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María Pertusa Pastor

Profesor Asistente

UNIVERSIDAD DE SANTIAGO DE CHILE. FACULTAD QUÍMICA Y BIOLOGÍA

Santiago, Chile

Determinantes moleculares del tráfico y función de canales TRP

Licenciado en Bioquímica, Universidad Autónoma de Barcelona. España, 2002
Neuroscience, Universidad Miguel Hernández. España, 2010

Profesor Asistente Full Time

UNIVERSIDAD DE SANTIAGO DE CHILE

Química y Biología

Santiago, Chile

2015 - A la fecha

Becario

Instiuto de Investigaciones Biomédicas de Barcelona

Barcelona, España

2003 - 2005
Becario Full Time

Instituto de Neurociencias de Alicante

Alicante, España

2005 - 2010
Investigador Postdoctoral

Universidad de Santiago de Chile

Santiago, Chile

2010 - 2013
Investigador Asociado

Universidad de Santiago de Chile

Santiago, Chile

2013 - 2014

Thesis director

2011 - 2013 Paulina Hardy Bioquímica Universidad de Santiago de Chile

2013 - 2014 Bastian Rivera Bioquímica Universidad de Santiago de Chile

2014 -2015 Jeremy Salas Bioquímica Universidad de Santiago de Chile

2016-217 Boris Lavanderos Bioquímica Universidad de Santiago de Chile

2016 - 2018 K. Valdebenito Bioquímica Universidad de Santiago de Chile

2016 -2018 Bastian Rivera Doctorado en Neurociencia Universidad de Santiago de Chile

2018-2019 Claudio Moreno Bioquímica Universidad de Santiago de Chile

Symposia / Plenary Lectures (Organizer / Invited speaker)

- SYMPOSIUM: TRP channels in cell physiology and physiopathology. Annual meeting of the Chilean Society for Neuroscience, 2019, La Serena, Chile. Organizer

-SYMPOSIUM: Canales Iónicos y Neurociencias. LXI Congreso Nacional de la Sociedad Méxicana de Ciencias Fisiológicas, 2018, Colima, México.

- SYMPOSIUM: Exploring key molecular determinants in cold sensing and neuropathic pain. Annual meeting of the Chilean Society for Neuroscience 2018. Puerto Varas, Chile. Speaker.

- SYMPOSIUM: Jornadas de Investigación básica - XI International meeting of the Asociación Chilena para el estudio del dolor (ACHED) IASP, Santiago, Chile. Speaker.

- SYMPOSIUM Second Meeting of Proyecto Anillo: Physiological TRP channels in thermal sensory transduction and synaptic plasticity, Santiago, Chile. 2014. Universidad de Santiago de Chile. Speaker.

Talks by invitation

-Faculty of Sciences, University of Chile, 2010

-Instituto de Neurociencias de Alicante, Spain, 2015

-Faculty of Medicine, University of Chile, 2016

-Instituto de Neurociencias de Alicante, Spain, 2017

-Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 2018.

-Faculty of Medicine, University of Chile, 2019

-Faculty of Sciences, University of Chile, 2019

-Instituto de Neurociencias de Alicante, Spain, 2019

Website:
www.minicad.cl

Special Young Neuroscientists Symposium

Sociedad Chilena de Neurociencia

Chile, 2011

Award to Young Neuroscientists from the Chilean Society for Neuroscience.


Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons Rivera, Bastián; Campos, Matías; Orio, Patricio; Madrid, Rodolfo; Pertusa, María Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing Cornejo, Víctor Hugo; González, Carolina; Campos, Matías; Vargas-Saturno, Leslie; Juricic, María de los Ángeles; Miserey-Lenkei, Stéphanie; Pertusa, María; Madrid, Rodolfo; Couve, Andrés Article ISI CELL REPORTS (2020)
Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison Pertusa, Maria; Rivera, Bastian; Gonzalez, Alejandro; Ugarte, Gonzalo; Madrid, Rodolfo Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Non-invasive Neurite Mechanics in Differentiated PC12 Cells Gárate, Fernanda; Pertusa, María; Arana, Yahaira; Bernal, Roberto Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2018)
IKD current in cold transduction and damage-triggered cold hypersensitivty González, Alejandro; Herrera, Gaspar; Ugarte, Gonzalo; Piña, Ricardo; Pertusa, María; Orio, Patricio; Madrid, Rodolfo Article ISI Advance In Experimental Medicine and Biology (2017)
Role of the Excitability Brake Potassium Current I-KD in Cold Allodynia Induced by Chronic Peripheral Nerve Injury González, Alejandro; Ugarte, Gonzalo; Restrepo, Carlos; Herrera, Gaspar; Piña, Ricardo; Gómez-Sánchez, José Antonio; Pertusa, María; Orio, Patricio; Madrid, Rodolfo Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2017)
Targeted overexpression of tumor necrosis factor-? increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons Rozas P.; Lazcano, P; Piña R.; Cho A.; Terse A.; Pertusa, M.; Madrid R.; Gonzalez-Billault C.; Kulkarni A.B.; Utreras, E Article ISI SCOPUS Pain (2016)
Time-resolved neurite mechanics by thermal fluctuation assessments Garate F.; Betz, T; Pertusa, M.; Bernal, R Article ISI SCOPUS PHYSICAL BIOLOGY (2015)
Bidirectional Modulation of Thermal and Chemical Sensitivity of TRPM8 Channels by the Initial Region of the N-terminal Domain Pertusa, M.; González A; Hardy P.; Madrid R.; Viana, F. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Intimacies and Physiological Role of the Polymodal Cold-Sensitive Ion Channel TRPM8 Madrid R.; Pertusa, M. Article SCOPUS Current Topics in Membranes (2014)
N-Glycosylation of TRPM8 Ion Channels Modulates Temperature Sensitivity of Cold Thermoreceptor Neurons Pertusa, M.; Madrid R.; Morenilla-Palao, C; Belmonte, C; Viana, F. Article ISI SCOPUS Journal of Biological Chemistry (2012)
Differential Role of the Menthol-Binding Residue Y745 in the Antagonism of Thermally Gated TRPM8 Channels Malkia, Annika; Pertusa, María; Fernández-Ballester, Gregorio; Ferrer-Montiel, Antonio; Viana, Félix Article ISI Molecular Pain (2009)
Lipid Raft Segregation Modulates TRPM8 Channel Activity Morenilla-Palao, Cruz; Pertusa, María; Meseguer, Víctor; Cabedo, Hugo; Viana, Félix Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats Pertusa, M.; García-Matas, S.; Mammeri, H.; Adell, A.; Rodrigo, T.; Mallet, J.; Cristòfol, R.; Sarkis, C.; Sanfeliu, C. Article ISI NEUROBIOLOGY OF AGING (2008)
Astrocytes aged in vitro show a decreased neuroprotective capacity Pertusa, M.; García-Matas, S.; Rodríguez-Farré, E.; Sanfeliu, C.; Cristòfol, R. Article ISI JOURNAL OF NEUROCHEMISTRY (2007)
Transcriptional Control of Cholesterol Biosynthesis in Schwann Cells by Axonal Neuregulin 1 Pertusa, Maria; Morenilla-Palao, Cruz; Carteron, Christelle; Viana, Felix; Cabedo, Hugo Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Carboxyl-terminal fragment of amyloid precursor protein and hydrogen peroxide induce neuronal cell death through different pathways Sebastià, J.; Pertusa, M.; Vílchez, D.; Planas, A. M.; Verbeek, R.; Rodríguez-Farré, E.; Cristòfol, R.; Sanfeliu, C. Article ISI Journal of neural transmission (Vienna, Austria : 1996) (2006)
Down's syndrome astrocytes have greater antioxidant capacity than euploid astrocytes Sebastià, Jordi; Cristòfol, Rosa; Pertusa, Maria; Vílchez, David; Torán, Núria; Barambio, Santiago; Rodríguez-Farré, Eduard; Sanfeliu, Coral Article ISI European Journal of Neuroscience (2004)
Neurotoxic effects of trimethyltin and triethyltin on human fetal neuron and astrocyte cultures: A comparative study with rat neuronal cultures and human cell lines Cristòfol, Rosa M; Gassó, Sergi; Vílchez, David; Pertusa, MarÍa; Rodríguez-Farré, Eduard; Sanfeliu, Coral Article ISI TOXICOLOGY LETTERS (2004)


Modulation of TRP channels by N-glycosylation and Phosphorylation. Pertusa, María; Madrid, Rodolfo BookSection (2015)
TRP channels in cold transduction. In the book TRP channels in Sensory Transduction González, Alejandro; Ugarte, Gonzalo; Piña, Ricardo; Pertusa, María; Madrid, Rodolfo BookSection (2015)
Mutagenesis and temperature-sensitive little machines Pertusa, María; Moldenhauer, Hans; Brauchi, Sebastián; Latorre, Ramón; Madrid, Rodolfo; Orio, Patricio BookSection (2012)


Millenium Nucleus of Ion Channels-Associated Diseases (MiNICAD) Iniciativa Científica Milenio, Ministerio de Enconomía (NC160011) Proyecto 2017-2020 Coinvestigador(a)
Functional unbalance of Kv1 channels and cold-sensitive TRP channels as a mechanism of cold hypersensitivity in orofacial neuropathic pain. FONDECYT (1161733) Proyecto 2016-2019 Coinvestigador(a)
CELLULAR AND MOLECULAR DETERMINANTS OF THE ABNORMAL COLD SENSITIVITY OF PRIMARY SENSORY NEURONS IN RESPONSE TO AXONAL DAMAGE. FONDECYT (1131064) Proyecto 2013-2016 Coinvestigador(a)
MOLECULAR DETERMINANTS OF COLD SENSITIVITY OF TRPM8 ION CHANNEL FONDECYT (11130144) Proyecto 2013-2016 Inv. Responsable
ROLE OF GABAA CHANNELS IN THE AXON INITIAL SEGMENT IN EPILEPSY FONDECYT (1130904) Proyecto 2013-2016 Coinvestigador(a)
Evolutionary adaptions of voltage-dependent potassium channels from an antartic organism. INACH (RT15-12) Proyecto 2012-2015 Coinvestigador(a)
Study of the physiological role of TRP channels in thermal transduction and synaptic plasticity PIA (ACT-1113) Proyecto 2012-2015 Coinvestigador(a)
PAPEL DEL DOMINIO N-TERMINAL EN LA OLIGOMERIZACION, TRAFICO Y FUNCION DEL CANAL IONICO TRPM8. FONDECYT (3110128) Proyecto 2010-2013 Inv. Responsable