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Andrea Alejandra Leiva Mendoza

Profesor Asociado

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Maternal hypercholesterolemia in human pregnancy: effects on placental cholesterol transport and in maternal and offspring lipid metabolism, lipoprotein function and endothelial function.

Educación

  •  Bioquimico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
  •  Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010

Experiencia Académica

  •   Associate Resercher Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2012 - 2014

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    SANTIAGO, Chile

    2014 - 2019

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Chile

    2019 - 2020

  •   Associate Professor Full Time

    UNIVERSIDAD SAN SEBASTIAN

    Medicina y Ciencia

    SANTIAGO, Chile

    2020 - 2023

  •   POFESORA TITULAR Full Time

    UNIVERSIDAD SAN SEBASTIAN

    Medicina y Ciencia

    SANTIAGO, Chile

    2023 - A la fecha

Experiencia Profesional

  •   Biochemist, technical assistant Full Time

    Pontificia Universidad Catolica de Chile

    Chile

    2004 - 2006

  •   PhD Student Full Time

    Pontificia Universidad Catolica de Chile

    Chile

    2006 - 2010

  •   Post-doctor Full Time

    Pontificia Universidad Catolica de Chile

    Chile

    2010 - 2012

  •   Associated Researcher Full Time

    Pontificia Universidad Catolica de Chile

    SANTIAGO, Chile

    2012 - 2014

  •   Assistant Professor Full Time

    Pontificia Universidad Catolica de Chile

    SANTIAGO, Chile

    2014 - 2019

  •   Sub-director PhD Program in Medical Sciences Full Time

    Pontificia Unversidad Católica de Chile

    Santiago, Chile

    2018 - A la fecha

  •   Visiting Professor. MSc in neurosciences and physiology Part Time

    Universidad de Sevilla

    Sevilla, España

    2018 - A la fecha

  •   Evaluator of grants from the Group Medicine G1 del grupo Medicina G1 Other

    Fondo Nacional de Ciencia y Tecnología (FONDECYT)

    Santiago, Chile

    2019 - A la fecha

  •   Profesor Asociado Full Time

    Pontificia Universidad Catolica de Chile

    SANTIAGO, Chile

    2019 - 2020

  •   Directora Doctorado en Enfermedades Crónicas Full Time

    Universidad San Sebastian

    Santiago, Chile

    2023 - A la fecha

Formación de Capital Humano


- Postdoctorate (sponsor researcher):
(2018-2021) Effects of maternal supraphysiological dyslipidaemia in pregnancies with gestational diabetes mellitus: impact from the feto-placental vascular function to the lipoprotein function in the
neonatal circulation.

- Direction of PhD thesis:
PhD Program in Medical Sciences, Pontificia Universidad Catolica de Chile
(2017-2020) Effects of maternal supraphysiological hypercholesterolemia in the traffic of cholesterol in the human placenta.
(2018-2021) Characterization and effects of LDL and HDL from women with hypercholesterolemia during pregnancy in the maternal vasculature and in the communication between endothelial cells and
macrophages.

PhD Program in Biological Sciences, Pontificia Universidad Catolica de Chile
(2018-2021) Rol of oxidized LDL in the process of autophagy and in the invasion and vascular remodeling capacity of trophoblast cells from pregnancies with preeclampsia.

- Direction of Master thesis:
Master in Medical Sciences, Universidad de Valparaíso
(2015-2017) Rol of adenosine receptor A1 in the effect of insulin over the L-arginine transports in human umbilical vein endothelial cells from pregnancies with gestational diabetes mellitus

Master in Physiology and Neurosciences, Universidad de Sevilla, España
(2018-2019) Role of cholesterol and its derivates in the formation of soluble endoglin and the pathogenesis of preeclampsia
(2018-2019) Role of maternal dyslipidemia in the development of preeclampsia

- Direction of undergraduate thesis: Biochemist Universidad de Antofagasta (1: 2014-2016), Biochemist PUC (2: 2016-2018; 2018-2019)
- Director of research units: Medicine PUC (6), Biochemist PUC (3), Nursing PUC (1), PhD in Medical Sciences PUC (2), PhD in Biological Sciences PUC (1)


Difusión y Transferencia


2011-2012 Explora (Club cientifico explorines para preescolares)
2012-2013 REDECs (Red de clubes científicos preescolares en 7 ciudades de Chile)
2013-2016 Club cientifico explorines para preescolares
2018 Taller de alimentación para parto saludable (San Felipe, Chile)


Premios y Distinciones

  •   Award for the best student of the career of biochemist

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2004

    .

  •   Award to the best work in the annual meeting of the Sociedad Chilena de cardiología y cirugía cardiovascular.

    SOCIEDAD CHILENA DE CARDIOLOGIA Y CIRUGIA CARDIOVASCULAR

    Chile, 2006

    .

  •   Award for the best research work

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2016

    Award for the best research work in the annual meeting of the obstetrics and gynecology division from the Pontifica Universidad Católica de Chile

  •   IFPA Award for middle career researchers

    International Federation of Placental Associations (IFPA)

    Argentina, 2019

    IFPA Award for middle career researchers in the are of placental biology


 

Article (67)

Association between maternal obesity, essential fatty acids and biomarkers of fetal liver function
Small extracellular vesicles from pregnant women with maternal supraphysiological hypercholesterolemia impair endothelial cell function in vitro
Aldosterone and renin concentrations were abnormally elevated in a cohort of normotensive pregnant women
Epigenetic Changes as a Possible Mechanism Leading to Increased Fetal Cardiovascular Disease Risk in Pregnancies with Gestational Diabetes Mellitus and/or Maternal Hypercholesterolemia
Human Placental Intracellular Cholesterol Transport: A Focus on Lysosomal and Mitochondrial Dysfunction and Oxidative Stress
Increased Circulating Levels of PCSK9 and Pro-Atherogenic Lipoprotein Profile in Pregnant Women with Maternal Supraphysiological Hypercholesterolemia
Primary Human Trophoblasts Mimic the Preeclampsia Phenotype after Acute Hypoxia-Reoxygenation Insult
The LDL receptor: Traffic and function in trophoblast cells under normal and pathological conditions
Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells
Effects of lipoproteins on endothelial cells and macrophages function and its possible implications on fetal adverse outcomes associated to maternal hypercholesterolemia during pregnancy
Increased Fetal Cardiovascular Disease Risk: Potential Synergy Between Gestational Diabetes Mellitus and Maternal Hypercholesterolemia
The polarized localization of lipoprotein receptors and cholesterol transporters in the syncytiotrophoblast of the placenta is reproducible in a monolayer of primary human trophoblasts
Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia
Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function
High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus
Maternal hypercholesterolemia during pregnancy: Potential modulation of cholesterol transport through the human placenta and lipoprotein profile in maternal and neonatal circulation
Foetoplacental epigenetic changes associated with maternal metabolic dysfunction
Human umbilical vein endothelium-derived exosomes play a role in foetoplacental endothelial dysfunction in gestational diabetes mellitus
Maternal dyslipidaemia in pregnancy with gestational diabetes mellitus: Possible impact on foetoplacental vascular function and lipoproteins in the neonatal circulation
Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature
Adenosine and preeclampsia
Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels
Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes
Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice
Insulin/adenosine axis linked signalling
Intracellular acidification increases adenosine transport in human umbilical vein endothelial cells
Maternal insulin therapy does not restore foetoplacental endothelial dysfunction in gestational diabetes mellitus
Molecular implications of adenosine in obesity
Preeclampsia associates with RECK-dependent decrease in human trophoblasts migration and invasion
Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer
A hypothesis for the role of RECK in angiogenesis
Are NHE1 and inducible nitric oxide synthase involved in human ovarian cancer?
Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus
Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus
Insulin requires A(1) adenosine receptors expression to reverse gestational diabetes-increased L-arginine transport in human umbilical vein endothelium
Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus
Modulation of intracellular ph in human ovarian cancer
Nitric oxide and pH modulation in gynaecological cancer
Nitric oxide is a central common metabolite in vascular dysfunction associated with diseases of human pregnancy
Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia
Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia
Cross-sectional and longitudinal lipid determination studies in pregnant women reveal an association between increased maternal LDL cholesterol concentrations and reduced human umbilical vein relaxation
Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T-84 Human Intestinal Epithelial Cells
Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction
Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium
Insulin restores L-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia
Insulin Reverses D-Glucose-Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells
Reduced L-Carnitine Transport in Aortic Endothelial Cells from Spontaneously Hypertensive Rats
Maternal Hypercholesterolemia in Pregnancy Associates With Umbilical Vein Endothelial Dysfunction Role of Endothelial Nitric Oxide Synthase and Arginase II
Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy
Mice long-term high-fat diet feeding recapitulates human cardiovascular alterations: an animal model to study the early phases of diabetic cardiomyopathy.
Role of equilibrative adenosine transporters and adenosine receptors as modulators of the human placental endothelium in gestational diabetes mellitus
Gestational Diabetes Reduces Adenosine Transport in Human Placental Microvascular Endothelium, an Effect Reversed by Insulin
Insulin-Increased L-Arginine Transport Requires A(2A) Adenosine Receptors Activation in Human Umbilical Vein Endothelium
New therapeutic approaches to treating hypertension in pregnancy.
Potential Role of Sodium-Proton Exchangers in the Low Concentration Arsenic Trioxide-Increased Intracellular pH and Cell Proliferation
Apolipoprotein A-I deficiency does not affect biliary lipid secretion and gallstone formation in mice
Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes mellitus or obesity in pregnancy.
Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes
Insulin Restores Gestational Diabetes Mellitus Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium
Insulin-Stimulated L-Arginine Transport Requires SLC7A1 Gene Expression and Is Associated With Human Umbilical Vein Relaxation
Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism.
Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes
Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones
Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones
PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function

Abstract (35)

ELEVETED MATERNAL LIPID LEVEL INCREASES CHOLESTEROL EFFLUX TO HDL IN HUMAN TROPHOBLAST BUT NOT IN PLACENTAL MICROVASCULAR ENDOTHELIAL CELLS
ENDOPLASMIC RETICULUM STRESS IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS FROM PRE-GESTATIONAL MATERNAL OBESITY
EXCESSIVE GESTATIONAL WEIGHT GAIN REDUCES THE RESPONSE TO VASOACTIVE MOLECULES IN HUMAN FETOPLACENTAL MICROVESSELS
HIGH D-GLUCOSE-INCREASED NITRIC OXIDE GENERATION LEADS TO HIGHER DEIODINASE 3 MRNA LEVEL IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
HUMAN MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA INCREASES THE EFFLUX OF CHOLESTEROL FROM PLACENTAL TROPHOBLAST AND MICROVASCULAR ENDOTHELIAL CELLS
HUMAN MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA LEADS TO ENDOTHELIAL DYSFUNCTION OF THE PLACENTAL MICROVASCULATURE
INCREASED MATERNAL LIPID LEVELS REDUCE THE PLACENTAL HDL AND LDL CHOLESTEROL UPTAKE IN HUMAN TROPHOBLAST
INSULIN RECOVERS ENDOTHELIAL DYSFUNCTION REQUIRING An ADENOSINE RECEPTOR ACTIVATION IN HUMAN UMBILICAL VEIN ENDOTHELIUM FROM LATE-ONSET PREECLAMPSIA
INSULIN THERAPY DOES NOT REVERSE GESTATIONAL DIABETES-ASSOCIATED FOETOPLACENTAL ENDOTHELIAL DYSFUNCTION
INSULIN THERAPY FAILS TO REVERSE THE HUMAN FOETOPLACENTAL ENDOTHELIAL DYSFUNCTION IN GESTATIONAL DIABETES MELLITUS
INSULIN THERAPY RESTORES THE EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 EXPRESSION IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS FROM GESTATIONAL DIABETES MELLITUS
MATERNAL OBESITY ASSOCIATES WITH FOETOPLACENTAL VASCULAR DYSFUNCTION INVOLVING ENDOPLASMIC RETICULUM STRESS AND ALTERED INSULIN VASCULAR REACTIVITY
MATERNAL SUPRAPHYSIOLOGICAL DYSLIPIDEMIA IN PREGNANCY WORSE VASCULAR RESPONSE OF UMBILICAL VEIN RINGS FROM GESTATIONAL DIABETES MELLITUS
MODULATION OF THE PLACENTAL HDL AND LDL CHOLESTEROL UPTAKE BY THE MATERNAL LIPIDS LEVEL IN HUMAN TROPHOBLAST
NEONATAL HIGH-DENSITY LIPOPROTEIN FROM PREGNANCIES WITH MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA IMPAIRS NITRIC OXIDE SYNTHASE ACTIVITY IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
NHE1 MODULATES INTRACELLULAR PH AND CELL PROLIFERATION IN HUMAN OVARIAN CANCER
PREVALENCE OF MATERNAL SUPRAPHYSIOLOGICAL DYSLIPIDEMIA IN A GROUP OF CHILEAN PREGNANT WOMEN WITH GESTATIONAL DIABETES MELLITUS
RECIC EXPRESSION IS INDUCED IN PLACENTAS FROM PREECLAMPSIA AND REDUCES MIGRATION, INVASION, AND ENDOVASCULAR REMODELLING OF FIRST TRIMESTER HUMAN TROPHOBLAST
SODIUM/PROTON EXCHANGER SUBTYPE 1 REGULATES INTRACELLULAR PH IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS FROM GESTATIONAL DIABETES MELLITUS
GESTATIONAL DIABETES AND FETO-PLACENTAL ENDOTHELIAL DYSFUNCTION: ROLE OF EXOSOMES FROM HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS ON L-ARGININE/NO SIGNALLING PATHWAY
INSULIN RECEPTOR A AND A(1) ADENOSINE RECEPTORS EXPRESSION ARE REQUIRED TO RESTORE HUMAN FETOPLACENTAL ENDOTHELIAL FUNCTION IN GESTATIONAL DIABETES MELLITUS
INSULIN RESTORES L-ARGININE AND ADENOSINE TRANSPORT REQUIRING ADENOSINE RECEPTORS ESPRESSION IN HUMAN FETOPLACENTAL ENDOTHELIUM FROM GESTATIONAL DIABETES MELLITUS
INSULIN-INCREASED ENDOTHELIAL L-ARGININE/NO SIGNALLING PATHWAY REQUIRES A(2B) ADENOSINE RECEPTORS ACTIVATION IN HUMAN UMBILICAL VEIN ENDOTHELIUM FROM LATE-ONSET PREECLAMPSIA
MATERNAL SUPRAPHYSIOLOGICAL HYPERCOLESTEROLEMIA LEADS TO ENDOTHELIAL DYSFUNCTION OF THE HUMAN FETOPLACENTAL MACRO AND MICROVASCULATURE
OBESITY IN PREGNANCY ALTERS RECYCLING OF HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORT 1 (HENT1) IN HUMAN UMBILICAL VEIN ENDOTHELIUM FROM GESTATIONAL DIABETES
Insulin requires normal expression of insulin receptor A and A(1) adenosine receptors activation to reverse the gestational diabetes-increased L-arginine transport in human umbilical vein endothelial cells
MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA LEADS TO REDUCED NITRIC OXIDE SYNTHASE ACTIVITY ASSOCIATED WITH REDUCED LEVELS OF TETRAHYDROBIOPTERIN IN HUVEC
INVOLVEMENT OF A(2A) ADENOSINE RECEPTORS IN INSULIN-INCREASED L-ARGININE TRANSPORT IN HUMAN UMBILICAL VEIN ENDOTHELIUM
SREBP-1C AND HCHOP-C/EBP alpha INVOLVEMENT IN INSULIN MODULATION OF HENT2 ACTIVITY IN HUMAN PLACENTA MICROVASCULAR ENDOTHELIUM FROM GESTATIONAL DIABETES
Differential Expression of A and B Isoforms of Insulin Receptor Are Involved in the Insulin-Mediated Recovery of Gestational Diabetes to Normal Phenotype in Human Placental Microvascular Endothelium
INSULIN ACTIVATES EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2 INVOLVING INSULIN RECEPTOR A IN HUMAN PLACENTA MICROVASCULAR ENDOTHELIAL CELLS FROM GESTATIONAL DIABETES
INSULIN RECEPTOR A IS INVOLVED IN GESTATIONAL DIABETES-REDUCED ADENOSINE TRANSPORT VIA HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
Insulin Reverses Gestational Diabetes-Increased L-Arginine Transport Via A(2A) Adenosine Receptors Activation in Human Umbilical Vein Endothelium
Maternal Supraphysiological Hypercholesterolemia Leads to Reduced Endothelium-Dependent Vasodilation of Umbilical Vein and Increased L-Arginine Transport in HUVEC
THE LACK OF THE HDL RECEPTOR SR-BI AFFECTS EMBRYO CHOLESTEROL CONTENT AND NEURAL TUBE CLOSURE IN MICE

BookSection (6)

Oxidative stress in pregnancies complicated by diabetes
Transplacental transport of calcium in health and disease
Maternal Hypercholesterolemia in Gestational Diabetes and the Association with Placental Endothelial Dysfunction
The Adenosine–Insulin Signaling Axis in the Fetoplacental Endothelial Dysfunction in Gestational Diabetes
Fetoplacental vascular pathophysiology in preeclampsia
Maternal and fetal metabolic dysfunction in pregnancy diseases associated with vascular oxidative and nitrative stress

Proyecto (18)

Maternal Supraphysiological hypercholesterolemia: Extra Virgin Olive Oil as a nutritional intervention during pregnancy to reduce the impact of this maternal condition
Characterization of "gestational diabesity" as a pregnancy metabolic condition causing micro and macrovascular fetoplacental endothelial dysfunction via mechanisms that are different to those described for gestational diabetes or maternal obesity.
Maternal supraphysiological hypercholesterolemia in human pregnancy: contribution of lipoproteins and exosomes to vascular dysfunction of the mother and offspring at birth and later in childhood.
Effects of maternal supraphysiological dyslipidaemia in pregnancies with gestational diabetes mellitus: impact from the feto-placental vascular function to the lipoprotein function in the neonatal circulation.
Effects of maternal supraphysiological dyslipidaemia in pregnancies with gestational diabetes mellitus=> impact from the feto-placental vascular function to the lipoprotein function in the neonatal circulation
Enhanced Platelet Tissue Factor-Dependent Procoagulant Activity in Hypercholesterolemia and in Pregnancy Dyslipidemia: Inhibition by Statins, HDL-cholesterol and Tissue Factor Pathway Inhibitor
Enhanced Platelet Tissue Factor-Dependent Procoagulant Activity in Hypercholesterolemia and in Pregnancy Dyslipidemia=> Inhibition by Statins, HDL-cholesterol and Tissue Factor Pathway Inhibitor.
Role of RECK in preeclampsia development: as a key regulator of cytotrophoblast invasiveness and spiral arteries remodeling.
Role of RECK in preeclampsia development=> as a key regulator of cytotrophoblast invasiveness and spiral arteries remodeling
INVOLVEMENT OF PCSK9 IN ‘HUMAN MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA’. EFFECTS ON PLACENTAL CHOLESTEROL TRAFFIC AND FUNCTION OF NEONATAL LIPOPROTEINS.
Involvement of PCSK9 in ‘human maternal supraphysiological hypercholesterolemia’. Effects on placental cholesterol traffic and functionality of neonatal lipoproteins.
ROLE OF INSULIN RECEPTORS AND ADENOSINE RECEPTORS IN PREVENTION OF FETOPLACENTAL ENDOTHELIAL DYSFUNCTION BY INSULIN IN WOMEN WITH GESTATIONAL DIABETES MELLITUS.
International network for the study of feto-placental vascular dysfunction in diseases of pregnancy
INTERNATIONAL NETWORKING BETWEEN RESEARCH CENTERS
Effect of maternal supraphysiological hypercholesterolemia in pregnancy in the endothelial function and atherosclerosis of the human placenta vasculature
EFFECT OF MATERNAL SUPRAPHYSIOLOGICAL HYPERCHOLESTEROLEMIA IN PREGNANCY IN THE ENDOTHELIAL FUNCTION AND ATHEROSCLEROSIS OF THE HUMAN PLACENTA VASCULATURE
Characterization of the pathohysiological mechanisms, and detection of common therapeutic targets in placental dysfunction in pathologies of the human pregnancy.
Metabolismo hepático del colesterol HDL mediado por el receptor SR-BI=> aspectos básicos, mecanismos de regulación e implicancias fisiopatológicas y farmacológicas.

Review (6)

Insulin therapy and fetoplacental vascular function in gestational diabetes mellitus
Is a low level of free thyroxine in the maternal circulation associated with altered endothelial function in gestational diabetes?
Role of Insulin and Adenosine in the Human Placenta Microvascular and Macrovascular Endothelial Cell Dysfunction in Gestational Diabetes Mellitus
New therapeutic approaches to treating hypertension in pregnancy
Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy
Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism
118
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

80
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

37
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

21
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

17
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

12
Claudette Cantin

Investigador Postdoctoral

Universidad San Sebastián

Santiago, Chile

12
Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

12
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

9
Francisco Westermeier

Universidad de Chile

Santiago, Chile

9
Tamara Sáez

Postdoctoral fellow

Obstetrics and Gynecology

University of Alberta

Edmonton, Canada

8
MARCO RAMIREZ

Associate Professor

Universidad de Antofagasta

Antofagasta, Chile

8
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

7
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

6
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Delia Chiarello

Investigador

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

5
Fernando Abarzua

Assitant researcher

Universidad de La Frontera

Temuco, Chile

5
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

5
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

4
Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

3
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

3
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

3
Ana Beltrán

Profesor asociado

Educación

Universidad de Antofagasta

Antofagasta, Chile

2
Sebastián Gutiérrez

Asistente de Investigación

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

2
MARCELO CORNEJO

Académico

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Sebastián Calligaris

Cordinador de Estudios Clínicos

Clínica Alemana

Santiago, Chile

1
Alvaro Martínez

Director Asociado de Propiedad Intelectual y Transferencia Tecnológica

FUNDACIÓN CIENCIA PARA LA VIDA (FCV)

Santiago, Chile

1
Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
natalia rodriguez

Encargada de Programa de Prevencion y Control VIH/Sida e ITS, Servicio de Salud Ñuble

Direccion de Atención Primaria

Servicio de Salud Ñuble

Chillán, Chile

1
Carlos Veas

BIOQIUMICO

MEDICINA

HOSPITAL REGIONAL GUILLERMO GRANT BENAVENTE

CONCEPCION, Chile

1
Carmen Aravena

Acádemico

Universidad de Valparaíso

San Felipe, Chile

1
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Bastian Sobrevia

Médico en etapa de Destinación y Formación

Servicio de Salud del Reloncaví

Puerto Montt, Chile

1
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Emilce Diaz

Profesor Asociado

Biomédico

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

1
Erica Castro

Investigadora

Obstetricia y Puericultura

Universidad de Atacama

Copiapó, Chile

1
Maria Yañez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

1
Daniela Mennickent

Académica

Departamento de Ciencias Básicas

Universidad Católica de la Santísima Concepción

Concepción, Chile

1
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile