Man

Juan Carlos Tapia Amaro

Profesor Asociado

UNIVERSIDAD DE TALCA

Talca, Chile

Líneas de Investigación


Development and emergence of mature neural circuits; Anatomical and functional decay of synapses; Neurodegenerative disorders; Cellular and molecular mechanisms underlying the decline of age-associated motor function; cancer and neurons.

Educación

  •  Biología Molecular y Celular, UNIVERSIDAD DE CONCEPCION. Chile, 2002
  •  Lic. en Bioquímica, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 1996
  •  Biología Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 2002

Experiencia Académica

  •   Profesor Full Time

    UNIVERSIDAD DE TALCA

    2015 - A la fecha

Experiencia Profesional

  •   Profesor Asociado Full Time

    Universidad de Talca

    Talca, Chile

    2015 - A la fecha

  •   Principal Investigator Full Time

    Columbia University

    New York, Estados Unidos

    2010 - 2015

  •   Postdoctoral Full Time

    Harvard University

    Cambridge, Estados Unidos

    2003 - 2009

Formación de Capital Humano


2020-Ongoing
CoTutor/Director: Postdoctorado Dr. Alejandro Maureira
Proyecto Postdoctoral ANID
Departamento de Ciencias BioMédicas
Universidad de Talca, Talca.

2020-Ongoing
CoTutor/Director: Postdoctorado Dr. Braulio Valdebenito
Proyecto Postdoctoral UTalca
Departamento de Ciencias BioMédicas
Universidad de Talca, Talca.

2022-Ongoing
Tutor Tesista Doctoral: Matias Osorio
Becario ANID
Programa de Doctorado en Ciencias BioMédicas
Departamento de Ciencias BioMédicas
Universidad de Talca, Talca.

2022-Ongoing
Tutor Tesista Doctoral: Francisca Torres
Becaria ANID
Programa de Doctorado en Ciencias BioMédicas
Departamento de Ciencias BioMédicas
Universidad de Talca, Talca.

2022-Ongoing
Tutor Tesista Doctoral: Gabriel Diaz
Becario UTalca
Programa de Doctorado en Ciencias BioMédicas
Departamento de Ciencias BioMédicas
Universidad de Talca, Talca.

2020-2022
Tutor: Tesista Magister: Alumno Felipe Franco
Becario UTalca
Programa de Magister en Ciencias BioMédicas
Departamento de Ciencias BioMédicas
Universidad de Talca, Talca

2020-2022
Tutor: Tesista Magister: Alumna Solange Besoain
Programa de Magister en Programa en Ciencias BioMédicas
Departamento de Ciencias BioMédicas
Universidad de Talca, Talca

2021-Ongoing
Tutor Tesista pregrado: Alumna Liesel Friederichs
Programa de Bioquímica
Instituto de Biología
Universidad de Talca, Talca

2020-2021
Tutor Tesista pregrado: Alumna Francia Jeldres
Programa de Tecnología Médica
Universidad de Talca.

2018-2020
Tutor Tesista pregrado: Alumno Matias Osorio
Programa de Tecnología Médica
Universidad de Talca.

2018-2020
Tutor Tesista pregrado: Alumno Felipe Franco
Programa de Tecnología Médica
Universidad de Talca.

2018-2019
CoTutor Tesis pregrado: Alumna Francisca Torres
Programa de Ingeniería en Biotecnología
Universidad Católica del Maule

2017-2018
Co-Tutor Tesis pregrado: Alumno Carlos Castillo
Programa de Tecnología Médica
Universidad de Talca.

2017-2018
Tutor Tesis pregrado: Alumno Carlos Cáceres
Programa de Tecnología Médica
Universidad de Talca.

2017-2018
Tutor Tesis pregrado: Alumno Luis Valdes
Programa de Tecnología Médica
Universidad de Talca.


Difusión y Transferencia


Speaker "Neuromuscular day"- Abril de 2019
Belo Horizonte - Brasil

Speaker XXXVII Reunião da Sociedade Brasileira de Neurociências- Setembro 2013
Belo Horizonte - Brasil


Premios y Distinciones

  •   IBRO Collaborative Research Program

    IBRO

    Francia, 2021

    Programa para fomentar el establecemiento de redes entre investigadores latinoamericanos

  •   CNPq

    Brazilian research council

    Brasil, 2021

    Caracterizacion de Sinapsis Colinergias en Animales VACHT KO

  •   FINEP Microscopia Eletrônica Seriada Tridimensional (3D Volume EM) na UFMG

    Zuckerberg Foundation

    Chile, 2021

    Establecer un centro de microscopía seriada volumétrica para latinoamérica. Esto permitirá acceso a todos los investigadores latinoamericanos para un centro avanzado de preparación, toma de imágenes y análisis utilizando microscopios electrónicos de ultima generación; fundamental para el desarrollo de todas las áreas de las ciencias básicas y aplicadas.

  •   Fondecyt Regular

    FONDECYT

    Chile, 2020

    Estudio del Desarrollo del Sistema Nervioso Autonómico

  •   Fondecyt Regular

    FONDECYT

    Chile

    CoInvestigador en el efecto de pre-eclampsia en la vasculatura y conexiones sinápticas en el SNC

  •   IBRO PROLAB

    IBRO

    Brasil, 2019

    Estudio de las Sinapsis Neuromusculares in Huntington's.

  •   Fondecyt Regular

    FONDECYT

    Chile, 2016

    Estudio del desarrollo de las conexiones sinapticas en el sistema nervioso parasimpático.

  •   Fondecyt Regular

    FONDECYT

    Chile, 2016

    CoPI Rol de la mutación TDP43 en ALS.

  •   U19 Collaborative Research Program

    HARVARD UNIVERSITY

    Estados Unidos, 2022

    International Investigator


 

Article (45)

Neuroprotective effect of CTK 01512-2 recombinant toxin at the spinal cord in a model of Huntington's disease.
Differential regulation of transposable elements (TEs) during the murine submandibular gland development
Locus-specific analysis of Transposable Elements during the progression of ALS in the SOD1G93A mouse model
Spatially Resolved Expression of Transposable Elements in Disease and Somatic Tissue with SpatialTE
Coarse-Grained Parameters for Divalent Cations within the SIRAH Force Field
Abnormalities in the Motor Unit of a Fast-Twitch Lower Limb Skeletal Muscle in Huntington's Disease
Analysis of the characteristics and components for the frailty syndrome in older adults from central Chile. The PIEI-ES study
The median eminence as the hypothalamic area involved in rapid transfer of glucose to the brain: functional and cellular mechanisms
Correlated Light-Serial Scanning Electron Microscopy (CoLSSEM) for ultrastructural visualization of single neurons in vivo
Distinct roles for motor neuron autophagy early and late in the SOD1(G93A) mouse model of ALS
Muscle atrophy is associated with cervical spinal motoneuron loss in BACHD mouse model for Huntington's disease
Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice
Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice
A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function
Saturated Reconstruction of a Volume of Neocortex
Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics
Comparative Strength and Dendritic Organization of Thalamocortical and Corticocortical Synapses onto Excitatory Layer 4 Neurons
Single-Cell Identity Generated by Combinatorial Homophilic Interactions between alpha, beta, and gamma Protocadherins
Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles Via NGF/GDNF Signaling
SVCT2 transporter expression is post-natally induced in cortical neurons and its function is regulated by its short isoform
Intricate interplay between astrocytes and motor neurons in ALS
Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions
Functional Significance of Isoform Diversification in the Protocadherin Gamma Gene Cluster
FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA
Glucose Transporter 1 and Monocarboxylate Transporters 1, 2, and 4 Localization within the Glial Cells of Shark Blood-Brain-Barriers
High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy
Pervasive Synaptic Branch Removal in the Mammalian Neuromuscular System at Birth
Shared Resistance to Aging and ALS in Neuromuscular Junctions of Specific Muscles
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology
Delayed Synapse Elimination in Mouse Levator Palpebrae Superioris Muscle
Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise
Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
The Interscutularis Muscle Connectome
Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo
Anti-homeostatic synaptic plasticity of glycine receptor function after chronic strychnine in developing cultured mouse spinal neurons
Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons
Changes on the properties of glycine receptors during neuronal development
Developmental-dependent action of microtubule depolymerization on the function and structure of synaptic glycine receptor clusters in spinal neurons
Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice
Modulation of glycine-activated ion channel function by G-protein beta gamma subunits
Early expression of glycine and GABA(A) receptors in developing spinal cord neurons. Effects on neurite outgrowth
Elevated expression of glucose transporter-1 in hypothalamic ependymal cells not involved in the formation of the brain-cerebrospinal fluid barrier
Neurite outgrowth in developing mouse spinal cord neurons is modulated by glycine receptors

Abstract (1)

Characterisation of motoneurones and interneurones in mouse dissociated spinal cord cultures

ConferencePaper (1)

A semi-automatic tool for the connectivity tracking of neuronal processes acquired using electron microscopy

Errata (1)

Functional Significance of Isoform Diversification in the Protocadherin Gamma Gene Cluster (vol 75, pg 402, 2012)

Proyecto (6)

Multi-synaptic axonal rearrangements in the developing parasympathetic neuronal network
Understanding ALS Disease Mechanisms using human induced pluripotent stem cells derived motor neurons (iMNs).
Three-Dimensional High Resolution Reconstruction of the In Vivo Adult Neural Stem Cell Niche
A connectomic analysis of ALS
Cellular and Molecular Analysis of Defects at Aging Neuromuscular Synapses
LAS PROPIEDADES Y EFECTOS CELULARES DE LA ACTIVACION DEL RECEPTOR DE GLICINA CAMBIAN DURANTE EL DESARROLLO DE NEURONAS ESPINALES EN CULTIVO
47
Juan Tapia

Profesor Asociado

UNIVERSIDAD DE TALCA

Talca, Chile

8
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

7
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

6
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

3
Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

3
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

2
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

2
Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

1
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

1
Eduardo Fuentes

Profesor Titular

Universidad de Talca

Talca, Chile

1
Cecilia Albala

Director, full professor

INTA/U CHILE

Santiago, Chile

1
Miguel Bustamante

DIRECTOR

OTEC

RYPA CAPACITACIÓN

Talca, Chile

1
Magdalena Cuevas

Profesor Asistente

Departamento de Fisiología

Universidad de Concepción

Concepción, Chile

1
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
Nery Jara

Profesor Asistente

Departamento de Farmacología

Universidad de Concepción

Concepción, Chile

1
Pamela Guevara

Full Professor

Electrical Engineering

Universidad de Concepcion

Concepcion, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Rodrigo Giacaman

Full Professor

Cariology Unit, Oral Rehabilitation

UNIVERSIDAD DE TALCA

Talca, Chile

1
Germán Lobos

Profesor Asociado

Economía y Finanzas

Universidad de Talca

Talca, Chile

1
Karina Oyarce

Profesora asistente - Investigadora

Facultad de Medicina y Ciencia

Universidad San Sebastián, sede Tres Pascualas

Concepción, Chile

1
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

1
Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

1
Monica Carrasco

Profesor Asociado

Escuela de Medicina

UNIVERSIDAD DE TALCA

Talca, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Juanita León

Directora Magíster y Especialidad en Odontogeriatría

REHABILITACIÓN BUCOMAXILOFACIAL

UNIVERSIDAD DE TALCA

talca, Chile