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María Pertusa Pastor

Profesor Asociado

UNIVERSIDAD DE SANTIAGO DE CHILE. FACULTAD QUÍMICA Y BIOLOGÍA

Santiago, Chile

Líneas de Investigación


Determinantes moleculares del tráfico y función de canales TRP

Educación

  •  Licenciado en Bioquímica, Universidad Autónoma de Barcelona. España, 2002
  •  PhD in Neuroscience, Universidad Miguel Hernández. España, 2010

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Química y Biología

    Santiago, Chile

    2021 - A la fecha

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Química y Biología

    Santiago, Chile

    2015 - 2020

Experiencia Profesional

  •   Becario

    Instiuto de Investigaciones Biomédicas de Barcelona

    Barcelona, España

    2003 - 2005

  •   Becario Full Time

    Instituto de Neurociencias de Alicante

    Alicante, España

    2005 - 2010

  •   Investigador Postdoctoral

    Universidad de Santiago de Chile

    Santiago, Chile

    2010 - 2013

  •   Investigador Asociado

    Universidad de Santiago de Chile

    Santiago, Chile

    2013 - 2014

Formación de Capital Humano


Thesis director

2011 - 2013 Paulina Hardy Bioquímica Universidad de Santiago de Chile

2013 - 2014 Bastián Rivera Bioquímica Universidad de Santiago de Chile

2014 - 2015 Jeremy Salas Bioquímica Universidad de Santiago de Chile

2016 - 2017 Boris Lavanderos Bioquímica Universidad de Santiago de Chile

2016 - 2018 Katherine Valdebenito Bioquímica Universidad de Santiago de Chile

2016 - 2018 Bastián Rivera Doctorado en Neurociencia Universidad de Santiago de Chile

2018 - 2019 Claudio Moreno Bioquímica Universidad de Santiago de Chile

2022 - Victoria Flores Bioquímica Universidad de Santiago de Chile


Difusión y Transferencia


Symposia / Lectures (Organizer / Invited speaker)

- SYMPOSIUM. Ion channels in Pain Neurophysiology. Annual meeting of the Chilean Society for Neuroscience, 2023, La Serena, Chile. Organizer.

- IBRO COURSE: Molecular and Cellular Mechanisms of Sensory Transduction. Universidad Autónoma de México, México, 2023. Keynote Speaker.

- SYMPOSIUM: TRP channels in cell physiology and physiopathology. Annual meeting of the Chilean Society for Neuroscience, 2019, La Serena, Chile. Organizer.

- SYMPOSIUM: Canales Iónicos y Neurociencias. LXI Congreso Nacional de la Sociedad Mexicana de Ciencias Fisiológicas, 2018, Colima, México. Speaker.

- SYMPOSIUM: Exploring key molecular determinants in cold sensing and neuropathic pain. Annual meeting of the Chilean Society for Neuroscience 2018. Puerto Varas, Chile. Speaker.

- SYMPOSIUM: Jornadas de Investigación básica - XI International meeting of the Asociación Chilena para el estudio del dolor (ACHED) IASP, Santiago, Chile. Speaker.

- SYMPOSIUM: Second Meeting of Proyecto Anillo: Physiological TRP channels in thermal sensory transduction and synaptic plasticity, Santiago, Chile. 2014. Universidad de Santiago de Chile. Speaker.

Talks by invitation

- Faculty of Sciences, University of Chile, 2010

- Instituto de Neurociencias de Alicante, Spain, 2015

- Faculty of Medicine, University of Chile, 2016

- Instituto de Neurociencias de Alicante, Spain, 2017

- Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 2018.

- Faculty of Medicine, University of Chile, 2019

- Faculty of Sciences, University of Chile, 2019

- Instituto de Neurociencias de Alicante, Spain, 2019

Website:

www.minicad.cl

www.minuspain.cl


Premios y Distinciones

  •   Special Young Neuroscientists Symposium

    Sociedad Chilena de Neurociencia

    Chile, 2011

    Award to Young Neuroscientists from the Chilean Society for Neuroscience.


 

Article (22)

Molecular determinants of TRPM8 function: key clues for a cool modulation
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons
Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function
Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons
Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing
Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison
Non-invasive Neurite Mechanics in Differentiated PC12 Cells
IKD current in cold transduction and damage-triggered cold hypersensitivty
Role of the Excitability Brake Potassium Current I-KD in Cold Allodynia Induced by Chronic Peripheral Nerve Injury
Targeted overexpression of tumor necrosis factor-alpha increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons
Time-resolved neurite mechanics by thermal fluctuation assessments
Bidirectional Modulation of Thermal and Chemical Sensitivity of TRPM8 Channels by the Initial Region of the N-terminal Domain
Intimacies and Physiological Role of the Polymodal Cold-Sensitive Ion Channel TRPM8
N-Glycosylation of TRPM8 Ion Channels Modulates Temperature Sensitivity of Cold Thermoreceptor Neurons
Differential Role of the Menthol-Binding Residue Y745 in the Antagonism of Thermally Gated TRPM8 Channels
Lipid Raft Segregation Modulates TRPM8 Channel Activity
Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats
Astrocytes aged in vitro show a decreased neuroprotective capacity
Transcriptional Control of Cholesterol Biosynthesis in Schwann Cells by Axonal Neuregulin 1
Carboxyl-terminal fragment of amyloid precursor protein and hydrogen peroxide induce neuronal cell death through different pathways
Down's syndrome astrocytes have greater antioxidant capacity than euploid astrocytes
Neurotoxic effects of trimethyltin and triethyltin on human fetal neuron and astrocyte cultures: A comparative study with rat neuronal cultures and human cell lines

BookSection (3)

Modulation of TRP channels by N-glycosylation and Phosphorylation.
TRP channels in cold transduction. In the book TRP channels in Sensory Transduction
Mutagenesis and temperature-sensitive little machines

Proyecto (9)

TRPM8 phosphorylation as a critical modulator of cold sensing
Millenium Nucleus of Ion Channels-Associated Diseases (MiNICAD)
Functional unbalance of Kv1 channels and cold-sensitive TRP channels as a mechanism of cold hypersensitivity in orofacial neuropathic pain.
CELLULAR AND MOLECULAR DETERMINANTS OF THE ABNORMAL COLD SENSITIVITY OF PRIMARY SENSORY NEURONS IN RESPONSE TO AXONAL DAMAGE.
MOLECULAR DETERMINANTS OF COLD SENSITIVITY OF TRPM8 ION CHANNEL
ROLE OF GABAA CHANNELS IN THE AXON INITIAL SEGMENT IN EPILEPSY
Evolutionary adaptions of voltage-dependent potassium channels from an antartic organism.
Study of the physiological role of TRP channels in thermal transduction and synaptic plasticity
PAPEL DEL DOMINIO N-TERMINAL EN LA OLIGOMERIZACION, TRAFICO Y FUNCION DEL CANAL IONICO TRPM8.
26
María Pertusa

Profesor Asociado

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE. FACULTAD QUÍMICA Y BIOLOGÍA

Santiago, Chile

4
Rodolfo Madrid

Full Professor

Departamento de Biología

UNIVERSIDAD DE SANTIGO DE CHILE

Santiago, Chile

2
Patricio Orio

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

2
Roberto Bernal

Assistant Professor

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Fernanda Gárate

Biofísico Senior

Facultad de Ciencias Biológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gonzalo Ugarte

Asistente de Investigación

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Bastian Rivera

Postdoctorado/ Profesor Adjunto I

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Pablo Lazcano

Asistente de Investigacion

CIIB

Universidad de Los Andes

Santiago, Chile

1
Pablo Rozas

Investigador

SymbiOx

Santiago, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

1
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile