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M. Cecilia Hidalgo Tapia

Professor

Universidad de Chile

Santiago, Chile

Functional role of calcium release through Ryanodine Receptors (RyR)/calcium channels of hippocampal neurons. Characterization of how cellular redox state regulates RyR activity, synaptic plasticity and memory.

Doctora en Ciencias, Mención Biología, Universidad de Chile. Chile, 1969
Bioquímica, Universidad de Chile. Chile, 1965
Ciencias Biologicas, UNIVERSIDAD DE CHILE. Chile, 1969

Professor Full Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

1965 - A la fecha
Senior Investigator Part Time

CENTRO DE ESTUDIOS CIENTIFICOS DE SANTIAGO

Santiago, Chile

1984 - 2002
Visiting Fellow Full Time

NATIONAL INSTITUTE OF HEALTH

Bethesda, MD, Estados Unidos

1969 - 1972
ASSOCIATE Part Time

HARVARD UNIVERSITY

BOSTON, Estados Unidos

1979 - 1986
STAFF SCIENTIST Full Time

BOSTON BIOMEDICAL RESEARCH INSTITUTE

BOSTON, Estados Unidos

1974 - 1986
Investigadora Senior Part Time

Instituto Milenio de Neurociencia Biomedica BNI

Medicina

Santiago, Chile

2011 - A la fecha
Investigadora Senior Part Time

Instituto Milenio de Neurociencia Biomedica BNI

Medicina

Santiago, Chile

2011 - A la fecha

Tutor, PhD thesis Rodrigo Torres, Universidad de Chile

Tutor, PhD thesis J Alex Córdova, Universidad de Chile

Tutor, PhD thesis Ismael Valdés, Universidad de Chile

Tutor, PhD thesis, Jamileth More, Universidad de Chile

Co-Tutor, PhD thesis Alejandra Arias, Universidad de Valparaiso

National Prize in Natural Sciences

GOBIERNO DE CHILE

Chile, 2006

This prize is awarded every other year to a scientist with a distinguished carrer in natural sciences. I was the first woman to recieve this award


N-Methyl-d-Aspartate Receptor Modulation by Nicotinamide Adenine Dinucleotide Phosphate Oxidase Type 2 Drives Synaptic Plasticity and Spatial Memory Impairments in Rats Exposed Pre- and Postnatally to Ethanol Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2020)
N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model More, Jamileth; Galusso, Nadia; Montecinos, Luis; Pablo Finkelstein, Jose; Bull, Ricardo; Luis Valdes, Jose Article ISI Frontiers in Aging Neuroscience (2018)
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K Hidalgo, Cecilia; Adasme ,Tatiana Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats Arias-Cavieres, Alejandra; Miguel Vicente, Jose; Adasme ,Tatiana; Hidalgo, Jorge; Humeres, Alexis; Valdes-Undurraga, Ismael; Barrientos, Genaro Article ISI SCOPUS FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of A beta-Oligomers Lobos, P; Bruna, B; Córdova, A; Barattini, P; Adasme, T; Hidalgo, C; Muñoz, P; Paula-Lima, A Article ISI SCOPUS NEURAL PLASTICITY (2016)
Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins Barrientos, G; Llanos, P; Hidalgo, J; Bolaños, P; Caputo, C; Riquelme, A.; Sanchez, G; Quest, AFG; Hidalgo, C Article ISI SCOPUS Frontiers in Physiology (2015)
Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors Llanos, P; Contreras-Ferrat, A; Barrientos, G; Valencia, M; Mears, D; Hidalgo, C Article ISI SCOPUS PLOS ONE (2015)
Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons Adasme, T; Paula Lima A.; Hidalgo, C Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
The cholesterol-lowering agent methyl-beta-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice Llanos, P; Contreras-Ferrat, A; Georgiev, T; Osorio-Fuentealba, C; Espinosa, A; Hidalgo, J; Hidalgo, C; Jaimovich, E Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2015)
Contribution of Ca2+ release channels to hippocampal synaptic plasticity and spatial memory. Potential redox modulation Article ISI Antioxid Redox Signal (2014)
Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release, which both impinge on GLUT4 translocation Contreras-Ferrat, A; Llanos, P; Vásquez, C; Espinosa, A; Osorio-Fuentealba, C; Arias-Calderon, M; Lavandero, S; Klip, A; Hidalgo, C; Jaimovich, E Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2014)
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates nnitochondrial Ca2+ uptake in primary hippocampal neurons Sanmartín, C.D., Paula-Lima, A.C., García, A., Barattini, P., Hartel, S., Núñez, MT, Hidalgo, C. Article ISI SCOPUS FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)
Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine Ronjat, M; Llanos, P; Montecinos, L; Bichraoui, H; De Waard, M; Hidalgo, C; Bull, R Article ISI SCOPUS Cell Calcium (2013)
Sub-lethal levels of amyloid beta-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons SanMartín, CD; Paula Lima A.C.; Hidalgo, C; Núñez M.T. Article ISI SCOPUS BioMetals (2012)
The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-beta Peptide Oligomers SanMartín, CD; Adasme, T; Hidalgo, C; Paula Lima A.C. Article ISI SCOPUS Neurodegenerative Diseases (2012)
Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF Paula-Lima, AC; Adasme, T; San-Martin, C; Sebollela A.; Hetz, C; Hidalgo, C Article ISI SCOPUS Antioxidants and Redox Signaling (2011)
High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-kappa B Activity Riquelme, D; Alvarez, A; Leal, N; Adasme, T; Espinoza, I; Troncoso, N; Härtel, S; Hidalgo, J; Hidalgo, C Article ISI SCOPUS Antioxidants and Redox Signaling (2011)
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation Adasme, T; Haeger, P; Paula Lima A.C.; Espinoza, I; Casas-Alarcon M.M.; Carrasco, MA; Hidalgo, C Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2011)
Iron Mediates N-Methyl-D-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity Muñoz, P; Humeres, A; Elgueta, C; Kirkwood A.; Hidalgo, C Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Modulation of cardiac ryanodine receptor activity by ROS and RNS Donoso, P; Sanchez, G; Bull, R; Hidalgo, C Article ISI SCOPUS Frontiers in Bioscience - Landmark (2011)
Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion Pedrozo, Z; Sanchez, G; Torrealba, N; Valenzuela, R; Fernández, C; Hidalgo, C; Lavandero, S; Donoso, P Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2010)
Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training Haeger, P; Alvarez, A; Leal, N; Adasme, T; Hidalgo, C Article ISI SCOPUS NEUROTOXICITY RESEARCH (2010)
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide Muñoz, JP; Chiong, M; Garcia, L; Troncoso, R; Toro, B; Pedrozo, Z; Diaz-Elizondo, J; Salas, D; Parra, V; Hidalgo, C; et al. Article ISI SCOPUS Free Radical Biology and Medicine (2010)
Mitochondria fine-tune the slow Ca2+ transients induced by electrical stimulation of skeletal myotubes Eisner, V; Parra, V; Lavandero, S; Hidalgo, C; Jaimovich, E Article ISI SCOPUS Cell Calcium (2010)
Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress Chiong, M; Parra, V; Eisner, V; Ibarra, C; Maldonado, C; Criollo, A; Bravo, R; Quiroga, C; Contreras, A; Cea, P; et al. Article ISI SCOPUS Apoptosis (2010)
Hypoxia stimulates via separate pathways ERK phosphorylation and NF-kappa B activation in skeletal muscle cells in primary culture Osorio-Fuentealba, C; Riquelme, D; Hidalgo, J; Hidalgo, C Article ISI SCOPUS JOURNAL OF APPLIED PHYSIOLOGY (2009)
NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells Espinosa, A; García, A; Härtel, S; Hidalgo, C; Jaimovich, E Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling Muñoz, JP; Collao, A; Chiong, M; Maldonado, C; Adasme, T; Carrasco, L; Ocaranza, P; Bravo, R; González, L; Díaz-Araya, G; et al. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis Parra, V; Eisner, V; Chiong, M; Criollo, A; Moraga, F; García, A; Haertel, S.; Jaimovich, E; Zorzano, A; Hidalgo, C; et al. Article ISI SCOPUS CARDIOVASCULAR RESEARCH (2008)
Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible robe in cardioprotection Sanchez, G; Escobar, M; Pedrozo, Z; Macho P; Domenech, R; Härtel, S; Hidalgo, C; Donoso, P Article ISI SCOPUS CARDIOVASCULAR RESEARCH (2008)
Ischemia enhances activation by Ca2+ and redox modification of ryanodine receptor channels from rat brain cortex Bull, R; Galvez, J; Sanchez, G; Donoso, P; Behrens, MI; Hidalgo, C Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2008)
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons Kemmerling, U; Muñoz, P; Sanchez, G; Klann, E; Hidalgo, C Article ISI SCOPUS CELL CALCIUM (2007)
Calcium, iron and neuronal function Hidalgo, C Article ISI IUBMB LIFE (2007)
Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex Bull, R; Humeres, A; Behrens, MI; Hidalgo, C Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S-glutathionylation Hidalgo, C; Sanchez, G; Barrientos, G; Aracena-Parks, P Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells Muñoz, P; Zavala, G; Castillo, K; Aguirre, P; Hidalgo, C Article ISI SCIELO BIOLOGICAL RESEARCH (2006)
Fast kinetics of calcium dissociation from calsequestrin Beltran, M; Barrientos, G; Hidalgo, C Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2006)
Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1 Aracena-Parks, P; Hidalgo, C Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase; ROS-elicited Ca2+ stimulates ERK, CREB, early genes Espinosa, A; Leiva, A; Peña, M; Debandi A.; Hidalgo, C; Jaimovich, E Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Cross talk between Ca2+ and redox signalling cascades in muscle and neurons through the combined activation of ryanodine receptors/Ca2+ release channels Hidalgo, C Article ISI SCOPUS PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2005)
Effects of S-glutathionylation and S-nitrosylation on calmodulin binding to triads and FKBP12 binding to type 1 calcium release channels Aracena, P; Tang, WT; Hidalgo, C Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2005)
Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle Sanchez, G; Pedrozo, Z; Hidalgo, C; Donoso, P Article ISI SCOPUS JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2005)
Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells Jaimovich, E; Kemmerling, U; Hidalgo, C Article ISI SCIELO BIOLOGICAL RESEARCH (2004)
Kinetic studies of calcium-induced calcium release in cardiac sarcoplasmic reticulum vesicles Sanchez, G; Hidalgo, C; Donoso, P Article ISI SCOPUS BIOPHYSICAL JOURNAL (2003)
S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels Aracena, P; Sanchez, G; Donoso, P; Hidalgo, C Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Annexin VI is attached to transverse-tubule membranes in isolated skeletal muscle triads Barrientos, G; Hidalgo, C Article ISI SCOPUS JOURNAL OF MEMBRANE BIOLOGY (2002)
Redox regulation of calcium release in skeletal and cardiac muscle Hidalgo, C; Aracena, P; Sanchez, G; Donoso, P Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2002)
Sodium transport in triads isolated from rabbit skeletal muscle Donoso, P; Hidalgo, C Article ISI SCOPUS JOURNAL OF MEMBRANE BIOLOGY (2002)
SH Oxidation Stimulates Calcium Release Channels (Ryanodine Receptors) From Excitable Cells Hidalgo, C; Bull, R; Pérez, CF; Donoso, P Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2000)
Sodium/calcium exchange in amphibian skeletal muscle fibers and isolated transverse tubules Cifuentes, F; Vergara, J; Hidalgo, C Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)
Sulfhydryl oxidation overrides Mg2+ inhibition of calcium-induced calcium release in skeletal muscle triads Donoso, P; Aracena, P; Hidalgo, C Article ISI SCOPUS BIOPHYSICAL JOURNAL (2000)
ATP stimulation of Na +/Ca 2+ exchange in cardiac sarcolemmal vesicles Berberian G.; Beauge L.; Hidalgo, C; DiPolo R. Article AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (1998)
Cyclic ADP-ribose activates caffeine-sensitive calcium channels from sea urchin egg microsomes Ferez C.F.; Marengo, J.J.; Bull, R; Hidalgo, C Article AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (1998)
Ca2+- and pH-dependent Halothane Stimulation of Calcium Release in Sarcoplasmic Reticulum from Frog Muscle. Beltrán, M., Bull, R., Donoso, P. and Hidalgo, C. Article ISI Am. J. Physiol. 271 C540-C546 (1996)
Calcium dependence of ryanodine-sensitive calcium channels from brain cortex endoplasmic reticulum Marengo, J.J.; Bull, R; Hidalgo, C Article FEBS LETTERS (1996)
Luminal pH regulates calcium release kinetics in sarcoplasmic reticulum vesicles Donoso, P; Beltran, M; Hidalgo, C Article BIOCHEMISTRY (1996)
Protons induce calsequestrin conformational changes Hidalgo, C; Donoso, P; Rodriguez, PH Article BIOPHYSICAL JOURNAL (1996)
Protons Induce Calsequestrin Conformational Changes. : 2130-2137 Hidalgo, C., Donoso, P. and Rodríguez, P. H. Article ISI Biophys. J. (1996)
Luminal Calcium Regulates Calcium Release in Triads Isolated from Frog and Rabbit Skeletal Muscle. Donoso, P., Prieto, H. and Hidalgo, C. Article ISI Biophys. J. (1995)
Luminal Calcium Regulation of Calcium Release from Sarcoplasmic Reticulum. Hidalgo, C. and Donoso, P. Article ISI Biosci Rep (1995)
pH Sensitive Calcium Release in Triads from Frog Skeletal Muscle. Rapid Filtration Studies. Donoso, P. and Hidalgo, C. Article ISI J. Biol. Chem. (1993)
Phospholipase C Activity in Membranes and a Soluble Fraction Isolated from Frog Skeletal Muscle. Carrasco, M.A., Sierralta, J. and Hidalgo, C Article ISI Biochim Biophys Acta. (1993)
Triads and Transverse Tubules Isolated from Skeletal Muscle Contain High Levels of Inositol 1,4,5-Trisphosphate. 268, 1511-1517 Hidalgo, C., Jorquera, J., Tapia, V. and Donoso, P. Article ISI J. Biol. Chem. (1993)
Inositol 1, 4, 5-Trisphosphatase Activity in Membranes Isolated from Amphibian Skeletal Muscle. Sánchez, X., Carrasco, M. A., Vergara, J. and Hidalgo, C. Article ISI FEBS Lett (1991)
Sodium/Calcium Exchange in Transverse Tubule Vesicles Isolated from Amphibian Skeletal Muscle. Hidalgo, C., Cifuentes, F. and Donoso, P. Article ISI Ann. N.Y. Acad. Sci. (1991)
Sodium-Calcium Exchange in Transverse Tubule Vesicles Isolated from Frog Skeletal Muscle. Donoso, P. and Hidalgo, C. Article ISI Biochem. Biophys. Acta. (1989)
Activation of Calcium Channels in Sarcoplasmic Reticulum from Frog Muscle by Nanomolar Concentrations of Ryanodine. Bull R., Marengo J. J., Suárez-Isla B., Donoso P., Sutko J. L. and C. Hidalgo. Article ISI Biophys. J. (1989)
Inositol Trisphosphate and Excitation-Contraction Coupling in Skeletal Muscle. Hidalgo, C. and Jaimovich, E. Article ISI J. Bioenerg. Biomemb. (1989)
Calcium Modulation of Phosphoinositide Kinases in Transverse Tubule Vesicles from Frog Skeletal Muscle. Carrasco, M. A., Magendzo, K., Jaimovich, E., and Hidalgo, C. Article ISI Arch Biochem Biophys (1988)
Inositol (1,4,5)-Trisphosphate Activates a Calcium Channel in Isolated Sarcoplasmic Reticulum Membranes. Suárez-Isla, B., Irribarra, V., Oberhauser, A., Larralde, L., Bull, R., Hidalgo, C. and Jaimovich, E. Article ISI Biophys. J. (1988)
Lipid-protein Interactions and the Function of the Ca2+-ATPase of Sarcoplasmic Reticulum. Hidalgo, C Article ISI Crit. Rev. Biochem. (1987)
Lipid Composition of Purified Transverse Tubule Membranes Isolated from Amphibian Skeletal Muscle. Pediconi, M. F., Donoso, P., Hidalgo, C. and Barrantes., F. J. Article ISI Biochem. Biophys. Acta. (1987)
Phosphorylation of Phosphatidylinositol by Transverse Tubule Vesicles and its Possible Role in Excitation-Contraction Coupling. Hidalgo, C., Carrasco, M. A., Magendzo, K. and Jaimovich, E. Article ISI FEBS Lett (1986)
Transverse Tubules from Frog Skeletal Muscle. Purification and Properties of Vesicles Sealed with the Inside-Out Orientation. Hidalgo, C., Parra, C., Riquelme, G. and Jaimovich, E. Article ISI Biochem. Biophys. Acta. (1986)
Calcium Transport in Transverse Tubules Isolated from Rabbit Skeletal Muscle. Biochem Hidalgo, C., González, M. E. and García, A. M. Article ISI Biochem. Biophys. Acta (1986)
Ion Pathways in Transverse Tubules. Quantification of Receptors in Membranes Isolated from Frog and Rabbit Skeletal Muscle. Jaimovich, E., Donoso, P., Liberona, J. L. and Hidalgo, C. Article ISI Biochem. Biophys. Acta. (1986)
Role of Lipids in Sarcoplasmic Reticulum: A Higher Lipid Content is Required to Sustain Phosphoenzyme Decomposition than Phosphoenzyme Formation. Hidalgo, C., de la Fuente, M. and González, M. E. Article ISI Arch Biochem Biophys (1986)
Lipid Phase of Transverse Tubule Membranes from Skeletal Muscle. An Electron Paramagnetic Resonance Study. Hidalgo, C Article ISI Biophys. J. (1985)
Characterization of the Ca2+-or Mg2+-ATPase of Transverse Tubule Membranes Isolated from Rabbit Skeletal Muscle. Hidalgo, C., González, M. E. and Lagos, R. Article ISI J. Biol. Chem. (1983)
Lipid-Protein Interactions and Calcium Transport in Sarcoplasmic Reticulum. Hidalgo, C Article ISI Ann. N.Y. Acad. Sci. (1982)
Lipid-Protein Interactions in Sarcoplasmic Reticulum are not Perturbed by Ionophore A23187. Pringle, M. J. and Hidalgo, C. Article ISI Biophys. J. (1982)
Reconstitution in Planar Lipid Bilayers of a Ca2+-dependent K+ Channel from Transverse Tubule Membranes Isolated from Rabbit Skeletal Muscle. Latorre, R., Vergara, C. and Hidalgo, C. Article ISI Proc Natl Acad Sci USA (1982)
Rotational Dynamics of Protein and Boundary Lipid in Sarcoplasmic Reticulum Membranes. Thomas, D. D., Bigelow, D. J., Squier, T. C. and Hidalgo, C. Article ISI Biophys. J. (1982)
Uncoupling of Ca2+ Transport in Sarcoplasmic Reticulum as a Result of Labeling Lipid Amino Groups and Inhibition of Ca2+-ATPase Activity by Modification of Lysine Residues of the Ca2+-ATPase Polypeptide. Hidalgo, C., Petrucci, D. A. and Vergara, C. Article ISI J. Biol. Chem. (1982)
Immunological and Biochemical Properties of Transverse Tubule Membranes Isolated from Rabbit Skeletal Muscle. Rosemblatt, M., Hidalgo, C., Vergara, C. and Ikemoto, N. Article ISI J. Biol. Chem. (1981)
Highly Purified Sarcoplasmic Reticulum Vesicles are Devoid of a Ca2+-independent (‘Basal’) ATPase Activity. Fernández, J., Rosemblatt, M. and Hidalgo, C. Article ISI Biochim Biophys Acta. (1980)
Inhibition of Calcium Transport in Sarcoplasmic Reticulum after Modification of Highly Reactive Amino Groups. Hidalgo, C Article ISI Biochem Biophys Res Commun. (1980)
Effect of the Lipid Environment on Protein Motion and Enzymatic Activity of the Sarcoplasmic Reticulum Calcium ATPase. Hidalgo, C., Thomas, D. D. and Ikemoto, N. Article ISI J. Biol. Chem. (1978)
Heterogeneity of SH Groups in Sarcoplasmic Reticulum. Hidalgo, C. and Thomas, D. D. Article ISI Biochem Biophys Res Commun. (1977)
Disposition of Proteins and Aminophospholipids in the Sarcoplasmic Reticulum Membrane. Hidalgo, C. and Ikemoto, N. Article ISI J. Biol. Chem. (1977)
Induction and General Properties of ß-Galactosidase and ß-Galactoside Permease in Pseudomonas BAL-31. Hidalgo, C., Reyes, J. and Goldschmidt, R. Article ISI J Bacteriol. (1977)
Stimulation of ß-Galactoside Transport in Pseudomonas BAL-31 by Infection with Bacteriophage PM2. Hidalgo, C., Reyes, J. and Espejo, R. T. Article ISI FEBS Lett (1977)
Role of Phospholipids in the Calcium-dependent ATPase of the Sarcoplasmic Reticulum: Enzymatic and ESR Studies with Phospholipid-Replaced Membranes. Hidalgo, C., Ikemoto, N. and Gergely, J. Article ISI J. Biol. Chem. (1976)
Sarcoplasmic Reticulum from Barnacle Muscle: Composition and Calcium Uptake Properties. García, A. M., Lennon, A. M. and Hidalgo, C. Article ISI FEBS Lett (1975)
Methylation Pattern of Lambda Deoxyribonucleic Acid. Hidalgo, C. and Nash, H. Article ISI J Virol (1972)
Methylation of Bacteriophage P1 DNA. Hidalgo, C. and Rosner, L. Article ISI VIROLOGY (1972)
Effect of Stimulation and Hyperpolarization on Non-Electrolyte and Sodium Permeability in Perfused Axons of Squid. Hidalgo, C. and Latorre, R. Article ISI J. Physiol. (London) (1970)
Temperature Dependence of Non-Electrolyte and Sodium Permeability in Giant Axon of Squid. Hidalgo, C. and Latorre, R. Article ISI J. Physiol. (London) (1970)
Effect of Temperature on Resting Potential in Giant Axons of Squid. Latorre, R. and Hidalgo, MC Article ISI NATURE (1969)
Effect of Temperature and Metabolic Inhibitors on Calcium-45 Outflow from Squid Giant Axons. Rojas, E. and Hidalgo, C. Article ISI Biochim Biophys Acta. (1968)
Sodium Transport Inhibition by Selective Mitochondrial Inhibitors in the Urinary Bladder of the Toad. Hidalgo, C. and Canessa-Fisher, M. Article ISI J Cell Physiol (1966)


Role of RyR2-mediated calcium release in synaptic plasticity, learning and memory in control and AD-model rats Hidalgo, C; More, J; Valdes, I; San-Martin, C; Muñoz, P; Barrientos, G; Valdés, JL; Sanchez, G; Paula Lima A. Abstract ISI JOURNAL OF NEUROCHEMISTRY (2015)
Cholesterol accumulation in skeletal muscle: a potential novel targetable pathway in insulin resistance Llanos, P; Contreras-Ferrat, A; Osorio, C; Espinosa, A; Hidalgo, J; Hidalgo, C; Jaimovich, E Abstract ISI FASEB JOURNAL (2014)
Abeta oligomers and iron stimulate calcium and ROS-dependent mitochondrial fragmentation in primary hippocampal neurons Paula-Lima, AC; Adasme, T; Hidalgo, C Abstract ISI JOURNAL OF NEUROCHEMISTRY (2013)
Methyl-beta-cyclodextrin increases GLUT4-mediated glucose transport in skeletal muscle fibers from insulin resistant mice Llanos, P; Contreras-Ferrat, A; Osorio-Fuentealba, C; Espinosa, A; Hidalgo, J; Hidalgo, C; Jaimovich, E Abstract ISI FASEB JOURNAL (2013)
Cell cholesterol levels determine glucose uptake and insulin resistance in skeletal muscle Llanos, P; Contreras-Ferrat, A; Osorio-Fuentealba, C; Espinosa, A; Hidalgo, C; Jaimovich, E Abstract ISI FASEB JOURNAL (2012)
MITOCHONDRIA MODULATE INTRACELLULAR CALCIUM SIGNALS THAT CONTROL ATP TRANSIENTS INDUCED BY ELECTRICAL STIMULATION OF SKELETAL MYOTUBES Eisner, VR; Parra, V; Lavandero, S; Hidalgo, C; Jaimovich, E Abstract ISI JOURNAL OF PHYSIOLOGICAL SCIENCES (2009)
Insulin Induces Intracellular Calcium Transients through Activation of NADPH Oxidase in Myotubes Espinosa, BA; Hidalgo, C; Jaimovich, E Abstract ISI FASEB JOURNAL (2008)
Ryanodine receptor-mediated calcium release stimulates gene expression in neurons Hidalgo, C; Adasme, T; Haeger, P Abstract ISI FEBS JOURNAL (2008)
A role for iron, calcium and reactive oxygen species on hippocampal synaptic plasticity Hidalgo, C; Muñoz, P Abstract ISI AMERICAN JOURNAL OF HEMATOLOGY (2007)
Depolarization of C2C12 myotubes leads to RyR1 S-glutatbionylation Aracena-Parks, P; Hidalgo, C Abstract ISI BIOPHYSICAL JOURNAL (2007)
Mitochondrial Ca2+ transients upon electrical stimulation of skeletal myotubes Eisner, V; Pavarotti, M; Hidalgo, C; Lavandero, S; Jaimovich, E Abstract ISI BIOPHYSICAL JOURNAL (2007)
TNP-8N(3)-ADP photoinactivation and labelling of sarcoplasmic reticulum of skeletal muscle Barrientos, G; Tahir, MW; Hidalgo, C Abstract ISI BIOPHYSICAL JOURNAL (2007)
Hypoxia induces calcium-dependent ERKs activation in skeletal muscle cells Osorio-Fuentealba, C; Hidalgo, C Abstract ISI PLACENTA (2006)
Physiology and pathology of iron in neuronal function Muñoz, P; Aguirre, P; Hidalgo, C Abstract ISI PLACENTA (2006)
Regulation of single RyR channels from brain by endogenous modulators Bull, R; Finkelstein, J; Maass, R.; Behrens, MI; Hidalgo, C Abstract ISI PLACENTA (2006)
Calcium release mediated by redox activation of ryanodine receptors induces CREB and ERK phosphorylation in N2a cells and hippocampal neurons Carrsaco, MA; Kemmerling, U; Muñoz, P; Hidalgo, C Abstract ISI FEBS JOURNAL (2005)
Increased cardiac activity enhances RyR2 S-glutathionylation Donoso, P; Sanchez, G; Pedrozo, Z; Domenech, R; Hidalgo, C Abstract ISI FEBS JOURNAL (2005)
The Education Committee of the International Union of Biochemistry and Molecular Biology Hidalgo, C Abstract ISI FEBS JOURNAL (2005)
Redox modification of ryanodine receptor/calcium release channels enhances calcium release in vesicles and stimulates ERK and CREB phosphorylation in neuronal cells in culture Hidalgo, C; Aracena, P; Sanchez, G; Kemmerling, U; Donoso, P Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2004)
CREB phosphorylation induced by hydrogen peroxide in N2A neurons Kemmerling, U; Hernandez, CS; Hidalgo, C Abstract ISI BIOPHYSICAL JOURNAL (2003)
Activation and s-glutathiolation of ryanodine receptor/calcium release channels from mammalian skeletal muscle by s-nitrosoglutathione Aracena, P; Hidalgo, C Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2002)
Cytoplasmic regulation by Ca2+ and Mg2+ of ryanodine receptors/calcium release channels from muscle and brain and its modification by channel oxidation Hidalgo, C; Donoso, P; Perez, C; Bull, R Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)
Oxidation of SH groups attenuates Mg2+ inhibition of calcium release in sarcoplasmic reticulum vesicles from skeletal muscle Donoso, P; Hidalgo, C Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)


Posttranslational modifications of cardiac ryanodine receptors/calcium release channels by reactive oxygen species and reactive nitrogen species Donoso, P; Hidalgo, C; Sanchez, G BookWhole SCOPUS Systems Biology of Free Radicals and Antioxidants (2014)


Calcium dependence of calcium release channels (ryanodine receptors) from skeletal and cardiac muscle Hidalgo, C; Donoso, P; Bull, R ConferencePaper ISI PUMPS, TRANSPORTERS, AND ION CHANNELS: STUDIES ON THEIR STRUCTURE, FUNCTION, AND CELL BIOLOGY (2005)
TNP-8N 3-ADP photoinactivation of the phosphatase activity of FITC-modified SERCA Barrientos, G; Hidalgo, C; Taylor M.; Cavieres J.D. ConferencePaper ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2003)
Activation of Ca2+-induced Ca2+ release through S-glutathionylation of release channels Aracena, P; Hidalgo, C ConferencePaper ISI XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL (2002)


Amyloid beta-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics? Paula-Lima, AC; Hidalgo, C EditorialMaterial ISI SCOPUS Frontiers in Cellular Neuroscience (2013)
Getting to the Heart of Mechanotransduction Hidalgo, C; Donoso, P EditorialMaterial ISI SCOPUS Science (2011)
Redox Control of Brain Calcium in Health and Disease Hidalgo, C EditorialMaterial ISI SCOPUS Antioxidants and Redox Signaling (2011)


Crosstalk between calcium and redox signaling: From molecular mechanisms to health implications Hidalgo, C; Donoso, P Review ISI ANTIOXIDANTS & REDOX SIGNALING (2008)
A role for reactive oxygen/nitrogen species and iron on neuronal synaptic plasticity Hidalgo, C; Muñoz, P Review ISI ANTIOXIDANTS & REDOX SIGNALING (2007)
Calcium microdomains and gene expression in neurons and skeletal muscle cells Hidalgo, C Review ISI SCOPUS CELL CALCIUM (2006)
The ryanodine receptors Ca2+ release channels: Cellular redox sensors? Hidalgo, C; Donoso, P Review ISI SCOPUS IUBMB LIFE (2005)
Redox regulation of RyR-mediated Ca2+ release in muscle neurons Hidalgo, C; Bull, R; Behrens, MI; Donoso, P Review BIOLOGICAL RESEARCH (2004)

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Juan Valdés

Head lab

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

Tatiana Adasme

Coordinadora de Estudios

Oficina de Apoyo a la Investigación Clínica

Universidad Chile

Santiago, Chile

Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

Karen Castillo

Académica Investigadora

,Centro de Investigación de Estudios Avanzados del Maule (CIEAM)

Universidad Catolica del Maule

Talca, Chile

Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

José Valdés

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

Andrea Paula-Lima

Profesora Asociada

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

Pablo Muñoz

Profesor titular

Patología y Fisiología

UNIVERSIDAD DE VALPARAÍSO

Valparaiso, Chile

Maria Aylwin

Associate Professor

Universidad de Talca

Talca, Chile

Paulina Donoso

Full Professor

Physiology and Biophysics

UNIVERSIDAD DE CHILE

Santiago, Chile

Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

139

M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

PAOLA HAEGER

Associated professor

Ciencias Biomedicas

Universidad Catolica del Norte

COQUIMBO, Chile

César Osorio

Associate Professor

Kinesiología

Universidad Metropolitana de Ciencias de la Educación

Santiago, Chile

Andres Chavez

Full Professor

Neuroscience

Universidad de Valparaiso

Valparaiso, Chile

Berta Espinosa

Full Professor

Tecnología Médica

Universidad de Chile

Santiago, Chile

Alfredo Criollo

Associated Professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

gabriela zavala

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

Erwin de la Fuente

PROFESOR ASOCIADO

CIENCIAS BIOMÉDICAS

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

Carol San Martín

Profesora Asistente

Neurología y Neurocirugía

Universidad de Chile

Santiago, Chile

Pabla Aguirre

Asistente de investigación

Biología

Universidad de Chile

Santiago, Chile

Leticia Gonzalez

Profesional Apoyo a la Investigacion

Pontificia Universidad Católica de Chile

Santiago, Chile

Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

Daniela Salas

Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

Jamileth More

Investigador

Neurologia

Hospital Clinico Universidad de Chile

Santiago, Chile

Denise Riquelme

Adjunct Professor

Biology

Universidad de Santiago

Santiago, Chile

José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

Barbara Bruna

Postdoctoral Researcher

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

Matias Escobar

Postdoctoral Researcher

Cancer Biology

University of Pennsylvania

Philadelphia, Chile

ALEXIS HUMERES

DIRECTOR

MORFOFUNCIÓN

Universidad Diego Portales

SANTIAGO, Chile

Italo Espinoza

Lab Manager

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

Pedro Lobos

Posdoctoral Research

Universidad de Chile

Santiago, Chile

Marioly Muller

Académico

Tecnología Médica

Universidad de Chile

Santiago, Chile

Jessica Díaz

Profesional especialista

Universidad Andrés Bello

Santiago, Chile

M. Cecilia Hidalgo Tapia

Líneas de Investigación

Educación

Doctora en Ciencias, Mención Biología, Universidad de Chile. Chile, 1969

Bioquímica, Universidad de Chile. Chile, 1965

Ciencias Biologicas, UNIVERSIDAD DE CHILE. Chile, 1969

Experiencia Académica

Professor Full Time

Senior Investigator Part Time

Visiting Fellow Full Time

ASSOCIATE Part Time

STAFF SCIENTIST Full Time

Investigadora Senior Part Time

Investigadora Senior Part Time

Formación de Capital Humano

Premios y Distinciones

National Prize in Natural Sciences

Article (101)

Abstract (23)

BookWhole (1)

ConferencePaper (3)

EditorialMaterial (3)