Man

Sebastián Enrique Illanes López

professor, Director of Reproductive Biology Laboratory

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Líneas de Investigación


Reproduction,pathophysiology and prediction of preeclampsia and preterm labor.

Educación

  •  Biology of Reproduccition, Universidad de los Andes. Chile, 2003
  •  Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 1995
  •  Obstetrics and Gynecology, universidad de los Andes. Chile, 2000
  •  Fetal Medicine, University of Bristol. Reino Unido, 2005

Experiencia Académica

  •   professor Full Time

    Universidad de los Andes

    Medicine

    Chile

    2013 - A la fecha

  •   Vicedean of Research Full Time

    universidad de los Andes

    Medicine

    Santiago, Chile

    2010 - 2014

  •   Honorary Associate Professor Other

    University of Queensland

    Australia

    2012 - A la fecha

Experiencia Profesional

  •   Professor Full Time

    Universidad de los andes

    Chile

    2013 - A la fecha

  •   Junior Lecturer Full Time

    Universidad de los andes

    Chile

    2000 - 2003

  •   Member of Perinatal Unit Other

    Clinica Davila

    Chile

    2005 - A la fecha

  •   Research Fellow Full Time

    University of Bristol

    Santiago, Chile

    2003 - 2005

  •   Honorary Research Fellow Full Time

    University of Bristol

    Santiago, Chile

    2005 - 2008

Formación de Capital Humano


Tesis Dirigidas:
1. Alexander Uamai. Tesis para el grado de Magister. University of Bristol. Molecular mechanisms involved in the Pathogenesis of Pre-Eclampsia and their use in the early detection of the condition. A critical Review of Literature. 2010
2. Fatima Firdous. Tesis para el grado de Magister. University of Bristol. Detection of streptococcus agalactiae in pregnant women. 2014.
3. Macarena Manriquez. Tesis para el grado de Magister. Universidad de los Andes. Asociación entre estado nutricional materno y crecimiento fetal intrauterino. 2014.
4. Roberto Araneda. Tesis para el grado de Magister. Universidad de Chile. Determinacion del papel de las microparticulas de Sincitotrofoblasto (STBM) como marcador precoz de disfunción endotelial en mujeres que presentan factores de riesgo para presentar preeclampsia. 2014.
5. Paula Valenzuela. Tesis de pregrado. Universidad Andrés Bello. Efecto de estrógeno (e2) y progesterona (p4) en las propiedades inmunomodulatorias de las células madres mesenquimales derivadas de fluido menstrual (mensc). 2015. Enmarcado en el Proyecto FONDECYT 1140119.
6. Rocio Salsoso. Tesis de Doctorado (PhD). Pontificia Universidad Católica de Chile. Regulación de la ruta l-arginina/no endotelial por receptores de insulina y de adenosina a2a y a2b en endotelio de vena umbilical humana en preeclampsia tardía. 2017.
7. Maria Farren. Tesis de Doctorado (PhD). University College Dublin. A Study of the Effect of Inositol on Women at risk of Developing Gestational Diabetes Mellitus. 2017.
8. Sebastian Venegas. Tesis de pregrado. Universidad de Chile. Efecto de Progesterona y Estradiol sobre la expresión de marcadores de implantación y propiedades de células madre endometriales obtenidas desde fluido menstrual. 2018. Enmarcado en el Proyecto FONDECYT 1140119.
9. Claudette Cantin. Tesis de Doctorado (PhD). Pontificia Universidad Católica de Chile. Caracterización y efectos de las ldl y hdl de mujeres con hipercolesterolemia durante el embarazo sobre la función vascular materna y la comunicación entre células endoteliales y macrófagos. 2019.

Tutorías:
1. Javier Caradeux; Fellow. Project: prediction of preeclampsia in the first trimester of pregnancy using a combination of variables combining maternal factors, Doppler of uterine arteries and blood pressure. Period 2009-2011. Source FONIS, Chile. Product of this work we published: First trimester prediction of early onset preeclampsia using demographic, clinical, and sonographic data: a cohort study. Prenat Diagn. 2013 Aug; 33:732-736. PMID: 23584890
2. Lara Monterio; Posdoctoral student. Project: The role of the aromatase pathway in 2-methoxyestradiol synthesis in the pathogenesis of preeclampsia. Period 2012-2013. Source Fondecyt, Chile. Product of this work we published: Placental aromatase is deficient in placental ischemia and preeclampsia. PLoS One. 2015 Oct 7; 10:e0139682. After his postdoctoral fellowship we started a second project: Role of FOXM1 in trophoblast invasion. Period 2018-2019. Source FONDECYT inicio, Chile. Product of this work we published: Reduced FOXM1 expression limits trophoblast migration and angiogenesis and is associated with preeclampsia. Reprod Sci. 2019 May; 26:580-590.
3. Alejandra Perez; postdoctoral student. Project: possible alteration in trophoblast-endothelial communication mediated by exosomes and miRNA, in preeclamptic patient. Period 2011-2012. Source Fondecyt, Chile.
4. Ignacio Valenzuela; Fellow. Project: we developed an early detection method based on the use of PCR to establish the use of an antibiotic prophylaxis to significantly reduce neonatal sepsis. Period 2012-2013. Source: FONDEF, Chile. Product of this work we published: Prevention of early-onset neonatal Group B streptococcal disease. Rev Obstet Gynecol. 2013; 6:63-68.
5. Paula Correa; Fellow. Project. prediction of gestational diabetes in the first trimester of pregnancy using maternal factors and biochemical biomarkers. Period 20014-2015. Source FONIS, Chile. Product of this work we published: First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study. J Perinat Med. 2019 Feb 25; 47:161-168.
6. Jose Galaz; Student. Project: evaluation of endothelial markers for prediction of FGR and PE. Product of this work we published: Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia. J Matern Fetal Neonatal Med. 2017 Mar;30(6):635-639
7. Yasna Palmeiro; Fellow. Project: evaluation of the impact of Chilean earthquake in neonatal outcomes. Product of this work we published: Effects of earthquake on perinatal outcomes: a Chilean register-based study. PLoS One. 2018 Feb 23; 13:e0191340.
8. Max Monckeberg; Fellow. Project: use of amniocentesis for management of bulging membranes. Product of this work we published: Patients with acute cervical insufficiency without intra-amniotic infection/inflammation treated with cerclage have a good prognosis. J Perinat Med. 2019 Jul 26;47:500-509.


Difusión y Transferencia


2019 Invited Speaker "Stress prenatal y neurodesarrollo” LXXIV Congreso anual de la Sociedad de Neurocirugía, Psiquiatría y eurología (SONESPYN) Puerto Varas, Chile. Nov 2019.
2019 Invited Speaker “Maternal brain-to-fetal brain communication mediated by small extracellular vesicles: A role in prenatal stress” 23rd International Conference on Prenatal Diagnosis and Therapy Singapore, Singapore. Sep 2019.
2019 Invited Speaker “First trimester gingival crevicular fluid placental alkaline phosphatase and the prediction of preeclampsia” 23rd International Conference on Prenatal Diagnosis and Therapy, Singapore, Singapore. Sep 2019.
2019 Invited Speaker "Predicción de patologías del embarazo en el primer trimestre”. Tópicos de Actualidad. Curso Dávila Santa María. Santiago, Chile. Jun 2019.
2018 Poster presentation: "Performance of First Trimester Screening of Preeclampsia Based on Uterine Artery Pulsatility Index and Maternal Risk Factors in Routine Clinical Care". International Society of Prenatal Diagnosis (ISPD) 22th International Conference, Amberes, Belgica. July 2018.
2018 Poster presentation: "Role of Amniocentesis in the Management of Cervical Insufficiency with Exposed Fetal Membranes in the Second Trimester of Pregnancy". International Society of Prenatal Diagnosis (ISPD) 22th International Conference, Amberes, Belgica. July 2018.
2017 Invited Speaker "Enfermedad periodontal; antigua relación nueva mirada”. CONGRESO FLASOG, Cancún, México. Nov 2017.
2017 Invited Speaker “Predicción DG que tan cerca estamos” CONGRESO FLASOG, Cancún, México. Nov 2017.
2017 Invited Speaker “Exámenes prenatales no invasivos”. CONGRESO FLASOG, Cancún, México. Nov 2017.
2017 Invited Speaker. "Fetal well-being in diabetic pregnancy”. Global Obstetrics Update 2017, Melbourne, Australia. Nov 2017.
2017 Invited Speaker. “Preclinical strategies for treating placental dysfunction”. International Federation of Placenta Associations (IFPA), Manchester, UK. Agu 2017.
2017 Poster presentation: "Plasmatic extracellular vesicles in first trimester of patients who develop spontaneous abortion. International Society of Prenatal Diagnosis (ISPD) 21th International Conference, San Diego, CA, USA, 9 - 12 July 2017.
2017 Poster presentation: "Implantation Properties of Endometrial Mesenchymal Stem Cells Isolated from Menstrual Fluid are Modulated by Menstrual Cycle Hormones". ISPD 21st International Conference on Prenatal Diagnosis. San Diego, CA, USA, 9 - 12 July 2017.
2017 Invited Speaker: "Periodontitis and pregnancy, una nueva mirada para una antigua relación. III Jornada de Investigación Clínica O&G. División de Obstetricia y Ginecología
Escuela de Medicina Pontificia Universidad Católica de Chile. Hotel Enjoy, Viña del Mar, Chile, May 3rd 2017.
2016 Invited Speaker: Diabetes, obesity and pregnancy: Deadly combination. XXI COMEGO. Mexico city, México, Jun 2016
2015 Invited speaker. “Fetal Programming”. 66 congreso Federación Mexicana de Colegios de Obstetricia y Ginecología (Femecog), Acapulco, Mexico, Nov 2015.
2015 Invited speaker. “Complications of pregnancy: clinical traslation of biomarkers”. International Federation of placental association meeting meeting (IFPA 2015), Brisbane, Australia, September 2015.
2015 Invited speaker. “Placental exosomes; good predictors of bad pregnancy outcomes?”. Workshop in exosomes, Karolinska institute, Stockholm, Sweden, June 2015.
2014 Invited speaker. “Exosomes as biomarkers in Biology of Reproduction”. Fetoscopy Meeting 2014, New York, USA.
2014 Invited speaker. “First trimester screening for adverse pregnancy outcomes: a reality?”, International Society of Prenatal Diagnosis (ISPD), 18th International Conference on Prenatal Diagnosis and Therapy, Brisbane, Australia, July.
2014 Invited speaker. “Prediction of preeclampsia: Pointing to the origin of the disease”, VII encuentro internacional de O & G, Pontificia Universidad Católica, Viña del Mar, Chile, April.
2013 Invited Speaker. “NIPD in pregnancy complications" and “exosomes, biomarkers of placental dysunction”. Consenso Latinoamericano en NIPD. Isla de Pascua. Dic, Chile.
2013 Invited Speaker. “Prenatal diagnosis without images”. XXXIV Congreso de la Sociedad Chilena de Obstetricia y Ginecología. Dic, Viña del Mar, Chile.
2013 Invited Speaker. “Prediction of preeclampsia: are we reaching the goal”. SICOG 2103 Singapore International Congress of Obstetrics & Gynaecology. Singapore August.
2013 Invited Speaker. “Non Invasive Prenatal Diagnosis for various diseases”. III Jornadas de Actualización en Obstetricia y Ginecología, jun 26th. Hotel Sheraton Santiago.
2013 Invited Speaker. “The embryo as a patient: Challenges for 21 century”. Inaugural Lecture of the academic year University of los Andes. Santiago, Chile. April.
2013 Invited Speaker. “Prediction of preeclampsia: pointing to the origin of the pathology”. I jornada de investigación clínico-básica en patologías del embarazo. Chillán, Santiago, Chile. April.
2012 Invited Speaker. “Non invasive prenatal diagnosis in the XXI century”. III Reunión Bienal ACOG-SOCHOG. Concepción, Chile. November.
2012 Invited Speaker. “Fetal programming: Rethinking the objectives of the specialty”. XLIII Reunión Nacional Anual FASGO 2012. Mendoza, Argentina. October.
2012 Invited Participant. “Biomarkers for the prediction of preeclampsia: metabolic pathways involved in 2-methoxyestradiol synthesis”. Fetoscopy Meeting 2012. Dublin, Ireland. October.
2012 Invited Speaker. “The role of methionine-homocysteine metabolism (MHM) in the physiopathology of preeclampsia (PE)”. Society of Gynecological Investigation 5th international summit meeting. Brisbane.


Premios y Distinciones

  •   sebastian Illanes

    University of Bristol

    Reino Unido, 2005

    Postgraduate training in England and with the support of the main Chilean funding agencies (Conicyt and Corfo),


 

Article (73)

A reasoned approach towards administering COVID-19 vaccines to pregnant women
Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and-9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus
Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia
Maternal exposure to a high-magnitude earthquake during pregnancy influences pre-reading skills in early childhood
Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle
Supplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis
The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction
Care of the Pregnant Woman with COVID-19 in Labor and Delivery: Anesthesia, Emergency cesarean delivery, Differential diagnosis in the acutely ill parturient, Care of the newborn, and Protection of the healthcare personnel
Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature.
Development and analytical validation of real-time PCR for the detection ofStreptococcus agalactiaein pregnant women
Diagnostic Performance of First Trimester Screening of Preeclampsia Based on Uterine Artery Pulsatility Index and Maternal Risk Factors in Routine Clinical Use
Increased Circulating Levels of Tissue-Type Plasminogen Activator Are Associated with the Risk of Spontaneous Abortion During the First Trimester of Pregnancy
Mechanisms and Evidence of Vertical Transmission of Infections in Pregnancy Including SARS-CoV-2
Routine screening for SARS CoV-2 in unselected pregnant women at delivery
Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia
Extracellular vesicle concentration in maternal plasma as an early marker of gestational diabetes
Normality Ranges of Menstrual Fluid Volume During Reproductive Life Using Direct Quantification of Menses with Vaginal Cups
Oral extracellular vesicles in early pregnancy can identify patients at risk of developing gestational diabetes mellitus
Patients with acute cervical insufficiency without intra-amniotic infection/inflammation treated with cerclage have a good prognosis
Small Extracellular Vesicles Released from Ovarian Cancer Spheroids in Response to Cisplatin Promote the Pro-Tumorigenic Activity of Mesenchymal Stem Cells
Ultrasound-Guided Extraction of Intrauterine Devices With Nonvisible Threads: 254 Consecutive Cases: An Effective, Noninvasive Technique
Effects of earthquake on perinatal outcomes: A Chilean register-based study
First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study
Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus
Reduced FOXM1 Expression Limits Trophoblast Migration and Angiogenesis and Is Associated With Preeclampsia
Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia
Oxidative damage and nitric oxide synthase induction by surgical uteroplacental circulation restriction in the rabbit fetal heart
Placental Exosomes as Early Biomarker of Preeclampsia: Potential Role of Exosomal MicroRNAs Across Gestation
Plasma cross-gestational sphingolipidomic analyses reveal potential first trimester biomarkers of preeclampsia
The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
Correlation between Maternal Characteristics during Early Pregnancy, Fetal Growth Rate and Newborn Weight in Healthy Pregnancies
Etiopathogenesis, prediction, and prevention of preeclampsia
Fetal programming and gestational diabetes mellitus
Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation
IFPA meeting 2015 workshop report II: mechanistic role of the placenta in fetal programming; biomarkers of placental function and complications of pregnancy
Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia
Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production1
Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction
Placental biomarkers and angiogenic factors in oral fluids of patients with preeclampsia
The Immunosuppressive Signature of Menstrual Blood Mesenchymal Stem Cells Entails Opposite Effects on Experimental Arthritis and Graft Versus Host Diseases
Applying SWATH Mass Spectrometry to Investigate Human Cervicovaginal Fluid During the Menstrual Cycle
NFAT5 Is Up-Regulated by Hypoxia: Possible Implications in Preeclampsia and Intrauterine Growth Restriction
Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia
A Gestational Profile of Placental Exosomes in Maternal Plasma and Their Effects on Endothelial Cell Migration
Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration
First-trimester uterine artery Doppler and adverse pregnancy outcome: a meta-analysis involving 55 974 women
Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200
Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy
Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnant pregnancy
Fas ligand(+) fallopian tube epithelium induces apoptosis in both Fas receptor(+) T lymphocytes and endometrial cells
First trimester prediction of early onset preeclampsia using demographic, clinical, and sonographic data: a cohort study
Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: a case control study
Levels of Key Enzymes of Methionine-Homocysteine Metabolism in Preeclampsia
Neonatal outcomes of pregnancies affected by haemolytic disease of the foetus and newborn and managed with intrauterine transfusion: a service evaluation
Porphyromonas gingivalis, Treponema denticola and toll-like receptor 2 are associated with hypertensive disorders in placental tissue: a case-control study
Preterm Labor: Understanding of the Mechanism Involved to Improve Prediction and Prevention
Fetal and neonatal alloimmune thrombocytopenia
Fetal evaluation of the modified-myocardial performance index in pregnancies complicated by diabetes
Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia
NFAT5 Is Activated by Hypoxia: Role in Ischemia and Reperfusion in the Rat Kidney
Pathogenesis of preeclampsia: The genetic component
Asociación entre periodontitis crónica, interleuquina -6 (IL-6) e índice de masa corporal (IMC) en embarazadas
Free fetal DNA levels in patients at risk of preterm labour
Increased free fetal DNA levels in early pregnancy plasma of women who subsequently develop preeclampsia and intrauterine growth restriction
Maternal and fetal serum transformed alpha-fetoprotein levels in normal pregnancy
Current aspects of the clinical management of haemolytic desease of the new born and foetus.
Determinación de sexo fetal mediante ADN libre fetal en plasma materno.
Early detection of cell-free fetal DNA in maternal plasma
Gestational-age-adjusted reference values for the modified myocardial performance index for evaluation of fetal left cardiac function
Maternal serum transformed alpha-fetoprotein levels in women with intrauterine growth retardation.
Comparison of different reference values of fetal blood flow velocity in the middle cerebral artery for predicting fetal anemia
Management of fetal growth restriction
Umbilical artery aneurysm: prenatal identification in three fetuses with trisomy 18

Abstract (19)

Early Prediction of Preeclampsia using Maternal Serum Total Cell Free DNA.
First Trimester Oral Extracellular Vesicles Characterization in Pregnancies Complicated by Gestational Diabetes Mellitus.
DETECTION OF CD63+MICRO-VESICLES, PLACENTAL ALKALINE PHOSPHATASE AND ANGIOGENIC MARKERS IN GINGIVAL CREVICULAR FLUID IN PREECLAMPTIC PATIENTS
FIRST TRIMESTER MULTIPARAMETRIC MODEL FOR GESTATIONAL DIABETES PREDICTION
Hypoxia Regulates the Response of Trophoblast-Derived Exosomes To Hyperglycemia and Displays a Difference Placental Exosome Profile in Plasma From Patients With Gestational Diabetes Mellitus.
Placenta-Derived Exosomes Promote Trophoblast Invasion and Spiral Arterial Remodeling - A Possible Role in the Physiopathology of Preeclampsia
Potential Role of Sphingosine Kinase-1 (SPHK1)/Sphingosine-1-Phosphate (S1P) Pathway in the Etiopathogenesis of Preeclampsia
CHARACTERISATION OF THE RELEASE OF PLACENTA-DERIVED EXOSOME IN GESTATIONAL DIABETES MELLITUS
Fluoxetine Treatment during Pregnancy: A Rat Model for Pregnancy Outcome under Antidepressant Use
Gestational-Age Variations in Placenta-Derived Exosome Bioactivity and Proteomic Profiling in Maternal Plasma during Normal Healthy Pregnancy
NFAT5 as a Novel Biomarker of Hypoxia: Role in Preeclampsia and Intra-Uterine Growth Restriction (IUGR)
PLASMA FROM FIRST TRIMESTER PRE-SYMPTOMATIC WOMEN WHO SUBSEQUENTLY DEVELOPED PREECLAMPSIA REDUCES EXTRAVILLOUS TROPHOBLAST CELLS MIGRATION, A POSSIBLE ROLE OF PLACENTAL-DERIVED PARTICLES
Aromatase Pathway Is Altered in Patients That Develop Preeclampsia (PE)
Hypoxia Increases Exosome Releases from Placental Mesenchymal Stem Cell (pMSC) and Promotes the Migration and Angiogenesis in Human Placental Microvascular Endothelial Cell (hPMEC).
INTRAUTERINE GROWTH RESTRICTION MODIFIES THE NORMAL GENE EXPRESSION IN KIDNEY FROM RABBIT FETUSES
PLACENTAL CELL-DERIVED EXOSOMES INCREASE IN MATERNAL CIRCULATION WITH GESTATIONAL AGE
Neonatal outcomes for pregnancies managed with intrauterine transfusion for haemolytic disease of the fetus and newborn
The RNA Levels of Keys Enzimes for the Methionine-Homocysteine Metabolism Are Elevated in Placenta of Preeclamptic (PE) Patients
SHORT CERVIX IS NOT CHARACTERIZED BY PLACENTAL APOPTOSIS: EXAMINING THE MATERNAL PLASMA FREE FETAL DNA (FFDNS) IN PATIENTS AT RISK FOR PRETERM LABOR

BookSection (9)

The Role of Placental Exosomes in Gestational Diabetes Mellitus
Clinical Management of Hemolytic Disease of the Newborn and Fetus
Fetal Therapy: Where Do We Stand
Genética y perinatología
Novel Screening Approaches for the Early Detection of Gestational Diabetes Mellitus
Restricción de crecimiento intrauterino
Inicio del Parto
Fetal therapy
Fisiología de la mama

EditorialMaterial (1)

Management of haemolytic disease of the foetus & newborn: Steps to improve the outcomes

Proyecto (22)

Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT)
Prenatal stress: maternal astrocyte-derived extracellular vesicles as a novel stress-transfer mechanism contributing to adverse offspring neurodevelopment
The pathogenic vicious cycle between periodontitis and gestational diabetes mellitus: communication via bacterial translocation and extracellular vesicles
Mirando al futuro: Efectos del estrés prenatal y perinatal asociado a la pandemia COVID-19 en el neurodesarrollo de niñas y niños de Chile
Role of mesenchymal stem cells in implantation and their contribution to the decidualization disorders present in preeclampsia
Validación de algoritmo multiparamétrico para la predicción temprana de Diabetes Gestacional mediante marcadores plasmáticos maternos
Fetal Assessment of Growth Study (FLAG II)
Diseño de un screening prenatal para el diagnóstico temprano de preeclampsia basado en la detección de biomarcadores placentarios y endoteliales en fluidos orales de embarazadas.
In vitro diagnostic for first trimester risk assignment of gestational diabetes
Early Screening of Pregnancy
Immunomodulatory characteristics of endometrial mesenchymal stem cells and their role in the etiopathogenesis of preeclampsia.
Possible alteration in trophoblast-endothelium communication mediated by exosomes and miRNA in preeclamptic patients.
Prediction of gestational diabetes in first trimester of pregnancy.
Prediction of preeclampsia using periodontal exosomes
Prediction of true preterm labor
The role of the aromatase pathway in 2-methoxyestradiol synthesis in the pathogenesis of preeclampsia.
Desarrollo de test de diagnostic molecular predictivo de parto premature en mujeres embarazadas
Intrauterine growth restriction induces changes in the embryonic kidney gene expression.
The methionine-homocysteine cycle and its effects on the metabolism of 2-methoxyoestradiol. The role of catechol-o-methyltransferase in the ethiopathogenesis of preeclampsia
Who’s at risk of preterm labour?
Prediction of pre-eclampsia in first trimester by combined maternal factors. Doppler of uterine arteries, blood pressure and biochemical markers of endothelial damage
Early detection of pre-eclampsia and intrauterine growth restriction by molecular death markers and apoptosis of trophoblastic cells in maternal plasma

Review (9)

Placental exosomes in normal and complicated pregnancy
Innate immune system and preeclampsia
Prediction Of Gestational Diabetes Early in Pregnancy: Targeting the Lorng-Term Complications
Preterm labour: association between labour physiology, tocolysis and prevention
The promising potent a of menstrual stem cells for antenatal diagnosis and cell therapy
Metabolic Pathways Involved in 2-Methoxyestradiol Synthesis and Their Role in Preeclampsia
Gestational Diabetes Mellitus: A Positive Predictor of Type 2 Diabetes?
Management of red cell alloimmunisation in pregnancy: the non-invasive monitoring of the disease
Noninvasive approach for the management of hemolytic disease of the fetus
118
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

14
Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

13
Lara Jorge

Profesora Asistente

Centro de Investigación e Innovación Biomédica

Universidad de los Andes

Santiago, Chile

11
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

7
Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

6
Valeria Ramirez

Profesor asistente

Universidad de Los Andes

Santiago, Chile

5
Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

5
Stephanie Acuña

Asistente de Investigación

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

5
Pia Venegas

Asesora Técnica

Enfermedades No Transmisibles

Ministerio de Salud

Santiago, Chile

5
Maroun Khoury

A/Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

4
Juan Kusanovic

Jefe CIMAF

Obstetricia y Ginecología

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

3
Francisco Valenzuela

Academico

Ciencias Básicas

UNIVERSIDAD DEL BÍO BÍO

Chillan, Chile

3
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

3
Yasna Palmeiro

PGTA; Student Researcher

Institute for Global Health

University College London

London, Reino Unido

3
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

3
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Mauricio Lozano

Asistente de Investigación

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

3
Paula Correa

Profesor instructor

oBSTETRICIA Y gINECOLOGÍA

UNIVERSIDAD DE LOS ANDES

SANTIAGO, Chile

3
antonio quintero

Profesor Asociado

Periodoncia e Implantología Oral

Universidad de los Andes

Santiago, Chile

2
javier caradeux

Médico Staff Obstetricia & Ginecología y Urgencia Maternidad

Obstetricia y Ginecología

Clínica Dávila

Santiago, Chile

2
Flavio Carrion

Director Científico, Programa de Inmunología Traslacional. Director Doctorado en Ciencias e Innovación en Medicina. ICIM, Facultad de Medicina

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

1
Manuel Donoso

JEFE DE DEPARTAMENTO

Departamento de Obstetricia, Ginecología y Biología de la Reproducción

UNIVERSIDA DE LOS ANDES

SANTIAGO, Chile

1
Eduardo Gratacos

Director

Centro Ceres

Centro Ceres

Quillota, Chile

1
Max Monckeberg

Profesor Investigador.

Ginecología Obstetricia y Biología de la Reproducción.

Universidad de Los Andes.

Santiago, Chile

1
gabriela zavala

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

1
Jorge Cifuentes

Investigador

Universidad de Los Andes

Santiago, Chile

1
Patricia Luz

Profesor asistente

Universidad de los Andes

Santiago , Chile

1
Sergio Mella

Profesor Asociado

Medicina Interna

Universidad de Concepción

Concepción, Chile

1
Claudio Figueroa

Profesor Asistente

Ciencias Biológicas y Quimicas

Universidad San Sebastian

Santiago, Chile

1
Felipe Reyes

Associate profesor - Head of UAB Fish transcriptomics platform

Universitat Autònoma de Barcelona

Barcelona, España

1
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

1
Kevin Maisey

Profesor Asistente

Centro de Biotecnología Acuícola

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Charlotte Hill

PhD(c)

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
edgardo corral

jefe servico de gineco obstericia

obstetricia y ginecologia

hospital regional de rancagua

rancagua , Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
carolina inostroza

investigador

Universidad de Los Andes

Santiago, Chile

1
Rodrigo Acuña

Profesor Asistente Investigador

Medicina

Universidad del Desarrollo

Santiago, Chile

1
Emma Hernandez

Académico 44 h, profesor titular

Oral Patology and Medicine

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

1
Maria Repetto

Profesor Titular

Center for Genetics and Genomics

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Abel Vasquez

Jefatura de Sección

Salud Ambiental

Instituto de Salud Publica de Chile

Santiago, Chile

1
Daniel Escobar

PROFESIONAL

SALUD AMBIENTAL

INSTITUTO DE SALUD PÚBLICA DE CHILE

SANTIAGO, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
RICARDO MANZO

PROFESIONAL

SALUD AMBIENTAL

INSTITUTO SALUD PUBLICA DE CHILE

SANTIAGO, Chile

1
Gino Nardocci

Investigador / Profesor Asistente

Universidad de Los Andes

Santiago, Chile

1
Reyna Peñailillo

Postdoctorado

Centro de Investigación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Anilei Hoare

Profesora Asistente

Medicina y Patología Oral

Universidad de Chile

SANTIAGO, Chile

1
Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile