolol Restricts the Mobility of Single EGF-Receptors on the Cell Surface before Their Internalization
Endoplasmic Reticulum Sorting and Kinesin-1 Command the Targeting of Axonal GABA(B) Receptors
Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration
Phosphatidic Acid Induces Ligand-independent Epidermal Growth Factor Receptor Endocytic Traffic through PDE4 Activation
Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis
A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins
Opposite Fate of Endocytosed CCR7 and Its Ligands: Recycling versus Degradation

Abstract (4)

Combining chemotherapy and targeted therapies against resistance and recurrence in ovarian cancer
Propranolol restricts the mobility of single quantum-dot labelled EGF-receptors on the cell surface
Inhibition of Phosphatidic Acid Phosphohydrolase activity induces EGFR, EGFvIII and ErbB2 endocytosis and decreases their mitogenic potential.
Novel proteins of the synaptic region are autoantigens associated with lupic neuropsychiatric manifestations

Proyecto (22)

Promoción del Uso Racional de Plantas Medicinales
Caracterización de compuestos derivados del Quillay
Development of improved cis-Ru(II) complexes as biomarkers for biological applications
Efecto de fármacos en la prevención de las infecciones recurrentes causadas por Clostridium difficile.
Synthetic functionalization and pharmacological evaluation of mithocondria-targeted dendrimers
Estudio del Efecto del Quitosano en Hidrogeles compuestos de PAV/PEG sobre la polarización de macrófagos
Estudio del Efecto del Quitosano en Hidrogeles compuestos de PAV/PEG sobre la polarización de macrófagos
Outer membrane vesicles (OMVs) in Salmonella Typhi=> new insights into OMV cargo selection, OMV-mediated delivery of proteins, and immune response elicited by OMVs
Polo Estratégico de Ingredientes Funcionales y Aditivos Especializados En La Región Del Maule y O’Higgins=> Cooperación, Articulación y Encadenamientos Productivos Para La Creación De Una Nueva Industria Con Valor Compartido - IFAE
Proyecto Polo estratégico de ingredientes funcionales y aditivos especializados en la region del Maule y O`Higgins=> cooperación, articulación y encadenamientos productivos para la creación de una nueva industria con valor compartido.
Efecto de fármacos en la prevención de las infecciones recurrentes causadas por Clostridium difficile
¿Which sweet cherry have a better anti-inflammatory effect?=> exploring different sweet cherry varieties grown in Chile.
Development and validation of protocols using Transfection Agents for in- vitro use. Transfection agents based on chemically modified nanoparticles.
Synthesis and characterization of a nanomarker for the detection of breast cancer cells
Synthesis of new Re (I) tricarbonyl complexes with Schiff bases or benzimidazoles derivatives as ancillary ligands, presenting improved photophysic and luminescent properties suitable in biological applications
Neuronal mechanisms mediating individual susceptibility to obesity
Tissue Factor increases proliferation and adhesion in a three dimensional model of the ovarian metastatic foci
Uptake, intracellular fate and membrane interaction of biodegradable polymeric nanoparticles in different cancer cells types
Estudio de la actividad ADP-ribosiltransferasa in vitro de la toxina NarE del patógeno humano Neisseria gonorrhoeae sobre péptidos antimicrobianos
Characterization of the Intracellular trafficking of GABA(B) Receptor
Control of epidermal growth factor receptor (EGFR) trafficking and cell surface expression by the cAMP/PKA pathway
Generación y desarrollo de nuevos fármacos para el tratamiento de cánceres dependientes del EGFR

Review (1)

Rhenium (I) Complexes as Probes for Prokaryotic and Fungal Cells by Fluorescence Microscopy: Do Ligands Matter?
30
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

8
Juan Fuentes

Académico

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

7
Alexander Carreño

Profesor asistente

Center of Applied Nanoscience

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

5
Manuel Gacitúa

Profesor asistente

Departamento de Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

5
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

4
Alexander Carreño

Profesor asistente

Doctorado en Fisico Química Molecular

Universidad Andrés Bello

Santiago, Chile

4
Rubén Polanco

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO (UNAB)

SANTIAGO, Chile

3
Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

3
Dayán Páez

Profesor Asociado

Facultad de Ciencias Exactas

Universidad Andrés Bello

Santiago, Chile

3
Ramiro Arratia

DIRECTOR DOCTORADO

CIENCIAS QUIMICAS

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
César Zúñiga

Profesor Investigador

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

2
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

1
VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

1
Maria Opazo

Profesor honorarios

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Jorge Cancino

Assistant Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
IVAN CALDERON

Associate Professor / Academic Coordinator / Principal Investigator

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

1
Claudia Saavedra

Full Professor

Departmento de Ciencias de la Vida

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Alejandro Hidalgo

Associate Professor

Escuela de Química y Farmacia

Universidad Andres Bello

Santiago, Chile

1
Marcelo Preite

Associate Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Coral Pardo

Investigador postdoctoral

Universidad Andrés Bello

Santiago, Chile

1
Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

1
Alvaro Becerra

Coordinador Academico

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

1
Marco Soto

Profesor Asociado

Química Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

1
Juan Castro

Post-Doctorante

Universidad Católica del Norte

Antofagasta, Chile

1
Cristian Vilos

Profesor Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

1
Daniela Geraldo

PROFESOR PART TIME

UNIVERSIDAD DIEGO PORTALES

SANTIAGO, Chile

1
Guido Mora

Académico/Investigador

Facultad Ciencias de la Salud

Universidad SEK

Santiago, Chile

1
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

1
Francisco Ceric

Jefe Laboratorio

Laboratorio de Neurociecia Afectiva

Facultad de Psicologia/Universidad del Desarrollo

Santiago, Chile

1
JOSÉ VALENZUELA

INSTITUT CURIE

PARIS, Francia

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Plinio Cantero

Profesor Adjunto

Química

Universidad Andrés Bello

Santiago de Chile, Chile

1
YORLEY DUARTE

profesor Asistente

Universidad Andrés Bello

Santiago, Chile

1
Matias Jaureguiberry

Head of Science and Product Development

Cellter

Santiago, Chile

1
Andrea Soza

Profesor Asociado

Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile