Man

Marcelo Alejandro Alarcón Lozano

Profesor

UNIVERSIDAD DE TALCA

Talca, Chile

Líneas de Investigación


Cardiovasuclar Disease, Chemistry and biological activity of natural product

Educación

  •  Cell Biology and Molecular Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2013
  •  Tecnólogo Médico, UNIVERSIDAD DE TALCA. Chile, 1997

Experiencia Académica

  •   Profesor Full Time

    UNIVERSIDAD DE TALCA

    Ciencias de la Salud

    Talca, Chile

    1997 - A la fecha

Experiencia Profesional

  •   Profesor Full Time

    Universidad de Talca

    Talca, Chile

    1997 - A la fecha

Formación de Capital Humano


- Desde el año 2006 a la Fecha con Tesistas de Pre-grado de la Carrera de Tecnología Médica

- Dos Tesistas del Magister de Ciencias Biomédicas de la Universidad de Talca

- Un Tesista de Doctorado del Doctorado de Ciencias Biomédicas de la Universidad de Talca



 

Article (110)

Effects of the age/rage axis in the platelet activation
Effects of the age/rage axis in the platelet activation.
In Vitro Assay of Quinoa (Chenopodium quinoa Willd.) and Lupin (Lupinus spp.) Extracts on Human Platelet Aggregation
In Vitro Assay of Quinoa (Chenopodium quinoa Willd.) and Lupin (Lupinus spp.) Extracts on Human Platelet Aggregation.
Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels
Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels.
Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging.
Older adults with frailty syndrome present an altered platelet function and an increased level of circulating oxidative stress and mitochondrial dysfunction biomarker GDF-15
Older adults with frailty syndrome present an altered platelet function and an increased level of circulating oxidative stress and mitochondrial dysfunction biomarker GDF-15.
Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study
Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study.
Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6
Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6.
Analysis of the characteristics and components for the frailty syndrome in older adults from central Chile. The PIEI-ES study.
Anti-aggregation effect on platelets of Indiplon a hypnotic sedative non-benzodiazepine drug
Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders
Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders.
Generation of platelet-derived microparticles through the activation of the toll-like receptor 4.
Increased platelet function during frailty
Increased platelet function during frailty.
Methodology of generation and purification of anti-beta 2 glycoprotein I antibodies.
Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging
Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases
Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases.
The cAMP/PKA Pathway Inhibits Beta-amyloid Peptide Release from Human Platelets.
New insights into the gene expression associated to amyotrophic lateral sclerosis.
Standardization of a fast and effective method for the generation and detection of platelet-derived microparticles by a flow cytometer.
Gene networks in neurodegenerative disorders.
Guanosine exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling
Immune System Dysfunction in the Elderly
Aqueous Extract of Tomato (Solanum lycopersicum L.) and Ferulic Acid Reduce the Expression of TNF-alpha and IL-1 beta in LPS-Activated Macrophages
Inhibitory effects of Cyperus digitatus extract on human platelet function in vitro
Platelets miRNAs and Cardiovascular Diseases
Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1 beta) and thrombus formation
A novel role of Eruca sativa Mill. (rocket) extract: antiplatelet (NF-κB inhibition) and antithrombotic activities.
A Novel Role of Eruca sativa Mill. (Rocket) Extract: Antiplatelet (NF-kappa B Inhibition) and Antithrombotic Activities
Chlorogenic Acid Inhibits Human Platelet Activation and Thrombus Formation
Chlorogenic acid inhibits human platelet activation and thrombus formation.
Inhibition of Platelet Activation and Thrombus Formation by Adenosine and Inosine: Studies on Their Relative Contribution and Molecular Modeling
Inhibition of platelet activation and thrombus formation by adenosine and inosine: studies on their relative contribution and molecular modeling.
Inhibitory effects of Cyperus digitatus extract on human platelet function in vitro.
Overrepresentation of Glutamate Signaling in Network-Based Pathway Analyses of Genome-Wide Association Studies in Alzheimer's Disease
Protective mechanisms of adenosine 5 '-monophosphate in platelet activation and thrombus formation
Protective mechanisms of adenosine 5’-monophosphate in platelet activation and thrombus formation
Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1β) and thrombus formation.
Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1β) and thrombus formation.
Thrombus formation induced by laser in a mouse model
Thrombus formation induced by laser in a mouse model.
A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease.
Effect of tomato industrial processing on phenolic profile and antiplatelet activity.
Mauritia flexuosa Presents In Vitro and In Vivo Antiplatelet and Antithrombotic Activities
Mauritia flexuosa Presents In Vitro and In Vivo Antiplatelet and Antithrombotic Activities.
PAMAM dendrimer derivatives as a potential drug for antithrombotic therapy
PAMAM dendrimer derivatives as a potential drug for antithrombotic therapy
Protective mechanisms of adenosine 5'-monophosphate in platelet activation and thrombus formation.
Protective Mechanisms of Guanosine from Solanum lycopersicum on Agonist-Induced Platelet Activation: Role of sCD40L
Protective mechanisms of guanosine from Solanum lycopersicum on agonist-induced platelet activation: role of sCD40L.
Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation: In Vitro, Ex Vivo and In Vivo Studies.
Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation: In Vitro, Ex Vivo and In Vivo Studies
Wnt/b-catenin signaling in Alzheimer’s disease
Bioassay-Guided Isolation and HPLC Determination of Bioactive Compound That Relate to the Antiplatelet Activity (Adhesion, Secretion, and Aggregation) from Solanum lycopersicum.
Bioassay-Guided Isolation and HPLC Determination of Bioactive Compound That Relate to the Antiplatelet Activity (Adhesion, Secretion, and Aggregation) from Solanum lycopersicum
Bioassay-guided Isolation and Identification of Bioactive Compound from Solanum lycopersicum with Antiplatelet Activity: food drug interaction
Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity
Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity
Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables
Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables.
Pathophysiology of the proatherothrombotic state in the metabolic syndrome
Pathophysiology of the proatherothrombotic state in the metabolic syndrome.
Pathophysiology of the proatherothrombotic state in the metabolic syndrome.
Physical activity reduces circulating TNF-alpha but not pro-thrombotic factors levels in patients with metabolic syndrome
Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome.
Increased concentrations of soluble vascular cell adhesion molecule-1 and soluble CD40L in subjects with metabolic syndrome.
Low prevalence of Factor V Leiden and the prothrombin G20210A mutation in a healthy population from the central-south region of Chile Baixa prevalência do Fator V Leiden e da mutação da protrombina g20210a em uma população sã da região centro-sul do Chile
Low prevalence of Factor V Leiden and the prothrombin G20210A mutation in a healthy population from the central-south region of Chile Baixa prevalência do Fator V Leiden e da mutação da protrombina g20210a em uma população sã da região centro-sul do Chile
The role of platelets in the pathophysiology of atherosclerosis (Review)
An insight into the pathophysiology of thrombosis in antiphospholipid syndrome
An insight into the pathophysiology of thrombosis in antiphospholipid syndrome.
Prevalence of cardiovascular risk factors in adult from Talca, Chile
Val/Leu(247) and Trp/Ser(316) polymorphisms in beta(2) glycoprotein I and their association with thrombosis in unselected Chilean patients
Val/Leu247 and Trp/Ser316 polymorphisms in beta 2 glycoprotein I and their association with thrombosis in unselected Chilean patients.
Hemostasis alterations in metabolic syndrome
High prevalence of classic cardiovascular risk factors in a population of university students from south central Chile
High prevalence of classic cardiovascular risk factors in a population of university students from South Central Chile Alta prevalencia de factores de riesgo cardiovascular clásicos en una población de estudiantes universitarios de la región centro-sur de Chile
Prevalence of antiphospholipid antibodies in Chilean patients with rheumatoid arthritis
Prevalence of antiphospholipid antibodies in Chilean patients with rheumatoid arthritis
Factor V Leiden and prothrombin G20210A among Chilean patients with venous and arterial thrombosis
Factor V Leiden and prothrombin G20210A among Chilean patients with venous and arterial thrombosis
Prevalence of antiphospholipid antibodies is not different in Chilean diabetic patients and normal individuals.
Prevalence of antiphospholipid antibodies is not different in Chilean diabetic patients and normal individuals
Prevalence of heparin-induced antibodies in patients with chronic renal failure undergoing hemodialysis
Prevalence of heparin-induced antibodies in patients with chronic renal failure undergoing hemodialysis
Prevalence and isotype distribution of antiphospholipid antibodies in unselected Chilean patients with venous and arterial thrombosis.
Prevalence and isotype distribution of antiphospholipid antibodies in unselected Chilean patients with venous and arterial thrombosis
Patients with essential hypertension present higher levels of sE-selectin and sVCAM-1 than normotensive volunteers.
Patients with essential hypertension present higher levels of sE-selectin and sVCAM-1 than normotensive volunteers
Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients.
Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients
Anti phospholipid antibodies in Chilean patients with systemic lupus erythematosus
Antiphospholipid antibodies in Chilean patients with systemic lupus erythematosus.
ANTIPHOSPHOLIPID ANTIBODIES IN CHILEAN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Prevalence of antiphospholipid antibodies in pregnancies without obstetric risk factors in Talca, Chile
Vascular access thrombosis is not related to presence of antiphospholipid antibodies in patients on chronic hemodialysis.
A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease.
Effect of tomato industrial processing on phenolic profile and antiplatelet activity.
Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome.
Increased concentrations of soluble vascular cell adhesion molecule-1 and soluble CD40L in subjects with metabolic syndrome.
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
Thrombus formation induced by laser in a mouse model.
Wnt/β-catenin signaling in Alzheimer's disease.

Abstract (3)

Inhibition of RhoA-RHO kinase pathway attenuates cocaine-induced microvascular endothelial cell dysfunction: studies under static and shear flow conditions
Mechanism of antiplatelet action induced by guanosine via increase in camp levels and its antithrombotic activity
Relation between the mechanism of antiplatelet action of adenosine from Solanum lycopersicum and its derivate inosine

Letter (2)

Prevalence of antiphospholipid antibodies in pregnancies without obstetric risk factors in Talca, Chile
Vascular access thrombosis is not related to presence of antiphospholipid antibodies in patients on chronic hemodialysis

Proyecto (10)

ESTUDIO MULTIDISCIPLINARIO SOBRE COMPUESTOS BIOACTIVOS DE VARIEDADES LOCALES CHILENAS DE PHASEOLUS VULGARIS L. Y SUS POTENCIALES EFECTOS EN LA PREVENCIÓN DE ENFERMEDADES CRÓNICAS NO TRANSMISIBLES
Synthesis and Pharmacological Evaluation of Mitochondria-Targeted Hydroquinone Derivatives with Antiplatelet Activity
Network to construct the know-how for production of health promoting compounds of Aristotelia chilensis in bioreactors.
Programa de Investigación de Excelencia Interdisciplinaria en Envejecimiento y Adulto Mayor (PIEI-ES)
Research on Mechanisms of Antiplatelet Action of Adenosine and other Bioactive Compounds from Solanum lycopersicum L
RESEARCH ON MECHANISMS OF ANTIPLATELET ACTION OF ADENOSINE AND OTHER BIOACTIVE COMPOUNDS FROM SOLANUM LYCOPERSICUM L
Characterization of the platelet antiaggregant and protecting cardiovascular activities of tomatoes (Solanum lycopersicum L.) extracts.
Centro de Estudios en Alimentos Procesados (CEAP)
Identificación y caracterización funcional de eventos de splicing aberrantes enel coreceptor de la señal Wnt, la proteína LRP6
Programa de Investigación en Factores de Riesgo de Enfermedades Cardiovasculares (PIFRECV)

Review (3)

Platelet miRNAs and cardiovascular diseases
The role of platelets in the pathophysiology of atherosclerosis (Review)
Hemostasis alterations in metabolic syndrome (review)
81
Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile

48
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

22
Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

13
Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Rodrigo Moore

Profesor Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

4
Gilda Carrasco

PROFESOR ASOCIADO

HORTICULTURA

UNIVERSIDAD DE TALCA

Talca, Chile

4
Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

4
margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

3
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

3
Diego Arauna

Investigador Postdoctorante

Universidad de Talca

Talca, Chile

3
Maria Yolanda Espinosa

Associate Professor

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

3
Oscar Forero

Asesor científico

Instituto de química de productos naturales

Universidad de Talca

Talca, Chile

2
Daniel Gonzalez

PROFESOR ASOCIADO

CIENCIAS BASICAS BIOMEDICAS

UNIVERSIDAD DE TALCA

Talca, Chile

2
PABLO PEREZ

Investigador Postdoctoral

Anatomía Patológica/Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

2
Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

2
Miguel Avila

Docente/Investigador

Universidad de las Américas

Santiago, Chile

2
Claudio Valenzuela

CONFERENCIANTE

ESCUELA DE MEDICINA

Universidad de Talca

Talca, Chile

2
Ricardo Castro

investigador

Instituto de ciencias químicas aplicadas

Universidad Autonomade Chile

Talca, Chile

1
Jose Yuri

Profesor Titular y Director del Centro de Pomáceas

Producción Agrícola

UNIVERSIDAD DE TALCA

Talca, Chile

1
Esteban Durán

Associate Professor

Depto de Microbiologia

UNIVERSIDAD DE TALCA

Talca, Chile

1
Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

1
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
John Amalraj

Professor Assistant

Instituto de Quimica de Recursos Naturales

Universidad de Talca

Talca, Chile

1
Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

1
Julio Rodríguez

Docente

Quimica Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Alvaro Cerda

Académico

Departamento de Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Armando Rojas

Profesor Titular, Director de Laboratorio Investigaciones Biomédicas

Ciencias Preclínicas

FACULTAD DE MEDICINA, UNIVERSIDAD CATOLICA DEL MAULE

Talca, Chile

1
Eduardo Aranda

Biochemist

Hematology

P. UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
María Furrianca

PROFESOR ASOCIADO

DEPARTAMENTO DE ENFERMERÍA

Universidad de Magallanes

Punta Arenas, Chile

1
Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
Emilio Moyano

Académico Invstigador

Psicologia Social y de las Organizaciones

UNIVERSIDAD DE TALCA

Talca, Chile

1
luis Urzua

DIRECTOR DE CARRERA

SALUD

Universidad Santo Tomás

Talca, Chile