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Cristian Andrés Vilos Ortiz

Profesor Jornada Completa

Universidad de Talca

Talca, Chile

Líneas de Investigación


Estrategias terapéuticas basadas en nanopartículas poliméricas, interacciones nano-bio, terapia combinatoria para el cancer colorectal, estudio de efectos citotóxicos en células sanguíneas, tecnología farmacéutica.

Educación

  •  Biotecnología, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2012
  •  Licenciatura en Tecnología Médica, UNIVERSIDAD DE TALCA. Chile, 2006
  •  Tecnólogo Médico, Mención Laboratorio Clínico, Inmunohematología y Banco de Sangre, UNIVERSIDAD DE TALCA. Chile, 2006

Experiencia Académica

  •   Instructor Part Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Química y Biologia

    Santiago, Chile

    2007 - 2012

  •   Profesor Asistente Full Time

    UNIVERSIDAD ANDRES BELLO

    Medicina

    Santiago, Chile

    2012 - 2017

  •   Postdoct Full Time

    Brigham and Women´s Hospital – Harvard Medical School

    Medicine

    Boston, Estados Unidos

    2013 - 2015

  •   Affiliate Researcher Full Time

    MIT - Massachusetts Institute of Technology

    The Koch Institute for Integrative Cancer Research at MIT

    Boston, Estados Unidos

    2013 - 2015

  •   Profesor Asociado Full Time

    UNIVERSIDAD ANDRES BELLO

    Medicina

    Santiago, Chile

    2017 - 2019

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE TALCA

    NA

    Talca, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Tecnólogo Medico Part Time

    Clinica Alemana de Santiago [Sección Hematología y Coagulación

    Santiago, Chile

    2007 - 2012

Formación de Capital Humano


Tutor de Pasantías de investigación:
– Francesc Martinez Trucharte, PhD Student in RTE Vall d’Hebron Institute of Research Barcelona, España. 2019/20 (four months)
– Guillermo Gamboa, PhD Student in Biomedical Sciences, University of Talca. 2019 (seven months).
– Irene Romayor Arredondo, PhD Student at Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of País Vasco UPV/EHU, Spain. 2019 (four months).
– Chile, Alba Herrero Alonso, PhD Student at Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of País Vasco UPV/EHU, Spain. 2019 (four months).
– Chile, Irene Aizpitarte Morán, PhD Student at University of País Vasco UPV/EHU, Spain. 2018 (one month).
– Chile, 2015: Soung Jae Bong (Undergraduate Student Chemical Engineering), University of Waterloo, Canada.
– USA, 2014: Sina Dolati (Undergraduate Student Life Sciences Program), University of Toronto, Canada.
– USA, 2014: Melanie Saddler (Undergraduate Student Medicinal Chemistry), University of Waterloo, Canada.

Miembro de comisión:
– Chile, 2016: Charlotte Badilla Muñoz, Tecnología Médica, Mención Bioanálisis Clínico, Inmunohematología y Banco de Sangre.
– Chile, 2016: Danilo Andres Barraza Vera (Ingeniería en Biotecnología), Universidad Andres Bello.
– Chile, 2016: Javiera Catalán Rozas (Ingeniería en Biotecnología), Universidad Andres Bello.
– Chile, 2016: Javier Salazar Muñoz (Programa Doctorado en Biotecnología), Universidad Andres Bello.
– Chile, 2016: Valeria O. Márquez Miranda (Programa Doctorado en Biotecnología), Universidad Andres Bello.
– Chile, 2016: Romina Victoria Sepúlveda Sepúlveda (Programa Doctorado en Biotecnología), Universidad Andres Bello.

Tutor unidad de investigación pregrado:
– Chile, 2016: Consuelo Rivera (Tecnología Médica), Universidad Andres Bello.
– Chile, 2016: Cristian Espinoza (Tecnología Médica), Universidad Andres Bello.
– Chile, 2016: Daniela Olea (Tecnología Médica), Universidad Andres Bello.
– Chile, 2015: Álvaro Molina (Tecnología Médica), Universidad Andres Bello.
– Chile, 2015: Daniela Bahamonde (Tecnología Médica), Universidad Andres Bello.

Tesis de Pregrado
– Chile, en curso: Fernanda Parra, Tecnología Médica, Universidad de Talca.
– Chile, 2019: Camilo Figueroa (Ingienería en Biotecnología), Universidad Andres Bello.

Tutor de Doctorado:
En Curso:
– Chile, Rocío Cikutovic, PhD Student in Biomedical Sciences, University of Talca, Talca, Chile
– Chile, Javier Salazar (Programa Doctorado en Biotecnología), Universidad Andres Bello.

Finalizado:
– Chile, Juan Pablo García (Programa Doctorado en Biotecnología), USACH (2020)
– Chile, María Francisca Matus (Programa de Doctorado en Ciencias Mención I+D de Productos Bioactivos), Universidad de Talca. Co-Tutor Doctorado (2018)

Postdoctorado:

– Dr. Bruno Cisterna. Postdoctoral FONDECYT Funding Nº 3170938 (2017 - 2019).
– Dr. Nitin Bharat Charbe. Co-Sponsor of the Postdoctoral FONDECYT Funding Nº 3180250 (2018 - 2020).


Difusión y Transferencia


Impacto de la nanomedicina en la medicina moderna. Columna en Newsletter Chile Global, Octubre 2014

Miembro de Comité Editorial
2015 – Presente
Consulting Editor de International Journal of Nanomedicine y Drug Design, Development and Therapy.
2013 – Presente
International Journal of Medical and Surgical Sciences.

Revisor de Revistas Científicas
• International Journal of Nanomedicine

• Drug Design, Development and Therapy
• OncoTargets and Therapy
• Electronic Journal of Biotechnology
• Scientific Report
• Nanotechnology Nanomedicine Biology and Medicine
Miembro de Sociedades Científicas
• American Society for Nanomedicine
• Controlled Release Society
• Sociedad de Biología de Chile
• European Society for Nanomedicine

Capítulos de Libros
• Chapter 10: Stimuli-Responsive Nanotheranostics. Basit Yameen, Jun Wu, Cristian Vilos, Andrew Whyte, David
Werstler, Lori Pollit , Omid C. Farokhzad. Nanotheranostics for Personalized Medicine: 267-296. World Scientific,
2016.

Patentes
• Constandil L., Ibarra P., Vilos C., Veláquez L., Pelissier T., Laurido C., Hernández A. Nanoparticles With
Biodegradable and Biocompatible Polymer PLGA, Loaded With the Drug for Human Use Pentoxifylline. Publication
number: WO2014075203 A8 – PCT number: PCT/CL2013/000084 – Also published as: WO2014075203A8. 2014.
Patente en evaluación.
• Shi J., Zeyu X., Votruba A., Vilos C., Farokhzad O. Lipid-polymer hybrid particles. Publication number:
US20130315831 A1 – Application number: US 13/820,351 – PCT number: PCT/US2011/050334 – Also published
as: WO2012031205A2, WO2012031205A3. 2012. Patente concedida.
• Vilos C., Velásquez LA., Constandil L., Rios M. Injectable veterinary composition for controlled, sustained release of
ceftiofur and florfenicol in animal species, based on polyhydroxybutyrate hydroxyvalerate (phbv) microparticles.
Publication number: WO2013071457 A1 – Application number: PCT/CL2012/000067 – Also published as
WO2013071457A4. 2012. Patente concedida.


Premios y Distinciones

  •   Nombramiento de Hijo Ilustre de la Comuna de Romeral

    Ilustre Municipalidad de Romeral

    Chile, 2015

    Como reconocimiento a su crecimiento profesional.


 

Article (49)

Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation
N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease
Mitochondrial Dysfunction in Skeletal Muscle Pathologies
Zebrafish, a model to develop nanotherapeutics that control neutrophils response during inflammation
A novel alendronate functionalized nanoprobe for simple colorimetric detection of cancer-associated hypercalcemia
Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules
Nanotechnology and primary hemostasis: Differential effects of nanoparticles on platelet responses
Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia
TGF-beta requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy
Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy
Antiplatelet effect of differentially charged PEGylated lipid-polymer nanoparticles
Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors
Bone Morphogenetic Protein and its Option as an Alveolar Cleft Treatment
Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines
Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines.
Optimization of fibrin gelation for enhanced cell seeding and proliferation in regenerative medicine applications
Targeted brain delivery nanoparticles for malignant gliomas.
Antiplatelet effect of differentially charged PEGylated lipid-polymer nanoparticles.
Chitosan functionalized thermosponge nano-carriers for prolonged retention and local delivery of chymopapain at the nucleus pulposus in porcine discs ex vivo
Mechanistic Studies on the Self-assembly of PLGA Patchy Particles and their Potential Applications in Biomedical Imaging
Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis
Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis.
Targeted nanoparticles for colorectal cancer
Targeted nanoparticles for colorectal cancer.
Techniques of structural characterization of dendrimers
Drug Delivery Nanocarriers from a Fully Degradable PEG-Conjugated Polyester with a Reduction-Responsive Backbone
Drug Delivery Nanocarriers from a Fully Degradable PEG-Conjugated Polyester with a Reduction-Responsive Backbone.
Multifunctional polymeric nanoparticles doubly loaded with SPION and ceftiofur retain their physical and biological properties
Multifunctional polymeric nanoparticles doubly loaded with SPION and ceftiofur retain their physical and biological properties.
Polymeric Nanoparticles in Dermocosmetic
Preclinical Development and In Vivo Efficacy of Ceftiofur-PLGA Microparticles
Prothrombin C20209T mutation in deep vein thrombosis: a case report
A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins.
Evaluation of ceftiofur-PHBV microparticles in rats
Evaluation of ceftiofur–PHBV microparticles in rats
Insight into nanoparticle cellular uptake and intracellular targeting.
Nanotechnology in Preclinical and Clinical Drug Development
In vivo biocompatibility of the PLGA microparticles in parotid gland
Paclitaxel-PHBV nanoparticles and their toxicity to endometrial and primary ovarian cancer cells
Paclitaxel-PHBV nanoparticles and their toxicity to endometrial and primary ovarian cancer cells.
Superparamagnetic Poly (3-hydroxybutyrate-co-3 hydroxyvalerate) (PHBV) nanoparticles for biomedical applications
Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections
Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity
Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery
Morphometric and Histopathologic Changes in Skeletal Muscle Induced for Injectable PLGA Microparticles
Morphometric and histopathologic changes in skeletal muscle induced for injectable PLGA microparticles [Cambios morfométricos e histopatológicos en el músculo esquelético inducidos por microparticulas de PLGA inyectables]
Nanodentistry: the Future of Dentistry Based on Nanotechnology Systems
Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts

Abstract (1)

Combining chemotherapy and targeted therapies against resistance and recurrence in ovarian cancer

BookWhole (1)

Stimuli-responsive nanotheranostics

EditorialMaterial (1)

Oxidative Stress in Disease and Aging: Mechanisms and Therapies

Proyecto (19)

Development of the novel LDL-receptor targeted liposome formulation for cancer treatment. FONDECYT POSTDOCTORAL (Dr. Nitin Bharat).
Inhibición del reclutamiento de neutrófilos durante una inflamación intestinal en pez cebra modulada por nanopartículas híbridas lípido-polímero. Investigadora Principal, Dra. Carmen Gloria Feijoo
Shynthesis of coagulation inhibitors coupled to nanoparticles with activity against factor Xa and platelet agregation. FONDECYT REGULAR. Principal Investigator=> Dra. Flavia Zacconi.
MAGNAMED, novel magnetic nanostructures for medical applications
Role of Renin angiotensin system in myogenesis and muscle regeneration=> new combined therapeutic strategies based in nanomedicine for muscular dystrophies. ECOS-CONICYT. Principal Investigator=> Dr. Claudio Cabello
Synergistic mechanism of nanotherapy based MAPK and MEK/ERK inhibitors for colorectal cancer. FONDECYT POSTDOCTORAL (Dr. Bruno Cisterna).
Systematically evaluation of the mechanistic synergism between MAPK kinase inhibitor with clinically approved cytotoxic agents. FONDECYT REGULAR.
Center for Development of Nanoscience and Nanotechnology. Basal Grant (CEDENNA) – CONICYT. Main Research (since 2018), Line-6, Nanobiomedicine.
Desarrollo y evaluación terapéutica de nanopartículas de PLA·DSPE-PEG(2000) con actividad antiplaquetaria
Desarrollo y caracterización de una estrategia terapéutica para el dolor crónico basada en nanopartículas de plga cargadas con el inhibidor de las proteínas map– kinasas imatinib. BECAS CHILE-CONICYT, POSTDOC.
Development and caracterization of peptide–nanoparticles with anti-angiogenesis activity.
Development of a polymeric solvent-free nanoparticles for efficient delivery of labile proteins
Development of nanoparticles redox-sensitive for intracelular drug delivery in prostate and colorectal cancer.
In vivo study of the effect of opioids in angiogenesis
Desarrollo de nanoaptículas superparamagnéticas PHBV-magnetita para su aplicación biomédica. Basal Grant (CEDENNA) – CONICYT.
Desarrollo de nanopartículas de PHBV cargadas con el quimioterapeutico paclitaxel para el cáncer ovárico. Basal Grant (CEDENNA) – CONICYT.
Propiedades farmacocinéticas de antibióticos betaláctamicos incorporados en polímeros biocompatibles. BECA TESIS EN LA INDUSTRIA. CONICYT.
Desarrollo de nuevas estrategias de liberación de antibióticos para cerdos, a partir de formulados de liberación controlada
Estudio de la actividad gastroprotectora del acido oleanolico, solidagenona y derivados en modelos basados en el cultivo de celulas epiteliales gastricas. FONDECYT REGULAR. Principal Investigator=> Dr. Jaime Rodriguez.

Review (3)

Targeted brain delivery nanoparticles for malignant gliomas
Insight into nanoparticle cellular uptake and intracellular targeting
Therapeutic Strategies Based on Polymeric Microparticles
49
Cristian Vilos

Profesor Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

10
Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

5
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

4
Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

3
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

3
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

3
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

3
Paula Solar

Académico Investigador

Universidad SEK

Santiago, Chile

3
Katherine Zepeda

alumno tesista

Quimica y Biologia

Universidad de Santiago de Chile

Santiago, Chile

2
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

2
Luis Constandil

Profesor Titular

Biología

Universidad de Santiago de Chile

Santiago, Chile

2
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Francisco Morales

Posdoctoral

Universidad de Chile. Centro FONDAP ACCDiS

Santiago, Chile

2
Carmen Feijóo

Profesor asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

2
VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

1
Juan Fuentes

Académico

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
NATALIA JUICA

Bioquímico

Facultad de Ciencias de la Salud

Universidad SEK

Santiago, Chile

1
EVA BUSTAMANTE

JEFE DE COORDINACION CIENTIFICA

INVESTIGACION Y DOCENCIA

FUNDACION ARTURO LOPEZ PEREZ

Santiago, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Alvaro Elorza

ASSOCIATE PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Juliano Casagrande

Profesor Titular

Fisica

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Maite Rodriguez

Profesor Jornada

Farmacia

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Daniel Escobar

PROFESIONAL

SALUD AMBIENTAL

INSTITUTO DE SALUD PÚBLICA DE CHILE

SANTIAGO, Chile

1
Aníbal Vargas

Investigador postdoctoral

Universidad de O'Higgins

Rancagua, Chile

1
Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

1
Daniel Aguayo

Assistant Professor

Molecular Biophysics & Bioinformatics Group

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
ROSALBA ESCAMILLA

Investigador asociado

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alejandro Tapia

Profesor Asistente

Facultad de Medicina

Universidad de Chile

Santiago, Chile

1
Mabel Moreno

Profesor

Universidad SEK

Santiago, Chile

1
Guillermo González

FACULTAD DE CIENCIAS UIVERSIDAD DE CHILE

Santiago, Chile

1
Juan García

Investigador

Biología

Universidad de Nario

Pasto, Colombia

1
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Patricia Arenas

Ingeniero de Proyectos

Patricia Arenas Riesco

Santiago, Chile

1
Juan Marín

Profesor Asociado

Departamento de Ciencias Básicas

Universidad del Bio Bio

Chillán, Chile

1
Dora Altbir

Full Professor

Physic Department

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Marlen Gutierrez

Investigador

Centro para el Desarrollo de la Nanociencia y Nanotecnologia

Universidad de Santiago de Chile

Santiago, Chile

1
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

1
Luigi Devoto

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile