Man

Attilio Gianpietro Rigotti Rivera

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

Líneas de Investigación


Lipid and lipoprotein metabolism; Dyslipidemias; Lifestyle, Mediterranean Diet; Well-being; Atherosclerosis; Chronic diseases

Educación

  •  Medical Doctor, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1988
  •  Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000
  •  Medicina Interna, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1991

Experiencia Académica

  •   Instructor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    1994 - 1998

  •   Assistant Professor Full Time

    Medicine

    Santiago, Chile

    1998 - 2002

  •   Associate Professor Full Time

    Medicine

    Santiago, Chile

    2002 - 2012

  •   Full Professor Full Time

    Medicine

    Santiago, Chile

    2012 - A la fecha

Experiencia Profesional

  •   Attending Physician in Lipidology Part Time

    Hospital Clínico Universidad Católica

    Santiago, Chile

    1997 - 2001

  •   Attending Physician in Lipidology and Gastroenterology Part Time

    Red de Salud UC CHRISTUS - Clínica Universidad Católica San Carlos de Apoquindo

    Santiago, Chile

    2001 - A la fecha

Formación de Capital Humano


Supervision of lab research rotation and thesis work of undergraduate (Medicine, Biology and Biochemistry), graduate (PhD in Medical Sciences) and postgraduate students


Premios y Distinciones

  •   Undergraduate Fellowship

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1981

    Academic performance

  •   Undergraduate Fellowship

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1982

    Academic performance

  •   Medical Society of Santiago Award

    Sociedad Médica de Santiago

    Chile, 1988

    Best publication of the year

  •   Internal Medicine Fellowship

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1988

    Support for Internal Medicine training

  •   Doctoral Fellowship

    Fundación Andes

    Chile, 1991

    Support for PhD training

  •   Postdoctoral Research Fellowship

    Howard Hughes Medical Institute

    Estados Unidos, 1994

    Support for postdoctoral training

  •   Young Investigator in Medicine Award

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2001

    Research excellence

  •   Chilean Academy of Medicine Award

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2008

    Research excellence

  •   Senior Investigator in Medicine Award

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2011

    Research excellence


 

Article (135)

Anthropometry, dietary intake, physical activity and sitting time patterns in adolescents aged 15–17 years: an international comparison in eight Latin American countries
Comparison of self-report versus accelerometer - measured physical activity and sedentary behaviors and their association with body composition in Latin American countries
Dietary Diversity and Micronutrients Adequacy in Women of Childbearing Age: Results from ELANS Study
Intake of Non-Nutritive Sweeteners in Chilean Children after Enforcement of a New Food Labeling Law that Regulates Added Sugar Content in Processed Foods
Methodological design for the assessment of physical activity and sedentary time in eight Latin American countries - The ELANS study
Ovarian cholesterol efflux: ATP-binding cassette transporters and follicular fluid HDL regulate cholesterol content in mouse oocytes
Socio-Demographic Correlates of Total and Domain-Specific Sedentary Behavior in Latin America: A Population-Based Study
Socio-demographic patterns of public, private and active travel in Latin America: Cross-sectional findings from the ELANS study
Assessment of Diet Quality in Chilean Urban Population through the Alternate Healthy Eating Index 2010: A Cross-Sectional Study
Association of moderate-to-vigorous physical activity with neck circumference in eight Latin American countries
Burnout in students of health-care professions. Risk and protection factors
Diet Quality and Diet Diversity in Eight Latin American Countries: Results from the Latin American Study of Nutrition and Health (ELANS)
Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia
Latin American consumption of major food groups: Results from the ELANS study
Non-HDL cholesterol levels in Chilean population and their association with diabetes mellitus and cardiovascular disease
Original research Socio-demographic patterning of self-reported physical activity and sitting time in Latin American countries: findings from ELANS
Prevalence and determinants of misreporting of energy intake among Latin American populations: results from ELANS study
Red Wine Grape Pomace Attenuates Atherosclerosis and Myocardial Damage and Increases Survival in Association with Improved Plasma Antioxidant Activity in a Murine Model of Lethal Ischemic Heart Disease
Socio-demographic patterning of objectively measured physical activity and sedentary behaviours in eight Latin American countries: Findings from the ELANS study
Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice
Energy intake and food sources of eight Latin American countries: results from the Latin American Study of Nutrition and Health (ELANS)
High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation
Persistently high psychological well-being predicts better HDL cholesterol and triglyceride levels: findings from the midlife in the US (MIDUS) longitudinal study
Promoting and Implementing the Mediterranean Diet in the Southern Hemisphere=> the Chilean Experience.
The Consumption of Beef Burgers Prepared with Wine Grape Pomace Flour Improves Fasting Glucose, Plasma Antioxidant Levels, and Oxidative Damage Markers in Humans: A Controlled Trial
Total and Added Sugar Intake: Assessment in Eight Latin American Countries
Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure
Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI
Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice
Impacto de la dieta mediterránea sobre las lipoproteínas de alta densidad
Inverse Associations between a Locally Validated Mediterranean Diet Index, Overweight/Obesity, and Metabolic Syndrome in Chilean Adults
Linking Positive Affect to Blood Lipids: A Cultural Perspective
Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin
Validation of a Spanish Version of the Mental Health Continuum-Short Form Questionnaire
Culture and Healthy Eating: The Role of Independence and Interdependence in the United States and Japan
Efecto del ciprofibrato sobre el metabolismo del colesterol HDL y la capacidad antioxidante plasmática en el ratón
Increased statin eligibility based on ACC/AHA versus NCEP guidelines for high cholesterol management in Chile
Latin American Study of Nutrition and Health (ELANS): rationale and study design
Validación de cuestionario autoaplicable para un índice de alimentación mediterránea en Chile
[Nicotinic acid increases cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia].
[Nicotinic acid increases cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia].
ANTIOXIDANT DYSFUNCTIONALITY OF HIGH-DENSITY LIPOPROTEINS (HDL) IN DECOMPENSATED DIABETIC PATIENTS
Nicotinic acid increases cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia
Nicotinic acid increases cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia [El ácido nicotínico aumenta el transporte celular de colesterol de las lipoproteínas de alta densidad en pacientes con hipoalfalipoproteinemia]
Standardization of the Food Composition Database Used in the Latin American Nutrition and Health Study (ELANS)
UNHEALTHY FOOD INTAKE IS LINKED TO HIGHER PREVALENCE OF METABOLIC SYNDROME IN CHILEAN ADULT POPULATION: CROSS SECTIONAL STUDY IN 2009-2010 NATIONAL HEALTH SURVEY
Wine grape pomace flour improves blood pressure, fasting glucose and protein damage in humans: a randomized controlled trial
[Risk of type 2 diabetes mellitus associated with statin therapy=> evidence and possible mechanisms].
A Latin American Perspective on the New ACC/AHA Clinical Guidelines for Managing Atherosclerotic Cardiovascular Disease
Association between diabetes mellitus and cardiovascular disease in Chilean adults. Analysis of the national health survey 2009-2010
Early Onset Intrauterine Growth Restriction in a Mouse Model of Gestational Hypercholesterolemia and Atherosclerosis
Excess cholesterol induces mouse egg activation and may cause female infertility
Maternal Hypertriglyceridemia: A Link Between Maternal Overweight-Obesity and Macrosomia in Gestational Diabetes
Perfil lipídico en mujeres embarazadas sanas de tres regiones de Chile
Physiological and pathological implications of cholesterol
Positive psychosocial factors and cardiovascular health
Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet
Protective role of high density lipoproteins in sepsis: basic issues and clinical implications
Cholesterol Levels and the Association of Statins With In-Hospital Mortality of Myocardial Infarction Patients Insights From a Chilean Registry of Myocardial Infarction
Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI
APOA5 Q97X Mutation Identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family
Niemann-Pick C2 Protein Expression Regulates Lithogenic Diet-Induced Gallstone Formation and Dietary Cholesterol Metabolism in Mice
"Cholesteryl ester transfer protein inhibition in the management of atherosclerotic cardiovascular disease: Second act ""a rebirth of hope"" Inhibición de la proteína de transferencia de ésteres de colesterol para el manejo de la enfermedad cardiovascular ateroesclerótica: El segundo acto ""una esperanza que renace"""
Aplicando psicología positiva en educación médica
Apolipoprotein A-I deficiency does not affect biliary lipid secretion and gallstone formation in mice
Applying positive psychology to medical education
Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice
Cholesteryl ester transfer protein inhibition in the management of atherosclerotic cardiovascular disease: second act "A rebirth of hope"
Inhibición de la proteína de transferencia de ésteres de colesterol para el manejo de la enfermedad cardiovascular ateroesclerótica: el segundo acto "Una esperanza que renace"
Npc1 deficiency in the C57BL/6J genetic background enhances Niemann-Pick disease type C spleen pathology
Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice
Prevalence of Metabolic Syndrome among Chilean adults
Prevalence of metabolic syndrome among chilean adults [Prevalencia de síndrome metabólico en población adulta chilena: Datos de la encuesta nacional de salud 2003]
Prevalence of metabolic syndrome among chilean adults Prevalencia de síndrome metabólico en población adulta chilena: Datos de la encuesta nacional de salud 2003
Prevalencia de síndrome metabólico en población adulta Chilena: Datos de la Encuesta Nacional de Salud 2003
Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones
The metabolic syndrome: From an aggravating condition to a pathogenic risk factor for chronic diseases [El síndrome metabólico: De factor agravante a principal factor de riesgo patogénico en diversas enfermedades crónicas]
The metabolic syndrome: From an aggravating condition to a pathogenic risk factor for chronic diseases El síndrome metabólico: De factor agravante a principal factor de riesgo patogénico en diversas enfermedades crónicas
Age-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition
Non-alcoholic fatty liver disease and its association with obesity, insulin resistance and increased serum levels of C-reactive protein in Hispanics
Normal Hepatic Cell Surface Localization of the High Density Lipoprotein Receptor, Scavenger Receptor Class B, Type I, Depends on All Four PDZ Domains of PDZK1
A NEW TWIST IN THE CHOLESTEROL METABOLISM-BASED ENTEROHEPATIC CONNECTION.
Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization
Trends in obesity and diabetes prevalence in a Chilean urban population: 1993-2001
TRENDS IN OBESITY AND DIABETES PREVALENCE IN A CHILEAN URBAN POPULATION: 1996-3-2001
Adenovirus-mediated hepatic syndecan-1 overexpression induces hepatocyte proliferation and hyperlipidaemia in mice
CETP expression enhances liver HDL-cholesteryl ester uptake but does not alter VLDL and biliary lipid secretion
Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations
Hypertension and the cardiometabolic syndrome in Chile: A review of concepts and consequences for the developing world
Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction
Liver heparan sulfate proteoglycans: Old molecules provide new insights on lipoprotein metabolism - Commentary
Molecular diagnosis and combined lipid lowering therapy of heterozygous familial hypercholesterolemia. Report of one case
Overexpression of the cholesterol-binding protein MLN64 induces liver damage in the mouse
Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse
Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility
Gallbladder disease is associated with insulin resistance in a high risk Hispanic population
NPC2 is expressed in human and murine liver and secreted into bile: Potential implications for body cholesterol homeostasis
PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function
Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat
EFECTO DE LA INFECCION PERIODONTAL POR PORPHYROMONAS GINGIVALIS EN EL DESARROLLO DE ATEROESCLEROSIS EN RATONES DEFICIENTES DE APOLIPOPROTEINA E
EFECTO DE SIMVASTATINA, CIPROFIBRATO Y ROSIGLITAZONA EN EL MANEJO DE LA DISLIPIDEMIA CAUSADA POR LA ADMINISTRACION DE RITONAVIR EN EL RATON
EL RATON DEFICIENTE EN LA APOLIPOPROTEINA E COMO MODELO EXPERIMENTAL DE ATEROESCLEROSIS (COMENTARIO EDITORIAL)
Nuevos receptores nucleares heterodiméricos: reguladores metabólicos con impacto en fisiopatología y su proyección terapéutica en dislipidemias y diabetes mellitus
Peroxisome proliferator-activated receptor gamma is a novel target of the nerve growth factor signaling pathway in PC12 cells
Physicians in biomedical research in Chile: A species under risk of extinction?
Cellular mechanisms of vitamin e uptake: Relevance in ?-tocopherol metabolism and potential implications for disease
Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells
FUNCTION AND REGULATION OF HEPATIC SCAVENGER RECEPTOR CLASS B TYPE I (SR-BI)
Biliary lipid secretion, bile acid metabolism, and gallstone formation are not impaired in hepatic lipase-deficient mice
Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium
Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice
Hepatic overexpression of caveolins increases bile salt secretion in mice
Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion
Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism
?-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice
alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice
HDL receptor SR-BI and cholesterol gallstones [3] (multiple letters)
Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice
Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestinal lumen.
Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet
Scavenger receptor class B type I (SR-BI) and high-density lipoprotein metabolism: Recent lessons from genetically manipulated mice
Scavenger Receptors and Atherosclerosis
Sterol carrier protein 2 gene transfer changes lipid metabolism and enterohepatic sterol circulation in mice
Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage
Getting a handle on 'good' cholesterol with the high-density lipoprotein receptor
Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology
MOLECULAR MEDICINE - PRESENT AND FUTURE
MOLECULAR-BIOLOGY AND MEDICINE - BASIC CONCEPTS
THE HDL RECEPTOR SR-BI: A NEW THERAPEUTIC TARGET FOR ATHEROSCLEROSIS?
Cholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in human gallbladder bile
Temporal and spatial pattern of expression of the HDL receptor SR-BI during murine embryogenesis
A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism
Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse
Modulation of intrahepatic cholesterol trafficking: Evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transport into rat bile

Abstract (26)

IMPACT OF HIGH DENSITY LIPOPROTEIN METABOLISM IN MOUSE EMBRYO PHYSIOLOGY
INVOLVEMENT OF HDL RECEPTOR SR-BI-MEDIATED VITAMIN E UPTAKE IN MURINE NEURAL TUBE CLOSURE
ROLE OF PRENATAL EXPOSURE TO ENVIRONMENTAL POLLUTANTS AND MATERNAL OBESITY IN FETAL PROGRAMMING OF CHRONIC DISEASES IN MICE
Standardization of Food Composition Database in Latin American Nutrition and Health Study (ELANS): Preliminary data
ALIMENTATE SANO: AN INTERNET TOOL TO EVALUATE AND PROMOTE HEALTHY LIFESTYLES FOR PREVENTION OF CHRONIC DISEASES
CONSUMPTION OF MEDITERRANEAN DIET COMPONENTS IS ASSOCIATED WITH LOWER CARDIOVASCULAR RISK. DATA FROM ALIMENTATE SANO, A CROSS-SECTIONAL INTERNET SURVEY
Exencephaly and IUGR in Mouse Embryos Lacking the HDL Receptor SR-BI
Postprandial Effect of Bread Prepared with Wine Grape Pomace Flour, on Glycemia, Plasma Antioxidant Capacity and Oxidative Damage
THE LACK OF THE HDL RECEPTOR SR-BI AFFECTS EMBRYO CHOLESTEROL CONTENT AND NEURAL TUBE CLOSURE IN MICE
DEFICIENCY OF NIEMANN-PICK C1 PROTEIN EXPRESSION PROTECTS AGAINST DIET-INDUCED GALLSTONE FORMATION IN MICE
Cardiovascular risk, cholesterol goal attainment, and lipid-lowering eligibility in chile. Findings from the first national health survey
High level of agreement between the NCEP ATPIII and IDF metabolic syndrome definition in the Chilean general population: Results from the first National Health Survey 2003
Adenovirus-mediated hepatic overexpression of syndecan-1 increases plasma lipoprotein cholesterol without changes in liver and biliary cholesterol content in mice
Hepatic HDL cholesterol uptake, VLDL production and biliary lipid secretion in human CETP transgenic mice
Functional role and regulation of hepatic scavenger receptor class B type I (SR-BI)
Cholesterol depletion induces PKA activity and transcytosis of the HDL scavenger receptor class B type I (SR-BI)
Co-purification of the sinusoidal (NTCP) and canalicular (BSEP) hepatic bile acid. transporters with lipid rafts in the mouse liver: Implications for bile acid transport?.
Effects of manipulations of cholesterol/bile acid metabolism on caveolin-1 expression in mouse liver.
Increased plasma lipoprotein cholesterol levels and impaired biliary lipid secretion in mice with loss of function of Niemann-Pick C1 protein
Scavenger class B type I (SR-BI) expression protects cells from oxidative stress
Caveolin-1 gene transfer changes biliary lipid secreation and hepatic cholesterol content.
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I (SR-BI)-deficient mice
Relevance of Niemann-Pick C1 (NPC1) protein in controlling biliary lipid secretion of dietary cholesterol in mice.
Biliary lipid secretion in Niemann-Pick C1 protein-deficient mice.
Expression and regulation of scavenger receptor class B type I (SR-BI) in humun and murine gallbladder epithelial cells.
Overexpression of sterol carrier protein-2 in mice leads to increased hepatic cholesterol content and enterohepatic circulation of bile acids.

EditorialMaterial (3)

Blood lipids during pregnancy: A progressively appreciated subject in basic and clinical research
STARTing to understand MLN64 function in cholesterol transport
The Tangier disease gene encodes yet another pathophysiologically relevant ATP-binding cassette protein

Letter (3)

Focusing on Students' Talents and Strengths in Medical Education
Health research in Latin America
HDL receptor SR-BI and cholesterol gallstones

Proyecto (35)

Nucleo Milenio en Resonancia Magnética Cardiovascular - Cardio RM
Nucleo Milenio en Resonancia Magnética Cardiovascular - Cardio RM
Understanding the relationship between venous thrombosis and atherosclerosis=> the monocyte link
Understanding the relationship between venous thrombosis and atherosclerosis: the monocyte link
Desarrollo y validación de un alimento funcional cárnico, rico en fibra y antioxidantes, a base de harina de bagazo de uva, para beneficiar el consumo de fibra y antioxidantes en la población chilena
Desarrollo y validación de un alimento funcional cárnico, rico en fibra y antioxidantes, a base de harina de bagazo de uva, para beneficiar el consumo de fibra y antioxidantes en la población chilena
SR-BI-dependent functionality of high density lipoproteins: mechanisms, regulation, pathogenic implications and therapeutic applications
SR-BI-dependent functionality of high density lipoproteins=> mechanisms, regulation, pathogenic implications and therapeutic applications
Tecnología de Imágenes por Resonancia Magnética para Enfermedades Asociadas al Envejecimiento: Cerebro, Corazón y Vasos
Tecnología de Imágenes por Resonancia Magnética para Enfermedades Asociadas al Envejecimiento=> Cerebro, Corazón y Vasis
IMPACT OF HIGH DENSITY LIPOPROTEIN METABOLISM IN MOUSE OOCYTE AND EMBRYO PHYSIOLOGY=> UNDERLYING MECHANISMS, PATHOLOGICAL IMPLICATIONS AND POTENTIAL INTERVENTIONS.
Relevancia de las proteínas Niemann Pick C en fisiología y fisiopatología
Role of the good cholesterol HDL on female fertility
Encuesta Latinoamericana de Nutrición y Salud (ELANS)
Role of good cholesterol HDL on female fertility
RELEVANCE OF THE HDL RECEPTOR SR-BI AND HDL FUNCTIONALITY IN CHOLESTEROL METABOLISM AND ATHEROSCLEROSIS: PHYSIOLOGICAL, PATHOPHYSIOLOGICAL AND PHARMACOLOGICAL IMPLICATIONS
RELEVANCE OF THE HDL RECEPTOR SR-BI AND HDL FUNCTIONALITY IN CHOLESTEROL METABOLISM AND ATHEROSCLEROSIS=> PHYSIOLOGICAL, PATHOPHYSIOLOGICAL AND PHARMACOLOGICAL IMPLICATIONS
Fortalecimiento del Programa de Doctorado en Ciencias Médicas y de la investigación avanzada en metabolismo, inflamación y enfermedades crónicas en la Escuela de Medicina de la Pontificia Universidad Católica de Chile
Participación del receptor de HDL SR-BI en la fertilidad femenina y el desarrollo embrionario del ratón
Participación del receptor de HDL SR-BI en la fertilidad femenina y el desarrollo embrionario del ratón
Programa Aliméntate Sano
METABOLISMO HEPATICO DEL COLESTEROL HDL MEDIADO POR EL RECEPTOR SR-BI: ASPECTOS BASICOS, MECANISMOS DE REGULACION E IMPLICANCIAS FISIOPATOLOGICAS Y FARMACOLOGICAS.
METABOLISMO HEPATICO DEL COLESTEROL HDL MEDIADO POR EL RECEPTOR SR-BI=> ASPECTOS BASICOS, MECANISMOS DE REGULACION E IMPLICANCIAS FISIOPATOLOGICAS Y FARMACOLOGICAS.
IMPORTANCIA DE MOLECULAS INVOLUCRADAS EN EL METABOLISMO LIPOPROTEICO HEPATICO COMO DETERMINANTES DE LA SECRECION BILIAR DE COLESTEROL Y DEL DESARROLLO DE LITIASIS BILIAR
IMPORTANCIA DE MOLECULAS INVOLUCRADAS EN EL METABOLISMO LIPOPROTEICO HEPATICO COMO DETERMINANTES DE LA SECRECION BILIAR DE COLESTEROL Y DEL DESARROLLO DE LITIASIS BILIAR
IMPORTANCIA DE MOLECULAS INVOLUCRADAS EN EL METABOLISMO LIPOPROTEICO HEPATICO COMO DETERMINANTES DE LA SECRECION BILIAR DE COLESTEROL Y DEL DESARROLLO DE LITIASIS BILIAR
IMPORTANCIA DE MOLECULAS INVOLUCRADAS EN EL METABOLISMO LIPOPROTEICO HEPATICO COMO DETERMINANTES DE LA SECRECION BILIAR DE COLESTEROL Y DEL DESARROLLO DE LITIASIS BILIAR
Regulación hepática de la expresión y función de SR-BI
ROL DEL METABOLISMO DE COLESTEROL LIPOPROTEICO Y DE LA PRESENCIA DE CAVEOLAS Y CAVEOLITAS EN EL HIGADO, SOBRE EL CONTROL DE LA DISPONIBILIDAD Y EL TRAFICO INTRAHEPATOCITARIO DE COLESTEROL DESTINADO A SECRECION BILIAR.
ROL DEL METABOLISMO HEPATICO DE LAS LIPOPROTEINAS DE ALTA DENSIDAD (HDL) EN LA SECRECION BILIAR DE COLESTEROL Y EN LA PATOGENIA DE LA COLELITIASIS
Patología molecular de la formación de cálculos vesiculares de colesterol y rol de la proteína SCP-2 en el transporte y secreción hepática de colesterol
PROPIEDADES CITOPROTECTORAS DEL SURFACTANTE BILIAR, FRENTE AL EFECTO TOXICO DE LAS SALES BILIARES
Rol de glicoproteínas biliares en la patogenia de la litiasis biliar por cálculos de colesterol=> efecto del ácido ursodeoxicólico sobre la expresión y actividad de glicoproteínas biliares con capacidad de modular la cristalización del colesterol biliar
Encuesta Latinoamericana de Nutrición y Salud (ELANS)
Programa Aliméntate Sano

Review (28)

Promoting and Implementing the Mediterranean Diet in the Southern Hemisphere: the Chilean Experience
Egg intake and cardiovascular disease: a scientific literature review
Origin, components and mechanisms of action of the Mediterranean diet
Risk of type 2 diabetes mellitus associated with statin therapy: evidence and possible mechanisms
Advances in the physiological and pathological implications of cholesterol
La hipótesis de Pedersen no es suficiente: Otros nutrientes además de la glucosa explicarían la macrosomía fetal en pacientes diabéticas gestacionales con sobrepeso y buen control glicémico
Nutrients other than glucose might explain fetal overgrowth in gestational diabetic pregnancies
Rememorando la contribución de Goldstein y Brown al estudio del metabolismo del colesterol: a un cuarto de siglo del Premio Nobel de Medicina
The contribution of Goldstein and Brown to the study of cholesterol metabolism
Abnormalities of lipid metabolism, gallstone disease and gallbladder function
Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism
El síndrome metabólico: De factor agravante a principal factor de riesgo patogénico en diversas enfermedades crónicas
The metabolic syndrome: From an aggravating condition to a pathogenic risk factor for chronic diseases
Determinants of transhepatic cholesterol flux and their relevance for gallstone formation
Myocardial infarction following atherosclerosis in murine models
Absorption, transport, and tissue delivery of vitamin E
Intensive cholesterol lowering therapy to reduce cardiovascular risk
HDL cholesterol: A new target in the treatment of lipid disorders and atherosclerosis?
NEW HETERODIMERIC NUCLEAR RECEPTORS: KEY METABOLIC REGULATORS WITH RELEVANCE IN THE PATHOPHYSIOLOGY AND THERAPY OF DYSLIPIDEMIAS AND DIABETES MELLITUS
New heterodimeric nuclear receptors: Key metabolic regulators with relevance in the pathophysiology and therapy of dyslipidemias and diabetes mellitus [Nuevos receptores nucleares heterodiméricos reguladores metabólicos con impacto en fisiopatología y su proyección terapéutica en dislipidemias y diabetes mellitus]
New heterodimeric nuclear receptors: Key metabolic regulators with relevance in the pathophysiology and therapy of dyslipidemias and diabetes mellitus Nuevos receptores nucleares heterodiméricos reguladores metabólicos con impacto en fisiopatología y su proyección terapéutica en dislipidemias y diabetes mellitus
Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1
Cellular mechanisms of vitamin E uptake: relevance in alpha-tocopherol metabolism and potential implications for disease
Hepatic cholesterol transport from plasma into bile: implications for gallstone disease
Influence of the HDL receptor SR-BI on lipoprotein - Metabolism and atherosclerosis
The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues
Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake
The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism
257
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

119
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

51
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

42
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

21
Guadalupe Echeverría

Manager

Center for Molecular Nutrition and Chronic Diseases

Pontificia Universidad Católica de Chile

Santiago, Chile

19
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

12
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

10
Victor Cortes

Associate professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

8
Gerson Ferrari

Profesor Asociado

Escular de Ciencias de la Actividad Física, el Deporte y la Salud, Facultad de Ciencias Médicas

Universidad de Santiago de Chile

Santiago, Chile

8
Pablo Mardones

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

6
Ines Urquiaga

Coordinador Cientifico

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

6
Nicolas Quezada

Adjunct Researcher

Digestive Surgery

Pontificia Universidad Catolica de Chile

Santiago, Chile

6
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

6
Nicolás Santander

Postdoctoral scholar

Pediatrics

University of California, San Francisco

San Francisco, Estados Unidos

5
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

4
Manuel Alvarez

Gastroenterologist and Chief of Institute of Medicine

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Marcela Bitran

Profesor Asociado

Escuela de Medicina

Pontificia Universidad Catolica de Chile

Santiago , Chile

4
JOSE SANTOS

Full Professor

Department of Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

4
Luis Villarroel

Profesor Asociado

Salud Publica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE SALUD PÚBLICA

Santiago, Chile

4
Valentina Serrano

PROFESOR ASISTENTE

NUTRICION, DIABETES Y METABOLISMO

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

4
paula margozzini

Académico investigador y profesor Asistente

Salud Pública

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Loni Berkowitz

Profesor Asistente - Investigador postdoctoral

Nutrición, diabetes y metabolismo

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

3
Francisca Salas

Asistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

3
Ada Cuevas

Médico

Nutrición Clínica

CLINICA LAS CONDES

Santiago, Chile

3
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

2
Gonzalo Martínez

Cardiólogo Intervencional

Cardiología

Hospital Clínico Universidad Católica

Santiago, Chile

2
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Leslie Landaeta

Profesor investigador

Universidad de Las Américas

Santiago, Chile

2
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

2
Pablo Irarrazaval

Professor

Electrical Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Pablo Strobel

Prrofesional de laboratorio

Facultad Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile

2
Maria Jose Garcia

Profesor Asistente Adjunto

Estadistica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Alvaro Martínez

Director Asociado de Propiedad Intelectual y Transferencia Tecnológica

Fundación Ciencia para la Vida

Santiago, Chile

2
Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

Santiago, Chile

2
Ximena Aguilera

Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy

Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)

Universidad del Desarrollo

Santiago, Chile

1
Eduardo Abbott

Profesor Asistente

Medicina Interna

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Erwin de la Fuente

PROFESOR/INVESTIGADOR

Ciencias Biomedicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

1
Carlos Valenzuela

INTA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Jose Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Facultad de Odontologia, Universidad de Chile

Santiago, Chile

1
David Contador

Universidad del Desarrollo

Santiago, Chile

1
Claudia Gonzalez

Associate Professor and Resarcher

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

1
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

1
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
José Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Claudio Vera

Assitant Professor

Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alberto Martin

Assistant professor

Centro de Genómica y Bioinformática

Universidad Mayor

Santiago, Chile

1
Rodrigo Alonso

Director Jefe Departamento

Nutrición Clínica

Clínica Las Condes

Santiago, Chile

1
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

1
Karen Fuenzalida

Encargado de confirmación diagnóstica de Errores Innatos del Metabolismo (EIM) mediante técnicas GCMS y LCMSMS

Instituto de Nutrición y Tecnología de Alimentos

Universidad de Chile

Santiago, Chile

1
Klaus Puschel

Full Professor

Family Medicine

FACULTAD MEDICINA PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Ramon Corbalan

Director

Division of Cardiovascular Diseases

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Monica Acevedo

Associate Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
oscar castillo

Director Escuela

Facultad de Medicina

Universidad Finis Terrae

Santiago, Chile

1
Leticia Gonzalez

Profesional Apoyo a la Investigacion

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Susana Eyheramendy

Associate Professor

Statistics

PONTIFICIA UNIVERSIDAD CATOLICXA DE CHILE

Santiago, Chile

1
Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marcelo Andia

Associate Professor

Radiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Hugo Verdejo

Profesor Asistente

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

1
Ana Pereira

Profesor Asistente

INSTITUTO NUTRICIÓN Y TECNOLOGÍA DE LOS ALIMENTOS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
JOSE MIRANDA

Estudiante de Doctorado

Nutrición, Diabetes y Metabolismo

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Patricia Burgos

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Carlos Cristi

Docente-Investigador Jerarquizado, Escuela de Educación Física.

Pontificia Universidad Catolica de Valparaiso

Viña del Mar, Chile

1
David Contador

Professor Instructor

School of Medicine

Universidad del Desarrollo

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
daniel duran

Profesor

Bioquímica Clínica e Inmunología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Patricio Ramos

academico

Instituto de ciencias biológicas

UNIVERSIDAD DE TALCA

Talca, Chile

1
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile