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Andrea Cristina Paula-Lima -

Assistant Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Neurobiology of Alzheimer´s disease; Glutamatergic signaling; Synapse dysfunction and excitotoxicity; Biological and molecular bases of neurodegeneration.

Educación

  •  Pharmacist, Universidade Federal do Rio de Janeiro. Brasil, 2003
  •  Biological Chemistry, UNIVERSIDADE FEDERAL DO RIO DE JANEIRO. Brasil, 2007
  •  Biotechnologist, Federal Technical School of Chemistry of Rio de Janeiro. Brasil, 1996

Experiencia Académica

  •   Assistant Professor Full Time

    Universidad de Chile

    Faculty of Medicine

    Santiago, Chile

    2010 - 2011

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Santiago, Chile

    2011 - A la fecha

  •   Postgraduate Coordinator Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Santiago, Chile

    2013 - 2018

  •   Director of Research (s) Full Time

    UNIVERSIDAD DE CHILE

    of Dentistry

    Santiago, Chile

    2016 - 2016

  •   Director of Research ICOD Full Time

    UNIVERSIDAD DE CHILE

    of Dentistry

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Postgraduate Coordinator Full Time

    Faculty of Dentistry - Universidad de Chile

    Santiago de Chile, Chile

    2013 - 2018

  •   Assistant Professor Full Time

    ICOD - Faculty of Dentistry - Universidad de Chile

    Santiago de Chile, Chile

    2011 - A la fecha

  •   Assistant Professor Full Time

    ICBM - Faculty of Medicine - Universidad de Chile

    Santiago de Chile, Chile

    2010 - 2011

  •   Assistant Professor Part Time

    Department of Neuroscience - Faculty of Medicine - Uniersidad de Chile

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


PhD Thesis:

1. "EXPERIMENTAL PERIODONTITIS INDUCED BY PORPHYROMONAS GINGIVALIS OR AGGREGATIBACTER ACTINOMYCETEMCOMITANS AND ITS ASSOCIATION WITH ALZHEIMER'S DISEASE"
Thesis to qualify for the degree of PhD in Dental Sciences, Faculty of Dentistry, University of Chile
Principal Tutor: Dr. Andrea Paula Lima.
Candidate: Mr. Jaime Díaz Zúñiga
Year: 2019

2. "MODIFICATION OF FUNCTIONAL CONNECTIVITY AS AN EARLY ALTERATION MECHANISM, OF SPACE MEMORY IN PATIENTS WITH COGNITIVE DETERIORATION"
Thesis to qualify for the degree of PhD in Biomedical Sciencess; Faculty of Medicine, University of Chile
Principal Tutor: Dr. Andrea Paula Lima.
Candidate: Iván Plaza Rosales
Year: 2020

3. "PARTICIPATION OF OXYGEN REAGENT SPECIES AND NUCLEAR SIGNALS OF Ca2 + IN GENE EXPRESSION DEPENDENT ON HIPOCAMPAL NEURAL ACTIVITY AND SINAPTOTOXICITY OF BETA AMYLOID PEPTIDE".
Thesis to qualify for the degree of PhD in Pharmacology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile
Co-Tutor: Dr. Andrea Paula Lima.
Candidate: Pedro Lobos Zambrano
2018-present

4. "PARTICIPATION OF PSERSTAT3 IN THE MITOCHONDRIAL FUNCTION AND NEURITOGENESIS OF NEURONS TREATED WITH PEGETY OLIGOMETERS? -AMILOID".
PhD in Sciences with mention in Molecular, Cellular and Neuroscience Biology, University of Chile
Student: Yorka Muñoz
Co-Tutor: Dr. Andrea Paula Lima.
Year: 2018

5. "Ca2+ SIGNALS EVOKED IN DENDRITES OF PRIMARY RAT HIPPOCAMPAL NEURONS ENGAGE RyR2-MEDIATED Ca2 + RELEASE FOR PROPAGATION TO THE NUCLEUS".
PhD in Biomedical Sciences; Faculty of Medicine, University of Chile
Student: Alex Córdova
Year 2016

6. "ROLE OF THE SIGNALING ROUTE IRE1? / XBP1 AS REGULATOR OF THE SECRETION OF THE PEPTIDE A? IN THE MURINE MODEL OF ALZHEIMER'S DISEASE (AD) ".
PhD in Biomedical Sciences, Faculty of Medicine, University of Chile
Student: Víctor Hugo Cornejo Corona
Co-tutor: Dr. Andrea Paula Lima.
Year: 2015

7. "THE CONSUMPTION OF ANTIOXIDANT N-ACETYLCISTEIN (NAC) MODULATES THE STATE REDOX CEREBRAL AND PREVENTS COGNITIVE DETERIORATION IN AN EXPERIMENTAL MODEL OF ALZHEIMER'S DISEASE"
PhD in Biomedical Sciences, Faculty of Medicine, University of Chile
Student: Jamileth Y. More de la Cruz
Principal Tutor: Dr. Andrea Paula Lima.
2019

Master Thesis:

1. "EFFECTS OF BETA-AMYLOID PEPTIDE OLIGOMETERS ON THE TRANSLOCATION OF Nrf2 TO THE NUCLEO AND EXPRESSION OF ANTIOXIDANT ZIMS, INDUCED BY BDNF IN PRIMARY CROPS OF HYPOCAMPAL NEURONS"
Thesis to qualify for the degree of Master in Biological Chemistry from Bernardo O'Higgins University
Candidate: Marilyn Solányela Fonseca Díaz
Principal Tutor: Dr. Andrea Paula Lima.
2018-present

2. "PARTICIPATION OF REACTIVE OXYGEN SPECIES AND THE NRF2 TRANSCRIPTION FACTOR IN INTRACELLULAR SIGNALING INDUCED BY BDNF IN PRIMARY CULTURE OF HYPOCAMPAL NEURONS."
Master in Biochemistry at the University of Chile.
Student: Bárbara Bruna Jara
Principal Tutor: Dr. Andrea Paula Lima.
Year: 2017

3. "DO RYANODINE RECEPTORS MODULATE ENDOPLASMIC RETICULUM-MITOCHONDRIA INTERFACE IN AN ALZHEIMER'S DISEASE MODEL?"
Student: Nadja Galusso
Principal Tutor: Dr. Andrea Paula Lima.
45 ECTS Master Thesis Degree Project, Department of Neurochemistry. Stockholm University
Year: 2016

4. "DETERIORATION IN LEARNING AND HIPOCAMPO DEPENDENT SPACE MEMORY AS A RESULT OF THE DECREASE IN THE EXPRESSION OF THE CALCIUM CHANNEL RECEIVER OF RYANODINE TYPE 2 (RYR2) IN THE HIPOCAMPO".
Student: Jamileth Y. More de la Cruz
Principal Tutor: Dr. Andrea Paula Lima.
Master's Program in Neurosciences, Faculty of Medicine, U. de Chile
Year: 2015

5. "ROLE OF REACTIVE OXYGEN SPECIES IN THE MODIFICATION OF THE MITOCHONDRIAL NETWORK AND THE EXPRESSION OF THE RYANODINE RECEIVER INDUCED BY THE PEPTIDE A OLIGOMETERS?"
Student: Pablo G. Barattini Matta
Principal Tutor: Dr. Andrea Paula Lima.
Master in Biochemistry, Faculty of Chemistry and Pharmacy, U. Chile.
Year: 2015

6. "ELECTROPHISIOLOGICAL FEATURES OF LEARNING AND SPACE MEMORY IN PATIENTS WITH ALZHEIMER'S DISEASE IN THE INITIAL PHASE".
Candidate: Rodrigo Félix Manrique Häfelin
Principal Tutor: Dr. Andrea Paula Lima.
Master in Medical and Biological Sciences, Mention Neurosciences, Faculty of Medicine, U. Chile
Start: 2013. Tutor. Conclusion: 06/10/2015


Difusión y Transferencia


1. Interview for the newspaper El Mercurio: Women are gaining ground in science and increasingly faster. https://digital.elmercurio.com/2019/03/08/A/DG3IE41T#zoom=page-width

2. Andrea Paula Lima, doctor in biochemistry. Future looks. Futuro 360. CNN Chile. https://www.futuro360.com/opinion/andrea-paula-lima-doctora-en-bioquimica-vamos-a-tener-la-capacidad-de-usar-la-mente-sin-estar-presente_20190206/

3. Alzheimer's Nerd Night https://youtu.be/fWKvxgKecp4 1770172019

4. New Woman Magazine News: Learn about the story of Andrea Paula Lima, the researcher who struggles to advance in the treatment of Alzheimer's. 6/18/2018.

5. ADN Radio Chile Woman STEM Interview: Andrea Paula Lima 6/18/2018

6. Conicyt Report: Andrea paula lima: "For women, science is not an easy path, but it is changing". 6/11/2018

7. News Chilean Society of Neurosciences. Dr. Andrea Paula Lima investigates treatment to reverse the cognitive deterioration of Alzheimer's. https://socneurociencia.cl/2018/05/31/la-dra-andrea-paula-lima-investiga-tratamiento-para-revertir-el-deterioro-cognitivo-del-alzheimer/

8. Interview for the newspaper El Mostrador: Alzheimer, An unresolved challenge. May 30, 2018. Highlighted for receiving the Award of Excellence for Young Researcher Adelina Gutiérrez.

9. News Faculty of Medicine. Dr. Andrea Paula Lima, best young scientist 2017. May 22, 2018.

10. Portfolio Health publication. Scientists analyze early signs of Alzheimer's with virtual reality. Diario Financiero - Health Portfolio. 05/08/2017.

11. Video Report of Chilevisión News about Alzheimer's, with research carried out by scientists from the Instituto Milenio de Neurociencia Biomédica, BNI, by doctors Andrea Paula Lima and Enzo Brunetti. www.youtube.com/watch?v=NoIcwqIk2uo 04/03/2017

12. Publication of El Mostrador - With virtual reality exercise scientists study early signs of Alzheimer 13/03/2017
Scientists of the University of Chile Pose Preventive Techniques against Alzheimer's - OdontoNews
http://webdental.cl/odontologia/?p=6889 04/04/2017

13. Report Portal Universidad de la Frontera: Researchers from the U. de Chile and UFRO share experiences in project formulation. July 1, 2016
Outstanding cooperation program to contribute to the development of its extension, teaching and research activities.

14. Reuters Agency Video: Eye Movement link to Alzheimer's disease. https://stock.adobe.com/ee/editorial/eye-movement-link-to-alzheimer-s/157771553

15. University of Chile Radio Program - To your health. Dr. Andréa Paula Lima Alzheimer's Disease and Music.

16. Publication of El Mostrador with his research on the detection of diseases such as Alzheimer's, through the study of eye movements. In this is mentioned his membership in BNI. https://www.elmostrador.cl/cultura/2015/10/29/neurocientificos-chilenos-detectan-enfermedades-psiquiatricas-por-el-movimiento-de-los-ojos/?php%20bloginfo(%27url%27) ;% 20?% 3E / culture

17. Radio Mentalized Program. Radio University of Chile. 3/31/2015 http://radio.uchile.cl/programas/mentalizados/en-esta-edicion-conversamos-con-la-doctora-andrea-paula-lima-sobre-el-cerebro-la-memoria-y -Alzheimer's disease/

18. Diario La Tercera Trends: Chilean scientists detect Schizophrenia and Alzheimer by eye movements http://www2.latercera.com/noticia/cientificos-chilenos- detectn- schizophrenia-y-alzheimer-by-eye-movements / # 29/10 / 2015.

19. News Cecilia Espinosa Cortes - Dr. Paula Lima is honored by the Royal Society. Meeting Frontiers UK-Brazil-Chile. 2014

20. El Mercurio Daily Report: Study of the Millennium Institute of Neurosciences Biomedical: Analysis of eye movements gives clues about Alzheimer's. December 16, 2013.
Outstanding study through the way in which patients explore and extract visual information and associated brain activity is aimed at improving diagnosis.

21. News "Young researcher of BNI wins international award" Pagina Web Biomedical Neuroscience Institute, University of Chile. 01/28/2013.
http://www.bni.cl/nv_detailed.php?did=75

22. Interview on research on findings about Alzheimer's. Radio Universidad de Chile, Milenio Program 08/04 / 201http: //radio.uchile.cl/programas/milenio/vicky-quevedo-entrevisto-al-academico-de-la-u-de-chile-daniel-espinoza-sobre -the-optimization-in-networks-and-with-andrea-paulalima-on-your-research-in-findings-on-the-alzheimer /

23. News "Andrea Paula-Lima: The cellular search in Alzheimer's" 04/09/2013. Website Faculty of Dentistry, University of Chile. 04/09/2013. http://www.odontologia.uchile.cl/noticias/90092/la-busqueda-celular-en-el-alzheimer

24. News "Prevent Alzheimer's" Regional Journal Arica Hoy. 03/19/2013 http://www.aricahoy.cl/?p=942

25. News "The scientist who studies a new possibility for Alzheimer's." 03/19/2013. Enciclope
News "Alzheimer: Andrea Paula-Lima investigates possible role of meats and dairy products in their treatment." 03/20/2013.

26. Pure online journal
Noticia.cl.http: //www.puranoticia.cl/front/contenido/2013/03/20/noticia-68303.php

27. News "Antioxidant that could prevent Alzheimer's." 03/21/2013. The Second Online.http: //www.lasegunda.com/Noticias/Buena-Vida/2013/03/832216/Antioxidante-que-podria-prevenir-el-Alzheimer

28. News "Scientific of U Chile investigates benefits of antioxidant that could prevent Alzheimer's." 03/21/2013. Terra.http: //noticias.terra.cl/nacional/cientifica-de-u-de-chile-investiga-beneficios-de-antioxidante-que-podria-prevenir-el-Alzheimer,8e4ce01a4fc8d310VgnCLD2000000ec6eb0aRCRD.html

29. News "Scientific investigates antioxidant benefits that could prevent Alzheimer's disease". Bio Bio Technology. Biobiochile.cl. 03/21/2013. http://bni.cl/var/files/biobio_paula.pdf

30. Interview live on Alzheimer's in the Conecta2 program on the international signal of National Television of Chile. 03/21/2013. http://www.facebook.com/Conecta2TvChile
News "Natural antioxidant could prevent Alzheimer's disease." - 24 Hours -

31. Interview on Alzheimer's in TVChile Program - INNOVA program of TV CHILE internacional. international signal of National Television of Chile. https://vimeo.com/71040875

32. News "Young Researcher of the Millennium Institute of Neuroscience Biomedical receives international award" Web page of the Millennium Scientific Initiative. News 14/03 / 2012.http: //www.iniciativamilenio.cl/noticias/noti_det.php? Id = 1418

33. Citizen Forum Program: Communication between neurons. INTERVIEW Radio Broadcast. Radio University of Chile2012

34. El Mercurio Daily Report: Scientists represent Chile in an international meeting with 23 novelties. June 30, 2011.
Outstanding young people selected at the Lindau Meeting in Germany.

35. Image of Researchers and creators of excellence. University of Chile. Building the Chile of the future. University of Chile. 2011

36. Newspaper El Mercurio 2011 Dentistry advances in equipment for Research. Periodistic note by Cecilia Espinosa Cortés


Premios y Distinciones

  •   UK-Brazil-Chile Frontiers of Science;

    ACADEMIA CHILENA DE CIENCIAS

    Reino Unido, 2014

    Invited by The Royal Society to represent Chile in the area research of Human Health in the UK-Brazil-Chile Frontiers of Science. Buckhamshire, UK, 23-26, February, 2014.

  •   Junior Faculty Award

    Society Alzheimer's and Parkinson's Diseases (AD / PD)

    Italia, 2013

    Junior Faculty Award at the 11 th International Conference on Alzheimer's and Parkinson's Diseases (AD / PD), Florence, Italy, for the exceptional professional contribution to the study of Alzheimer's disease.

  •   Young Members of TWAS Affiliation

    The World Academy of Sciences

    China, 2012

    Selected as an affiliate member of TWAS (The World Academy of Sciences) for the period 2012-2016. TWAS annually elects excellence scientists younger than 40 years for their affiliation as Young Member for a period of five years. To be elected, Young Members of TWAS must live and work in a developing country.

  •   http://www.icdb.cl/pdf/El%20Mercurio-%2030-jul-2011-%20Lindau%20Meeting.pdf

    Foundation Lindau at Lake Constance Nobelprizewinners Meetings

    Alemania, 2011

    Selected to participate in the 61st Lindau Nobel Laureate Meeting dedicated to Physiology / Medicine. Selected to participate in the 61st Lindau Nobel Laureate Meeting dedicated to Physiology / Medicine. Qualified in global competition among young researchers by the Council for the Lindau Nobel Laureate Meetings / Foundation Lindau at Lake Constance Nobelprizewinners Meetings, Lindau, Germany.

  •   Junior Faculty Award

    Society for Alzheimer's and Parkinson's Diseases (AD / PD)

    España, 2011

    Junior Faculty Award at the 10th International Conference on Alzheimer's and Parkinson's Diseases (AD / PD), Barcelona, Spain, for the exceptional professional contribution to the study of Alzheimer's disease.

  •   Society for Neuroscience Chapter Postdoctoral Trainee Travel Award.

    Society for Neuroscience

    Estados Unidos, 2010

    Society for Neuroscience Chapter Postdoctoral Trainee Travel Award. Presentation of postdoctoral work in the Award section of the "40th Neuroscience Meeting" held in San Diego, USA. November, 2008.

  •   Conesul Young Scientist Award

    Brazilian Society for Biochemistry and Molecular Biology

    Brasil, 2009

    For the postdoctoral work titled "Changes in ryanodine receptor expression and activity in hippocampal neurons exposed to BDNF or beta-amyloid peptide oligomers", presented at the Symposium "SBBq Cone Sul" in the XXXVIII Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology (Sociedade Brasileira of Biochemistry and Molecular Biology - SBBq) in Águas de Lindóia, São Paulo, Brazil

  •   Honor to Merit

    Federação of Societies for Experimental Biology

    Chile, 2006

    Distinction for Merit awarded by the Federation of Societies for Experimental Biology (FESBE) for the presentation of the poster entitled "Taurine accumulation of extracellular glutamate blocks and Prevents neurotoxicity induced by ?-amyloid in hippocampal and cortical neurons" in the XXI Annual Meeting of the Federação of Societies for Experimental Biology (FESBE), of Lindóia - São Paulo - Brazil

  •   Scholarship Grade A

    Fundação de Amparo à Pesquisa Nacional do Rio de Janeiro

    Chile, 2005

    Scholarship Grade 10 issued by the National Foundation for Research Support of Rio de Janeiro (Fundação de Amparo à Pesquisa Nacional do Rio de Janeiro - FAPERJ) for carrying out the second stage of the doctoral thesis (03/08/2005-13/08/2007). This is a scholarship specifically granted to outstanding doctoral students.

  •   PREMIO DE EXCELENCIA CIENTÍFICA “ADELINA GUTIERREZ” DE LA ACADEMIA CHILENA DE CIENCIAS

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2017

    El Premio de Excelencia Científica tiene por objetivo premiar la trayectoria científica de jóvenes investigadoras nacionales o extranjeras residentes en Chile.

  •   The Border Science Program

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2012

    The Border Science Program is promoted by The Chilean Academy of Sciences, in order to recognize the excellence and potential of young scientists in different areas of science and link them to the activities of the Academy. The main objectives of this program are to stimulate interdisciplinary scientific discussion, the creation of links and the development of joint initiatives by the new generations of Chilean scientists. and promote the contact of this group of young Chilean scientists with scientists who participate in similar programs in other countries (International Academy of Young Scientists, TWAS, NAS or others). Along with this, it is expected that in the near future the selected group will be integrated and collaborate in the activities of the Academy.


 

Article (47)

Differential navigational strategies during spatial learning in a new modified version of the Oasis maze
Latin America: Reduced S&T Investment Puts Sustainable Development at Risk
Salud oral en personas mayores: un desafío multidimensional para Chile
Serotype b of Aggregatibacter actinomycetemcomitans triggers pro-inflammatory responses and amyloid beta secretion in hippocampal cells: a novel link between periodontitis and Alzheimer ' s disease?
Serotype b of Aggregatibacter actinomycetemcomitans triggers pro-inflammatory responses and amyloid beta secretion in hippocampal cells=> a novel link between periodontitis and Alzheimer ' s disease?
Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory
N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model
N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model.
Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K
RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid beta Peptide Oligomers
RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid Beta Peptide Oligomers.
Astaxanthin protects primary hippocampal neurons against noxious effects of A ?-oligomers
Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of Abeta-Oligomers
H2O2 activates Matrix Metalloproteinases through Nuclear Factor Kappa B Pathway and Ca2+ signals in human Periodontal Fibroblasts
H2O2 activates matrix metalloproteinases through the nuclear factor kappa B pathway and Ca2+ signals in human periodontal fibroblasts
Inhibitory ryanodine prevents ryanodine receptor-mediated Ca(2+) release without affecting endoplasmic reticulum Ca(2+) content in primary hippocampal neurons
Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons
Contribution of Ca(2+) Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation.
Ryanodine receptor-mediated Ca(2+) release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca(2+) uptake in primary hippocampal neurons.
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates nnitochondrial Ca2+ uptake in primary hippocampal neurons
Amyloid beta-peptide oligomers, ryanodine receptor-mediated Ca(2+) release, and Wnt-5a/Ca(2+) signaling: opposing roles in neuronal mitochondrial dynamics?
Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease.
Amyloid-? oligomers induce differential gene expression in adult human brain slices
Amyloid-beta oligomers induce differential gene expression in adult human brain slices.
Sub-lethal levels of amyloid beta-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons
Sub-lethal levels of amyloid β-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons.
The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-beta Peptide Oligomers
The antioxidant N-acetylcysteine prevents the mitochondrial fragmentation induced by soluble amyloid-β peptide oligomers.
A beta Oligomers Induce Glutamate Release from Hippocampal Neurons
Abeta oligomers induce glutamate release from hippocampal neurons.
Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF
Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation.
Human apolipoprotein A-I binds amyloid-beta and prevents A beta-induced neurotoxicity
Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity.
Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line
Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line
Activation of GABA(A) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons
Activation of GABA(A) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons.
Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders
Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders.
Neuroprotection against Abeta and glutamate toxicity by melatonin: are GABA receptors involved?
Neuroprotection against Abeta and glutamate toxicity by melatonin: are GABA receptors involved?
Dual role of glutamatergic neurotransmission on amyloid beta(1-42) aggregation and neurotoxicity in embryonic avian retina.
Dual role of glutamatergic neurotransmission on amyloid beta(1-42) aggregation and neurotoxicity in embryonic avian retina.

Abstract (2)

Role of RyR2-mediated calcium release in synaptic plasticity, learning and memory in control and AD-model rats
Abeta oligomers and iron stimulate calcium and ROS-dependent mitochondrial fragmentation in primary hippocampal neurons

BookSection (2)

Bases clínicas, genéticas e bioquímicas da fisiopatologia e do tratamento da Doença de Parkinson.
O eixo hormonal GH/IGF-1, a atividade física e o envelhecimento: benefícios e riscos potenciais da suplementação.

EditorialMaterial (1)

Amyloid beta-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics?

Proyecto (19)

CANCER LEAVES A TRAIT OF DIMINISHED IMMUNE TOLERANCE THAT PROTECTS FROM ALZHEIMER’S DISEASE
UNVEILING HOW NEURONAL CALCIUM SIGNALS REACH THE NUCLEUS FOLLOWING SYNAPSE ACTIVATION
ASOCIACIÓN ENTRE ENFERMEDAD PERIODONTAL Y ENFERMEDAD DE ALZHEIMER
EXPERIMENTAL PERIODONTAL INFECTION INDUCED BY PORPHYROMONAS GINGIVALIS OR AGGREGATIBACTER ACTINOMYCETEMCOMITANS AND ITS ASSOCIATION WITH ALZHEIMER’S DISEASE. LOOKING FOR THE POTENTIAL RISK FACTOR.
CM-BIOMEDICAL NEUROSCIENCE INSTITUTE
DEFECTIVE CALCIUM/REDOX SIGNALING AND ANOMALOUS ELECTRICAL BRAIN ACTIVITY IN RATS INJECTED WITH AMYLOID BETA OLIGOMERS=> FUNCTIONAL AND BEHAVIORAL CORRELATES WITH ALZHEIMER´S PATIENTS.
MICROSCOPIO DE CAMPO EVANESCENTE O TIRF
MOTORIZED MICROSCOPE “CELL OBSERVER” WITH LED FLUORESCENCE SYSTEM
System Storage and Advanced Biomedical Computing Services (SASIBA)
ACQUISITION OF AN ULTRACENTRIFUGE WITH 4 ROTORS
CONFOCAL MICROSCOPY PLATFORM FOR USE IN ADVANCED BIOMEDICAL RESEARCH
ACQUISITION OF A SCANNING ELECTRON MICROSCOPE AND ANCILLARY EQUIPMENT (SEMEDX) (SEM-EDX) FOR ADVANCED RESEARCH IN DENTAL SCIENCES
BIOMED-HPC=> RED DE BIOLOGÍA Y MEDICINA COMPUTACIONAL DE ALTO RENDIMIENTO.
ESTUDIO DE PATRONES OSCILATORIOS ANORMALES EN SUJETOS CON ENFERMEDAD DE ALZHEIMER INCIPIENTE Y EN ROEDORES INYECTADOS CON OLIGÓMEROS DEL PÉPTIDO BETA-AMILOIDE.
EPIFLUORESCENCE MICROSCOPE TO STIMULATE INTERDISCIPLINARY RESEARCH USING CELL BIOLOGY APPROACHES IN THE FACULTY OF DENTISTRY, UNIVERSIDAD DE CHILE.
UNRAVELING THE CALCIUM SIGNALING PATHWAYS THAT MEDIATE THE NEURONAL DYSFUNCTIONS INDUCED BY AMYLOID-BETA PEPTIDE OLIGOMERS.
RENOVACIÓN ACADÉMICA PARA EL DESARROLLO DE LA MEDICINA MOLECULAR
ROLE OF RYANODINE RECEPTORS ON NEURONAL CALCIUM SIGNALS AND SYNAPTIC PLASTICITY ALTERATIONS INDUCED BY THE BETA-AMYLOID PEPTIDE.
ROLE OF RYANODINE RECEPTORS ON NEURONAL CALCIUM SIGNALS AND SYNAPTIC PLASTICITY ALTERATIONS INDUCED BY THE BETA-AMYLOID PEPTIDE.

Review (2)

Contribution of Ca2+ Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation
Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease
32
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

12
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

9
Tatiana Adasme

Associate Researcher

Centro de Investigación Clínica Avanzada (CICA)

Universidad Chile

Santiago, Chile

5
Jamileth More

Investigador

Neurologia

Hospital Clinico Universidad de Chile

Santiago, Chile

5
Barbara Bruna

Asistente de Investigación

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

5
Andrea Paula-Lima

Profesora Asociada

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

3
Carol San Martín

Profesora Asistente

Universidad Mayor de Chile

Santiago, Chile

3
José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

3
jose valdes

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

2
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Rolando Vernal

Profesor Titular

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Emma Hernandez

Académico 44 h, profesor titular

Oral Patology and Medicine

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

1
Jorge Gamonal

Académico

Odontología Conservadora

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pablo Muñoz

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

1
PAOLA HAEGER

Associated professor

Ciencias Biomedicas

Universidad Catolica del Norte

COQUIMBO, Chile

1
Ian Cavalla

Assistant professor

Conservative dentistry

Universidad de Chile

Santiago, Chile

1
Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

1
Italo Espinoza

Lab Manager

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile