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Juan Pablo Acevedo Cox

Profesor Asistente

Universidad de los Andes

Santiago, Chile

Profesor asistente e Investigador; Ingeniería de Biomateriales y Tecnología de Microfluidos; Ingeniería de Proteínas

Biología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2003
DOCTOR EN CIENCIAS DE LA INGENIERIA C/M INGENIERIA QUIMICA, UNIVERSIDAD DE CHILE. Chile, 2008

Postdoctoral fellow Full Time

Max-Planck Institut für Kohlenforschung

Mûlheim an der Ruhr, Alemania

2008 - 2011
Visiting Faculty/miembro investigador Full Time

Harvard-MIT's Division of Health Sciences and Technology

Boston, Chile

2011 - 2012
Profesor asistente e Investigador Full Time

Universidad de los Andes

Medicina

Santiago, Chile

2012 - A la fecha

Profesor Asistente Full Time

Universidad de los Andes

Santiago, Chile

2012 - A la fecha

2016-2018: CORFO Technology Contract (Director). “Development of a new Bioink for cellularized 3D bioprinting of high resolution using the Polyjet technology” 15CONTEC-47942
2015-2017: FONDEF IDEA en dos etapas (Director). “Applied engineering for design and production of small-diameter cellularized coronary graft” ID15I10545

2015-2017: FONDEF IDEA en dos etapas (Investigador Asociado). “Desarrollo de un proceso de síntesis de policaprolactona a partir de ciclohexanona combinando dos reacciones biocatalíticas mediante el uso de dióxido de carbono supercrítico” ID14I10219

2014: Silicon Valley-Go to Market, Corfo, Finalist (Director).

2014-2020: PMI (Institutional Improvement Program): Development of the Biomedical Engineering Research as a Platform to Potentiate the Tissue Engineering and Cell Therapy Research. MECESUP. UAN1301(Principal Investigator).

2013-2016: Corfo, R & D Project line 2: Stemfit: Potency test for adult stem cells, N° 13IDL2-18745 (Director).

2013-2014: MIT-Chile seed Fund for collaborative project with Prof. Robert Langer and Ali Khademhosseini from MIT in Stem cells diagnostic devices (Director).

2011-2012: FAI Fellowship from the University of the Andes for a Visiting Faculty stay at MIT.

2008-2011: Postdoctoral scholarship “Max Planck Society”. Max-Planck-Institut für Kohlenforschung (Prof. Manfred T. Reetz)

2006: Fellowship of University of Chile for patenting process, “Development of industrial enzymes: Cold-active proteases”, Asenjo J.A., Andrews B.A., Acevedo J.P, Reyes F., Burzio L. (US $ 48.000)

2006: Fellowship of OTRI Chile for patenting process, “Development of industrial enzymes: Cold-adapted Lipases”, Asenjo J.A., Andrews B.A., Parra L.P., Reyes F., Acevedo J.P., Burzio L. (US $ 48.000)

2004-2007: Doctoral scholarship “National Commission for Scientific and Technological
Research” CONICYT

2003: Graduated with high honors from Catholic University of Chile, ranked second in generation

2000-2002: Fellowship of John Paul II Foundation, Santiago, Chile


Single cell migration profiling on a microenvironmentally tunable hydrogel microstructure device that enables stem cell potency evaluation Ros E.; Encina M.; GonzÃ¡lez F.; Contreras R.; Luz-Crawford P.; Khoury M.; Acevedo J.P. Article ISI SCOPUS LAB ON A CHIP (2020)
Cold-adaptation of a methacrylamide gelatin towards the expansion of the biomaterial toolbox for specialized functionalities in tissue engineering Zaupa, Alessandro; Byres, Nicholas; Dal Zovo, Chiara; Acevedo, Cristian A.; Angelopoulos, Ioannis; Terrazaa, Claudia; Nestle, Nikolaus; Abarzua-Illanes, Phammela N.; Quero, Franck; Diaz-Calderon, Paulo; Olguin, Yusser; Akentjew, Tamara L.; Wilkens, Camila A.; Padilla, Cristina; Zacconi., Flavia C.; Pino-Lagos, Karina; Blaker, Jonny J.; Khoury, Maroun; Enrione, Javier; Acevedo, Juan Pablo Article ISI SCOPUS MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)
Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries Akentjew, Tamara L.; Terraza, Claudia; Suazo, Cristian; Maksimuck, Jekaterina; Wilkens, Camila A.; Vargas, Francisco; Zavala, Gabriela; Ocana, Macarena; Enrione, Javier; Garcia-Herrera, Claudio M.; Valenzuela, Loreto M.; Blaker, Jonny J.; Khoury, Maroun; Pablo Acevedo, Juan Article ISI SCOPUS NATURE COMMUNICATIONS (2019)
Microtechnology applied to stem cells research and development Acevedo, Juan Pablo; Angelopoulos, Ioannis; van Noort, Danny; Khoury, Maroun Article ISI SCOPUS REGENERATIVE MEDICINE (2018)
Bioprinted 3D vascularized tissue model for drug toxicity analysis Massa S.; Sakr M.A.; Seo J.; Bandaru P.; Arneri A.; Bersini S.; Zare-Eelanjegh E.; Jalilian E.; Cha B.-H.; Antona S.; Enrico A.; Gao Y.; Hassan S.; Acevedo J.P.; Dokmeci M.R.; Zhang Y.S.; Khademhosseini A.; Shin S.R. Article ISI SCOPUS BIOMICROFLUIDICS (2017)
Layer-by-layer approach for a uniformed fabrication of a cell patterned vessel-like construct Wilkens, Camila A; Rivet, Christopher J; Akentjew, Tamara L; Alverio, Julian; Khoury, Maroun; Acevedo, Juan Pablo Article ISI SCOPUS BIOFABRICATION (2017)
One-step combined focused epPCR and saturation mutagenesis for thermostability evolution of a new cold-active xylanase Acevedo, Juan Pablo; Reetz, Manfred T.; Asenjo, Juan A.; Parra, Loreto P. Article ISI SCOPUS ENZYME AND MICROBIAL TECHNOLOGY (2017)
Directed evolution of phenylacetone monooxygenase as an active catalyst for the Baeyer-Villiger conversion of cyclohexanone to caprolactone Loreto P. Parra; Juan Pablo Acevedo; Manfred T. Reetz Article Biotechnology and Bioengineering (2015)
A New Type of Stereoselectivity in Baeyer–Villiger Reactions: Access to E- and Z-Olefins Acevedo J.P.; Zhang Z.G.; Roiban G.D.*; Polyak I.; Reetz M.T. Article Adv. Synth. Catal. (2013)
Cloning, expression and decoding of the cold adaptation of a new widely represented thermolabile subtilisin-like protease Acevedo J.P.; Rodriguez V.; Saavedra M.; Muñoz M.; Salazar O.; Asenjo J.A.; Andrews B.A. Article J. Appl. Microbiol. (2013)
Coordinated endotelial nitric oxide synthase activation by translocation and phosphorylation determines flow-induced nitric oxide production in resistance vessels Figueroa XF; González DR; Puebla M; Acevedo JP; Rojas-Libano D; Durán WN; Boric MP Article Journal of Vascular Research (2013)
Hydrogel-coated microfluidic channels for cardiomyocyte culture Annabi N.; Acevedo J.P.; Selimovic S.; Ribas J.; Bakooshli M.A.; Heintze D.; Weiss A.S.; Cropek D.; Khademhosseini A. Article Lab on a Chip (2013)
Reducing Codon Redundancy and Screening Effort of Combinatorial Protein Libraries Created by Saturation Mutagenesis Kille S.; Acevedo-Rocha C.G.; Parra L.P.; Zhang Z.G.; Opperman D.J.; Reetz M.T.; Acevedo J.P. Article ACS Synth. Biol. (2013)
Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution Kille S.; Acevedo J.P.; Zilly F.E.; Reetz M.T. Article Nature Chemistry (2011)
Tuning a P450 Enzyme for Methane Oxidation Zilly F.E.; Acevedo J.P.; Augustyniak W.; Deege A.; Häusing U.W.; Reetz M.T. Article Angew. Chem. Int. Ed. (2011)
Directed evolution of enantioconvergency: the case of an epoxide hydrolase-catalyzed reaction of a racemic epoxide Zheng H.; Kahakeaw D.; Acevedo J.P.; Reetz M.T. Article ChemCatChem (2010)
Induced allostery in the directed evolution of an enantioselective Baeyer-Villiger monooxygenase Wu S.; Acevedo J.P.; Reetz M.T. Article Proc. Natl. Acad. Sci. U.S.A. (2010)
Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme Reetz M.T.; Soni P.; Acevedo J.P.; Sanchis J. Article Angew. Chem. Int. Ed. (2009)
Cloning and fusion expression of a cold-active lipase from marine Antarctic origin Parra L.P.; Reyes F.; Acevedo J.P.; Salazar O.; Andrews B.A.; Asenjo J.A. Article Enzyme Microb. Tech. (2008)
Cloning of complete genes for novel hydrolytic enzymes from Antarctic sea water bacteria by use of an improved genome walking technique Acevedo J.P.; Reyes F.; Parra L.P.; Salazar O.; Andrews B.A.; Asenjo J.A. Article Journal of Biotechnology (2008)


Automated Micro-Fabrication of a Small Diameter Vascular Graft Mimicking the Structure and Mechanical Properties of Human Vessels Wilkens, CA; Akentjew, TL; Terraza, CF; Blaker, JJ; Garcia-Herrera, CM; Enrione, JI; Valenzuela, LM; Khoury, M; Acevedo, JP Abstract ISI TISSUE ENGINEERING PART A (2017)
A NEW TOOL FOR THE ASSESSMENT OF STEM CELLS (SC) POTENCY USING MICROFLUIDIC-BASED 3D DIRECTED MIGRATION Acevedo, J; Ros, E; Khoury, M Abstract ISI (2016)


Arthroscopic device for the treatment of osteoarthritis through 3D bioprinting of chondral lesions Juan Pablo Acevedo; Khoury, Maroun Proyecto (2019)
Producción automatizada y escalable de prótesis coronarias bioinspiradas y de pequeño calibre con contenido celular y mecánica natural CORFO (18COTE-97983) Proyecto 2018-2020 Director(a)
Desarrollo de una biotinta para bioimpresión 3D celularizada a alta resolución utilizando la tecnología Polyjet CORFO Contrato Tecnológico (15CONTEC-47942) Proyecto 2016-2018 Director(a)
Desarrollo de un proceso de síntesis de policaprolactona a partir de ciclohexanona combinando dos reacciones biocatalíticas mediante el uso de dióxido de carbono supercrítico FONDEF (ID14I10219) Proyecto 2015-2016 Investigador(a)
Ingeniería aplicada para diseño y producción de prótesis coronarias celularizadas de pequeño calibre FONDEF (ID15I10545) Proyecto 2015-2017 Director(a)
Desarrollo de una plataforma en Ingeniería biomédica para potenciar la investigación en terapia celular e Ingeniería de Tejidos MECESUP (UAN1301) Proyecto 2014-2020 Inv. Principal
Fundamentals of natural polymers and composites for applications in food science and technology, and tissue engineering PCI (RED140144) Proyecto 2014-2015 Inv. Principal
A new in vitro migration assay for functional isolation of mesenchymal stem cell subpopulation (MSCs) and therapeutic quality control MISTI Program (MIT) (2012 - 2013 Grant Recipients) Proyecto 2013-2014 Director(a)
Desarrollo de un Test de Potencia Terapéutica, Stemfit, para Células Madre adultas de origen Hematopoyéticas y Mesenquimal CORFO Innova Proyecto I+D Aplicada linea 2 (13IDL2-18745) Proyecto 2013-2016 Director(a)
Potency Test for Stem Cell Therapy Corfo (13GTM-21982) Proyecto 2013-2014 Director(a)
Estudio de migración y funcionalidad de subpoblaciones de células madre mesenquimales y desarrollo de dispositivos de migración como nueva herramienta de clasificación y selección de subpoblaciones FAI Universidad de los Andes (11/2012) Proyecto 2012-2013 Director(a)
Cardiac based microfluidic biosensor US Army, USA (Proyecto DOD=> US Army Corps of Engineers) Proyecto 2011-2012 Investigador(a)
Chemo- and stereoselective methodologies in organic chemistry using protein engineering and directed evolution of enzymes (Lipases, Epoxide Hydrolases and monooxygenases) Max Planck Society Proyecto 2008-2011 Postdoctorado
Research, Development and Production of Comercial Cryophilic Proteases and Lipases from Antartic Krill and Bacteria FONDEF (D04I1374) Proyecto 2006-2008 Investigador(a)