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Monica Alejandra Carrasco Pastenes

Profesor Asociado

UNIVERSIDAD DE TALCA

Talca, Chile

Líneas de Investigación


Regulations between Neurons and its surrounding in both health and disease. With focus on understanding ALS Disease Mechanisms using human IPSC patient-derived motor neurons.

Educación

  •  Biología Molecular y Celular, UNIVERSIDAD DE CONCEPCION. Chile, 2005
  •  Lic. en Bioquímica, UNIVERSIDAD DE CONCEPCION. Chile, 1999
  •  Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 2001

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE TALCA

    Talca, Chile

    2015 - A la fecha

Experiencia Profesional

  •   Postdoctoral

    Harvard University

    Estados Unidos

    2006 - 2009

  •   Research Associate

    Columbia University

    Estados Unidos

    2010 - 2015

Formación de Capital Humano


2022-Ongoing
Cotutora Tesista Doctoral: Matias Osorio
Programa en Ciencias BioMedicas
Departamento de Ciencias BioMedicas
Universidad de Talca, Talca.

2020-2022
Cotutora: Tesista Magister: Alumno Felipe Franco
Programa de Magister en Ciencias BioMedicas
Departamento de Ciencias BioMedicas
Universidad de Talca, Talca

2020-2022
Cotutora: Tesista Magister: Alumna Solange Besoain
Programa de Magister en Ciencias BioMedicas
Departamento de Ciencias BioMedicas
Universidad de Talca, Talca

2015-2020.
Tutora Tesista Doctoral: Alumna Daniela Caceres
Programa en Ciencias BioMedicas
Departamento de Ciencias BioMedicas
Universidad de Talca, Talca.


Premios y Distinciones

  •   Best talks at IPS 2017: Pluripotent Stem Cells and Gene Editing Symposium: From Bench Success Clinical Promises.

    UNIVERSIDAD DE LOS ANDES

    Chile, 2017

    Best talks at IPS 2017: Pluripotent Stem Cells and Gene Editing Symposium: From Bench Success Clinical Promises. Organized by the Universidad de los Andes and Universidad del Desarrollo (Chile) in collaboration with the University of Cambridge (UK) Event Date: March 30-31, 2017 Event Time: 9:00-18:00 CLST

  •   Milton-Safenowitz Post Doctoral Fellowship for ALS Research

    ALSA

    Estados Unidos, 2006

    We have taken a multifaceted approach to the study of ALS disease mechanisms. We use mouse models of ALS to study the interactions between motor neurons (the cells of the nervous system that control movement) and glia, (the cells that support and surround neurons in the spinal cord). With the advent of the new stem cell technologies, we have also initiated studies aimed at exploring the interactions between neurons and glia in human ALS.


 

Article (24)

Locus-specific analysis of Transposable Elements during the progression of ALS in the SOD1G93A mouse model.
Spatially Resolved Expression of Transposable Elements in Disease and Somatic Tissue with SpatialTE
Coarse-Grained Parameters for Divalent Cations within the SIRAH Force Field
Altered lactate metabolism in Huntingtons disease is dependent on GLUT3 expression
Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species
Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells
Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations
Accelerated high-yield generation of limb-innervating motor neurons from human stem cells
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells"
Intricate interplay between astrocytes and motor neurons in ALS
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
Anti-homeostatic synaptic plasticity of glycine receptor function after chronic strychnine in developing cultured mouse spinal neurons.
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons.
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing
Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues
Ependymal cell differentiation and GLUT1 expression is a synchronous process in the ventricular wall
The presence of glia stimulates the appearance of glycinergic synaptic transmission in spinal cord neurons
Elevated expression of glucose transporter-1 in hypothalamic ependymal cells not involved in the formation of the brain-cerebrospinal fluid barrier.

Review (1)

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain
8
Monica Carrasco

Profesor Asociado

Escuela de Medicina

UNIVERSIDAD DE TALCA

Talca, Chile

1
Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

1
Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
Gustavo Moraga

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

1
María Miró

Académico

Facultad de Salud

Universidad Santo Tomás

Valdivia, Chile

1
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

1
Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

1
Juan Tapia

Profesor Asociado

UNIVERSIDAD DE TALCA

Talca, Chile

1
Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

1
Maite Castro

Professor

Faculty of Sciences

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile