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Rodrigo Herrera Molina

Group Leader (staff member)

Leibniz Institute for Neurobiology

Magdeburg, Alemania

Líneas de Investigación


1) Synaptic mechanisms of learning and memory and amnesia and linked to calcium homeostasis and neuronal signalling 2) Novel bio-nanomaterials for neuronal recording in vitro and in vivo 3) Novel biopeptides for treating inflammation and amnesia

Educación

  •  Biomedical Science / Neurobiology, UNIVERSIDAD DE CHILE. Chile, 2010
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 2004
  •  EMBO Laboratory Leadership, EMBO Solutions GmbH. Alemania, 2019
  •  Advanced training course for gene technology, BioMed Concept GmbH. Alemania, 2018

Experiencia Académica

  •   Lecturer for Neuroscience PhD students Other

    Universidad de los Andes

    Santiago, Chile

    2014 - A la fecha

  •   Lecturer for Neuroscience MSc and PhD students Other

    Universidad Bernardo O’Higgins

    Santiago, Chile

    2018 - A la fecha

  •   Lecturer for Neuroscience MSc students Other

    Otto von Guericke University

    Magdeburg, Alemania

    2014 - A la fecha

Experiencia Profesional

  •   PhD Student Full Time

    Universidad de Chile

    Santiago, Chile

    2006 - 2010

  •   Postdoctoral Researcher Full Time

    Leibniz Institute for Neurobiology

    Magdeburg, Alemania

    2012 - 2016

  •   Lecturer for Neuroscience PhD students Other

    Universidad de los Andes

    Santiago, Chile

    2014 - A la fecha

  •   Invited Guest Scientist Other

    Universidad Bernardo O’Higgins

    Santiago, Chile

    2017 - A la fecha

  •   Co-Group Leader Full Time

    Leibniz Institute for Neurobiology

    Magdeburg, Alemania

    2017 - 2017

  •   Group Leader (staff member) Full Time

    Leibniz Institute for Neurobiology

    Magdeburg, Alemania

    2018 - A la fecha

  •   Group Leader Full Time

    Leibniz Institute for Neurobiology

    Magdeburg, Alemania

    2019 - A la fecha

  •   Associated Reasearcher Part Time

    Universidad Bernardo O'Higgins

    Santiago, Chile

    2020 - A la fecha

Formación de Capital Humano


Supervision of students (MSc, MD, and PhD):
2021 – Currently Liang Yi, M.D. Master student
2020 – Currently Harini Srinivasan, MSc thesis
2017 – Currently Ayse Malci, PhD thesis
2016 – Currently Xiao Lin, PhD thesis

Former students supervised (last 5 years only):
2018 Benedikt Auer MSc and Lennart Junge, M.D.
2017 Sampath Vemula, PhD
2016 Ting Jiao, MSc and Abaya Prakash, MSc


Premios y Distinciones

  •   Hugo Junkers Award 2020

    State of Saxony-Anhalt, Germany

    Alemania, 2020

    Category: “Most innovative approaches in basic research” (3er place)

  •   Hugo Junkers Award 2016

    State of Saxony-Anhalt, Germany

    Alemania, 2016

    Category: “Most innovative approaches in basic research” (2nd place)

  •   Young Investigator Colloquia Award

    International Society for Neurochemistry

    Canada, 2019

    Young Investigators Colloquia: Signalling, development and disease: “Neuroplastins are essential for synapse formation and memory: Is the Neuroplastin-PMCA-dependent Ca2+ regulation a mechanism for these functions?”


 

Article (26)

Neuroplastin expression is essential for hearing and hair cell PMCA expression
Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation
Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity
Electrochemical Roughening and Carbon Nanotube Coating of Tetrodes for Chronic Single-Unit Recording
The Interaction of TRAF6 With Neuroplastin Promotes Spinogenesis During Early Neuronal Development
Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?
Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition
Intracellular Ca2+ Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K
A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation
alpha(V)beta(3) Integrin regulates astrocyte reactivity
Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway
Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation
Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration
Structure of Excitatory Synapses and GABAA Receptor Localization at Inhibitory Synapses Are Regulated by Neuroplastin-65
The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment
Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of alpha v beta(3) integrin and syndecan-4
Astrocytic alpha(V)beta(3) Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1
Modulation of interferon-gamma-induced glial cell activation by transforming growth factor beta 1: A role for STAT1 and MAPK pathways
The Cell Adhesion Molecule Neuroplastin-65 Is a Novel Interaction Partner of gamma-Aminobutyric Acid Type A Receptors
ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alpha v beta 3 integrin that activates PKC alpha and RhoA
REDUCTION OF beta-AMYLOID-INDUCED NEUROTOXICITY ON HIPPOCAMPAL CELL CULTURES BY MODERATE ACIDOSIS IS MEDIATED BY TRANSFORMING GROWTH FACTOR beta
Direct Thy-1/alpha(V)beta(3) integrin interaction mediates neuron to astrocyte communication
Pro- and anti-inflammatory cytokines regulate the ERK pathway: Implication of the timing for the activation of microglial cells
Transforming growth factor-beta 1 produced by hippocampal cells modulates microglial reactivity in culture

Abstract (2)

Csk-Binding-Protein mediates Thy-1 signaling and neurite retraction caused by astrocyte alpha v beta 3 integrin in neuronal cultures.
POSSIBLE ROLE FOR THY-1/ALPHAVBETA3 INTEGRIN: INHIBITION OF NEURITE OUTGROWTH BY CELL-CELL CONTACT BETWEEN NEURONS AND ASTROCYTES

Patent (1)

Electrode device, electrophysiological recording system and computer program

Review (2)

The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function
Thy-1-Interacting Molecules and Cellular Signaling in Cis and Trans
31
Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

9
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

4
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
ARELI CÁRDENAS

Académica e Investigadora

Universidad Bernardo O'Higgins

Santiago, Chile

2
Mauricio Sandoval

Lab Manager

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
Tatiana Adasme

Associate Researcher

Centro de Investigación Clínica Avanzada (CICA)

Universidad Chile

Santiago, Chile

1
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

1
Barbara Bruna

Asistente de Investigación

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

1
Edgardo Rojas

Académico e Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo OHiggins

Santiago, Chile

1
Alejandro Luarte

Staff Scientist

Neurociencias

Instituto de Neurociencia Biomédica

santiago, Chile

1
Leonardo Pérez

Investigador docente

Universidad de Chile

Santiago, Chile

1
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

1
Reinaldo Uribe

Instructor Adjunto

Neurología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Andrea Paula-Lima

Profesora Asociada

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Raúl Lagos

Research associate

Department of Pharmacology

University of Cambridge

Cambridge, Reino Unido

1
Rodrigo Vergara

Profesor asistente

Kinesiología

Universidad Metropolitana de Ciencias de la Educación

Santiago, Chile

1
Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Carlos Lafourcade

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

1
Ricardo Matute

Associate Professor

Centro Integrativo de Biología y Química Aplicada (CIBQA)

Universidad Bernardo O'Higgins

Santiago , Chile

1
Felipe Oyarzún

Profesor Asociado

Ciencias y Tecnología Farmacéuticas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
MARIANNE BRENET

Investigador

SymbiOx Inc.

Macul, Chile

1
Katherine Saud

Lab Manager

Terapia Celular

Bioscell S.A.

Santiago, Chile