Man

Karina de las Mercedes Pino Lagos

Group Leader/Associate Professor

Universidad de los Andes

Santiago, Chile

Líneas de Investigación


Transplantation Immunology; Tolerance Induction; Autoimmunity

Educación

  •  Immunology, Dartmouth College. Estados Unidos, 2012
  •  Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Lic en Ingeniería en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2004

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2013 - 2015

  •   Investigator Full Time

    Universidad de los Andes

    Medicine

    Santiago, Chile

    2015 - 2016

  •   Associate Professor Full Time

    Universidad de los Andes

    Medicine

    Santiago, Chile

    2016 - A la fecha

Experiencia Profesional

  •   Researcher Full Time

    Dartmouth College

    Lebanon, Estados Unidos

    2010 - 2011

  •   Researcher Full Time

    Universidad de Chile

    Santiago, Chile

    2011 - 2011

  •   Visitor Scholar Full Time

    Dartmouth College

    Lebanon, Estados Unidos

    2012 - 2012

Formación de Capital Humano


• Carolina Rojas (Co-Tutor). Student of “PhD in Odontology” Program, Faculty of Odontology, Universidad de Chile. Activity: PhD Thesis (2020-Present)
• Masyelly Rojas (Tutor). Student of “PhD in Biomedicine” Program, Faculty of Medicine, Universidad de los Andes. Activity: Lab Rotation (2018-2019)
• Carolina Rojas (Tutor). Student of “PhD in Odontology” Program, Faculty of Odontology, Universidad de Chile. Activity: Lab Rotation (2018-2019)
• Diego Prieto (Thesis Co-Director). Student of “Master in Odontology” Program, Faculty of Odontology, Universidad de los Andes. Activity: Master thesis. 2018-2019.
• Pamina Contreras (Tutor). Undergraduate student of the “Engineering in Molecular Biotechnology” Career, Faculty of Sciences, Universidad de Chile. Activity: Undergrad Thesis 2018-2019.
•. Karina Oyarce. Postdoctoral Fellow. Faculty of Medicine, Universidad de los Andes. 2017-2018
• Mauricio Campos (Thesis Co-Director). Student of “PhD in Biomedical Sciences” Program, Faculty of Medicine, Universidad de Chile. Activity: PhD thesis. 2017-2020.
• Pamina Contreras (Tutor). Undergraduate student of the “Engineering in Molecular Biotechnology” Career, Faculty of Sciences, Universidad de Chile. Activity: Lab Rotation 2016-2017.
• Ricardo Fuentes (Tutor). Undergraduate student of the “Medical Technology” career, Faculty of Medicine, Universidad Pedro de Valdivia. Activity: Undergraduate thesis. 2015-2016.
• Carla Álvarez (Tutor). PhD student of the “PhD in Biomedical Sciences Program”, Faculty of Medicine, Universidad de Chile. Activity: Lab Rotation. 2016-2017.
• Claudia Terraza (Tutor). Undergraduate student of “Engineering in Molecular Biotechnology” Career, Faculty of Sciences, Universidad de Chile. Activity: Lab Rotation and Undergraduate thesis. 2015-2016.
• Luz Yáñez (Tutor). Undergraduate student of “Engineering in Biotechnology” Career, Universidad Francisco de Paula Santander, Cucuta, Colombia. Activity: Professional Practice and Thesis. 2015-2016.
• Tania Gajardo (Tutor). Undergraduate student of “Engineering in Molecular Biotechnology” Career, Faculty of Sciences, Universidad de Chile. Activity: Lab Rotation and Undergraduate thesis (defended in August, 2015). 2014-2015.
• Mauricio Campos (Tutor). Undergraduate student of “Engineering in Molecular Biotechnology” Career, Faculty of Sciences, Universidad de Chile. Activity: Lab Rotation and Undergraduate thesis (defended in December, 2014). 2013-2014.
• Francisco Pérez (Tutor). Undergraduate student of “Engineering in Molecular Biotechnology” Career, Faculty of Sciences, Universidad de Chile. Activity: Lab Rotation and Undergraduate thesis (not presented/defended). 2012-2013.
• Rodrigo Morales (Tutor). PhD student of the “Cellular and Molecular Biology and Neurosciences Program”, Faculty of Sciences, Universidad de Chile. Activity: Lab Rotation. 2013.
• Paulina García (Tutor). PhD student of the “Biomedical Sciences Program”, Faculty of Medicine, Universidad de Chile. Activity: Research proposal for the “Advanced Immunology” Course, 2013.
• Gabriel Arellano (Tutor). PhD student of the “Biomedical Sciences Program”, Faculty of Medicine, Universidad de Chile. Activity: research proposal for the “Advanced Immunology” Course, 2013.
• Javier Pizarro (Tutor). Master student, Faculty of Medicine, Universidad de Chile. Activity: research proposal for the “Advanced Immunology” Course, 2013.
• Franz Strauss (Tutor). Master student, Faculty of Medicine, Universidad de Chile. Activity: Research proposal for the “Advanced Immunology” Course, 2013.
• Cristián Gutiérrez (Tutor). Undergraduate student of “Medical Technology” Career, Faculty of Medicine, Universidad de Chile. Activity: Lab Rotation, 2013.
• Darío Vergara (co-tutor). Undergraduate student of “Medical Technology” Career, Faculty of Medicine, Universidad de Chile. Actity: Undergraduate Thesis, 2013.


Difusión y Transferencia


• Co-Organizer of the Annual Reunion of the Chilean Association of Immunology 2019. November 20-22nd, Viña del Mar. Chile. 2019 (Postponed).
• Co-Organizer of the II Simposio Arte & Ciencia. September 23-24, Universidad de los Andes, Santiago. Chile. 2019.
• Co-Organizer of the III Jornadas Científicas en Salud. August 1-2, Universidad de los Andes, Santiago. Chile. 2019.
• Co-Organizer of the Annual Reunion of the Chilean Association of Immunology 2018. November 13th, Convention Center Araucano Park, Santiago. Chile. 2018.
• Evaluator of projects submitted to XIII Congreso Regional Explora CRECyT RM Sur Oriente, September 2018.
• Hostess of 2 high school students (Katherine Medel & Mayra Encina) as participants of “Un día con un científic@” program organized by PAR Explora Región Metropolitana Sur Oriente, June 2018.
• Co-organizer of the 3rd International Symposium, Cancer and inflammation: from cell biology to therapy. Universidad Austral de Chile, Valdivia, Chile, 2018
• Tutor of high school students Camila Astrain and Andrea Lange, Bradford School, Santiago, Chile. Participation at the Scientific Fair 2017 at Instituto Nacional with poster presentation, Santiago-Centro. Santiago, Chile. September 6th, 2017. “Effect of immunosuppressive drugs on Foxp3+ Regulatry T cells population in vivo”. Camila Astrain, Andrea Lange, Mauricio Campos-Mora, Tania Gajardo, Karina Oyarce, Claudio Soto and Karina Pino-Lagos.
• Co-Organizer of the II Jornadas Científicas en Salud. August 3-4, Universidad de los Andes, Santiago. Chile. 2017.
• Co-Organizer of the Reunion of the Chilean Association of Immunology 2017. April 28th, Pontificia Universidad Católica de Valparaiso, Valparaiso. Chile. 2017.
• Member of FONDECYT Study Group (Medicine G2-G3). 2016-2018.
• Member of the Accreditation Council for the PhD program at Universidad de los Andes. 2016-2017.
• Member of the PhD in Biomedicine Council, Universidad de los Andes. 2015-Present.
• Member of the PhD in Biomedical Sciences Council, Faculty of Medicine, Universidad de Chile. 2013-2014.
• Guest Editor. Frontiers in Immunology. 2014-Present.
• Co-Organizer of “II Symposium on Immune Regulation 2014: From Basic Science to Novel Immunotherapeutic Strategies”. Faculty of Medicine, Universidad de Chile. October, 2014. Santiago, Chile.
• Co-Organizer of “I Symposium on Immune Regulation 2013: From Basic Science to Novel Immunotherapeutic Strategies”. Faculty of Medicine, Universidad de Chile. November, 2013. Santiago, Chile.
• Participant in EXPLORA Iniciative. “How does your immune system combat the flu?” Class offered to “Escuela Básica Hermanos Matte”, Santiago. Octubre 2014, Chile.
• Participant in EXPLORA Iniciative. “How does your immune system react to a transplanted organ?” Class offered to “Liceo Francisco Tello González”, Rancagua. Octubre 2013, Chile.


Premios y Distinciones

  •   Full Scholarship for Graduate Studies

    DARTMOUTH COLLEGE

    Estados Unidos, 2006

    Scholarship to enroll into a PhD program at this Institution

  •   Beca Postdoctorado

    FONDECYT

    Chile, 2011

    I renounced to this scholarship.

  •   Best Basic Research Award

    Sociedad Chilena de Trasplante

    Chile, 2013

    Monetary award

  •   Best Basic Research

    Sociedad Chilena de Trasplante

    Chile, 2015

    Monetary award

  •   Fellowship to attend to a Course Overseas

    UNIVERSIDAD DE LOS ANDES

    Chile, 2015

    Funding to attend to a course at King´s College London, UK

  •   Dr. Federico Leighton Annual Award for the Best Undergraduate Thesis

    SOCIEDAD DE BIOLOGIA DE CHILE

    Chile, 2015

    One of my students received this award.


 

Article (27)

Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response
T regulatory cells-derived extracellular vesicles and their contribution to the generation of immune tolerance
CD4+Foxp3+T Regulatory Cells Promote Transplantation Tolerance by Modulating Effector CD4+T Cells in a Neuropilin-1-Dependent Manner
Cold-adaptation of a methacrylamide gelatin towards the expansion of the biomaterial toolbox for specialized functionalities in tissue engineering
A novel biomaterial based on salmon-gelatin and its in vivo evaluation as sterile wound-dressing
IFN-g and IL-33 modulate mesenchymal stem cells function targeting Th1/Th17 axis in a murine skin transplantation model
IFNg and IL-33 modulate mesenchymal stem cells function targeting Th1/Th17 axis in a murine skin transplantation model
Vitamin C Fosters the In Vivo Differentiation of Peripheral CD4(+) Foxp3(-) T Cells into CD4(+) Foxp3(+) Regulatory T Cells but Impairs Their Ability to Prolong Skin Allograft Survival
IL-33 enhances retinoic acid signaling on CD4+ T cells
Alarmin' Immunologists: IL-33 as a Putative Target for Modulating T Cell-Dependent Responses
Exogenous interleukin-33 targets myeloid-derived suppressor cells and generates periphery-induced Foxp3(+) regulatory T cells in skin-transplanted mice
Neuropilin-1(+) regulatory T cells promote skin allograft survival and modulate effector CD4(+) T cells phenotypic signature
Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid A promote allograft acceptance in vivo
Retinaldehyde dehydrogenase activity is triggered during allograft rejection and it drives Th1/Th17 cytokine production
A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines
Neuropilin-1 in Transplantation Tolerance
A Retinoic Acid-Rich Tumor Microenvironment Provides Clonal Survival Cues for Tumor-Specific CD8(+) T Cells
A retinoic acid-dependent checkpoint in the development of CD4(+) T cell-mediated immunity
Mast Cells Condition Dendritic Cells to Mediate Allograft Tolerance
Cyclosporin A-treated Dendritic Cells may affect the outcome of organ transplantation by decreasing CD4(+)CD25(+) regulatory T cell proliferation
Retinoic acid: A key player in immunity
Retinoic Acid Can Directly Promote TGF-beta-Mediated Foxp3(+) Treg Cell Conversion of Naive T Cells
The enigmatic role of mast cells in dominant tolerance
Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3(+)CD4(+) regulatory T cells
Retinoic Acid in the Immune System
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
Mast cells are essential intermediaries in regulatory T-cell tolerance

EditorialMaterial (1)

Editorial: Searching for immune tolerance Manipulating New Molecules and Exploiting New Concepts on lymphocyte Biology

Proyecto (21)

Brain astrocyte-derived extracellular vesicles promote protective Treg induction in the GALT and restore gut tolerance in stressed rats
Role of mesenchymal stem cells in implantation and their contribution to the decidualization disorders present in preeclampsia
Investigating the anti-angiogenic effect of exosome-mediated delivery of functionally active miRNA-149-3p, 145-5p and 6131 to tumor tissue
Investigating the anti-angiogenic effect of exosome-mediated delivery of functionally active miRNA-149-3p,145-5p and 6131 to tumor tissue
Role of IL-35, all-trans retinoic acid, and T regulatory-derived exosomes in inhibiting the tooth-supporting bone resorption during periodontitis through modulation of the Th17/Treg imbalance
Role of IL-35, all-tras retinoic acid , and T regulatory-derived exosomes in inhibiting the booth-supporting bone resorption during periodontitis through modulation of the Th17/Treg imbalance
Functional impact of MSC mitochondrial transfer to T lymphocytes and its clinical relevance in a Graft versus Host Disease
Functional impact of MSC mitochondrial transfer to T lymphocytes and its relevante in a draft versus host disease model
Neuropilin-1 and IL-33: two targets of study to comprehend Foxp3+ regulador T cells biology in transplantation tolerante
Neuropilin-1 and IL-33=> two new targets of study to comprehend Foxp3+ regulatory T cells biology in transplantation tolerance
Expansión y caracterización ex vivo de células T reguladoras humanas para el re-establecimiento de la homeostasis inmune en respuestas inflamatorias indeseadas
Study of Neuropilin-1 expression as a potential biomarker in the progression of pediatric patients with acute leukemia and transplanted with non-related umbilical cord blood
Development, production and characterization of anti-MICA recombinant antibodies of human origen with therapeutical potential for the treatment of gastric cancer
Development, production and characterization of anti-MICA recombinant antibodies of human origin with therapeutical potential for the treatment of gastric cancer
Fc gamma receptors and regulatory B cells: a novel network behind the immune response governing systemic esclerosis
Fcgamma receptors and regulatory B cells=> A novel network behind the immune response governing systemic sclerosis
Retinoic acid and IL-33: the dynamic duo controlling the polarization of T cell-mediated immunity
Retinoic acid and IL-33=> the dynamic duo controlling the polarization of T cell-mediated immunity
Fortalecimiento de lineas de investigacion en terapias celulares para autoinmunidad y trasplante
Expansion and characterization ex vivo of human regulatory T cells for the establishment of the immune homeostasis in unwanted inflammatory responses
Improvement of the protocol to expand human regulatory T cells

Review (2)

Mesenchymal stem cells and their immunosuppressive role in transplantation tolerance
The essential role of chemokines in the selective regulation of lymphocyte homing
41
Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

4
Diego Catalán

Profesor Asistente

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

4
Mauricio Campos Mora

Ph.D student

Universidad de Chile

Santiago, Chile

3
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

3
Mario Rosemblatt

Executive Director

-

Fundacion Ciencia & Vida

Santiago, Chile

3
Maroun Khoury

A/Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

2
Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

2
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Angela Court

Asistente de Investigación

Medicina Nanoregenerativa

Universidad de Los Andes

Santiago, Chile

1
Vinicius Ramos Henriques

Profesor Asistente

Advanced Center for Chronic Diseases - ACCDiS

Univesidad de Chile

Santiago, Chile

1
Franck Quero

Profesor Asociado

Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

1
Rina Ortiz

Profesora investigadora

Física

Universidad Técnica Federico Santa María

Valparaiso, Chile

1
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

1
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

1
Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

1
Paulo Diaz

Profesor Asociado

Escuela de Nutrición y Dietética

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

1
Cristina Padilla

Administrador de laboratorio e Investigador

Centro de Investigaciones Biomedicas

Universidad de Los Andes

Santiago, Chile

1
Javier Enrione

Profesor Titular

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

1
Flavia Zacconi

Associate Professor

Organic Chemistry

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Marzena Pepczynska

Posdoctorado

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Franck Quero

Profesor Asistente

Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

1
Rolando Vernal

Profesor Titular

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Juan Pablo Acevedo

Profesor Asistente

Universidad de los Andes

Santiago, Chile

1
DONALD BROWN

PROFESOR TITULAR

FACULTAD DE CIENCIAS

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Victor Aliaga

Investigador Asociado

Universidad de Chile

Santiago, Chile

1
Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

1
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

1
Ignacio Cárcamo

Médico Cirujano

Universidad de Los Andes

Santiago, Chile

1
Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

1
Natalia Villalón

Docente de Cirugía

Escuela de Medicina

Universidad de Los Andes

Santiago, Chile

1
Veronica Ramos

Bioquímico

Inmunologia, VIH y Alergias

Hospital Clínico Universidad de Chile

Santiago, Chile

1
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile