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Jeffri Stevens Retamal Santibañez

Profesor asistente

Universidad de Santiago de Chile

Santiago, Chile

Bioquímico, doctor en Ciencias Farmacéuticas y Farmacología, con énfasis en señalización de biología celular/farmacólogo. Científico experimentado, experto en señalización del dolor y farmacología de receptores acoplados a proteína G (GPCR), con más

Farmacologia y ciencias farmaceuticas, MONASH UNIVERSITY. Australia, 2021
Bioquimica, UNIVERSIDAD ANDRES BELLO. Chile, 2013
Bioquimico, UNIVERSITE DE MONS-HAINAUT. Chile, 2010

Asistente de investigación Full Time

UNIVERSIDAD DE SANTIAGO DE CHILE

Quimica y biologia

Chile

2013 - A la fecha
research assistant Full Time

MONASH UNIVERSITY

Pharmaceutical science

Melbourne, Australia

2016 - A la fecha
Postdoctoral Full Time

MONASH UNIVERSITY

Pharmacy and Pharmaceutical science

Melbourne, Australia

2020 - 2021
Research associate Full Time

NEW YORK UNIVERSITY

Dentistry

New York, Estados Unidos

2021 - 2023

Best publication

MONASH UNIVERSITY

Australia, 2020

Best publication in the faculty, 2020 Ph-responsive nanoparticles, Published in nature nanotechnology
Beca Chile para doctorado en el extrajero

MONASH UNIVERSITY

Chile, 2017

Beca chile para doctorado en el extrajero


Acaricidal activity of geraniol-loaded lignin nanoparticles for the control of Brevipalpus chilensis: an eco-friendly approach to crop protection Juica N.; Bustos-Quevedo, G; Devis S.; Oneto N.; Klagges, C.; Retamal J.; Constandil L. Article ISI SCOPUS Environmental Science: Nano (2025)
N-methyl-D-aspartate receptor activation is downstream coupled to pannexin 1 opening by Src kinase in dorsal horn neurons: an essential link for mechanical hyperalgesia in nerve-injured rats Zepeda-Morales, Katherine; Bravo, David; Aranguiz-Barrera, Jonathan; Ampuero, Estibaliz; Renard, Georgina M.; Pelissier, Teresa; Hernandez, Alejandro; Retamal, Jeffri S.; Constandil, Luis Article ISI SCOPUS Pain (2025)
Mice expressing fluorescent PAR<sub>2</sub> reveal that endocytosis mediates colonic inflammation and pain Latorre, Rocco; Hegron, Alan; Peach, Chloe J.; Teng, Shavonne; Tonello, Raquel; Retamal, Jeffri S.; Klein-Cloud, Rafael; Bok, Diana; Jensen, Dane D.; Gottesman-Katz, Lena; et al. Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats Bravo, David; Maturana, Carola J.; Hernandez, Alejandro; Pelissier, Teresa; Barra, Rafael; Burgos, Hector; Constandil, Luis Article ISI SCOPUS International Journal of Molecular Sciences (2022)
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice De Logu, Francesco; Nassini, Romina; Hegron, Alan; Landini, Lorenzo; Jensen, Dane D.; Latorre, Rocco; Ding, Julia; Marini, Matilde; Monteiro de Araujo, Daniel Souza; Ramirez-Garcia, Paulina; et al. Article ISI NATURE COMMUNICATIONS (2022)
Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain Latorre, Rocco; Ramirez-Garcia, Paulina D.; Hegron, Alan; Grace, James L.; Retamal, Jeffri S.; Shenoy, Priyank; Tran, Mai; Aurelio, Luigi; Flynn, Bernard; Poole, Daniel P.; et al. Article ISI BIOMATERIALS (2022)
A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes Mai, Quynh N.; Shenoy, Priyank; Quach, Tim; Retamal, Jeffri S.; Gondin, Arisbel B.; Yeatman, Holly R.; Aurelio, Luigi; Conner, Joshua W.; Poole, Daniel P.; Canals, Meritxell; et al. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice Retamal, Jeffri S.; Grace, Megan S.; Dill, Larissa K.; Ramirez-Garcia, Paulina; Peng, Scott; Gondin, Arisbel B.; Bennetts, Felix; Alvi, Sadia; Rajasekhar, Pradeep; Almazi, Juhura G.; et al. Article ISI LABORATORY INVESTIGATION (2021)
The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability Peng, Scott; Grace, Megan S.; Gondin, Arisbel B.; Retamal, Jeffri S.; Dill, Larissa; Darby, William; Bunnett, Nigel W.; Abogadie, Fe C.; Carbone, Simona E.; Tigani, Tara; et al. Article ISI LABORATORY INVESTIGATION (2020)
A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain RamÃrez-GarcÃa P.D.; Retamal J.S.; Shenoy P.; Imlach W.; Sykes M.; Truong N.; Nowell C.J.; Khor S.Y.; Layani L.M.; Lumb C.; et al. Article ISI SCOPUS NATURE NANOTECHNOLOGY (2019)
Burst-Like Subcutaneous Electrical Stimulation Induces BDNF-Mediated, Cyclotraxin B-Sensitive Central Sensitization in Rat Spinal Cord Pelissier T.; Villanueva L.; Constandil L. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2018)
Pannexin 1: A novel participant in neuropathic pain signaling in the rat spinal cord Bravo D.; Ibarra P.; Retamal J.; Pelissier T.; Laurido C.; Hernandez A.; Constandil L. Article ISI SCOPUS PAIN (2014)


Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain Retamal, Jeffri S.; Ramirez-Garcia, Paulina D.; Shenoy, Priyank A.; Poole, Daniel P.; Veldhuis, Nicholas A. Review ISI Frontiers in Molecular Neuroscience (2019)

HÉCTOR BURGOS

INVESTIGADOR

FACULTAD DE CIENCIAS

UNIVERSIDAD SANTO TOMÁS, Chile

SANTIAGO, Chile

Luis Constandil

Profesor Titular

Biología

Universidad de Santiago de Chile

Santiago, Chile

NATALIA JUICA

Bioquímico

Facultad de Ciencias de la Salud

Universidad SEK

Santiago, Chile

David Bravo

CEO

Research and Innovation

Pannex Therapeutics

Santiago, Chile

Jeffri Retamal

Profesor asistente

Biologia

Universidad de Santiago de Chile

Santiago, Chile

Jeffri Stevens Retamal Santibañez

Líneas de Investigación

Educación

Farmacologia y ciencias farmaceuticas, MONASH UNIVERSITY. Australia, 2021

Bioquimica, UNIVERSIDAD ANDRES BELLO. Chile, 2013

Bioquimico, UNIVERSITE DE MONS-HAINAUT. Chile, 2010

Experiencia Académica

Asistente de investigación Full Time

research assistant Full Time

Postdoctoral Full Time

Research associate Full Time

Premios y Distinciones

Best publication

Beca Chile para doctorado en el extrajero

Article (12)

Acaricidal activity of geraniol-loaded lignin nanoparticles for the control of Brevipalpus chilensis: an eco-friendly approach to crop protection

N-methyl-D-aspartate receptor activation is downstream coupled to pannexin 1 opening by Src kinase in dorsal horn neurons: an essential link for mechanical hyperalgesia in nerve-injured rats

Mice expressing fluorescent PAR<sub>2</sub> reveal that endocytosis mediates colonic inflammation and pain

NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats

Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Burst-Like Subcutaneous Electrical Stimulation Induces BDNF-Mediated, Cyclotraxin B-Sensitive Central Sensitization in Rat Spinal Cord

Pannexin 1: A novel participant in neuropathic pain signaling in the rat spinal cord

Review (1)

Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain

HÉCTOR BURGOS

Luis Constandil

NATALIA JUICA

David Bravo

Jeffri Retamal