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Rodolfo Madrid Montecinos

Full Professor

UNIVERSIDAD DE SANTIGO DE CHILE

Santiago, Chile

Líneas de Investigación


Fisiología Sensorial, termotransducción, nocicepción, canales de iones.

Educación

  •  Molecular Biology, Cell Biology and Neuroscience, UNIVERSIDAD DE CHILE. Chile, 2001
  •  Sciences, UNIVERSIDAD DE CHILE. Chile, 1993

Experiencia Académica

  •   Postdoctoral Fellow Full Time

    University of Washington

    Seattle, Estados Unidos

    2001 - 2003

  •   Postdoctoral Fellow Full Time

    Instituto de Neurociencias de Alicante (UMH-CSIC)

    Alicante , España

    2004 - 2008

  •   Assistant Professor Full Time

    Universidad de Santiago de Chile

    Química y Biología

    Santiago , Chile

    2008 - 2013

  •   Associate Professor Full Time

    Universidad de Santiago de Chile

    Química y Biología

    Santiago, Chile

    2013 - 2021

  •   Director of the Doctoral Program in Neuroscience Full Time

    Universidad de Santiago de Chile

    Química y Biología

    Santiago , Chile

    2013 - 2016

  •   Vice Dean of Research Full Time

    Universidad de Santiago de Chile

    Química y Biología

    Santiago , Chile

    2016 - 2018

  •   Director of Research Full Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Santiago, Chile

    2018 - 2019

  •   Full Professor Full Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Química y Biología

    Santiago, Chile

    2021 - A la fecha

Formación de Capital Humano


Thesis direction

Graduate Students (PhD, MSc)

- Andrés Parra / PhD / Univ. Miguel Hernández. Cold thermoreceptors of the cornea: functional characteristics and physiological role (2008-2012).

- Carlos Restrepo / MSc / Universidad de Chile. PAPEL DE LA CORRIENTE DE FRENO IKD EN LA ALODINIA AL FRÍO INDUCIDA POR LESIÓN EN NEURONAS SENSORIALES PRIMARIAS (2011-2013).

- Ricardo Piña / PhD / Universidad de Chile. BASES MOLECULARES DE LA RESPUESTA ELECTROFISIOLÓGICA ALTERADA DE NEURONAS SENSORIALES PRIMARIAS DEL GANGLIO TRIGÉMINO SOMETIDAS A LESIÓN PERIFÉRICA (2012-2015).

- Gaspar Herrera / PhD / Universidad de Valparaíso. Injury-associated changes in the functional expression of KCNA channels in cold-sensitive primary sensory neurons and their impact on the detection threshold to cold of free nerve endings. (2015- )

- Bastián Rivera / PhD / Universidad de Santiago de Chile. Bases moleculares de la modulación del canal iónico termosensible TRPM8 por proteína quinasa C. (2015- 2018)

Undergraduate Students

- Paulina Hardy / Bioquímico / Universidad de Santiago de Chile. Papel de los primeros 40 aminoácidos en el tráfico y función del canal iónico termosensible TRPM8. (2011-2013).

- Simón Salgado / Ingeniero en Biotecnología / Universidad de Santiago de Chile. Estudio del efecto de extractos naturales sobre la respuesta al frío del canal iónico termosensible TRPM8 (2012-2013).

- Bastián Rivera / Bioquímico / Universidad de Santiago de Chile. Identificación de regiones en el extremo amino terminal responsables de la mayor sensibilidad a frío y mentol del TRPM8 de pollo respecto a su ortólogo en ratón (2013-2014).

- Jeremy Salas / Bioquímico / Universidad de Santiago de Chile. Bases moleculares de la sensibilidad térmica del canal iónico TRPM8. (2014-2015).

- Richard Pino / Bioquímico / Universidad de Santiago de Chile. Papel del canales termosensible TRPM8 y de la corriente IKD en la sensibilidad térmica alterada de neuronas sensoriales primarias del ganglio trigémino en respuesta a lesión axonal (2014-2015).

- Katherine Valdebenito / Bioquímico / Universidad de Santiago de Chile. USO DE VECTORES ADENOASOCIADOS PARA LA REVERSIÓN DEL FENOTIPO DE DOLOR NEUROPÁTICO EN ANIMALES CON NEURALGIA TRIGEMINAL EN RESPUESTA A LESIÓN AXONAL. (2016 - 2017)

- Claudio Moreno / Bioquímico / Universidad de Santiago de Chile. Papel de la fosforilación basal de las serinas 26, 29, 541 y 542 en el tráfico y función del canal termosensible TRPM8. (2018 - 2019)

- Camilo Guevara / Biólogo / Universidad Nacional de Colombia. Uso de vectores adenoasociados como herramienta para el tratamiento del dolor neuropático trigeminal en respuesta a daño axonal (2018).

Supervised Postdoctoral Researchers (last five years)

- Dr. Alejandro González (FONDECYT Grant # 3150431). 2014-2016 Papel de los nociceptores polimodales en las alteraciones sensoriales de la córnea inducidas por lesión.

- Dr. Ricardo Piña (VRIDEI-USACH 2013-2016, contraparte Anillo). Determinantes celulares y moleculares de la respuesta al calor de las neuronas termorreceptoras de frío del sistema somatosensorial.

- Dr. Gonzalo Ugarte (VRIDEI-USACH 2018-2019). Bases neurales y moleculares de la alodinia al frío en un modelo de dolor neuropático orofacial.

- Dr. Bastián Rivera (Núcleo Milenio MiNICAD, 2018-2020). Regulación del tráfico y función del canal TRPM8 por modificaciones postraduccionales.

- Dr. Darwin Contreras (FONDECYT Grant # 3190897). 2019-2021 Rol de TRPV1 en la modulación de la plasticidad y la transmisión sináptica hipocampal en un modelo animal de Trastorno de Déficit Atencional e Hiperactividad.


Difusión y Transferencia


Symposia / Plenary Lectures (Organizer / Invited speaker)

- SYMPOSIUM: TRP channels in cell physiology and physiopathology. Annual meeting of the Chilean Society for Neuroscience, 2019, La Serena, Chile. Speaker.

- SYMPOSIUM: Exploring key molecular determinants in cold sensing and neuropathic pain. Annual meeting of the Chilean Society for Neuroscience 2018. Puerto Varas, Chile. Speaker.

- LATP Course From molecules to behavior - The quest for new treatments of neuropathologies Latin American Training Program 2018, Valparaíso, Chile. Speaker (two talks).

- SYMPOSIUM: Jornadas de Investigación básica - XI International meeting of the Asociación Chilena para el estudio del dolor (ACHED) IASP, Santiago, Chile. Speaker.

- MiNICAD Course: Actualización en Farmacología de canales iónicos y su relevancia en clínica. Programa Taller del Núcleo MiIlenio de enfermedades asociadas a canales iónicos (MiNICAD) and Centro de Investigación Clínica Avanzada (CICA). Santiago, Chile. Speaker.

- SYMPOSIUM: Kv1 channels as modulators of hyperexcitability in neuropathic pain , 2017. Sixth International Meeting of The Special Interest Group on Neuropathic Pain (NeuPSIG), 2017. Gothenburg, Sweden, Speaker.

- SYMPOSIUM: Avances recientes en la neurobiología del dolor: nuevos blancos moleculares para el desarrollo farmacológico , 2016. XXXVIII Meeting of the Sociedad de Farmacología de Chile (SOFARCHI). Speaker.

- SYMPOSIUM: 25 Years ACHED. 2015. Asociación Chilena para el Estudio del Dolor (ACHED). Speaker.

- SYMPOSIUM: Spring Symposium in TRP channels. Third Meeting of Proyecto Anillo Physiological TRP channels in thermal sensory transduction and synaptic plasticity, Santiago, Chile. 2015. Organizer and Speaker.

- SYMPOSIUM: From single molecules to complex multicellular organisms. CiSNe Summer Symposium in Biophysics and Neurobiology. 2015. Universidad Austral de Chile. Speaker.

- SYMPOSIUM: Neurobiology of Sensory Transduction. IX CONGRESO NACIONAL/ X SEMINARIO INTERNACIONAL DE NEUROCIENCIAS, Cartagena de Indias, Colombia. 2014. Speaker.

- SYMPOSIUM Second Meeting of Proyecto Anillo: Physiological TRP channels in thermal sensory transduction and synaptic plasticity, Santiago, Chile. 2014. Universidad de Santiago de Chile. Organizer and Speaker.

- SYMPOSIUM: Painful Polyneuropathies, Satellite Symposium of the 15th World Congress of The International Association for the Study of Pain, Santiago, Chile. 2014. Speaker.

- SYMPOSIUM: First Meeting of Proyecto Anillo: Physiological TRP channels in thermal sensory transduction and synaptic plasticity, Santiago, Chile. 2013. Speaker and Organizer.

- SYMPOSIUM: Neural circuits, from molecules to behavior. 2012. Max Planck Institute, Jupiter Fl, USA. Speaker.

- SYMPOSIUM: A TRiP to the Senses: TRP channels in sensory transduction. 2012. 1st meeting of the Federation of Neuroscience Societies in Latin America, the Caribbean and the Iberian Peninsula (FALAN), Cancun, Mexico. Speaker and Organizer.

- SYMPOSIUM: Ion channel: from biophysics to physiology. University de Santiago de Chile. 2011. Organizer.

- SYMPOSIUM: From molecules to neural networks. Neurophysiology remixes on sensing and integration. 2011. XXVI Reunión Anual de la Sociedad Chilena de Ciencias Fisiológicas, Panimávida, Chile. Speaker.

- SYMPOSIUM: TRP CHANNELS IN SENSORY TRANSDUCTION. V Meeting of the Chilean Society for Neuroscience, Valdivia, Chile 2010 Speaker and Organizer.

- SYMPOSIUM: A Convergence of Young Minds: Symposium for Early Career Investigators in Neuroscience and Biophysics. 2009. Speaker.

Talks by invitation

-Department of Ophthalmology, University of Washington, USA 2001

-Faculty of Sciences, University of Chile, 2003

-P. Catholic University of Chile, 2003

-Faculty of Chemistry and Biology, University of Santiago de Chile, 2008

-University of Valparaíso - CINV, 2009

-Department of Physics, University of Santiago de Chile, 2010

-University of Valparaíso - CINV 2012

-Faculty of Sciences, University of Chile, 2014

-Instituto de Neurociencias de Alicante, Spain, 2015

-Faculty of Medicine, University of Chile, 2016

-Austral University of Chile - CiSNe, 2017

-University of Valparaíso - CINV, 2017

-Instituto de Neurociencias de Alicante, Spain, 2017

-Department of Physiology. P. Catholic University of Chile, 2017

-Instituto de Neurociencias de Alicante, Spain, 2019

Website:
www.minicad.cl



 

Article (27)

Constitutive phosphorylation as a key regulator of TRPM8 channel function
Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons
Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing
Role of TRPM8 Channels in Altered Cold Sensitivity of Corneal Primary Sensory Neurons Induced by Axonal Damage
Role of TRPM8 channels in altered cold sensitivity of corneal primary sensory neurons induced by axonal damage.
Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison
Role of the Excitability Brake Potassium Current I-KD in Cold Allodynia Induced by Chronic Peripheral Nerve Injury
Role of the excitability brake potassium current IKD in cold allodynia induced by chronic peripheral nerve injury.
The IKD current in cold detection and pathological cold pain
Targeted overexpression of Tumor Necrosis Factor α increases Cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons.
A Transient Receptor Potential Ion Channel in Chlamydomonas Shares Key Features with Sensory Transduction-Associated TRP Channels in Mammals
TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor
Bidirectional Modulation of Thermal and Chemical Sensitivity of TRPM8 Channels by the Initial Region of the N-terminal Domain
Intimacies and physiological role of the polymodal cold-sensitive ion channel TRPM8.
Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability
N-Glycosylation of TRPM8 Ion Channels Modulates Temperature Sensitivity of Cold Thermoreceptor Neurons
Role of I-h in the firing pattern of mammalian cold thermoreceptor endings
A cool ion channel in cold transduction
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea
Characteristics and physiological role of hyperpolarization activated currents in mouse cold thermoreceptors
Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels
Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors.
Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals.
Cyclic AMP cascade mediates the inhibitory odor response of isolated toad olfactory receptor neurons
Tonic and phasic receptor neurons in the vertebrate olfactory epithelium
Calcium mediates the activation of the inhibitory current induced by odorants in toad olfactory receptor neurons
IKD current in cold transduction and damage-triggered cold hypersensitivity

BookSection (4)

Postranslational regulation of TRP channels.
TRP channels in cold transduction
Mutagenesis and temperature-sensitive little machines.
Inhibitory responses to odorants in vertebrate olfactory neurons.

BookWhole (1)

TRP channels in Sensory Transduction

Proyecto (10)

Millennium Nucleus for the Study of Pain (MiNuSPain)
Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD)
FONDECYT Grant # 1170307 Axonal synthesis and trafficking of voltage-gated potassium channels.
Millenium Nucleus of Ion Channels-Associated Diseases (MiNICAD)
FONDECYT Grant # 1161733 Functional unbalance of Kv1 channels and cold-sensitive TRP channels as a mechanism of cold hypersensitivity in orofacial neuropathic pain.
FONDECYT Grant # 1151043 TNF-alpha increases Cdk5 activity regulating orofacial pain through phosphorylation of TRPV1 and P2X2 ion channels.
FONDECYT Grant # 1130862 Conductance-based modeling of the dynamic response of cold thermoreceptors.
FONDECYT Grant # 1131064 Cellular and molecular determinants of the abnormal cold sensitivity of primary sensory neurons in response to axonal damage.
CONICYT Anillo ACT-1113 Study of the physiological role of TRP channels in thermal transduction and synaptic plasticity
FONDECYT Grant # 1100983 Molecular and cellular bases of neuropathic pain: role of IKD in cold-induced allodynia following injury in primary sensory neurons
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Rodolfo Madrid

Full Professor

Departamento de Biología

UNIVERSIDAD DE SANTIGO DE CHILE

Santiago, Chile

5
Patricio Orio

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

4
María Pertusa

Profesor Asistente

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE. FACULTAD QUÍMICA Y BIOLOGÍA

Santiago, Chile

2
Matias Campos

Business Developer

Fundación LEITAT Chile

Santiago, Chile

2
Gonzalo Ugarte

Asistente de Investigación

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

1
Melissa Alegría

Académico Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Bastian Rivera

Postdoctorado/ Profesor Adjunto I

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Ricardo Piña

Profesor Asociado

Biología

Universidad Metropolitana de Ciencias de la Educación

Ñuñoa , Chile

1
Ricardo Delgado

Profesor Adjunto

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGIA

Santiago, Chile

1
Jean Maidana

Profesor Adjunto

Ingeniería

Universidad Andrés Bello

Viña del Mar, Chile