Man

Roxana Jacqueline Pincheira Barrera

Profesor Asociado

Universidad de Concepcion

Concepción, Chile

Líneas de Investigación


Cancer Biology; Signal transduction; Gene Expression, Oncogenes and tumor supressors network

Educación

  •  Biomedical Sciences, Universidad de Chile. Chile, 2000
  •  Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1991

Experiencia Académica

  •   Investigador Asistente Other

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago, Chile

    1991 - 1992

  •   Investigador Asistente Other

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago, Chile

    1991 - 1992

  •   PhD Thesis Other

    University of Texas Medical Branch

    Galveston, Estados Unidos

    1996 - 2000

  •   Postdoctorate Other

    INDIANA UNIVERSITY-PURDUE UNIVERSITY INDIANAPOLIS

    Indianapolis, Estados Unidos

    2001 - 2005

  •   Postdoctorate Other

    University of California San Francisco

    California, Estados Unidos

    2005 - 2007

  •   Profesor Asistente Investigador Other

    University of California San Francisco

    San Francisco, Estados Unidos

    2008 - 2009

  •   Profesor Asociado Other

    UNIVERSIDAD DE CONCEPCION

    Ciencias Biológicas

    Concepción, Chile

    2010 - A la fecha

Experiencia Profesional

  •   Postdoctorate Other

    Purdue University Indianapolis

    Indianapolis, Estados Unidos

    2001 - 2005

  •   Postdoctorate Other

    University of California San francisco

    California, Estados Unidos

    2005 - 2007

  •   Profesor Asistente Investigador Other

    University of California San Francisco

    San Francisco, Estados Unidos

    2008 - 2009

  •   Profesor Asociado Full Time

    Universidad de Concepción

    Concepción, Chile

    2010 - A la fecha

Formación de Capital Humano


Fechas Nombre Institución Role Actividad
2018- Claudia Alvarez Universidad de Concepcion Tutor PhD thesis student (Doctorado en Biología Celular y Molecular)
2014-2017 Ginessa Salgado Universidad de Concepcion Tutor Ms Student (Biochemistry and Bioinformatics)
2014-2017 Elizabeth Riffo Universidad de Concepcion Tutor Ms Student (Biochemistry and Bioinformatics)
2014-2018 Carlos Farkas Universidad de Concepcion Tutor PhD thesis student (Doctorado en Biología Celular y Molecular)
2013-2017 Viviana Hermosilla Universidad de Concepcion Tutor PhD thesis student (Doctorado en Biología Celular y Molecular)
2013-2015 Daniel Sanhueza Universidad de Concepcion Tutor Undergrad thesis (Biochemistry)
2012-2013 Elizabeth Riffo Universidad de Concepcion Tutor Undergrad thesis (Biochemistry)
2012-2013 Ginessa Salgado Universidad de Concepcion Tutor Undergrad thesis (Biology)
2012-2013 Carlos Farkas Universidad de Concepcion Tutor Undergrad thesis (Bioingeniering)
2012-2013 Marcela Morales Universidad de Concepcion Tutor Undergrad thesis (Bioingeniering)
2012-2013 Francisco Fuentes Universidad de Concepcion Tutor Undergrad thesis (Bioingeniering)
2011-2015 David Escobar Universidad de Concepcion Tutor PhD thesis student (Doctorado en Biología Celular y Molecular)
2011-2015 Tania Campos Universidad de Concepcion Tutor PhD thesis student (Doctorado en Biología Celular y Molecular)
2011-2012 M. Fernanda Sanchez Universidad de Concepcion Tutor Undergrad thesis (Bioingeniering)
2011-2012 Marisol Armijo Universidad de Concepcion Co-tutor Undergrad thesis (Bioingeniering)
2006-2010 Mary Matli University of California San Francisco, USA Supervisor Laboratory Manager at UCSF laboratory
2006-2010 Xiaochen Wang University of California San Francisco, USA Supervisor Laboratory Technitiant .UCSF laboratory


Difusión y Transferencia


La difusión desarrollada se enfoca en la participación del investigador y/o sus alumnos en colegios de la región del Bio Bio promoviendo la investigación básica y su aplicación en el contexto de patología crónicas como lo es el cáncer. A su vez el grupo de investigación invita a alumnos de variados colegios de la región a visitas guiadas al laboratorio.


Premios y Distinciones

  •   Student fellowship

    UNIVERSIDAD DE CONCEPCION

    Chile, 1990

    Student Fellowship

  •   International course,"Molecular and Cellular Aspects of Cancer"

    INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS

    Venezuela, 1995

    Awared by the Organization de los Estados Americanos.

  •   Advanced Research Fellowship

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 1995

    SCHOLARSHIP AWARDED BY THE NATIONAL RESEARCH AND TECHNOLOGY COUNCIL OF CHILE

  •   RAININ RESEARCH PRIZE

    ASILOMAR CONFERENCE ON NEURAL SIGNALING

    Estados Unidos, 2008

    PRIZE FOR OUTSTANDING POSTER

  •   UCSF ACADEMIC SENATE

    UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

    Chile, 2009

    TRAVEL AWARD TO PRESENT AT THE KEYSTONE SYMPOSIUM ON NEUROSCIENCE

  •   NEW INVESTIGATOR AWARD

    UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

    Chile, 2009

    GRANT ENTITLED:SALL2 SINGLE NUCLEOTIDE POLYMORPHISMS IN COLON CANCER

  •   AACR MINORITY SCHOLAR IN CANCER RESEARCH AWARD

    AMERICAN ASSOCIATION FOR CANCER RESEARCH

    Estados Unidos, 2009

    AWARD TO ASSIST TO THE FRONTIERS IN BASIC CANCER RESEARCH MEETING.BOSTON,USA.

  •   REGIONAL DIRECTOR CHILEAN BIOCHEMISTRY SOCIETY

    SOCIEDAD DE BIOQUIMICA DE CHILE

    Chile, 2011

    REGIONAL DIRECTOR


 

Article (31)

Cytosolic NUAK1 enhances ATP production by maintaining proper glycolysis and mitochondrial function in cancer cells
Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions
DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress
Identification of a nuclear localization signal and importin beta members mediating NUAK1 nuclear import inhibited by oxidative stress
Streamlined computational pipeline for genetic background characterization of genetically engineered mice based on next generation sequencing data.
A Trichostatin A (TSA)/Spl-mediated mechanism for the regulation of SALL2 tumor suppressor in Jurkat T cells
SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes
Developmental SALL2 transcription factor: a new player in cancer
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
Rheb Promotes Cancer Cell Survival Through p27Kip1-Dependent Activation of Autophagy
Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin
Wild Type p53 Transcriptionally Represses the SALL2 Transcription Factor under Genotoxic Stress
M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells
Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer
Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis
Role of elF3a in regulating cell cycle progression.
Sall 2 is a novel p75NTR interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth.
The Sal12 Transcription Factor Is a Novel p75NTR Binding Protein That Promotes the Development and Function of Neurons
TNFR1 complexes and selectively uses Jak2,C-Src and Pl 3-kinase to engage signalling pathways that regulate transcription factor activity and gene expression/J Inmunology
Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase
Akt regulates basal and induced processing of NF-kB2 (p100) to p52
Cell type-specific expression of the I kappa B kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation
Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth
Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells
Identification of a 170-kDa protein over-expressed in lung cancers
Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: implications for alternative functions of p170
Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase
Increased expression of c-rel, from the NF-?B/Rel family, in T cells from patients with systemic lupus erythematosus
Increased expression of c-rel, from the NF-kappa B/Rel family, in T cells from patients with systemic lupus erythematosus
Dissection of drug-binding-induced conformational changes in P-glycoprotein.
Conformational changes of P-glycoprotein by nucleotide binding

Abstract (1)

p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress.

BookSection (1)

The Sall2 transcription factor is a novel p75NTR binding protein that promotes the development and function of neurons.

Proyecto (11)

Mechanisms of regulation of cancer cells metabolism counteracting oxidative stress
Unraveling the role and mechanism of SALL2 transcription factor in colorectal cancer
MOLECULAR MECHANISMS OF CANCER CELL RESISTANCE TO METABOLIC STRESS=> THE ROLE OF NUAK1 SIGNALING
REGULATION AND FUNCTION OF THE SALL2 TRANSCRIPTION FACTOR DURING CELLULAR STRESS
Integrating signaling pathways, transcriptional regulation and cell behavior in the study of mechanisms of carcinogenesis
INTERRUPTED RHEB-TO-AMPK FEEDBACK SIGNALING WITH CYTOPLASMIC P27 RETENTION=> MECHANISMS AND BIOLOGICAL CONSEQUENCES.
UNIVERSIDAD DE CONCEPCIÓN – TRANSFERENCIA BIOTERIO AL SERVICIO DE EMPRESAS Y LABORATORIOS
CHARACTERIZATION OF SALL2 TRANSCRIPTION FACTOR AND ITS RELATIOSHIP TO P53 TUMOR SUPPRESSOR
Role of sall2 in p53 tumor suppressor function
Sall2 Single Nucleotide Polymorphisms in colorectal cancer
Regulation of the Sall2 transcription factor by the p53 tumor suppressor in colon cancer patients

Review (1)

Rheb signaling and tumorigenesis: mTORC1 and new horizons
36
Roxana Pincheira

Profesor Asociado

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

15
Ariel Castro

Associate Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

7
Carlos Farkas

PostDoctoral Fellow

CancerCare Manitoba

University of Manitoba

Winnipeg, Canada

5
Matias Hepp

Profesor asistente - Investigador

Ciencias Basicas

universidad catolica de la santisima concepcion

Concepcion, Chile

4
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Patricio Órdenes

Docente

Facultad de Ciencias de la Salud

Universidad San Sebastián

Concepción, Chile

1
Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

1
José Gutiérrez

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Sebastián Riquelme

Estudiante doctorado

Virología

Universidad de Chile

Santiago, Chile

1
Viviana Hermosilla

Colaborador Docente

Departamento de Bioquímica y Biología Molecular

Universidad de Concepción

Concepción, Chile

1
Patricia Luz

Profesor asistente

Universidad de los Andes

Santiago , Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Karina Oyarce

Investigadora

Facultad de Ciencias de la Salud

Universidad San Sebastián, sede Tres Pascualas

Concepción, Chile

1
María José Barahona

Investigador asociado

Universidad de Concepción

Concepción, Chile

1
Magdiel Salgado

INVESTIGADOR

BIOLOGIA CELULAR

Universidad de Concepción

CONCEPCION, Chile

1
Patricia Burgos

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile