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María Yolanda Espinosa Parrilla

Full Professor

Universidad de Magallanes

Punta Arenas, Chile

Líneas de Investigación


1. Non-coding RNAs in gastric cancer 2. Identification of aging biomarkes 3. Population genetics and disease susceptibility 4. Hereditary Cancer 5. Genomic evolution of non-coding RNAs in primates

Educación

  •  Biology, UNIVERSIDAD DE BARCELONA. España, 1993
  •  PhD in Biology, UNIVERSIDAD DE BARCELONA. España, 2000
  •  Antartic sciences, UNIVERSIDAD DE MAGALLANES. Chile, 2017

Experiencia Académica

  •   PhD student Full Time

    Center of Medical and Molecular Genetics. Oncologic Research Institute (IRO). "Duran y Reynals" Hospital

    Barcelona, España

    1996 - A la fecha

  •   PhD student Full Time

    Wallenberg Laboratoriet

    Lund University

    Malmö, Suecia

    1998 - 1998

  •   Postdoctoral Researcher Full Time

    INSERM-U393, Hôpital Necker

    Paris V

    Paris, Francia

    2000 - 2003

  •   "Ramón y Cajal" Researcher Full Time

    Center for Genomic Regulation (CRG)

    Barcelona, España

    2004 - 2008

  •   Associate Professor Full Time

    Universitat Pompeu Fabra and Universidad de Chile

    Barcelona, España

    2012 - 2015

  •   Visiting professor Part Time

    Universitat Pompeu Fabra

    Barcelona, España

    2015 - 2019

  •   Associate Professor Full Time

    UNIVERSIDAD DE MAGALLANES

    Punta Arenas, Chile

    2015 - 2024

  •   Full Professor Full Time

    UNIVERSIDAD DE MAGALLANES

    Punta Arenas, Chile

    2024 - A la fecha

Experiencia Profesional

  •   PhD student Full Time

    Center of Medical and Molecular Genetics. Oncologic Research Institute (IRO). "Duran y Reynals" Hospital

    Barcelona, España

    1996 - 2000

  •   PhD student Full Time

    Departament of Clinical Chemistry. Wallenberg Laboratoriet, University of Lund

    Malmö, Suecia

    1998 - 1998

  •   Postdoctoral Researcher Full Time

    Departament of Genetics. INSERM-U393, Hôpital Necker

    Paris, Francia

    2000 - 2003

  •   "Ramón y Cajal" Researcher Full Time

    Center for Genomic Regulation (CRG)

    Barcelona, España

    2004 - 2008

  •   Marie Curie Researcher Full Time

    Universitat Pompeu Fabra y Universidad de Chile

    Barcelona, España

    2009 - 2012

  •   Associate Professor Full Time

    Universidad Pompeu Fabra (UPF)

    Barcelona, España

    2012 - 2015

  •   Associate Professor Full Time

    Universidad de Magallanes

    Punta Arenas, Chile

    2015 - 2024

  •   Visiting Professor Other

    Universitat Pompeu Fabra (UPF)

    Barcelona, España

    2015 - 2019

  •   Full professor Full Time

    Universidad de Magallanes

    Punta Arenas, Chile

    2024 - A la fecha

Formación de Capital Humano


POSTDOCTORAL RESEARCHERS

January - September 2013
Ingrid Balcells Ortega
Subject: RNAs in primates: a comparative genomics approach

MS theses:

Ivonne Belén Troncoso Aburto, RUT: 19.286.492-5
2024 – present
Subject: Identificacion of circRNAs as predictive biomarkers for early detection of gastric cancer
MS. Program in Bioinformatics (Universidad de Magallanes).

Jenssy Dahiana Opazo Cortés, 16.815.593-K
2024 – present
Codirection with Dr. Andrea Silva Baez
Subject: Microbiota Nasofaríngea y expresión génica: Relación con la anosmia persitente en pacientes con COVID-19 prolongado
MS.in sciences, mention in Genetics (Universidad Austral de Chile).

Laura Camila Carvajal Silva, RUT: 16.301.983-3
June 2023 – Awarded with maximum distinction
Codirection with Dr. Ricardo Verdugo Salgado
Subject: Nivel Predictivo de un Puntaje de Riesgo Poligénico para Severidad de la Infección COVID-19 en Población Chilena
MS. Program in Genetics (Universidad de Chile).

Vanessa Jacqueline Diez de Medina, RUT: 15.914.156-K
October 2023 – Awarded with maximum distinction
Codirection with Dr. Alicia Colombo Flores
Subject: Comparación de kits comerciales para la obtención de ARN a partir de concentrado de leucocitos de sangre periférica para su preservación en los Biobancos de la Red Chilena de Genómica del COVID-19 (C19-GenoNet)
MS. in “Diagnóstico Molecular para su aplicación en el Laboratorio Clínico e Investigación” (Universidad de Chile).PHD STUDENTS

PH D Theses:

Mariom Carvajal Morales,
October 2024 – present
Subject: Study of the Synanthropic Spiders of Medical Importance in Austral Patagonia
Ph D program on sciences, mention in Molecular Biology (Universidad de Magallanes).

Alonso de la Rivera Morales,
April 2022 – present
Subject: Hereditary breast cancer in Magallanes: first steps towards the molecular diagnosis of breast cancer in the Magallanes and Chilean Antarctic region through whole exome sequencing
Ph D program in sciences, mention in Molecular Biology (Universidad de Magallanes).

Daniela Zapata Contreras,
April 2019 – present
Subject: Role of microRNAs in the pathogenesis involved in the progression of precancerous gastric lesions to gastric cancer
Ph D program in sciences, mention in Molecular Biology (Universidad de Magallanes).

Alicia Gallego Jiménez
2012 - 2016
Subject: Study of the frequency and functionality of microRNA edition in human brain disorders
Awarded Excellent, cum laude, November 2016
https://www.tdx.cat/handle/10803/585943

Ignasi Torruella Loran
2011 - 2016
Subject: Functional analysis of genetic variants in microRNAs associated with gastric cancer
Awarded Excellent, October 2016
https://www.tdx.cat/handle/10803/482207

María López Valenzuela
2009 - 2014
Subject: Genetic and genomic variation in microRNA regions among primates: functional and evolutionary implications
Awarded Excellent, January 2015
https://www.tdx.cat/handle/10803/383030

Margarita Muiños Gimeno
2004 - 2009
Analysis of genetic variation in microRNA-mediated regulation and the susceptibility to anxiety disorders
Awarded Excellent cum laude, December 2009
http://www.tdx.cat/handle/10803/7192

Monica Guidi
2004 - 2009
Post-transcriptional regulation of NTRK3 by miRNAs in the context of neuronal differentiation
Awarded Excellent cum laude, January 2009
http://www.tdx.cat/handle/10803/7114

SPECIALIZED TECHNICIANS
January 1997 - July 2000: Marta Morell
January 1998 - December: David Otero
January 2004 - December 2008: Birgit Kagerbauer
January 2010 - January 2015: Eva Garcia-Ramallo
July 2015 - April 2016: Maria Karla Ramírez Viña
October 2017 - April 2020: Maria Karla Ramírez Viña
June 2018 - Novembre 2023: Oscar Gallardo Vidal
October 2020 - November 2023: Paula Zuñiga Pacheco
January 2022 - November 2023: Constanza Morgado
March 2021 - October 2024- Cynthia Douglas
Novembre 2024 - present - Valeria Bahamonde Bahamonde
January 2025 - present - Alexis Sobarzo Bustamante


Difusión y Transferencia


Dissemination of scientific work to the community through various interviews on Radio, TV and newspapers.
The following would be the most outstanding of the last 5 years:
19-07-2023 Interview in the TV show Alma Mater in UMAG TV. https://www.youtube.com/watch?v=S7Bgz61ibCI
02-04-2023 TV Interview in the show “Retruco”, Pinguino Multimedia.
31-03-2023 Multimedia Report in “Radio Polar”. https://radiopolar.com › interesantes-datos-de-los-virus-se-comparte-en-seminario-del-cadi-umag/
10-03-2023 Multimedia Interview in the show “Buenos días region”, Radio Polar. http://www.facebook.com/radiopolar/videos/753798172727309/...
03-01-2023 Editorial in the newspaper “La Prensa Austral”. https://laprensaaustral.cl/2023/01/03/primer-biobanco-para-mejorar-la-salud-humana/
05-11-2022 TV interview in Canal 24h TVN Santiago.
04-11-2022 Newspaper Report in “La Tercera”. http://www.latercera.com/que-pasa/noticia/cientificos-chilenos-realizan-prometedor-estudio-para-detectar-biomarcadores-para-diagnostico-precoz-de-cancer...
23-10-2022 Newspaper Report in “La Prensa Austral”. https://laprensaaustral.cl/2022/10/23/a-traves-de-un-estudio-genetico-desarrollado-en-el-cadi-umag-grupo-cientifico-gemma-investiga-biomarcadores-para-el...
17-04-2022 Special Science Newpaper Report in “El Magallanes”. https://laprensaaustral.cl/2022/04/18/avanzan-investigaciones-enfocadas-en-la-prevencion-y-tratamiento-de-enfermedades-como-cancer-alzheimer-y-parkinson-en-magallanes/
23-01-2022 Newspaper Report in “El Magallanes”. https://laprensaaustral.cl/2022/01/25/energias-renovables-biomedicina-y-estudios-subantarticos-los-hitos-cientificos-de-la-umag/
14-01-2021 Multimedia Interview in the show “Nuestra Mañana” in “Pingüino Multimedia”. http://www.facebook.com/pinguinomultimedia/videos/761280641153327
13-01-2021 Multimedia interview in “Radio Polar”. https://youtu.be/A4FJmsvUHCQ
16-12-2020 Interview in “Radio Soberania”. http://www.facebook.com/soberaniaradio/videos/402531784317279
02-12-2020 TV interview in “Televisión Nacional Red Austral” www.facebook.com/redaustral/posts/1735136563317207
02-12-2020 Radio Interview in “Radio Polar”. http://www.radiopolar.com/noticia_161682.html
02-12-2020 Multimedia report in “Cooperativa Punta Arenas”. https://cooperativa.cl/noticias/sociedad/salud/coronavirus/punta-arenas-estudio-genetico-de-covid-19...
28-10-2020 Newspaper Report in “La Tercera”. https://www.latercera.com/que-pasa/noticia/por-que-las-personas-mayores-no-pueden-hacerse-cargo-de-su-salud-el-cuestionamiento-de-especialistas-a-las-medidas-a-ese...
07-10-2020 Newspaper Report in “La Prensa Austral”. https://archivo.laprensaaustral.cl/cronica/comenzo-campana-reclutamiento-de-voluntarios-para-estudio-sobre-el-covid/
05-10-2020 Newspaper Report in “El Magallánico”. https://elmagallanico.com/2020/10/invitan-a-personas-recuperadas-de-covid-19-a-participar-en-estudio-genetico-sobre-la-enfermedad
30-07-2020 Multimedia Interview in the show “Más conocimiento”. http://www.youtube.com/watch?v=mS72O5NP7VY
26-07-2020 Newspaper Report in “La Prensa Austral”. https://www.facebook.com/udemagallanes/posts/1744243592383670/
21-07-2020 Newspaper Report in “El mostrador”. http://www.elmostrador.cl/cultura/2020/07/21/investigadores-buscaran-los-factores-geneticos-asociados-a-la-gravedad-de-covid-19-en-la-poblacion-chilena/
22-09-2019 Newspaper Report in “El Magallanes”. https://archivo.laprensaaustral.cl/cronica/cadi-de-la-universidad-de-magallanes-realizara-investigacion-del-cancer-gastrico/
14-05-2019 Special Science Newpaper Report in “El Magallanes”. https://archivo.laprensaaustral.cl/ciencia/investigacion-sobre-cancer-gastrico-leucemias-linfaticas-y-envejecimiento-dan-inicio-a-labor-del-cadi-umag/
13-04-2019 Editorial in “La Prensa Austral”. http://www.umag.cl/vcm/wp-content/uploads/2019/04/CADI-UMAG-el-proyecto-m%C3%A1s-emplem%C3%A1tico-del-Pedze.jpg


Premios y Distinciones

  •   Accreditation of Advanced Research

    Agency for the Quality of the University System in Catalonia

    España, 2011

    In order to be eligible for a full professorship, which is the most advanced stage in a candidate's academic career and is awarded an indefinite contract, candidates must be in possession of an accreditation of advanced research issued by AQU Catalunya.

  •   Marie Curie Outgoing fellowship

    European Research Council (FP7)

    Chile, 2009

    These Fellowships are held in the EU or associated countries and last for one to two years. fund positions outside Europe for researchers based in the EU or associated countries. This grant lasted three years.

  •   Marie Curie Individual Fellowship

    European Research Council

    Francia, 2000

    Postdoctoral fellow

  •   Price for the best Spanish publication in the field of Thrombsis and Haemostasis in year 1999

    ROCHE diagnostics

    España, 2000

    Premio a la mejor publicación del año 1999 en el campo de la hematología y la hemostasia


 

Article (32)

The Chilean COVID-19 Genomics Network Biorepository: A Resource for Multi-Omics Studies of COVID-19 and Long COVID in a Latin American Population
A second update on mapping the human genetic architecture of COVID-19
Analysis of Scientometric Indicators in Publications Associated with Healthy Aging in the World, Period 2011-2020
Signatures of genetic variation in human microRNAs point to processes of positive selection and population-specific disease risk
Ancient genomes in South Patagonia reveal population movements associated with technological shifts and geography
Older adults with frailty syndrome present an altered platelet function and an increased level of circulating oxidative stress and mitochondrial dysfunction biomarker GDF-15
Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease
A Novel Child Burial from Tierra del Fuego: A Preliminary Report
Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders
Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging
rs12416605:C > T in MIR938 associates with gastric cancer through affecting the regulation of the CXCL12 chemokine gene
RNA editing independently occurs at three mir-376a-1 sites and may compromise the stability of the microRNA hairpin
Differences in molecular evolutionary rates among microRNAs in the human and chimpanzee genomes
Functional Implications of Human-Specific Changes in Great Ape microRNAs
MicroRNA Genetic Variation: From Population Analysis to Functional Implications of Three Allele Variants Associated with Cancer
Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: Results from the EPIC-EURGAST study
An Ancestral miR-1304 Allele Present in Neanderthals Regulates Genes Involved in Enamel Formation and Could Explain Dental Differences with Modern Humans
DRD4 dopamine receptor alleles in Chilean students of different ethnic origin and its relation with the risk for attention deficit/hyperactivity disorder
A founder effect at the EPCAM locus in Congenital Tufting Enteropathy in the Arabic Gulf
Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways
MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
Design and evaluation of a panel of single-nucleotide polymorphisms in microRNA genomic regions for association studies in human disease
Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells
Allele Variants in Functional MicroRNA Target Sites of the Neurotrophin-3 Receptor Gene (NTRK3) as Susceptibility Factors for Anxiety Disorders
Mutations of the <i>RET</i> gene in isolated and syndromic Hirschsprung's disease in human disclose major and modifier alleles at a single locus
Molecular screening of the <i>ZFHX1B</i> gene in prenatally diagnosed isolated agenesis of the <i>corpus callosum</i>
Expression of the SMADIP1 gene during early human development
Large-scale deletions and <i>SMADIP1</i> truncating mutations in syndromic hirschsprung disease with involvement of midline structures
Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiency
Protein S secretion differences of missense mutants account for phenotypic heterogeneity
Absence of linkage between type III protein S deficiency and the PROS1 and C4BP genes in families carrying the protein S Heerlen allele
Protein S deficiency: a database of mutations. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis

BookSection (2)

MicroRNA mediated regulation and the susceptibility to anxiety disorders.
Analysis of the Protein S gene in Protein S Deficiency

ConferencePoster (21)

Genetic variation and population differentiation in the mature and seed microRNA regions are related to human phenotypic diversity and cancer.
Allele-specific effects of rs12416605:C/T in miR-938 on the regulation of gastric cancer genes.
Analysis of the patterns of miR-376-a1 editing in human placenta and primate brain cortex.
MIR938 associates with gastric cáncer in Europeans through affecting the regulation of CXCL12 in an allele specific fashion.
Insights into South American population history, from ancient DNA from Tierra del Fuego
Analysis of nucleotide changes in miRNAs along great apes evolution reveals functional consequences for human specific miRNA substitutions
Analysis of the functional consequences of five microRNA allele variants associated with cancer
Differences in evolutionary rates among microRNA categories in the human and chimpanzee genomes
Functional consequences of cancer associated variants in six human microRNAs
Spectrum of nucleotide changes in human microRNAs along great apes evolution: functional implications
Accelerated evolution of primate-specific microRNAs in the human genome
Analysis of nucleotide changes in miRNAs genes along primate evolution
Genetic variants in mIR-499a, miR-938 and miR-1206 associate with gastric cancer in Europeans from the EPIC-EURGAST study
miRNA clusters in cromosome 7 including MIR29, MIR25, MIR93 and MIR106 genes associate with gastric cancer in Europeans: Results from the EPIC-EURGAST study’
Functional implications of a polymorphism in a primate-specific miRNA.
The miR-29 family of microRNA genes and let-7i associate with gastric cancer in European populations: Results from the EPIC-EURGAST study
Transcriptome Analysis In A Murine Model Of Anxiety Overexpressing The Neurotrophin-3 Receptor (ntrk3)
Association analysis reveals several microRNAs involved in the susceptibility to eating disorders 
Differential miRNA-mediated regulation of isoforms of the recepetor for neurotrophin-3 (NTRK3) 
Patterns of association of microRNAs with schizophrenia symptoms
Large-scale deletions versus truncating mutations at the ZFHX1B locus in Mowat-Wilson syndrome: genotype-phenotype correlations.

Letter (1)

Consenso para la consejer�a gen�tica y diagn�stico molecular oncol�gicos: Declaraci�n de Punta Arenas

Proyecto (5)

Circular RNAs as players in Gastric Cancer by acting as microRNA sponges: new insights into the involvement of non-coding RNAs in the progression of cancer
Covid-19 y su impacto en salud cardiovascular: efectos a corto y mediano plazo de la infección por sars-cov-2 sobre el riesgo cardio metabólico en población adulta
Estudio de la variación genética a nivel de genoma completo para la susceptibilidad y la gravedad de COVID-19 en la población chilena
Assessment of AID-related somatic signatures and their role in tumor progression of class switched vs non switched B-cell neoplasm
Assessment of the role of genetic variation in microRNAs on the susceptibility and physiopathology of Gastric Cancer

Review (1)

How Protein Depletion Balances Thrombosis and Bleeding Risk in the Context of Platelet's Activatory and Negative Signaling
3
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

1
Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

3
Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile

1
Gerardo Acosta

Full Professor

INSTITUTO DE MEDICINA PREVENTIVA VETERINARIA, FACULTAD DE CIENCIAS VETERINARIAS, UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

2
Temistocles Prieto

ASSOCIATED RESEARCHER

Centro Gaia Antartica

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

4
Eduardo Fuentes

Profesor Titular

Universidad de Talca

Talca, Chile

1
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

2
Christian Gonzalez

Full Professor

Biologia

Universidad de Chile

Santiago, Chile

1
Cristian Núñez

Profesor de Fisiología

Escuela de Medicina

Universidad de Magallanes

Punta Arenas, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

62
María Yolanda Espinosa

Full Professor

Universidad de Magallanes

Punta Arenas, Chile

1
María Furrianca

PROFESOR ASOCIADO

DEPARTAMENTO DE ENFERMERÍA

Universidad de Magallanes

Punta Arenas, Chile

1
Melissa Calegaro

Principal Investigator, head lab

Research Vice Presidency

Universidad Mayor

Santiago, Chile

1
Claudio Cappelli

R&D Director

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Estefania Nova

Associate Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

1
Christian Muñoz

Profesor Asociado

Tecnología Médica

Universidad de Antofagasta

Antofagasta, Chile

1
Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

2
Diego Arauna

Investigador Postdoctorante

Universidad de Talca

Talca, Chile

1
Victor Sierpe

Investigador Asociado

Instituto de la Patagonia

Universidad de Magallanes

Punta Arenas, Chile

3
Daniela Zapata

Profesional de apoyo en investigación

Centro Asistencial Docente y de Investigación

Universidad de Magallanes

Punta Arenas, Chile

1
Hector Montecino

Investigador Postdoctoral

Centro de Estudios en Alimentos Procesados

Talca, Chile