Apl.png_thumb90

Andrea Cristina Paula-Lima -

Profesora Asociada

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Neurobiology of Alzheimer´s disease; Endoplasmic reticulum, Mitochondria & Neuronal Calcium Signaling; Neuroinflammation.

Educación

  •  Biotechnologist, Federal Institute of Chemistry of Rio de Janeiro. Brasil, 1996
  •  Pharmacist, Federal University of Rio de Janeiro. Brasil, 2003
  •  PhD in Biological Chemistry, Federal University of Rio de Janeiro. Chile, 2007
  •  University teaching, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Post Doctorate , UNIVERSIDAD DE CHILE. Chile, 2011

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2010 - 2011

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Santiago, Chile

    2011 - A la fecha

  •   Associate Professor Part Time

    UNIVERSIDAD DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2019 - A la fecha

  •   Coordinadora de Postgrado Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Santiago, Chile

    2013 - 2018

Experiencia Profesional

  •   Técnica de Laboratorio de Bacteriología Clínica Full Time

    Fiocruz

    Rio de Janeiro, Brasil

    1996 - 1996

  •   Asistente de Docencia en Laboratorio Part Time

    Instituto Federal de Química do Rio de Janeiro

    Rio de Janeiro, Chile

    1995 - 1995


 

Article (11)

Astaxanthin Counteracts Excitotoxicity and Reduces the Associated Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation
Differential navigational strategies during spatial learning in a new modified version of the Oasis maze
Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease
Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory
Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K
Contribution of Ca(2+) Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation.
Amyloid beta-peptide oligomers, ryanodine receptor-mediated Ca(2+) release, and Wnt-5a/Ca(2+) signaling: opposing roles in neuronal mitochondrial dynamics?
Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease.
Amyloid-beta oligomers induce differential gene expression in adult human brain slices.
Sub-lethal levels of amyloid β-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons.

Abstract (1)

Role of RyR2-mediated calcium release in synaptic plasticity, learning and memory in control and AD-model rats

Proyecto (20)

El serotipo b Aggregatibacter actinomycetemcomitans es parte del consorcio de bacterias periodontales que participan en la etiología de la enfermedad de Alzheimer
CANCER LEAVES A TRAIT OF DIMINISHED IMMUNE TOLERANCE THAT PROTECTS FROM ALZHEIMER’S DISEASE
UNVEILING HOW NEURONAL CALCIUM SIGNALS REACH THE NUCLEUS FOLLOWING SYNAPSE ACTIVATION
ASOCIACIÓN ENTRE ENFERMEDAD PERIODONTAL Y ENFERMEDAD DE ALZHEIMER
EXPERIMENTAL PERIODONTAL INFECTION INDUCED BY PORPHYROMONAS GINGIVALIS OR AGGREGATIBACTER ACTINOMYCETEMCOMITANS AND ITS ASSOCIATION WITH ALZHEIMER’S DISEASE. LOOKING FOR THE POTENTIAL RISK FACTOR.
CM-BIOMEDICAL NEUROSCIENCE INSTITUTE
DEFECTIVE CALCIUM/REDOX SIGNALING AND ANOMALOUS ELECTRICAL BRAIN ACTIVITY IN RATS INJECTED WITH AMYLOID BETA OLIGOMERS=> FUNCTIONAL AND BEHAVIORAL CORRELATES WITH ALZHEIMER´S PATIENTS.
MICROSCOPIO DE CAMPO EVANESCENTE O TIRF
MOTORIZED MICROSCOPE “CELL OBSERVER” WITH LED FLUORESCENCE SYSTEM
System Storage and Advanced Biomedical Computing Services (SASIBA)
ACQUISITION OF AN ULTRACENTRIFUGE WITH 4 ROTORS
CONFOCAL MICROSCOPY PLATFORM FOR USE IN ADVANCED BIOMEDICAL RESEARCH
ACQUISITION OF A SCANNING ELECTRON MICROSCOPE AND ANCILLARY EQUIPMENT (SEMEDX) (SEM-EDX) FOR ADVANCED RESEARCH IN DENTAL SCIENCES
BIOMED-HPC=> RED DE BIOLOGÍA Y MEDICINA COMPUTACIONAL DE ALTO RENDIMIENTO.
ESTUDIO DE PATRONES OSCILATORIOS ANORMALES EN SUJETOS CON ENFERMEDAD DE ALZHEIMER INCIPIENTE Y EN ROEDORES INYECTADOS CON OLIGÓMEROS DEL PÉPTIDO BETA-AMILOIDE.
EPIFLUORESCENCE MICROSCOPE TO STIMULATE INTERDISCIPLINARY RESEARCH USING CELL BIOLOGY APPROACHES IN THE FACULTY OF DENTISTRY, UNIVERSIDAD DE CHILE.
UNRAVELING THE CALCIUM SIGNALING PATHWAYS THAT MEDIATE THE NEURONAL DYSFUNCTIONS INDUCED BY AMYLOID-BETA PEPTIDE OLIGOMERS.
RENOVACIÓN ACADÉMICA PARA EL DESARROLLO DE LA MEDICINA MOLECULAR
ROLE OF RYANODINE RECEPTORS ON NEURONAL CALCIUM SIGNALS AND SYNAPTIC PLASTICITY ALTERATIONS INDUCED BY THE BETA-AMYLOID PEPTIDE.
ROLE OF RYANODINE RECEPTORS ON NEURONAL CALCIUM SIGNALS AND SYNAPTIC PLASTICITY ALTERATIONS INDUCED BY THE BETA-AMYLOID PEPTIDE.
8
Andrea Paula-Lima

Profesora Asociada

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

5
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

3
Jamileth More

Investigador

Neurologia

Hospital Clinico Universidad de Chile

Santiago, Chile

2
jose valdes

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Barbara Bruna

Asistente de Investigación

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

2
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

2
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Tatiana Adasme

Associate Researcher

Centro de Investigación Clínica Avanzada (CICA)

Universidad Chile

Santiago, Chile

2
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

1
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

1
Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

1
José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile