Img_0303.jpg_thumb90

Enrique Alberto Guzman Gutierrez

Profesor Asociado

Universidad de Concepción

Concepción, Chile

Líneas de Investigación


Diagnóstico prenatal; Diabetes Gestacional; hormonas tiroídeas

Educación

  •  Magíster en Bioquímica Clínica e Inmunología, UNIVERSIDAD DE CONCEPCION. Chile, 2010
  •  Magíster en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011
  •  Doctorado en Ciencias Biológicas mención Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2014
  •  Tecnólogo Médico con mención en Bioanálisis Clínico, Hematología y Banco de Sangre, UNIVERSIDAD DE CONCEPCION. Chile, 2007
  •  Biología molecular y Biomedicina, UNIVERSIDAD DE SEVILLA. España, 2014

Experiencia Académica

  •   Asistente Full Time

    UNIVERSIDAD SAN SEBASTIAN

    Ciencias de la Salud

    Concepción, Chile

    2014 - 2018

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CONCEPCION

    Farmacia

    Concepcion, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Profesor Asistente Part Time

    Universidad San Sebastian

    Concepcion, Chile

    2009 - 2010

  •   Tecnólogo Médico Full Time

    Hospital Clínico Herminda Martin

    CHILLAN, Chile

    2008 - 2009

  •   Profesor Investigador Full Time

    Universidad San Sebastián

    Concepcion, Chile

    2014 - 2018

  •   Profesor Asistente Full Time

    Universidad de Concepción

    Concepcion, Chile

    2018 - A la fecha


 

Article (18)

Maternal thyroid profile in first and second trimester of pregnancy is correlated with gestational diabetes mellitus through machine learning

Araya, Juan; Rodriguez, Andres; Lagos-SanMartin, Karin; Gutierrez-Vega, Sebastian; Ortega-Contreras, Bernel; Valderrama-Gutierrez, Barbara; Gonzalez, Marcelo

Article ISI
PLACENTA  (2021)

High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus

Armella A,; Loyola, Marco; , Ambart Ester Covarrubias Cisternas; Gonzalez, Marcelo; Ramos, MP

Article
PLOS ONE  (2020)

Role of proteases in dysfunctional placental vascular remodelling in preeclampsia

Gutierrez, Jaime A.; Salsoso, Rocio; Toledo, Fernando

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2020)

The activity of IKCa and BKCa channels contributes to insulin-mediated NO synthesis and vascular tone regulation in human umbilical vein

Rojas, Susana; Valdivia, Luz; Vallejos, Natalia; Ceballos, Karen; Rivas, Coralia; Escudero, Carlos; Toledo, Fernando; Cid, Marcela

Article SCOPUS
Nitric Oxide  (2020)

Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels

Cantin, C

Article ISI SCOPUS
MOLECULAR ASPECTS OF MEDICINE  (2017)

Insulin requires A(1) adenosine receptors expression to reverse gestational diabetes-increased L-arginine transport in human umbilical vein endothelium

Guzmán-Gutierrez, E; Armella A,; Toledo, F; Pardo, F; Leiva, A; Sobrevia, L

Article ISI SCOPUS
PURINERGIC SIGNALLING  (2016)

Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium

Westermeier, F; Salomon, C; Farias, M; Arroyo, P; Fuenzalida, B; Sáez, T; Salsoso, R; Sanhueza, C; Guzmán-Gutierrez, E; Pardo, F; et al.

Article ISI SCOPUS
FASEB Journal  (2015)

Insulin restores L-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia

Salsoso, R; Guzmán-Gutierrez, E; Sáez, T; Bugueño, K; Ramirez, M. A.; Farias, M; Pardo, F; Leiva, A; Sanhueza, C; Mate, A; et al.

Article ISI SCOPUS
PLACENTA  (2015)

Insulin Reverses D-Glucose-Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells

González M; Rojas, S; Avila, P; Cabrera, L; Villalobos, R; Palma, C; Aguayo, C; Peña, E; Gallardo, V; Guzmán-Gutierrez, E; et al.

Article ISI SCOPUS
PLOS ONE  (2015)

Maternal Hypercholesterolemia in Pregnancy Associates With Umbilical Vein Endothelial Dysfunction Role of Endothelial Nitric Oxide Synthase and Arginase II

Leiva, A; de Medina, CD; Salsoso, R; Sáez, T; San Martín, S; Abarzua, F; Farias, M; Guzmán-Gutierrez, E; Pardo, F; Sobrevia, L

Article ISI SCOPUS
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY  (2013)

Role of equilibrative adenosine transporters and adenosine receptors as modulators of the human placental endothelium in gestational diabetes mellitus

Pardo E.; Arroyo, P; Salomon, C; Westermeier, E; Salsoso, R; Sáez, T; Guzmán-Gutierrez, E; Leiva, A; Sobrevia, L

Article ISI SCOPUS
PLACENTA  (2013)

Gestational Diabetes Reduces Adenosine Transport in Human Placental Microvascular Endothelium, an Effect Reversed by Insulin

Salomon, C; Westermeier, F; Puebla, C; Arroyo, P; Guzmán-Gutierrez, E; Pardo, F; Leiva, A; Casanello, P; Sobrevia, L

Article ISI SCOPUS
PLOS ONE  (2012)

Insulin-Increased L-Arginine Transport Requires A(2A) Adenosine Receptors Activation in Human Umbilical Vein Endothelium

Guzmán-Gutierrez, E; Westermeier, F; Salomon, C; González M; Pardo, F; Leiva, A; Sobrevia, L

Article ISI SCOPUS
PLOS ONE  (2012)

Potential Role of Sodium-Proton Exchangers in the Low Concentration Arsenic Trioxide-Increased Intracellular pH and Cell Proliferation

Aravena, C; Cornejo, M; Torres, V; Guzmán-Gutierrez, E; Pardo, F; Leiva, A; Sobrevia, L; Ramirez, M. A.

Article ISI SCOPUS
PLOS ONE  (2012)

Insulin Restores Gestational Diabetes Mellitus Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium

Westermeier, F; Salomon, C; González M; Puebla, C; Guzmán-Gutierrez, E; Cifuentes, F; Leiva, A; Casanello, P; Sobrevia, L

Article ISI SCOPUS
DIABETES  (2011)

Insulin-Stimulated L-Arginine Transport Requires SLC7A1 Gene Expression and Is Associated With Human Umbilical Vein Relaxation

González M; Gallardo, V; Rodriguez, N; Salomon, C; Westermeier, F; Guzmán-Gutierrez, E; Abarzua, F; Leiva, A; Casanello, P; Sobrevia, L

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2011)

Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes

Sobrevia, L; Salomon, C; Westermeier, F; Puebla, C; Cifuentes, F; Guzmán-Gutierrez, E; Leiva, A; Casanello, P; Abarzua, F; Nien, J. K.

Article ISI SCOPUS
Placenta  (2011)

Differential expression of functional nucleoside transporters in non-differentiated and differentiated human endothelial progenitor cells

Guzmán-Gutierrez, E; Sandoval, C; NOVA, E; Vera, JC; Lamperti, L; Krause, B; Salomon, C; Sepúlveda, C; Aguayo, C; Sobrevia, L

Article ISI SCOPUS
PLACENTA  (2010)

Abstract (7)

GESTATIONAL DIABETES DECREASES TERMINAL VILLOUS VASCULATURE IN HUMAN PLACENTA

Venegas, A; Armella A,; Veas, C; Escudero, CA; González M; Sobrevia, L; Guzmán-Gutierrez, E

Abstract ISI
PLACENTA  (2015)

GESTATIONAL DIABETES DIFFERENTIALLY MODIFIES THYROID HORMONE TRANSPORTER EXPRESSION IN HUMAN PLACENTAL COTYLEDON

Armella A,; Venegas, A; Veas, C; Escudero, CA; González M; Sobrevia, L; Guzmán-Gutierrez, E

Abstract ISI
PLACENTA  (2015)

INSULIN RESTORES L-ARGININE AND ADENOSINE TRANSPORT REQUIRING ADENOSINE RECEPTORS ESPRESSION IN HUMAN FETOPLACENTAL ENDOTHELIUM FROM GESTATIONAL DIABETES MELLITUS

Sobrevia, L; Sáez, T; Salsoso, R; Silva, L; Villalobos, R; Araos, J; Naranjo, L; Guzmán-Gutierrez, E; Gutierrez, J; Sanhueza, C; et al.

Abstract ISI
PLACENTA  (2015)

Insulin requires normal expression of insulin receptor A and A(1) adenosine receptors activation to reverse the gestational diabetes-increased L-arginine transport in human umbilical vein endothelial cells

Sáez, T; Guzmán-Gutierrez, E; Salsoso, R; Pardo, F; Sanhueza, C; Leiva, A; Sobrevia, L

Abstract ISI
ANGIOGENESIS  (2014)

INVOLVEMENT OF A(2A) ADENOSINE RECEPTORS IN INSULIN-INCREASED L-ARGININE TRANSPORT IN HUMAN UMBILICAL VEIN ENDOTHELIUM

Guzmán-Gutierrez, E; Salomon, C; Westermeier, F; Arroyo, P; Pardo, F; Leiva, A; Sobrevia, L

Abstract ISI
PLACENTA  (2012)

Differential Expression of A and B Isoforms of Insulin Receptor Are Involved in the Insulin-Mediated Recovery of Gestational Diabetes to Normal Phenotype in Human Placental Microvascular Endothelium

Salomon, C; Westermeier, F; Guzman, E; Leiva, A; Casanello, P; Luis S

Abstract
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE  (2011)

ADENOSINE TRANSPORT IS MEDIATED BY DIFFERENT NUCLEOSIDE TRANSPORTERS IN NON-DIFFERENTIATED AND DIFFERENTIATED HUMAN ENDOTHELIAL PROGENITOR CELLS

Guzman, E; Lamperti, L; Salomon, C; Krause, B; Sobrevia, L; Aguayo, C

Abstract
PLACENTA  (2010)

BookSection (2)

Transplacental transport of calcium in health and disease

Sobrevia, Luis; Saez, Tamara; Fuenzalida, Bárbara; Salsoso, Rocio; Jawerbaum, Alicia; Vazquez, Mary C; Arroyo, Pablo; Guzman-Gutierrez, Enrique; Pardo, Fabian; Leiva, Andrea; et al.

BookSection
 (2014)

The Adenosine–Insulin Signaling Axis in the Fetoplacental Endothelial Dysfunction in Gestational Diabetes

Guzman-Gutierrez, Enrique; Arroyo, Pablo; Pardo, Fabian; Leiva, Andrea; Sobrevia, L; Sobrevia, L

BookSection
 (2013)

Proyecto (2)

Caracterización De Alteraciones Mecánicas Y Viscoelásticas De Membrana Plasmática Y Su Asociación Con Mecanismos De Síntesis De Óxido Nítrico E Hiperpolarización De Membrana En Células Vasculares Fetales Humanas Expuestas A Diabesidad Gestacional

Gonzalez, Marcelo

Proyecto
 (2021)

Caracterización De Los Sistemas Oxitocinérgico Y Tiroideo, En La Unidad Feto Placentaria Según Tipo De Parto

Contreras G Yolanda

Proyecto
 (2020)

Review (2)

Is a low level of free thyroxine in the maternal circulation associated with altered endothelial function in gestational diabetes?

Guzmán-Gutierrez, E; Veas, C; Leiva, A; Escudero, C; Sobrevia, L

Review ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2014)

Role of Insulin and Adenosine in the Human Placenta Microvascular and Macrovascular Endothelial Cell Dysfunction in Gestational Diabetes Mellitus

Guzmán-Gutierrez, E; Arroyo, P; Salsoso, R; Fuenzalida, B; Sáez, T; Leiva, A; Pardo, F; Sobrevia, L

Review ISI SCOPUS
MICROCIRCULATION  (2014)

1
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

2
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

2
Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Emilce Diaz

Profesor Asociado

Biomédico

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

1
Liliana Lamperti

Vicedecana

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE FARMACIA

Concepción, Chile

2
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

8
Marcelo González

Profesor Asociado

Obstetricia y Ginecología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

14
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

2
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

21
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

3
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

4
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

2
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

2
MARCO RAMIREZ

Associate Professor

Universidad de Antofagasta

Antofagasta, Chile

3
Fernando Abarzua

medico staff

obstetricia

Hospital Hernan Henriquez Aravena

Temuco, Chile

25
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

7
Francisco Westermeier

Universidad de Chile

Santiago, Chile

9
Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

31
Enrique Guzman

Profesor Asociado

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

5
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Estefania Nova

Associate Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

3
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

1
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

1
natalia rodriguez

Matrona - Gestión y Análisis de Proceso Asistencial- Ginecología No GES

Servicio de Obstetricia y Ginecología

Hospital Clínico Herminda Martin

Chillán, Chile

1
Juan Araya

Profesor Asociado

Análisis Instrumental

Universidad de Concepción

Concepción, Chile

1
Carmen Aravena

Acádemico

Universidad de Valparaíso

San Felipe, Chile

3
Carlos Veas

BIOQIUMICO

MEDICINA

HOSPITAL REGIONAL GUILLERMO GRANT BENAVENTE

CONCEPCION, Chile

1
Ana Beltrán

Profesor asociado

Educación

Universidad de Antofagasta

Antofagasta, Chile

1
Claudette Cantin

Profesor Asistente

Universidad San Sebastián

Puerto Montt, Chile

1
Sebastián Gutiérrez

Asistente de Investigación

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

5
Tamara Sáez

Postdoctoral fellow

Obstetrics and Gynecology

University of Alberta

Edmonton, Canada

1
Daniela Mennickent

Académica

Departamento de Ciencias Básicas

Universidad Católica de la Santísima Concepción

Concepción, Chile

1
MARCELO CORNEJO

Académico

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Roberto Villalobos

Académico

Facultad de Medicina

Universidad de Valparaíso

San Felipe, Chile