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Maria Yolanda Espinosa Parrilla

Associate Professor

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

Líneas de Investigación


1. Non-coding RNAs in gastric cancer 2. Population genetics and disease susceptibility 3. Genomic evolution of non-coding RNAs in primates

Educación

  •  Biology, UNIVERSIDAD DE BARCELONA. España, 1993
  •  PhD in Biology, UNIVERSIDAD DE BARCELONA. España, 2000
  •  Diploma in Antartic Issues, UNIVERSIDAD DE MAGALLANES. Chile, 2017

Experiencia Académica

  •   PhD student Full Time

    Center of Medical and Molecular Genetics. Oncologic Research Institute (IRO). "Duran y Reynals" Hospital

    Barcelona, España

    1996 - A la fecha

  •   PhD student Full Time

    Wallenberg Laboratoriet

    Lund University

    Malmö, Suecia

    1998 - 1998

  •   Postdoctoral Researcher Full Time

    INSERM-U393, Hôpital Necker

    Paris V

    Paris, Francia

    2000 - 2003

  •   "Ramón y Cajal" Researcher Full Time

    Center for Genomic Regulation (CRG)

    Barcelona, España

    2004 - 2008

  •   Associate Professor Full Time

    Universitat Pompeu Fabra and Universidad de Chile

    Barcelona, España

    2012 - 2015

  •   Visiting professor Part Time

    Universitat Pompeu Fabra

    Barcelona, España

    2015 - 2019

  •   Associate Professor Full Time

    UNIVERSIDAD DE MAGALLANES

    Punta Arenas, Chile

    2015 - A la fecha

Experiencia Profesional

  •   PhD student Full Time

    Center of Medical and Molecular Genetics. Oncologic Research Institute (IRO). "Duran y Reynals" Hospital

    Barcelona, España

    1996 - 2000

  •   PhD student Full Time

    Departament of Clinical Chemistry. Wallenberg Laboratoriet, University of Lund

    Malmö, Suecia

    1998 - 1998

  •   Postdoctoral Researcher Full Time

    Departament of Genetics. INSERM-U393, Hôpital Necker

    Paris, Francia

    2000 - 2003

  •   "Ramón y Cajal" Researcher Full Time

    Center for Genomic Regulation (CRG)

    Barcelona, España

    2004 - 2008

  •   Marie Curie Researcher Full Time

    Universitat Pompeu Fabra y Universidad de Chile

    Barcelona, España

    2009 - 2012

  •   Associate Professor Full Time

    Universidad Pompeu Fabra (UPF)

    Barcelona, España

    2012 - 2015

  •   Associate Professor Full Time

    Universidad de Magallanes

    Punta Arenas, Chile

    2015 - A la fecha

  •   Visiting Professor Other

    Universitat Pompeu Fabra (UPF)

    Barcelona, España

    2015 - 2019

Formación de Capital Humano


POSTDOCTORAL RESEARCHERS

January - September 2013
Ingrid Balcells Ortega
Subject: RNAs in primates: a comparative genomics approach

PHD STUDENTS

April 2019 - present
Daniela Zapata Contreras
Subject: role of allele variants microRNAs in the pathophysiology of gastric cancer

November 2017 - present
Pablo Villegas Mirón
Subject: Genome scan analysis on non-protein coding regulatory elements

2012 - 2016
Alicia Gallego Jiménez
Subject: Study of the frequency and functionality of microRNA edition in human brain disorders
Awarded Excellent, cum laude, November 2016
https://www.tdx.cat/handle/10803/585943

2011 - 2016
Ignasi Torruella Loran
Subject: Functional analysis of genetic variants in microRNAs associated with gastric cancer
Awarded Excellent, October 2016
https://www.tdx.cat/handle/10803/482207

2009 - 2014
María López Valenzuela
Subject: Genetic and genomic variation in microRNA regions among primates: functional and evolutionary implications
Awarded Excellent, January 2015
https://www.tdx.cat/handle/10803/383030

2004 - 2009
Margarita Muiños Gimeno
Analysis of genetic variation in microRNA-mediated regulation and the susceptibility to anxiety disorders
Awarded Excellent cum laude, December 2009
http://www.tdx.cat/handle/10803/7192

2004 - 2009
Monica Guidi
Post-transcriptional regulation of NTRK3 by miRNAs in the context of neuronal differentiation
Awarded Excellent cum laude, January 2009
http://www.tdx.cat/handle/10803/7114

SPECIALIZED TECHNICIANS
January 1997 - July 2000: Marta Morell
January 1998 - December: David Otero
January 2004 - December 2008: Birgit Kagerbauer
January 2010 - January 2015: Eva Garcia-Ramallo
July 2015 - April 2016: Maria Karla Ramírez Viña
October 2017 - April 2020: Maria Karla Ramírez Viña
October 2020 - Present: Paula Zuñiga Pacheco


Difusión y Transferencia


Dissemination of scientific work to the community through various interviews on Radio, TV and newspapers.
The following would be the most outstanding of the last 3 years:

2021:
- January 13, 2021- Radio Polar interview.
https://youtu.be/A4FJmsvUHCQ
-January 14 - Morning Interview "Nuestra Mañana" in "Pingüino Multimedia".
https://www.facebook.com/pinguinomultimedia/videos/761280641153327

2020:
- July 21, 2020. Report in the newspaper "El mostrador": "Investigadores buscarán los factores genéticos asociados a la gravedad de COVID-19 en la población chilena"
https://www.elmostrador.cl/cultura/2020/07/21/investigadores-buscaran-los-factores-geneticos-asociados-a-la-gravedad-de-covid-19-en-la-poblacion-chilena/
- July 24, 2020. Interview Radio UMAG TV
https://youtu.be/19jUbFHb3pQ
- July 26, 2020. Report in the newspaper "La Prensa Austral": "Investigadores del CADI UMAG se unen a equipo que buscará los factores genéticos asociados a la gravedad de COVID-19 en la población chilena"
https://www.facebook.com/udemagallanes/posts/1744243592383670/
- July 30, 2020, Interview in "Más Conocimiento" online.
https://www.youtube.com/watch?v=mS72O5NP7VY
https://www.youtube.com/watch?v=sJjbXw2PXOw
- October 5, 2020. Interview in "El Magallánico": "Invitan a personas recuperadas de Covid-19 a participar en estudio genético sobre la enfermedad".
https://elmagallanico.com/2020/10/invitan-a-personas-recuperadas-de-covid-19-a-participar-en-estudio-genetico-sobre-la-enfermedad
- October 7, 2020. Report in the newspaper "La Prensa Austral": "Comenzó campaña de reclutamiento de voluntarios para estudio sobre el Covid."
https://archivo.laprensaaustral.cl/cronica/comenzo-campana-recluntación-de-voluntarios-para-estudio-sobre-el-covid/
- October 28, 2020. Report at the "Qué Pasa" Magazine, in "La Tercera" Newspaper: ¿Por qué las personas mayores no pueden hacerse cargo de su salud? El cuestionamiento de especialistas a las medidas a ese grupo en pandemia.
https://www.latercera.com/que-pasa/noticia/por-que-the-elderly-people-not-can-become-cargo-de-su-salud-el-cuestionamiento-de-especialistas-a- the-measures-to-that-group-in-pandemic / NVOXLJS4XZCRJFJVYWQJFWGXF4 /
- December 2, 2020. Report in the newspaper "Radio Polar": "ESTUDIO GENÉTICO DE COVID-19 AHORA BUSCA RECLUTAR VOLUNTARIOS ASINTOMÁTICOS Y QUE FUERON HOSPITALIZADOS."
http://www.radiopolar.com/noticia_161682.html
- December 2, 2020.Interview in "Radio Cooperativa Punta Arenas": "Estudio genético de Covid-19 busca reclutar voluntarios."
https://cooperativa.cl/noticias/sociedad/salud/coronavirus/punta-arenas-estudio-genetico-de-covid-19-busca-reclutar-voluntarios/2020-12-02/164138.html
-2 December 2020. Interview in "Televisión nacional red austral"
https://www.facebook.com/redaustral/posts/1735136563317207
- December 16, 2020. Interview in "Radio Soberania". https://www.facebook.com/soberaniaradio/videos/402531784317279

2019:
- April 13, 2019. Opinion column in the newspaper "La Prensa Austral": "Cadi-umag el proyecto más emblemático del pedze."
http://www.umag.cl/vcm/wp-content/uploads/2019/04/CADI-UMAG-el-proyecto-m%C3%A1s-emplem%C3%A1tico-del-Pedze.jpg
- May 14, 2019- Report in the science section of the "Magallanes" magazine of "La prensa Austral" Newspaper. https://archivo.laprensaaustral.cl/ciencia/investigacion-sobre-cancer-gastrico-leucemias-linfaticas-y-envejecimiento-dan-inicio-a-labor-del-cadi-umag/
- September 22, 2019- Report in "La prensa Austral" Newspaper". https://archivo.laprensaaustral.cl/cronica/cadi-de-la-universidad-de-magallanes-realizara-investigacion-del-c


Premios y Distinciones

  •   Accreditation of Advanced Research

    Agency for the Quality of the University System in Catalonia

    España, 2011

    In order to be eligible for a full professorship, which is the most advanced stage in a candidate's academic career and is awarded an indefinite contract, candidates must be in possession of an accreditation of advanced research issued by AQU Catalunya.

  •   Marie Curie Outgoing fellowship

    European Research Council (FP7)

    Chile, 2009

    These Fellowships are held in the EU or associated countries and last for one to two years. fund positions outside Europe for researchers based in the EU or associated countries. This grant lasted three years.

  •   Marie Curie Individual Fellowship

    European Research Council

    Francia, 2000

    Postdoctoral fellow

  •   Price for the best Spanish publication in the field of Thrombsis and Haemostasis in year 1999

    ROCHE diagnostics

    España, 2000

    Premio a la mejor publicación del año 1999 en el campo de la hematología y la hemostasia


 

Article (36)

Signatures of genetic variation in human microRNAs point to processes of positive selection and population-specific disease risk
Ancient genomes in South Patagonia reveal population movements associated with technological shifts and geography
Older adults with frailty syndrome present an altered platelet function and an increased level of circulating oxidative stress and mitochondrial dysfunction biomarker GDF-15
Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease
A Novel Child Burial from Tierra del Fuego: A Preliminary Report
Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders
Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging
rs12416605:C > T in MIR938 associates with gastric cancer through affecting the regulation of the CXCL12 chemokine gene
RNA editing independently occurs at three mir-376a-1 sites and may compromise the stability of the microRNA hairpin
Differences in molecular evolutionary rates among microRNAs in the human and chimpanzee genomes
Functional Implications of Human-Specific Changes in Great Ape microRNAs
microRNA Genetic Variation, from Population Analysis to Functional Implications of Three Allele Variants Associated with Cancer
Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study
An ancestral miR-1304 allele present in Neanderthals regulates genes involved in enamel formation and could explain dental differences with modern humans
DRD4 dopamine receptor alleles in Chilean students of different ethnic origin and its relation with the risk for attention deficit/hyperactivity disorder
A founder effect at the EPCAM locus in Congenital Tufting Enteropathy in the Arabic Gulf
Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways
MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
Design and evaluation of a panel of single-nucleotide polymorphisms in microRNA genomic regions for association studies in human disease
Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells.
Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders
Human genetics branches out in Barcelona
Mutations of the RET gene in isolated and syndromic Hirschsprung's disease in human disclose major and modifier alleles at a single locus
Molecular screening of the ZFHX1B gene in prenatally diagnosed isolated agenesis of the corpus callosum
Frameshift mutation of the zinc finger homeo box 1 B gene in syndromic corpus callosum agenesis (Mowat-Wilson syndrome)
Expression of the SMADIP1 gene during early human development
Large-scale deletions and SMADIP1 truncating mutations in syndromic Hirschsprung disease with involvement of midline structures.
Homozygosity for the protein S Heerlen allele is associated with type I PS deficiency in a thrombophilic pedigree with multiple risk factors
Optimization of a simple and rapid single-strand conformation analysis for detection of mutations in the PROS1 gene: identification of seven novel mutations and three novel, apparently neutral, variants
Protein S deficiency: a database of mutations--summary of the first update
Protein S secretion differences of missense mutants account for phenotypic heterogeneity
Analysis of the protein s gene in protein s deficiency
Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiency
Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiency
Absence of linkage between type III protein S deficiency and the PROS1 and C4BP genes in families carrying the protein S Heerlen allele
Protein S deficiency: a database of mutations. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis

BookSection (2)

MicroRNA mediated regulation and the susceptibility to anxiety disorders.
Analysis of the Protein S gene in Protein S Deficiency

ConferencePoster (21)

Genetic variation and population differentiation in the mature and seed microRNA regions are related to human phenotypic diversity and cancer.
Allele-specific effects of rs12416605:C/T in miR-938 on the regulation of gastric cancer genes.
Analysis of the patterns of miR-376-a1 editing in human placenta and primate brain cortex.
MIR938 associates with gastric cáncer in Europeans through affecting the regulation of CXCL12 in an allele specific fashion.
Insights into South American population history, from ancient DNA from Tierra del Fuego
Analysis of nucleotide changes in miRNAs along great apes evolution reveals functional consequences for human specific miRNA substitutions
Analysis of the functional consequences of five microRNA allele variants associated with cancer
Differences in evolutionary rates among microRNA categories in the human and chimpanzee genomes
Functional consequences of cancer associated variants in six human microRNAs
Spectrum of nucleotide changes in human microRNAs along great apes evolution: functional implications
Accelerated evolution of primate-specific microRNAs in the human genome
Analysis of nucleotide changes in miRNAs genes along primate evolution
Genetic variants in mIR-499a, miR-938 and miR-1206 associate with gastric cancer in Europeans from the EPIC-EURGAST study
miRNA clusters in cromosome 7 including MIR29, MIR25, MIR93 and MIR106 genes associate with gastric cancer in Europeans: Results from the EPIC-EURGAST study’
Functional implications of a polymorphism in a primate-specific miRNA.
The miR-29 family of microRNA genes and let-7i associate with gastric cancer in European populations: Results from the EPIC-EURGAST study
Transcriptome Analysis In A Murine Model Of Anxiety Overexpressing The Neurotrophin-3 Receptor (ntrk3)
Association analysis reveals several microRNAs involved in the susceptibility to eating disorders 
Differential miRNA-mediated regulation of isoforms of the recepetor for neurotrophin-3 (NTRK3) 
Patterns of association of microRNAs with schizophrenia symptoms
Large-scale deletions versus truncating mutations at the ZFHX1B locus in Mowat-Wilson syndrome: genotype-phenotype correlations.

Proyecto (13)

Estudio de la variación genética a nivel de genoma completo para la susceptibilidad y la gravedad de COVID-19 en la población chilena
Assessment of AID-related somatic signatures and their role in tumor progression of class switched vs non switched B-cell neoplasm
Assessment of the role of genetic variation in microRNAs on the susceptibility and physiopathology of Gastric Cancer
Developing an European American NGS Network (DEANN)
Genètica de les Poblacions Humanes
Variabilidad genética y genómica en regiones de microRNAs=> hacia la identificación de novedades evolutivas y funcionales en microRNAs -Genetic and genomic variability in human miRNAs=> identification of functional and evolutionary novelties in miRNAs-
MapbyAdmixtureChl-Mapping Genes involved in Psychiatric Disorders by Admixture Linkage Disequilibrium in Chilean populations
Desarrollo de un microarray de oligonucleótidos de RNAs no codificantes para CGH y análisis de perfiles de expresión
SIROCCO=> Silencing RNAs=> organisers and coordinators of complexity in eukaryotic organisms
CIBER Epidemiología y Salud Pública.
Role of the neurotrophic factors and serotoninergic neurotransmitters in eating disorders
Desarrollo de métodos de alto rendimiento para el diagnóstico y caracterización de reordenamientos cromosómicos implicados en patología humana
Genetic basis of disorders associated with genomic duplications=> anxiety disorders and other chromosome 15 rearrangements
34
Maria Yolanda Espinosa

Associate Professor

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

3
Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

3
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

2
Temistocles Prieto

ASSOCIATED RESEARCHER

Centro Gaia Antartica

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

2
Diego Arauna

Investigador Postdoctorante

Universidad de Talca

Talca, Chile

2
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
Victor Sierpe

Investigador Asociado

Instituto de la Patagonia

Universidad de Magallanes

Punta Arenas, Chile

1
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
María Furrianca

PROFESOR ASOCIADO

DEPARTAMENTO DE ENFERMERÍA

Universidad de Magallanes

Punta Arenas, Chile

1
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile