Man

Luis Federico Batiz

Full Professor

Universidad de Los Andes

Santiago, Chile

Líneas de Investigación


1- Neurogenesis and CNS development 2- Extracellular vesicles (exosomes) 3- Prenatal stress 4- Cell biology of neural stem cells 5- Neuropathology of neuropsychiatric disorders 6- Biomarkers

Educación

  •  Medical Doctor, MD, Universidad Nacional de Cuyo. Argentina, 1999
  •  Master of Science, MSc (Cell Biology), Universidad Austral de Chile. Chile, 2003
  •  Doctor in Science, PhD (Cellular & Molecular Biology), UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2008

Experiencia Académica

  •   Academic Assistant (Category II) Part Time

    UNIVERSIDAD NACIONAL DE CUYO

    Medical Sciences

    Mendoza, Argentina

    1995 - 1998

  •   Academic Assistant (Category I) Part Time

    UNIVERSIDAD NACIONAL DE CUYO

    Medical Sciences

    Mendoza, Argentina

    1999 - 1999

  •   Academic Assistant Part Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Medicine

    Valdivia, Chile

    2001 - 2002

  •   Assistant Professor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Medicine

    Valdivia, Chile

    2008 - 2013

  •   Associate Professor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Medicine

    Valdivia, Chile

    2013 - 2016

  •   Associate Professor Full Time

    UNIVERSIDAD DE LOS ANDES

    Medicine

    Santiago, Chile

    2016 - 2022

  •   Full Professor Full Time

    UNIVERSIDAD DE LOS ANDES

    Medicine

    Santiago, Chile

    2022 - A la fecha

Experiencia Profesional

  •   Director of the Honors Program in Research (PHIM). Faculty of Medicine Other

    Universidad Austral de Chile

    Valdivia, Chile

    2009 - 2016

  •   Member of the Honors Programs Council Other

    Universidad Austral de Chile

    Valdivia, Chile

    2012 - 2016

  •   Director. Center for Interdisciplinary Studies on the Nervous System Other

    Universidad Austral de Chile

    Valdivia, Chile

    2012 - 2016

  •   Director PhD Program in Biomedicine Other

    Universidad de los Andes

    Santiago, Chile

    2016 - 2023

  •   Director. Centro de Investigación Biomédica (CIB) Other

    Universidad de los Andes

    Santiago de Chile, Chile

    2016 - A la fecha

  •   Co-Director PhD Program in Biomedicine Other

    Universidad de los Andes

    Santiago, Chile

    2023 - A la fecha

Formación de Capital Humano


Undergraduate students (Finished)
Supervisor (Thesis)
2018 Martin Held N. Caracterización de las alteraciones en el desarrollo cerebelar en un modelo mutante para la proteína alfa-SNAP. School of Chemistry and Pharmacy. Universidad Austral de Chile. Supervisor.
2017 Melisa Aravena A. Rol de alfa-SNAP en el desarrollo y plasticidad pancreática. School of Medical Technology. Universidad Austral de Chile. Supervisor.
2016 Bryan G. Hinrichsen M. Consecuencias de la mutación hyh (M105I) en la estructura y función de alfa-SNAP: estudios de dinámica molecular e interacción proteína-proteína. School of Biochemistry. Universidad Austral de Chile. Supervisor.
2014 Cristian A. Parga F. Consecuencias de la mutación M105I de alfa-SNAP en su interacción con membranas lipídicas. School of Biochemistry. Universidad Austral de Chile. Supervisor.
2014 Silvia Loreto Ojeda T. Caracterización de la interacción proteína-proteína de alfa-SNAP y sus consecuencias frente a la mutación M105I. School of Biochemistry. Universidad Austral de Chile. Supervisor.
2013 Alexis Arcos B. Rol de ?-SNAP en el mantenimiento de las uniones adherentes mediadas por N-cadherina y la sobrevida de las células de la granulosa de folículos ováricos. School of Medical Technology. Universidad Austral de Chile. Supervisor.
2012 Camilo A. Muñoz C. Estudio de las consecuencias de la mutación puntual M105I en la proteína alfa-SNAP en su capacidad de interacción con membrana plasmática. School of Medical Technology. Universidad Austral de Chile. Supervisor.
2012 Guillermo Márquez S. Distribución subcelular de N-cadherina y alfa-SNAP durante el desarrollo cerebral de ratones wild type y mutantes hyh. School of Medical Technology. Universidad Austral de Chile. Supervisor.

Supervisor (Honors Program in Medical Research)
2018 Joaquín Daszenies and León Raposo. Alfa-SNAP como factor clave en el proceso de invasión y metástasis de células tumorales. Honors Program in Research of the Faculty of Medicine. Universidad Austral de Chile. Supervisor.
2017 Camila Santiagos. Rol de alfa-SNAP en el proceso neurogénico de las células de Purkinje y el desarrollo del cerebelo. Honors Program in Research of the Faculty of Medicine. Universidad Austral de Chile. Supervisor.
2015 Pedro de la Fuente and Alexis Delgado. Estudio del desarrollo neocortical en ratones hyh mutantes para alfa-SNAP. Honors Program in Research of the Faculty of Medicine. Universidad Austral de Chile. Supervisor.
2015 Diego Gianetti. Rol de alfa-SNAP en el desarrollo de la retina. Honors Program in Research of the Faculty of Medicine. Universidad Austral de Chile. Supervisor.
2014 Cristian Fernandoi and Tomás Contreras. Estudio de las consecuencias de la mutación M105I de alfa-SNAP en la secreción de insulina y la homeostasis de la glucosa in vivo. Honors Program in Research of the Faculty of Medicine. Universidad Austral de Chile. Supervisor.

Advisor (Committee)
2016 Isidora I. Vicencio Andaur. Participación de huntingtina en la secreción de exosomas astrogliales. School of Biochemistry. Universidad Austral de Chile. Advisor
2016 Dayana E. Pérez A. Ácido fosfoascórbico como un agente neuroprotector de la Enfermedad de Huntington. School of Biochemistry. Universidad Austral de Chile. Advisor.
2014 Nancy P. Pineda M. El enriquecimiento ambiental produce cambios moleculares y morfológicos en el cerebro de un modelo murino de Sindrome de Rett. School of Biochemistry. Universidad Austral de Chile. Advisor.
2014 Esteban A. Corales T. Caracterización de sitios de unión para señales de destinación en la subunidad ?2 del complejo adaptador de proteínas AP-2. School of Biochemistry. Universidad Austral de Chile. Advisor.
2014 Pamela J. Garrido G. Modulación del transporte de potasio astrocitario por alzas de potasio extracelular. School of Biochemistry. Universidad Austral de Chile. Advisor.
2014 Paulina B. Troncoso E. Estudio de posibles vías de salida de ácido ascórbico desde astrocitos. School of Biochemistry. Universidad Austral de Chile. Advisor.
2013 Irma Karen Lopez C. Expresión del canal de potasio Kir 7.1 y del intercambiador NHE3 en ratones nulos para TASK2. School of Biochemistry. Universidad Austral de Chile. Advisor.
2013 Felipe J. Baeza L. Modulación aguda del metabolismo de glucosa por efecto del lactato en neuronas del bulbo olfatorio. School of Biochemistry. Universidad Austral de Chile. Advisor.
2012 Magdalena A. Esparza C. Estudio de la disponibilidad del transportador de ácido ascórbico, SVCT2, en la membrana plasmática. School of Biochemistry. Universidad Austral de Chile. Advisor.
2012 Melissa V. Hott O. Expresión de la proteína asociada con plasticidad neuronal ARC en células de neuroblastoma y neuronas corticales infectadas con HSV-1. School of Biochemistry. Universidad Austral de Chile. Advisor.
2012 Patricia A. Ojeda P. La deleción de MECP2 en corticotropos y melanotropos de la glándula pituitaria contribuye al desarrollo del fenotipo asociado al síndrome de Rett. School of Biochemistry. Universidad Austral de Chile. Advisor.

Graduate Students (Finished)
Master Thesis
Advisor (Committee)
2014 Ilse Pamela Alonso V. Efectos postnatales de cronodisrupción gestacional: studio de epimutaciones en promotores génicos asociados a mecanismos fisiopatológicos. Magíster en Neurociencias. Facultad de Medicina. Universidad Austral de Chile. Advisor.

PhD Thesis
Supervisor
2019 Felipe A. Bustamante B. Nuevas aproximaciones a la patogenia de las enfermedades del neurodesarrollo: roles no canónicos de alfa-SNAP en la neurobiología de las células madre neurales. PhD Program in Medical Science. Universidad Austral de Chile. Supervisor
2018 María Paz Miró P. Rol de alfa-SNAP en la homeostasis de la glucosa: consecuencias de la mutación M105I de alfa-SNAP en la liberación de insulina y disponibilidad de GLUT4 en membrana plasmática. PhD Program in Cellular & Molecular Biology. Universidad Austral de Chile. Supervisor.

Advisor (Committee)
2017 Claudia P. Yefi R. Rol de ERAD en la biogénesis lisosomal y autofagia: un mecanismo clave en la plasticidad celular. PhD Program in Veterinar Sciences. Universidad Austral de Chile. Advisor.
2016 Anita Plaza F. Efecto del transplante de células madre mesenquimales alogénicas en la progresión del carcinoma oral de células escamosas en estadio de displasia: evaluación pre-clínica. PhD Program en Medical Science. Universidad Austral de Chile. Advisor
2016 Felipe A. Beltrán G. Participación de ácido ascórbico en la falla metabólica asociada a la enfermedad de Huntington. PhD Program in Cellular & Molecular Biology. Universidad Austral de Chile. Advisor.
2015 Tamara F. Sotelo H. Mecanismos de estimulación de la liberación de lactato por tanicitos en respuesta a un aumento de la glucosa extracelular. PhD Program in Cellular & Molecular Biology. Universidad Austral de Chile. Advisor.
2015 Hugo A. Roa R. Rescate fenotípico del ratón nulo para el canal de potasio TASK2 (K2p5.1) por expresión de su secuencia silvestre, y evaluación de las mutantes puntuales TASK2 R224A Y TASK2 K245A, en el túbulo proximal de riñón. PhD Program in Cellular & Molecular Biology. Universidad Austral de Chile. Advisor.
2014 Marianne Rivas B. Efecto de la concentración de glucosa sobre la expresión de genes inducidos por vasopresina en células musculares lisas. PhD Program in Cellular & Molecular Biology. Universidad Austral de Chile. Advisor.


Difusión y Transferencia


Papers at National Meetings (since 2012)
1- Acuña DA, Márquez GC, Toro GC, Miró MP, Ojeda L, Parga C, Muñoz CA, Cavieres V, Burgos PV, Muñoz RI, Bátiz LF (2015). Defects in N-cadherin-based adherens junctions of radial glial cells precedes disruption of the ventricular zone in ?-SNAP mutant mice. II International Symposium “Cancer and Inflammation: from adherens junctions to disease”. Valdivia, Chile.
2- Held M, Santiagos C, Albornoz G, Lema C, Riadi M, Rojas J, Salgado F, Rojas F, Forttes I, Acuña DA, Batiz LF (2015). Role of ?-SNAP in the development of the cerebellum. II International Symposium “Cancer and Inflammation: from adherens junctions to disease”. Valdivia, Chile.
3- Miró MP, Aravena M, Contreras T, Fernandoi C, Batiz LF (2015). Role of ?-SNAP on ‘in vivo’ glucose homeostasis: insights from a spontaneous mutant mouse model. II International Symposium “Cancer and Inflammation: from adherens junctions to disease”. Valdivia, Chile.
4- Hinrichsen B, Muñoz RI, Mardones G, Gonzalez W, Canan J, Acuña DA, Kähne T, Ojeda L, Batiz LF (2015). Interactome study of ?-SNAP in the central nervous system development and the M105I mutation. II International Symposium “Cancer and Inflammation: from adherens junctions to disease”. Valdivia, Chile.
5- Velásquez ZD, Miró MP, Acuña DA, Batiz LF (2015).The M105I mutation of ?SNAP increases the sensitivity to activate apoptosis through caspase-3 in mouse embryonic fibroblasts. II International Symposium “Cancer and Inflammation: from adherens junctions to disease”. Valdivia, Chile.
6- Miro MP, Fernandoi C, Contreras T, Batiz LF (2015). Role of ?-SNAP on glucose homeostasis: insights from an in vivo model. XXVIII Annual Meeting of the Chilean Society for Cell Biology. Puerto Varas, Chile.
7- Velasquez ZD, Arcos A, Gianetti D, Toro GC, De Paola M, Michaut MA, Batiz LF (2013). Alpha-SNAP regulates N-cadherin-based adherens junctions and survival of granulosa cells: insights from an in vivo model. XXVII Annual Meeting of the Chilean Society for Cell Biology. Puerto Varas, Chile.
8- Muñoz C, Márquez G, Toro G, Batiz, LF (2012). La mutación espontánea M105I de alfa-SNAP altera la capacidad de interacción con membranas de la proteína. II Jornadas de Investigación de la Facultad de Medicina - Universidad Austral de Chile. Valdivia, Chile.
9- Márquez G, Toro G, Muñoz C, Batiz LF (2012). Rol de alfa-SNAP en la formación/estabilidad de las uniones adherentes dependientes de N-cadherina durante el desarrollo del SNC. II Jornadas de Investigación de la Facultad de Medicina - Universidad Austral de Chile. Valdivia, Chile.
10- Toro G, Muñoz C, Márquez G, Ross B, Mardones G, Bátiz LF (2012). The M105I mutation of ?SNAP reduces its brain membrane binding properties. XXVI Annual Meeting of the Chilean Society for Cell Biology. Puerto Varas, Chile.

Papers at International Meetings (since 2012)
1- Velásquez ZD, Held M, Miró MP, Jara MC, Bustamante F, Acuña D, Muñoz RI, Bátiz LF (2016). Alpha-SNAP is involved in the formation/stabilization of N-cadherin-based adherens junctions and survival of neural stem cells. 2nd FALAN Congress. Buenos Aires, Argentina.
2- Held M, Santiagos S, Albornoz G, Lema C, Riadi M, Rojas J, Salgado F, Rojas F, Forttes I, Acuña D, Muñoz RI, Bátiz LF (2016). Role of ?-SNAP in the development of the cerebellum. 2nd FALAN Congress. Buenos Aires, Argentina.
3- Hinrichsen B, Parga C, Muñoz RI, Canan J, Acuña D, Ojeda L, Mardones G, Gonzalez W, Kähne T, Batiz LF (2016). The hyh (M105I) mutation of ?-SNAP alters its protein- and lipid-binding properties in the developing central nervous system. 2nd FALAN Congress. Buenos Aires, Argentina.
4- Acuña DA, Márquez G, Toro G, Muñoz C, Miró MP, Velásquez ZD, Ojeda L, Cavieres V, Burgos PV, Muñoz RI, Bátiz LF (2016). Mutant alpha-SNAP (M105I) alters subcellular distribution of N-cadherin and provokes disruption of embryonic brain ventricular zone. 2nd FALAN Congress. Buenos Aires, Argentina.
5- Batiz LF, Acuña DA, Velasquez ZD, Muñoz RI, Miro MP, Hinrichsen BG,; Roquero-Mañueco MC, Marquez GC, Muñoz CA, Cavieres VA, Mardones GA, Kaehne T, Jimenez AJ, 13; Burgos PV (2015). Role of alpha-SNAP in the maintenance of N-cadherin-based adherens junctions during brain developmentrio. 9th World Congress International Brain Research Organization (IBRO). Rio de Janeiro, Brazil.
6- De Paola MM; Cappa AI; Rinaldini E; Batiz, LF; Michaut MA (2015).La mutación M105I en ?SNAP produce múltiples defectos en la fertilidad de hembras hyh. III Reunión Conjunta de Sociedades de Biología de la República Argentina. San Miguel de Tucumán, Argentina.
7- Miró MP, Aravena M, Fernandoi C, Contreras T, Batiz LF (2015). Role of ?-SNAP on glucose homeostasis: insights from an in vivo model., XXXVIII Anual meeting of the Sociedad Española de Bioquímica y Biología Celular (SEBBM) Valencia, Spain.
8- Velásquez ZD., Miró MP., Acuña D., Bátiz LF (2015). M105I mutation of ?SNAP increases the sensitivity to activate apoptosis through caspase-3 in mouse embryonic fibroblasts. XXXVII Anual meeting of the Sociedad Española de Bioquímica y Biología Celular (SEBBM). Valencia, Spain
9- Parga C, Muñoz C, Vivar JP, Marquez G, Toro G, Miro MP, Muñoz RI, Brauchi S, Batiz LF (2015). The M105I (hyh) mutation of alpha-SNAP reduces its membrane lipid-binding properties. EMBO Workshop: Current Advances in Membrane Trafficking: Implications for Polarity and Diseases. Puerto Natales, Chile.
10- Miró MP, Aravena M, Fernandoi C, Contreras T, Batiz LF (2015). Role of ?-SNAP on glucose homeostasis: insights from an in vivo model., EMBO Workshop: Current Advances in Membrane Trafficking: Implications for Polarity and Diseases. Puerto Natales, Chile.
11- Miró MP, Velásquez ZD, Parga C, Márquez G, Toro GC, Arcos A, Muñoz C, Cavieres V, Muñoz RI, Mardones G, Burgos PV, Batiz LF (2014). Defects in N-cadherin-based adherens junctions precede disruption of neural stem cells in alpha-SNAP mutant mice. 20th Biennial Meeting of the International Society for Developmental Neuroscience. Montreal, Canada.
12- Batiz LF, Marquez G, Toro GC, Arcos A, Velasquez ZD, Miro MP, Ojeda SL, Parga C, Muñoz C, Cavieres V, Burgos PV, Muñoz RI (2013). Defects in N-cadherin-based adherens junctions of radial glial cells precede disruption of the ventricular zone in alpha-SNAP mutant mice. Neuroscience 2013, Society for Neuroscience. San Diego, USA.
13- Velasquez Z, Toro GC, Marquez G, Muñoz C, Parga C, Ojeda SL, Miro MP, Oliver C, Gonzalez CA, Muñoz RI, Batiz LF (2013). Role of membrane trafficking and adherens junctions during fetal and neonatal brain development: insights from in vivo and in vitro models. 40th Annual Meeting of the Fetal and Neonatal Physiological Society. Puerto Varas, Chile.
14- Parga C, Ojeda SL, Toro GC, Muñoz CA, Marquez GC, Muñoz RI, Mardones G, Batiz LF (2013). Biochemical consequences of hyh (M105I) mutation on alpha-SNAP protein durng brain development. XII Congress of the Panamerican Association for Biochemistry and Molecular Biology (PABMB). Puerto Varas, Chile.
15- De Paola MM, Arcos A, Bello OD, Cappa AI, Rinaldi E, Mayorga LS, Batiz LF, Michaut MA (2013). Analysis of alpha-SNAP/NSF complex in the mouse oocyte physiology. XII Congress of the Panamerican Association for Biochemistry and Molecular Biology (PABMB). Puerto Varas, Chile.
16- Arcos A, Toro G, Gianetti D, de Paola MM, Michaut MA, Bátiz LF (2012). Role of ?-SNAP in the maintenance of N-cadherin-based adherens junctions in mouse ovarian follicle. XLVII Reunión Anual de la Sociedad Argentina de Investigación Bioquímica y Biología Molecular (SAIB). Mendoza, Argentina.
17- Batiz LF, Muñoz CA, Márquez GC, Toro GC, Ross B, Acuña D, Burgos P, Mardones G (2012). Role of alpha-SNAP in brain development: Consequences of hyh (M105I) mutation on protein function. Neuroscience 2012, Society for Neuroscience. New Orleans, USA.
18- Batiz LF, Oliver C, Gonzalez CA, Alvial G, Flores CA, Rodriguez EM (2012). N-cadherin function in ependymal cells survival. Gordon Research Conferences: Signaling by Adhesion Receptors. Waterville, USA.

Organization of National/International Meetings (since 2012)
- 2012 Organizer of the Jornadas de Investigación de la Facultad de Medicina. Valdivia, Chile
- 2013 / 2015 Co-organizer of the International Symposium “Cancer and Inflammation: from adherens junctions to disease”. Valdivia, Chile.
- 2013-2016 Organizer of the CISNe-UACh Symposiums. Valdivia, Chile.
- 2017 Co-organizer of the II Jornadas Científicas en Salud - Facultad de Medicina, Universidad de los Andes. Santiago, Chile.


Premios y Distinciones

  •   Undergraduate Students Research Fellowship.

    Universidad Nacional de Cuyo

    Argentina, 1997

    Honor to distinguished undergraduate students of the School of Medicine to perform research activities.

  •   Undergraduate Students Research Fellowship

    Universidad Nacional de Cuyo

    Argentina, 1998

    Honor to distinguished undergraduate students of the School of Medicine to perform research activities.

  •   Best Undergraduate Student Research Paper

    Argentinian Federation of Cardiology

    Argentina, 1998

    Award to the best paper from undergraduate students during the XVII National Congress of Cardiology. Rosario, Argentina.

  •   Graduate Student Fellowship (MSc Program)

    Ministerio de Cultura y Educacion. Gobierno de Argentina.

    Argentina, 1999

    Fellowship of the "Fondo para el mejoramiento de la calidad de la Educacion superior (FOMEC)". Ministry of Culture and Education. Argentina.

  •   Academic Assistant Fellowship

    UNIVERSIDAD AUSTRAL DE CHILE

    Chile, 2001

    Fellowship from the Direccion de Estudios de Postgrado (Graduate Studies Direction). Universidad Austral de Chile.

  •   Graduate Student Fellowship (PhD Program)

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2003

    4-year fellowship to perform PhD studies. National Commission for Scientific and Technological Research (CONICYT-Chile).

  •   Best Research Paper in Neurosciences

    Sociedad Chilena de Neurocirugía

    Chile, 2004

    Award to the best paper in Neurosciences from the Chilean Society for Neurosurgery (CSN). XLVII Congress of the CSN, Viña del Mar, Chile.

  •   CONICYT Travel Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2005

    Fellowship to attend the 49th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida (SRHSB) in Barcelona, Spain.

  •   CONICYT Travel Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2006

    Fellowship to attend the 50th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida (SRHSB) in Cambridge, UK.

  •   Short Research Stay Fellowship

    UNIVERSIDAD AUSTRAL DE CHILE

    Chile, 2006

    Fellowship from the MECESUP RUCH 0115 Project "National Network of Molecular Biosciences PhD Programs". Chile

  •   Graduate Student Research Fellowship (PhD Thesis)

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2007

    Fellowship from the National Commission for Scientific and Technological Research (CONICYT-Chile) to finish the PhD thesis project.

  •   Best Professor Award

    UNIVERSIDAD AUSTRAL DE CHILE

    Chile, 2009

    Award from the School of Medicine (2nd year students), Universidad Austral de Chile. Valdivia, Chile.

  •   NIH Travel Fellowship

    NATIONAL INSTITUTES OF HEALTH (NIH)

    Estados Unidos, 2009

    Fellowship from the National Institutes of Health (NIH) to attend the Hydrocephalus Workshop (Hydrocephalus Association) in Baltimore, USA.

  •   Best National PhD Thesis Award

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2010

    Award from the Chilean Academy of Sciences to the best PhD Thesis in Science developed in Chile (2010). Santiago, Chile.

  •   MECESUP2 Short-term Research Stay Fellowship

    UNIVERSIDAD AUSTRAL DE CHILE

    Chile, 2011

    Fellowship from the UACh-MECESUP2 Project to perform a short research stay in the Leibniz Institute for Neurobiology, Magdeburg, Germany.


 

Article (32)

Sumoylation in astrocytes induces changes in the proteome of the derived small extracellular vesicles which change protein synthesis and dendrite morphology in target neurons
Alpha-SNAP (M105I) mutation promotes neuronal differentiation of neural stem/progenitor cells through overactivation of AMPK
Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?
Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults
Safety and Non-Inferiority Evaluation of Two Immunization Schedules with an Inactivated SARS-CoV-2 Vaccine in Adults: A Randomized Clinical Trial
eNOS-dependent S-nitrosylation of the NF-kappa B subunit p65 has neuroprotective effects
Maternal exposure to a high-magnitude earthquake during pregnancy influences pre-reading skills in early childhood
The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?
A Role for mir-26a in Stress: A Potential sEV Biomarker and Modulator of Excitatory Neurotransmission
Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity
Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response
Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination
Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells
Pleiotropic effects of alpha-SNAP M105I mutation on oocyte biology: ultrastructural and cellular changes that adversely affect female fertility in mice
Role of adherens junctions and apical-basal polarity of neural stem/progenitor cells in the pathogenesis of neurodevelopmental disorders: a novel perspective on congenital Zika syndrome
Altered lactate metabolism in Huntingtons disease is dependent on GLUT3 expression
alpha-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility
Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination
Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche
Disruption of CDH2/N-cadherin-based adherens junctions leads to apoptosis of ependymal cells and denudation of brain ventricular walls
A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus
Neuroependymal Denudation is in Progress in Full-term Human Foetal Spina Bifida Aperta
New ependymal cells are born postnatally in two discrete regions of the mouse brain and support ventricular enlargement in hydrocephalus
A simple PCR-based genotyping method for M105I mutation of alpha-SNAP enhances the study of early pathological changes in hyh phenotype
DEFECTIVE CELL-CELL ADHESION IN HYH MUTANT MICE: A PATHOGENIC MECHANISM UNDERLYING CEREBRAL VENTRICULAR SURFACE DISRUPTION AND HYDROCEPHALUS?
Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia
Disruption of the Neurogenic Niche in the Subventricular Zone of Postnatal Hydrocephalic hyh Mice
Sperm from Hyh Mice Carrying a Point Mutation in alpha SNAP Have a Defect in Acrosome Reaction
Patterned neuropathologic events occurring in hyh congenital hydrocephalic mutant mice
POSTNATAL EPENDYMOGENESIS OCCURING IN WILD-TYPE HYH MICE INCREASES SIGNIFICANTLY IN HYDROCEPHALIC HYH MICE
Heterogeneous expression of hydrocephalic phenotype in the hyh mice carrying a point mutation in alpha-SNAP
Cellular mechanisms involved in the stenosis and obliteration of the cerebral aqueduct of hyh mutant mice developing congenital hydrocephalus

Abstract (2)

Soluble factors derived from brain pericytes promote neural stem cells to generate oligodendrocytes
Defects in N-cadherin-based adherens junctions precede disruption of neural stem cells in alpha-SNAP mutant mice

Proyecto (19)

Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT)
Prenatal Stress: Maternal astrocyte-derived extracellular vesicles as a novel stress-transfer mechanism contributing to adverse offspring neurodevelopment
Brain astrocyte-derived extracellular vesicles promote protective Treg induction in the GALT and restore gut tolerance in stressed rats.
Mirando al futuro: Efectos del estrés prenatal y perinatal asociado a la pandemia COVID-19 en el neurodesarrollo de niñas y niños de Chile
Use of protein biomarkers in plasma-derived extracellular vesicles to improve the diagnosis of bipolar disorder
“ALERT-NeurodEV”: Early detection of prenatal stress-induced neurodevelopmental changes by umbilical cord blood biomarkers
Effect of genetic variants in calcium channel genes on cardiac function in bipolar disorder
Maternal brain-to-fetal brain communication under stress conditions: role of astrocyte derived-extracellular vesicles
Canonical and non-canonical roles of alpha-SNAP in the pathogenesis of neurodevelopmental disorders=> focus on modulation of autophagy and AMPK signaling
Desarrollo de una plataforma de análisis de interacciones moleculares para el fortalecimiento de la investigación en ciencias biomédicas y biotecnológicas en la UACh
Centro de Investigación Sur-Austral en Enfermedades del Sistema Nervioso (CISNe)
Chile potencia Biotecnológica=> Búsqueda caracterización valorización y comercialización de bioproductos de especies marinas.
Etiopatogenia de la hidrocefalia y otros trastornos del desarrollo cerebral=> rol de alfa-SNAP en la sobrevida/apoptosis de las células de la zona ventricular
Disruption of the neuroepithelium/ependyma (ventricular zone) during development leads to hydrocephalus, abnormal brain development and impaired postnatal neurogenesis. Strategies aimed to diminish/repair the outcomes of ventricular zone disruption
Neurodevelopmental disorders and the cross-talk between membrane trafficking and cell adhesion=> Role of alpha-SNAP in the maintenance of N-cadherin-based adherens junctions of neuroepithelial/radial glial cells during embryonic neurogenesis.
Investigación de trastornos del desarrollo cerebral e hidrocefalia congénita=> alteraciones del neuroepitelio y del líquido cefalorraquídeo como mecanismo etiopatogénico común
Defects in ventricular zone cells lead to congenital hydrocephalus
Congenital hydrocephalus and the alterations in cerebrospinal composition.
Effects of Sotalol on reperfusion arrhythmias.

Review (2)

Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes
Exosomes as Novel Regulators of Adult Neurogenic Niches
45
Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

7
Francisco Rivera

Associate Professor in Integrative Neurobiology

Molecular and Integrative Biosciences Research Programme

University of Helsinki

Helsinki, Finlandia

6
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

5
Alejandro Luarte

Profesor Investigador

Neurociencias

Universidad de Los Andes

santiago, Chile

3
Esteban Rodríguez

INSTITUTO DE ANATOMÍA, HISTOLOGÍA Y PATOLOGÍA, FACULTAD DE MEDICINA, UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
María Miró

Académico

Facultad de Salud

Universidad Santo Tomás

Valdivia, Chile

2
Ariel Caviedes

Postdoctorado

Escuela de psicología

Universidad Adolfo Ibánez

Santiago, Chile

2
INGRID EHRENFELD

FULL PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

2
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Carlos Lafourcade

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Chile

2
Maite Castro

Professor

Faculty of Sciences

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Luis Molina

PROFESOR ASISTENTE

CIENCIAS BÁSICAS

Universidad San Sebastián

Puerto Montt, Chile

2
Maria Guerra

Profesor Asociado

INSTITUTO DE ANATOMÍA, HISTOLOGÍA Y PATOLOGÍA, FACULTAD DE MEDICINA, UNIVERSIDAD AUSTRAL DE CHILE

Universidad Austral de Chile

Valdivia , Chile

2
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
César González

Profesor Asistente

Facultad de Medicina y Ciencias

Universidad San Sebastián

Puerto Montt, Chile

1
Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

1
Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

1
Victor Aliaga

Postdoctorante

Universidad de O'Higgins

Santiago, Chile

1
Roberto Henzi

Postdoctorado

CIIB

Universidad de Los Andes

Las condes, Chile

1
Rodrigo Vergara

Investigador

Psicología

Universidad San Sebastián

Valdivia, Chile

1
Vinicius Ramos Henriques

Associate Professor

Advanced Center for Chronic Diseases - ACCDiS

Univesidad de Chile

Santiago, Chile

1
PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Felipe Gordillo

UNIVERSIDAD CATÒLICA DEL MAULE

Talca, Chile

1
Alfredo Ramírez

Profesor Asociado

Instituto de Ciencia Animal

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Maroun Khoury

Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

1
Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

1
Patricia Luz

Profesor asistente

Universidad de los Andes

Santiago , Chile

1
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

1
Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

1
Paulina Troncoso

Bioquimica PhD

Laboratorio Clínico Banco de Sangre Anatomía Patológica

Clínica Alemana de Santiago

Santiago, Chile

1
Angela Court

Asistente de Investigación

Medicina Nanoregenerativa

Universidad de Los Andes

Santiago, Chile

1
Marcelo Ratto

Profesor titular

Ciencia Animal

Universidad Austral de Chile

Valdivia, Chile

1
Diego Halabi

Profesor Auxiliar

Escuela de Odontología

Universidad Austral de Chile

Valdivia, Chile

1
Monica Carrasco

Profesor Asociado

Escuela de Medicina

UNIVERSIDAD DE TALCA

Talca, Chile

1
Lara Jorge

Profesora Asistente

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Aaron Cortes

Jefe de Investigación

Dirección Médica

Clínica Universidad de los Andes

Santiago, Chile

1
Matías Pizarro

research assistant

Psicología

Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez.

Santiago, Chile

1
GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

1
Luis Piña

Investigador Postdoctoral

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

1
Alexander Ortloff

Académico

UNIVERIDAD CATÓLICA DE TEMUCO

Temuco, Chile

1
Yasna Palmeiro

Research Fellow

Institute for Global Health

University College London

London, Reino Unido

1
Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

1
FELIPE MELO

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Paula Muñoz

Clinical Research Center Director

Universidad del Desarrollo

Santiago, Chile