Man

César Aliro González Higuera

Profesor Asistente

Universidad San Sebastián

Puerto Montt, Chile

Líneas de Investigación


Básicamente mi interés científico ha estado centrado en el modelado de enfermedades neurodegenerativas mediante sistemas in vitro (cultivos bidimensionales y organoides cerebrales) utilizando células madres pluripotentes inducidas.

Educación

  •  Biologia celular y molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007

Experiencia Académica

  •   Profesor de Histologia general e Histologia Bucodentaria Part Time

    Universidad San Sebastian

    Facultad de Ciencias de la Salud, Facultad de Odontologia

    Valdivia, Chile

    2004 - 2009

  •   Profesor de Histologia general y Biologia Celular Part Time

    Universidad San Sebastian

    Medicina y Ciencias

    Puerto Montt, Chile

    2017 - 2018

  •   Profesor de Biologia Celular Part Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Medicina

    Puerto Montt, Chile

    2017 - 2017

  •   Profesor de Histologia y Fisiologia Full Time

    Universidad San Sebastian

    Medicina y Ciencias

    Puerto Montt, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Postdoctoral Fellow Full Time

    University of Texas Health Science Center at Houston

    Houston, Estados Unidos

    2010 - 2017


 

Article (17)

Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer's Disease
Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic And Pathological Abnormalities In A Mouse Model Of Alzheimer’s Disease
Modeling amyloid beta and tau pathology in human cerebral organoids
Neurospheres from neural stem/neural progenitor cells (NSPCs) of non-hydrocephalic HTx rats produce neurons, astrocytes and multiciliated ependyma: the cerebrospinal fluid of normal and hydrocephalic rats supports such a differentiation
Increased susceptibility to A beta toxicity in neuronal cultures derived from familial Alzheimer's disease (PSEN1-A246E) induced pluripotent stem cells
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
Cell Junction Pathology of Neural Stem Cells Is Associated With Ventricular Zone Disruption, Hydrocephalus, and Abnormal Neurogenesis
Understanding How the Subcommissural Organ and Other Periventricular Secretory Structures Contribute via the Cerebrospinal Fluid to Neurogenesis
Disruption of CDH2/N-cadherin-based adherens junctions leads to apoptosis of ependymal cells and denudation of brain ventricular walls
A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus
A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus
Disruption of the Neurogenic Niche in the Subventricular Zone of Postnatal Hydrocephalic hyh Mice
Organ Culture of the Bovine Subcommissural Organ: Evidence for Synthesis and Release of the Secretory Material
Organ culture of the bovine subcommissural organ=> Evidence for synthesis and release of the secretory material
The dispersed cell culture as model for functional studies of the subcommissural organ: preparation and characterization of the culture system
Isograft and xenograft of the subcommissural organ into the lateral ventricle of the rat and the formation of Reissner's fiber
The ependymocytes of the bovine subcommissural organ are functionally coupled through gap junctions

Proyecto (1)

Production of a human cerebral organoid model of Alzheimer’s disease.
15
César González

Profesor Asistente

Facultad de Medicina y Ciencias

Universidad San Sebastián

Puerto Montt, Chile

2
Alexander Ortloff

Académico

UNIVERIDAD CATÓLICA DE TEMUCO

Temuco, Chile

2
Luis Federico Batiz

Associate Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de los Andes

Santiago, Chile

2
Roberto Henzi

Postdoctorado

CIIB

Universidad de Los Andes

Las condes, Chile

1
Teresa Caprile

Associate profesor

DPTO. BIOLOGIA CELULAR,

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

1
Nicole Lichtin

Encargada genomica y genética de leguminosas de grano

Ciencia en Plantas

CGNA

Temuco, Chile

1
Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

1
Fernando Hinostroza

Profesor part-time

Ciencias básicas

Universidad Católica del Maule

Talca, Chile