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Luis Ernesto Constandil Córdova

Profesor Titular

Universidad de Santiago de Chile

Santiago, Chile

Líneas de Investigación


I performed doctoral studies in the field of Physiological Sciences at the Pontifical Catholic University of Chile and my post-doctoral studies at the University of Auvergne in France. I am currently a Titular Professor at the University of Santiago of Chile where I develop different research topics. In the first place, I research the Neurobiology of Chronic Pain, where I study the mechanisms involved in the initiation and maintenance of chronic pain. In this topic, I identified new pharmacological targets that could be used for new drugs or new pharmaceutical formulations to relieve chronic pain, and I had development new chronic pain models. Additionally, I worked on the development and characterization of nano and micro polymeric particles to improve the effectiveness of drugs, bioavailability and decrease side effects of drugs loaded with these particles. At the moment, I presented two innovative patents

Educación

  •  Licenciado en Biología, Pontificia Universidad Católica de Chile. Chile, 1991
  •  Fisiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997

Experiencia Académica

  •   Profesor Titular Full Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Química y Biología

    Santiago, Chile

    1997 - A la fecha

Formación de Capital Humano


Cantidad de Tesis dirigidas de Licenciatura/Bachillerato/Bachelor: 9
Cantidad de Tesis dirigidas de Magíster/Master/DEA: 5
Cantidad de Tesis dirigidas de Doctorado/PhD: 5



 

Article (35)

The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition
Effect of supercritical incorporation of cinnamaldehyde on physical-chemical properties, disintegration and toxicity studies of PLA/lignin nanocomposites
Hypertension in Prenatally Undernourished Young-Adult Rats Is Maintained by Tonic Reciprocal Paraventricular-Coerulear Excitatory Interactions
A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain
Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats
Antinociception Induced by Copper Salt Revisited: Interaction with Ketamine in Formal inInduced Intraplantar and Orofacial Pain in Mice
Burst-Like Subcutaneous Electrical Stimulation Induces BDNF-Mediated, Cyclotraxin B-Sensitive Central Sensitization in Rat Spinal Cord
Single and Repeated Administration of Methylphenidate Modulates Synaptic Plasticity in Opposite Directions via Insertion of AMPA Receptors in Rat Hippocampal Neurons
The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat
Role of the spinal TrkB-NMDA receptor link in the BDNF-induced long-lasting mechanical hyperalgesia in the rat: A behavioural study
beta(2)-Adrenoceptor stimulation restores frontal cortex plasticity and improves visuospatial performance in hidden-prenatally-malnourished young-adult rats
Preclinical Development and In Vivo Efficacy of Ceftiofur-PLGA Microparticles
Evaluation of ceftiofur-PHBV microparticles in rats
Pannexin 1: A novel participant in neuropathic pain signaling in the rat spinal cord
Stage-dependent C-reflex, pain-like behavior and opioid analgesia during the induction of chronic arthritis in rats
Antinociceptive Effect of Rat D-Serine Racemase Inhibitors, L-Serine-O-Sulfate, and L-Erythro-3-Hydroxyaspartate in an Arthritic Pain Model
Antinociceptive interaction of (+/-)-CPP and propentofylline in monoarthritic rats
Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections
Cyclotraxin-B, a New TrkB Antagonist, and Glial Blockade by Propentofylline, Equally Prevent and Reverse Cold Allodynia Induced by BDNF or Partial Infraorbital Nerve Constriction in Mice
Antihyperalgesic Effects of Clomipramine and Tramadol in a Model of Posttraumatic Trigeminal Neuropathic Pain in Mice
Involvement of spinal cord BDNF in the generation and maintenance of chronic neuropathic pain in rats
Changes of Meningeal Excitability Mediated by Corticotrigeminal Networks: A Link for the Endogenous Modulation of Migraine Pain
Effect of modafinil on learning performance and neocortical long-term potentiation in rats
Effect of interleukin-1 beta on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function
Effect of interleukin-1? on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function
Antinociceptive effect and interaction of uncompetitive and competitive NMDA receptor antagonists upon capsaicin and paw pressure testing in normal and monoarthritic rats
Central nervous system networks involved in the processing of meningeal and cutaneous inputs from the ophthalmic branch of the trigeminal nerve in the rat
Effects of interleukin-1 beta on spinal cord nociceptive transmission in intact and propentofylline-treated rats
Expression of nitric oxide synthase isoforms in the dorsal horn of monoarthritic rats: effects of competitive and uncompetitive N-methyl-D-aspartate antagonists
Biphasic effect of apomorphine on rat nociception and effect of dopamine D-2 receptor antagonists
Blockade of supraspinal 5-HT1A receptors potentiates the inhibitory effect of venlafaxine on wind-up activity in mononeuropathic rats
Venlafaxine-induced depression of wind-up activity in mononeuropathic rats is potentiated by inhibition of brain 5-HT1A receptor expression in vivo
Interleukin-1 beta increases spinal cord wind-up activity in normal but not in monoarthritic rats
Nitric oxide synthase and soluble guanylate cyclase are involved in spinal cord wind-up activity of monoarthritic, but not of normal rats
Perinatal neuroendocrine regulation. Development of the circadian time-keeping system

Abstract (1)

Respiratory chemosensory drive is reduced by somatostatin in the isolated CNS of newborn mouse

Proyecto (18)

Preclinical study on the participation of pannexin 1 (Panx1) in spinal cord circuitry and its role in the mechanisms of chronic pain
Desarrollo Integral del cultivo de bacalao de profundidad para el escalamiento sustentable y el fortalecimiento de la competitividad del Clúster Acuícola chileno
Uso de cationes bivalentes (Cu2, y Mg2) para potenciar los efectos analgésicos de metadona y ketamina
“Nanopartículas con polímero biodegradable y biocompatible PLGA cargadas con el fármaco de uso humano pentoxifilina para el tratamiento del dolor crónico.”
Influence of brain-derived neurotrophic factor (BDNF) on 5-HT2A receptor functionality=> consequences on SSRI efficacy in experimental neuropathic pain
ROLE OF SPINAL CORD LTP IN THE TRIGGERING AND MAINTENANCE OF CHRONIC PAIN=> A LONG-LASTING STUDY IN THE RAT.
A PUTATIVE ROLE FOR BDNF IN GENERATING A TRANSCRIPTION-DEPENDENT FEED-FORWARD LOOP IN THE SPINAL DORSAL HORN, AND ITS INVOLVEMENT IN THE PERSISTENCE OF NEUROPATHIC PAIN
Centro de desarrollo en Nanociencia y Tecnología. CONICYT- Programa de financiamiento Basal para Centros científicos y tecnológicos de excelencia
Estudios de los mecanismos neurobiológicos involucrados en el origen de la cefalea
Habilitación de un centro de nanociencia y nanotecnología en el edificio de líneas de I+D estratégicas de la Universidad de Santiago de Chile. Investigador principal, Luís Velásquez Cumplido.
Rol de la glía cortical sobre la modulación córticofuga de las entradas nociceptivas trigeminales=> Potencial blanco para nuevas terapias contra los dolores cráneo-faciales
ROL DE LA GLIA ESPINAL EN LA ETIOPATOGENIA DEL DOLOR CRONICO=> ESTUDIO NEUROFISIOLOGICO EN UN MODELO EXPERIMENTAL DE MONOARTRITIS CON PROYECCION AL HUMANO
Mecanismos de plasticidad neuronal cortical implicados en la fisiopatología del dolor orofacial
ROL DE LOS CIRCUITOS CORTICO-TRIGEMINALES Y SUS MEDIADORES EN LA ETIOPATIOGENIA DE LA MIGRAÑA=> ESTUDIO EN UN MODELO EXPERIMENTAL CON PROYECCIONES AL HUMANO.
Participación de los circuitos corticales en la modulación del dolor orofacial=> estudios anátomo-funcionales en un modelo de nocicepción trigeminal en la rata
Potenciación del efecto antinociceptivo de un antidepresivo por un antagonista de receptores 5-HT1A=> estudio del mecanismo de acción
CARACTERIZACION DEL NUCLEO SUPRAQUIASMATICO COMO OSCILADOR CIRCADIANO EN EL FETO DE LA OVEJA
CARACTERIZACION DEL NUCLEO SUPRAQUIASMATICO COMO OSCILADOR CIRCADIANO EN EL FETO DE OVEJA

Review (1)

Interactions of pannexin 1 with NMDA and P2X7 receptors in central nervous system pathologies: Possible role on chronic pain
42
Luis Constandil

Profesor Titular

Biología

Universidad de Santiago de Chile

Santiago, Chile

4
Héctor Burgos

DOCENTE E INVESTIGADOR

FACULTAD DE CIENCIAS

Universidad Mayor, Chile

SANTIAGO, Chile

4
Cristian Vilos

Profesor Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

3
AMPARO CASTILLO

DOCENTE

PSICOLOGÍA

Universidad Santo Tomás

SANTIAGO, Chile

3
David Bravo

CEO

Research and Innovation

Pannex Therapeutics

Santiago, Chile

3
Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

3
rafael barra

Academico investigador

Escuela de Medicina

universidad de santiago de Chile

Santiago de Chile, Chile

2
Katherine Zepeda

alumno tesista

Quimica y Biologia

Universidad de Santiago de Chile

Santiago, Chile

2
Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Marc Zeise

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
DARWIN CONTRERAS

Profesor por horas

Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Adrián Rojas

Profesor adjunto I

Ingeniería Industrial/Ingeniería Química

Universidad de Santiago de Chile

Santiago, Chile

1
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

1
Jose Marcos

Academico Jornada Completa

Escuela de Ciencias Agrícolas y Veterinarias

Universidad Vina del Mar

Viña del Mar, Chile

1
Edison Salas

Director de laboratorio de nanotecnología

Aintech

Santiago, Chile

1
Julio Romero

Full Professor

Departamento de Ingeniería Química y Bioprocesos

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Víctor Parraguez

Profesor Titular

Ciencias Biológicas Animales

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

1
Claudia Carvallo

Investigadora Principal, Centro de investigación e Innovación en Gerontología Aplicada (CIGAP)

Biología

Universidad Santo Tomás

Santiago, Chile

1
Paula Solar

Directora de Investigación y Posgrado

Dirección de Investigación y Posgrado

Universidad SEK

Santiago, Chile

1
MARIA JOSE GALOTTO

Full Professor

Food Science and Technology Department

Universidad de Santiago de Chile

Santiago, Chile

1
Francisco Rodríguez

ASSOCIATE PROFESSOR

DEPARTAMENTO DE CIENCIA Y TECNOLOGÍA DE LOS ALIMENTOS

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
Claudia Torres

Full Professor

Instituto de Anatomía, Histología y Patología

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
Mauricio Yañez

UNIVERSIDAD DE SANTIAGO DE CHILE

SANTIAGO, Chile

1
Arnaldo Gatica

Gerente General y fundador

IDEAlim EIRL

San Francisco de Mostazal , Chile

1
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

1
Carolina Villegas

Profesora Adjunto y Postdoctoral Research Fondecyt

Ciencia y Tecnología de los Alimentos

Universidad de Santiago de Chile

Santiago, Chile

1
Alejandra Torres

Academica Jornada Completa

Ciencia y Tecnologia de los Alimentos

UNIVERSITY OF SANTIAGO DE CHILE

Santiago, Chile