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Roxana Jacqueline Pincheira Barrera

Profesor Asociado

Universidad de Concepcion

Concepción, Chile

Cancer Biology; Signal transduction; Gene Expression, Oncogenes and tumor supressors network

Biomedical Sciences, Universidad de Chile. Chile, 2000
Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1991

Investigador Asistente Other

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1991 - 1992
Investigador Asistente Other

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1991 - 1992
PhD Thesis Other

University of Texas Medical Branch

Galveston, Estados Unidos

1996 - 2000
Postdoctorate Other

INDIANA UNIVERSITY-PURDUE UNIVERSITY INDIANAPOLIS

Indianapolis, Estados Unidos

2001 - 2005
Postdoctorate Other

University of California San Francisco

California, Estados Unidos

2005 - 2007
Profesor Asistente Investigador Other

University of California San Francisco

San Francisco, Estados Unidos

2008 - 2009
Profesor Asociado Other

UNIVERSIDAD DE CONCEPCION

Ciencias Biológicas

Concepción, Chile

2010 - A la fecha

Postdoctorate Other

Purdue University Indianapolis

Indianapolis, Estados Unidos

2001 - 2005
Postdoctorate Other

University of California San francisco

California, Estados Unidos

2005 - 2007
Profesor Asistente Investigador Other

University of California San Francisco

San Francisco, Estados Unidos

2008 - 2009
Profesor Asociado Full Time

Universidad de Concepción

Concepción, Chile

2010 - A la fecha

Fechas Nombre Institución Role Actividad
2018- Claudia Alvarez Universidad de Concepcion Tutor PhD thesis student (Doctorado en Biología Celular y Molecular)
2014-2017 Ginessa Salgado Universidad de Concepcion Tutor Ms Student (Biochemistry and Bioinformatics)
2014-2017 Elizabeth Riffo Universidad de Concepcion Tutor Ms Student (Biochemistry and Bioinformatics)
2014-2018 Carlos Farkas Universidad de Concepcion Tutor PhD thesis student (Doctorado en Biología Celular y Molecular)
2013-2017 Viviana Hermosilla Universidad de Concepcion Tutor PhD thesis student (Doctorado en Biología Celular y Molecular)
2013-2015 Daniel Sanhueza Universidad de Concepcion Tutor Undergrad thesis (Biochemistry)
2012-2013 Elizabeth Riffo Universidad de Concepcion Tutor Undergrad thesis (Biochemistry)
2012-2013 Ginessa Salgado Universidad de Concepcion Tutor Undergrad thesis (Biology)
2012-2013 Carlos Farkas Universidad de Concepcion Tutor Undergrad thesis (Bioingeniering)
2012-2013 Marcela Morales Universidad de Concepcion Tutor Undergrad thesis (Bioingeniering)
2012-2013 Francisco Fuentes Universidad de Concepcion Tutor Undergrad thesis (Bioingeniering)
2011-2015 David Escobar Universidad de Concepcion Tutor PhD thesis student (Doctorado en Biología Celular y Molecular)
2011-2015 Tania Campos Universidad de Concepcion Tutor PhD thesis student (Doctorado en Biología Celular y Molecular)
2011-2012 M. Fernanda Sanchez Universidad de Concepcion Tutor Undergrad thesis (Bioingeniering)
2011-2012 Marisol Armijo Universidad de Concepcion Co-tutor Undergrad thesis (Bioingeniering)
2006-2010 Mary Matli University of California San Francisco, USA Supervisor Laboratory Manager at UCSF laboratory
2006-2010 Xiaochen Wang University of California San Francisco, USA Supervisor Laboratory Technitiant .UCSF laboratory

La difusión desarrollada se enfoca en la participación del investigador y/o sus alumnos en colegios de la región del Bio Bio promoviendo la investigación básica y su aplicación en el contexto de patología crónicas como lo es el cáncer. A su vez el grupo de investigación invita a alumnos de variados colegios de la región a visitas guiadas al laboratorio.

Student fellowship

UNIVERSIDAD DE CONCEPCION

Chile, 1990

Student Fellowship
International course,"Molecular and Cellular Aspects of Cancer"

INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS

Venezuela, 1995

Awared by the Organization de los Estados Americanos.
Advanced Research Fellowship

CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

Chile, 1995

SCHOLARSHIP AWARDED BY THE NATIONAL RESEARCH AND TECHNOLOGY COUNCIL OF CHILE
RAININ RESEARCH PRIZE

ASILOMAR CONFERENCE ON NEURAL SIGNALING

Estados Unidos, 2008

PRIZE FOR OUTSTANDING POSTER
UCSF ACADEMIC SENATE

UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

Chile, 2009

TRAVEL AWARD TO PRESENT AT THE KEYSTONE SYMPOSIUM ON NEUROSCIENCE
NEW INVESTIGATOR AWARD

UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

Chile, 2009

GRANT ENTITLED:SALL2 SINGLE NUCLEOTIDE POLYMORPHISMS IN COLON CANCER
AACR MINORITY SCHOLAR IN CANCER RESEARCH AWARD

AMERICAN ASSOCIATION FOR CANCER RESEARCH

Estados Unidos, 2009

AWARD TO ASSIST TO THE FRONTIERS IN BASIC CANCER RESEARCH MEETING.BOSTON,USA.
REGIONAL DIRECTOR CHILEAN BIOCHEMISTRY SOCIETY

SOCIEDAD DE BIOQUIMICA DE CHILE

Chile, 2011

REGIONAL DIRECTOR


Cytosolic NUAK1 enhances ATP production by maintaining proper glycolysis and mitochondrial function in cancer cells Escalona E, Muñoz M, Pincheira R, Elorza ÁA, Castro AF Article ISI FRONTIERS IN ONCOLOGY (2020)
Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions Elizondo-Vega, Roberto; Oyarce, Karina; SALGADO, MAGDIEL; Barahona, Maria Jose; Recabal, Antonia; Ordenes, Patricio; Lopez, Sergio; Pincheira, Roxana;; Luz-Crawford, Patricia; Garcia-Robles, Maria Angeles Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2020)
DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress Fuentes-Villalobos, Francisco; Farkas P., Carlos; Riquelme-Barrios, Sebastian; Armijo, M.E.; Soto-Rifo, Ricardo; Pincheira, Roxana;; Castro, Ariel F. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2019)
Identification of a nuclear localization signal and importin beta members mediating NUAK1 nuclear import inhibited by oxidative stress Palma M.; Riffo E.N.; Suganuma T.; Washburn M.P.; Workman J.L.; Pincheira R.; Castro A.F. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2019)
Streamlined computational pipeline for genetic background characterization of genetically engineered mice based on next generation sequencing data. Farkas, C; Fuentes-Villalobos, F; Rebolledo-Jaramillo, B; Benavides, F; Castro, A F; Pincheira, R Article BMC genomics (2019)
A Trichostatin A (TSA)/Spl-mediated mechanism for the regulation of SALL2 tumor suppressor in Jurkat T cells Hepp, Matias I.; Escobar, David; Farkas, Carlos; Hermosilla, Viviana E.; Alvarez, Claudia; Amigo, Roberto; Gutierrez, Jose L.; Castro, Ariel F.; Pincheira, Roxana; Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2018)
SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes Hermosilla, Viviana E.; Salgado, Ginessa; Riffo, Elizabeth; Escobar, David; Hepp, Matias I.; Farkas, Carlos; Galindo, Mario; Morin, Violeta; Garcia-Robles, Maria A.; Castro, Ariel F.; Pincheira, Roxana; Article ISI SCOPUS Molecular Oncology (2018)
Developmental SALL2 transcription factor: a new player in cancer Hermosilla, Viviana E.; Hepp, Matias I.; Escobar, David; Farkas, Carlos; Riffo, Elizabeth N.; Castro, Ariel F.; Pincheira, Roxana Article ISI SCOPUS CARCINOGENESIS (2017)
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival Campos, T.; Ziehe J.; Fuentes-Villalobos, F.; Riquelme O.; Peña D.; Troncoso R.; Lavandero S.; Morin, V; Pincheira, R; Castro A F. Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Cell Research (2016)
Rheb Promotes Cancer Cell Survival Through p27Kip1-Dependent Activation of Autophagy Campos, T.; Ziehe J.; Palma M.; Escobar, D.; Tapia, JC; Pincheira, R; Castro, AF Article ISI SCOPUS MOLECULAR CARCINOGENESIS (2016)
Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin Escobar, D.; Hepp, MI; Farkas, C; Campos, T.; Sodir, NM; Morales M.; Alvarez, CI; Swigart, L; Evan, GI; Gutierrez, JL; Nishinakamura, R; Castro, AF; Pincheira, R Article ISI SCOPUS Cell Death and Disease (2015)
Wild Type p53 Transcriptionally Represses the SALL2 Transcription Factor under Genotoxic Stress Farkas, C; Martins, CP; Escobar, D.; Hepp, MI; Donner, DB; Castro, AF; Evan, G; Gutierrez, JL; Warren, R; Pincheira, R Article ISI SCOPUS PLOS ONE (2013)
M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells Castro A F.; Campos, T.; Babcock J.T.; Armijo, M.E.; Martinez-Conde A.; Pincheira, R; Quilliam L.A. Article ISI SCOPUS Journal of Cellular Biochemistry (2012)
Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer Lacher M.D.; Pincheira R.J.; Castro A F. Article SCOPUS Small GTPases (2011)
Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis Lacher, MD; Pincheira, R; Zhu, Z.; Camoretti-Mercado, B; Matli, M; Warren, RS; Castro, AF Article ISI SCOPUS Oncogene (2010)
Role of elF3a in regulating cell cycle progression. Dong Z,Liu Z,Ciu P,Pincheira R,Yang Y, Zhang JT Article ISIS Exp Cell Res (2009)
Sall 2 is a novel p75NTR interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth. Pincheira Article ISIS (2009)
The Sal12 Transcription Factor Is a Novel p75NTR Binding Protein That Promotes the Development and Function of Neurons Pincheira, Roxana;; Donner, David B.; Goetzl, EJ Article ISI ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2008)
TNFR1 complexes and selectively uses Jak2,C-Src and Pl 3-kinase to engage signalling pathways that regulate transcription factor activity and gene expression/J Inmunology Pincheira R,Castro AF,Ozes ON, Donner DB. Article ISIS Journal of Inmunology (2008)
Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase Satpathy, Nbnati; Cao, Liyun; Pincheira, Roxana;; Emerson, Robert; Bigsby, Robert; Nakshatri, Harikrishna; Matei, Daniela Article ISI CANCER RESEARCH (2007)
Akt regulates basal and induced processing of NF-kB2 (p100) to p52 Gustin, JA; Korgaonkar, C; Pincheira, R; Li, Q.; Donner, DB Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Cell type-specific expression of the I kappa B kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation Gustin, JA; Ozes, ON; Akca, H; Pincheira, R; Mayo, LD; Li, QT; Guzman, JR; Korgaonkar, CK; Donner, DB Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth Dong, ZZ; Liu, LH; Han, BG; Pincheira, R; Zhang, JT Article ISI ONCOGENE (2004)
Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells Gustin, JA; Pincheira, R; Mayo, LD; Ozes, ON; Kessler, KM; Baerwald, MR; Korgaonkar, CK; Donner, DB Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
Identification of a 170-kDa protein over-expressed in lung cancers Pincheira, R; Chen, Q; Zhang, JT Article ISI BRITISH JOURNAL OF CANCER (2001)
Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: implications for alternative functions of p170 Pincheira, R; Chen, Q; Huang, ZS; Zhang, JT Article ISI EUROPEAN JOURNAL OF CELL BIOLOGY (2001)
Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase Mayo, LD; Kessler, KM; Pincheira, R; Warren, RS; Donner, DB Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Increased expression of c-rel, from the NF-?B/Rel family, in T cells from patients with systemic lupus erythematosus Burgos P.; Bull, P; Metz, C; Pincheira, R; Massardo, L; Errazuriz, C; Jacobelli, S.; González A; Bono M.R. Article SCOPUS JOURNAL OF RHEUMATOLOGY (2000)
Increased expression of c-rel, from the NF-kappa B/Rel family, in T cells from patients with systemic lupus erythematosus Burgos P.; Metz, C; Bull, P; Pincheira, R; Massardo, L; Errazuriz, C; Bono, MR.; Jacobelli, S.; González A Article ISI JOURNAL OF RHEUMATOLOGY (2000)
Dissection of drug-binding-induced conformational changes in P-glycoprotein. Wang, G; Pincheira, R; Zhang, JT Article EUROPEAN JOURNAL OF BIOCHEMISTRY (1998)
Conformational changes of P-glycoprotein by nucleotide binding Wang, G; Pincheira, R; Zhang, M; Zhang, JT Article BIOCHEMICAL JOURNAL (1997)


p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress. Farkas, C; Martins C.; Escobar, D.; Castro A.; Donner, D; Pincheira, R Abstract ISI CANCER RESEARCH (2013)


The Sall2 transcription factor is a novel p75NTR binding protein that promotes the development and function of neurons. Pincheira R,Donner D; Goetzl Edward J. BookSection (2008)


Mechanisms of regulation of cancer cells metabolism counteracting oxidative stress Castro, Ariel Fernando; Pincheira, Roxana Jacqueline; Morin, Violeta Marilyn Proyecto (2020)
Unraveling the role and mechanism of SALL2 transcription factor in colorectal cancer Pincheira, Roxana Jacqueline; Castro, Ariel Fernando; Torres, Vicente Armando Proyecto (2019)
MOLECULAR MECHANISMS OF CANCER CELL RESISTANCE TO METABOLIC STRESS=> THE ROLE OF NUAK1 SIGNALING FONDECYT (1160731) Proyecto 2016-2020 Coinvestigador(a)
REGULATION AND FUNCTION OF THE SALL2 TRANSCRIPTION FACTOR DURING CELLULAR STRESS FONDECYT (1151031) Proyecto 2015-2019 Inv. Responsable
Integrating signaling pathways, transcriptional regulation and cell behavior in the study of mechanisms of carcinogenesis Proyecto Enlace, Vicerrectoría de investigación y Desarrollo UdeC (VRID - Enlace) Proyecto 2012-2014 Coinvestigador(a)
INTERRUPTED RHEB-TO-AMPK FEEDBACK SIGNALING WITH CYTOPLASMIC P27 RETENTION=> MECHANISMS AND BIOLOGICAL CONSEQUENCES. FONDECYT (1120923) Proyecto 2012-2016 Coinvestigador(a)
UNIVERSIDAD DE CONCEPCIÓN – TRANSFERENCIA BIOTERIO AL SERVICIO DE EMPRESAS Y LABORATORIOS GORE Bio Bio (30116843-0) Proyecto 2012-2016 Director(a)
CHARACTERIZATION OF SALL2 TRANSCRIPTION FACTOR AND ITS RELATIOSHIP TO P53 TUMOR SUPPRESSOR FONDECYT (1110821) Proyecto 2011-2015 Inv. Responsable
Role of sall2 in p53 tumor suppressor function Proyecto DIUC, Dirección de Investigación UdeC (Diuc-Regular) Proyecto 2010-2011 Inv. Responsable
Sall2 Single Nucleotide Polymorphisms in colorectal cancer Academic Senate Individual Investigator Grant. UCSF, USA (UCSF) Proyecto 2009-2010 Inv. Responsable
Regulation of the Sall2 transcription factor by the p53 tumor suppressor in colon cancer patients Dorothy Rodbell Cohen Cancer Program. Lehman Brothers Foundation. USA (Lehman Brothers Foundation) Proyecto 2007-2008 Coinvestigador(a)


Rheb signaling and tumorigenesis: mTORC1 and new horizons Armijo, ME; Campos, T.; Fuentes-Villalobos, F; Palma, ME; Pincheira, R; Castro, AF Review ISI SCOPUS INTERNATIONAL JOURNAL OF CANCER (2016)