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Juan Pablo Acevedo Cox

Profesor Asistente

Universidad de los Andes

Santiago, Chile

Profesor asistente e Investigador; Ingeniería de Biomateriales y Tecnología de Microfluidos; Ingeniería de Proteínas

Biología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2003
DOCTOR EN CIENCIAS DE LA INGENIERIA C/M INGENIERIA QUIMICA, UNIVERSIDAD DE CHILE. Chile, 2008

Postdoctoral fellow Full Time

Max-Planck Institut für Kohlenforschung

Mûlheim an der Ruhr, Alemania

2008 - 2011
Visiting Faculty/miembro investigador Full Time

Harvard-MIT's Division of Health Sciences and Technology

Boston, Chile

2011 - 2012
Profesor asistente e Investigador Full Time

Universidad de los Andes

Medicina

Santiago, Chile

2012 - A la fecha

Profesor Asistente Full Time

Universidad de los Andes

Santiago, Chile

2012 - A la fecha

2016-2018: CORFO Technology Contract (Director). “Development of a new Bioink for cellularized 3D bioprinting of high resolution using the Polyjet technology” 15CONTEC-47942
2015-2017: FONDEF IDEA en dos etapas (Director). “Applied engineering for design and production of small-diameter cellularized coronary graft” ID15I10545

2015-2017: FONDEF IDEA en dos etapas (Investigador Asociado). “Desarrollo de un proceso de síntesis de policaprolactona a partir de ciclohexanona combinando dos reacciones biocatalíticas mediante el uso de dióxido de carbono supercrítico” ID14I10219

2014: Silicon Valley-Go to Market, Corfo, Finalist (Director).

2014-2020: PMI (Institutional Improvement Program): Development of the Biomedical Engineering Research as a Platform to Potentiate the Tissue Engineering and Cell Therapy Research. MECESUP. UAN1301(Principal Investigator).

2013-2016: Corfo, R & D Project line 2: Stemfit: Potency test for adult stem cells, N° 13IDL2-18745 (Director).

2013-2014: MIT-Chile seed Fund for collaborative project with Prof. Robert Langer and Ali Khademhosseini from MIT in Stem cells diagnostic devices (Director).

2011-2012: FAI Fellowship from the University of the Andes for a Visiting Faculty stay at MIT.

2008-2011: Postdoctoral scholarship “Max Planck Society”. Max-Planck-Institut für Kohlenforschung (Prof. Manfred T. Reetz)

2006: Fellowship of University of Chile for patenting process, “Development of industrial enzymes: Cold-active proteases”, Asenjo J.A., Andrews B.A., Acevedo J.P, Reyes F., Burzio L. (US $ 48.000)

2006: Fellowship of OTRI Chile for patenting process, “Development of industrial enzymes: Cold-adapted Lipases”, Asenjo J.A., Andrews B.A., Parra L.P., Reyes F., Acevedo J.P., Burzio L. (US $ 48.000)

2004-2007: Doctoral scholarship “National Commission for Scientific and Technological
Research” CONICYT

2003: Graduated with high honors from Catholic University of Chile, ranked second in generation

2000-2002: Fellowship of John Paul II Foundation, Santiago, Chile


Single cell migration profiling on a microenvironmentally tunable hydrogel microstructure device that enables stem cell potency evaluation Article ISI SCOPUS LAB ON A CHIP (2020)
Cold-adaptation of a methacrylamide gelatin towards the expansion of the biomaterial toolbox for specialized functionalities in tissue engineering Acevedo, Cristian A.; Terrazaa, Claudia; Quero, Franck; Zacconi, Flavia C.; Enrione, Javier Article ISI SCOPUS MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)
Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries Suazo, Cristian; Maksimuck, Jekaterina; Vargas, Francisco; Ocana, Macarena; Enrione, Javier; Valenzuela, Loreto M.; Pablo Acevedo, Juan Article ISI SCOPUS NATURE COMMUNICATIONS (2019)
Microtechnology applied to stem cells research and development van Noort, Danny Article ISI SCOPUS REGENERATIVE MEDICINE (2018)
Bioprinted 3D vascularized tissue model for drug toxicity analysis Sakr M.A.; Bandaru P.; Arneri A.; Bersini S.; Zare-Eelanjegh E.; Jalilian E.; Cha B.-H.; Antona S. Article ISI SCOPUS BIOMICROFLUIDICS (2017)
Layer-by-layer approach for a uniformed fabrication of a cell patterned vessel-like construct Wilkens, Camila A; Rivet, Christopher J; Akentjew, Tamara L; Alverio, Julian Article ISI SCOPUS BIOFABRICATION (2017)
One-step combined focused epPCR and saturation mutagenesis for thermostability evolution of a new cold-active xylanase Article ISI SCOPUS ENZYME AND MICROBIAL TECHNOLOGY (2017)
Directed evolution of phenylacetone monooxygenase as an active catalyst for the Baeyer-Villiger conversion of cyclohexanone to caprolactone Loreto P. Parra; Juan Pablo Acevedo; Manfred T. Reetz Article Biotechnology and Bioengineering (2015)
A New Type of Stereoselectivity in Baeyer–Villiger Reactions: Access to E- and Z-Olefins Acevedo J.P.; Zhang Z.G.; Roiban G.D.*; Polyak I.; Reetz M.T. Article Adv. Synth. Catal. (2013)
Cloning, expression and decoding of the cold adaptation of a new widely represented thermolabile subtilisin-like protease Acevedo J.P.; Rodriguez V.; Saavedra M.; Muñoz M.; Salazar O.; Asenjo J.A.; Andrews B.A. Article J. Appl. Microbiol. (2013)
Coordinated endotelial nitric oxide synthase activation by translocation and phosphorylation determines flow-induced nitric oxide production in resistance vessels Figueroa XF; González DR; Puebla M; Acevedo JP; Rojas-Libano D; Durán WN; Boric MP Article Journal of Vascular Research (2013)
Hydrogel-coated microfluidic channels for cardiomyocyte culture Annabi N.; Acevedo J.P.; Selimovic S.; Ribas J.; Bakooshli M.A.; Heintze D.; Weiss A.S.; Cropek D.; Khademhosseini A. Article Lab on a Chip (2013)
Reducing Codon Redundancy and Screening Effort of Combinatorial Protein Libraries Created by Saturation Mutagenesis Kille S.; Acevedo-Rocha C.G.; Parra L.P.; Zhang Z.G.; Opperman D.J.; Reetz M.T.; Acevedo J.P. Article ACS Synth. Biol. (2013)
Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution Kille S.; Acevedo J.P.; Zilly F.E.; Reetz M.T. Article Nature Chemistry (2011)
Tuning a P450 Enzyme for Methane Oxidation Zilly F.E.; Acevedo J.P.; Augustyniak W.; Deege A.; Häusing U.W.; Reetz M.T. Article Angew. Chem. Int. Ed. (2011)
Directed evolution of enantioconvergency: the case of an epoxide hydrolase-catalyzed reaction of a racemic epoxide Zheng H.; Kahakeaw D.; Acevedo J.P.; Reetz M.T. Article ChemCatChem (2010)
Induced allostery in the directed evolution of an enantioselective Baeyer-Villiger monooxygenase Wu S.; Acevedo J.P.; Reetz M.T. Article Proc. Natl. Acad. Sci. U.S.A. (2010)
Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme Reetz M.T.; Soni P.; Acevedo J.P.; Sanchis J. Article Angew. Chem. Int. Ed. (2009)
Cloning and fusion expression of a cold-active lipase from marine Antarctic origin Parra L.P.; Reyes F.; Acevedo J.P.; Salazar O.; Andrews B.A.; Asenjo J.A. Article Enzyme Microb. Tech. (2008)
Cloning of complete genes for novel hydrolytic enzymes from Antarctic sea water bacteria by use of an improved genome walking technique Acevedo J.P.; Reyes F.; Parra L.P.; Salazar O.; Andrews B.A.; Asenjo J.A. Article Journal of Biotechnology (2008)


Automated Micro-Fabrication of a Small Diameter Vascular Graft Mimicking the Structure and Mechanical Properties of Human Vessels Akentjew, TL; Terraza, CF Abstract ISI TISSUE ENGINEERING PART A (2017)
A NEW TOOL FOR THE ASSESSMENT OF STEM CELLS (SC) POTENCY USING MICROFLUIDIC-BASED 3D DIRECTED MIGRATION Abstract ISI CYTOTHERAPY (2016)


Arthroscopic device for the treatment of osteoarthritis through 3D bioprinting of chondral lesions Juan Pablo Acevedo Proyecto (2019)
Producción automatizada y escalable de prótesis coronarias bioinspiradas y de pequeño calibre con contenido celular y mecánica natural CORFO (18COTE-97983) Proyecto 2018-2020 Director(a)
Desarrollo de una biotinta para bioimpresión 3D celularizada a alta resolución utilizando la tecnología Polyjet CORFO Contrato Tecnológico (15CONTEC-47942) Proyecto 2016-2018 Director(a)
Desarrollo de un proceso de síntesis de policaprolactona a partir de ciclohexanona combinando dos reacciones biocatalíticas mediante el uso de dióxido de carbono supercrítico FONDEF (ID14I10219) Proyecto 2015-2016 Investigador(a)
Ingeniería aplicada para diseño y producción de prótesis coronarias celularizadas de pequeño calibre FONDEF (ID15I10545) Proyecto 2015-2017 Director(a)
Desarrollo de una plataforma en Ingeniería biomédica para potenciar la investigación en terapia celular e Ingeniería de Tejidos MECESUP (UAN1301) Proyecto 2014-2020 Inv. Principal
Fundamentals of natural polymers and composites for applications in food science and technology, and tissue engineering PCI (RED140144) Proyecto 2014-2015 Inv. Principal
A new in vitro migration assay for functional isolation of mesenchymal stem cell subpopulation (MSCs) and therapeutic quality control MISTI Program (MIT) (2012 - 2013 Grant Recipients) Proyecto 2013-2014 Director(a)
Desarrollo de un Test de Potencia Terapéutica, Stemfit, para Células Madre adultas de origen Hematopoyéticas y Mesenquimal CORFO Innova Proyecto I+D Aplicada linea 2 (13IDL2-18745) Proyecto 2013-2016 Director(a)
Potency Test for Stem Cell Therapy Corfo (13GTM-21982) Proyecto 2013-2014 Director(a)
Estudio de migración y funcionalidad de subpoblaciones de células madre mesenquimales y desarrollo de dispositivos de migración como nueva herramienta de clasificación y selección de subpoblaciones FAI Universidad de los Andes (11/2012) Proyecto 2012-2013 Director(a)
Cardiac based microfluidic biosensor US Army, USA (Proyecto DOD=> US Army Corps of Engineers) Proyecto 2011-2012 Investigador(a)
Chemo- and stereoselective methodologies in organic chemistry using protein engineering and directed evolution of enzymes (Lipases, Epoxide Hydrolases and monooxygenases) Max Planck Society Proyecto 2008-2011 Postdoctorado
Research, Development and Production of Comercial Cryophilic Proteases and Lipases from Antartic Krill and Bacteria FONDEF (D04I1374) Proyecto 2006-2008 Investigador(a)