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Juan Carlos Tapia Amaro

Profesor

UNIVERSIDAD DE TALCA

Talca, Chile

Development and emergence of mature neural circuits; Structure and function of neural circuits; Anatomical and functional decay of neuronal circuits; Neurodegenerative disorders

Biología Molecular y Celular, UNIVERSIDAD DE CONCEPCION. Chile, 2002
Lic. en Bioquímica, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 1996
Biología Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 2002

Profesor Full Time

UNIVERSIDAD DE TALCA

2015 - A la fecha

Profesor

Universidad de Talca

Chile

2015 - A la fecha
Principal Investigator

Columbia University

Estados Unidos

2010 - 2015
Postdoctoral

Harvard University

Estados Unidos

2003 - 2009

Tesis Pre-Grado:
Carlos Cáceres: Marcaje de Neuronas Ganglionares Utilizando GFP- Plasmidios
Luis Valdes: Marcaje de Neuronas Ganglionares Utilizando GFP- AAV virus

CoTutor Tesis Post-Grado:
Daniela Caceres.


Analysis of the characteristics and components for the frailty syndrome in older adults from central Chile. The PIEI-ES study Palomo, Ivan; Giacaman, Rodrigo A.; Leon, Soraya; Lobos, German; Bustamante, Miguel; Wehinger, Sergio; Carlos Japia, Juan; Fuentes, Manuel; Alarcon, Marcelo; Garcia, Francisco; Albala, Cecilia; Fuentes, Eduardo Article ISI SCOPUS ARCHIVES OF GERONTOLOGY AND GERIATRICS (2019)
Correlated Light-Serial Scanning Electron Microscopy (CoLSSEM) for ultrastructural visualization of single neurons in vivo Hirabayashi, Y; Tapia, JC; Polleux, F Article ISI SCOPUS NATURE (2018)
Distinct roles for motor neuron autophagy early and late in the SOD1(G93A) mouse model of ALS Rudnick N.D.; Griffey C.J.; Guarnieri P.; Gerbino V.; Wang X.; Piersaint J.A.; Tapia J.C.; Rich M.M.; Maniatis T. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Muscle atrophy is associated with cervical spinal motoneuron loss in BACHD mouse model for Huntington's disease Valadão, Priscila Aparecida Costa; de Aragão, Bárbara Campos; Andrade, Jéssica Neves; Magalhães-Gomes, Matheus Proença S.; Foureaux, Giselle; Joviano-Santos, Julliane Vasconcelos; Nogueira, José Carlos; Ribeiro, Fabíola Mara; Tapia, Juan Carlos; Guatimosim, Cristina; Smith, Yoland Article ISI SCOPUS EUROPEAN JOURNAL OF NEUROSCIENCE (2017)
Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice Sheu, Shu-Hsien; Tapia, Juan Carlos; Tsuriel, Shlomo; Lichtman, Jeff W Article SCOPUS eLife (2017)
A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency Simon, Christian M.; Janas, Anna M.; Lotti, Francesco; Tapia, Juan Carlos; Pellizzoni, Livio; Mentis, George Z. Article ISI CELL REPORTS (2016)
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function Sharma, Aarti; Lyashchenko, Alexander K.; Lu, Lei; Nasrabady, Sara Ebrahimi; Elmaleh, Margot; Mendelsohn, Monica; Nemes, Adriana; Tapia, Juan Carlos; Mentis, George Z.; Shneider, Neil A. Article NATURE COMMUNICATIONS (2016)
hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function Ye, Junqiang; Beetz, Nadine; O’Keeffe, Sean; Tapia, Juan Carlos; Macpherson, Lindsey; Chen, Weisheng V.; Bassel-Duby, Rhonda; Olson, Eric N.; Maniatis, Tom Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Saturated Reconstruction of a Volume of Neocortex Kasthuri, N; Hayworth, KJ; Berger, DR; Schalek, RL; Conchello, JA; Knowles-Barley, S; Lee D.; Vazquez-Reina, A; Kaynig, V; Jones, TR; Roberts, M; Morgan, JL; Tapia, JC; Seung, HS; Roncal, WG; Vogelstein, JT; Burns, R; Sussman, DL; Priebe, CE; Pfister, H; Lichtman, JW Article ISI CELL (2015)
Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics Hayworth, KJ; Xu, CS; Lu, ZY; Knott, GW; Fetter, RD; Tapia, JC; Lichtman, JW; Hess, HF Article ISI NATURE METHODS (2015)
Comparative Strength and Dendritic Organization of Thalamocortical and Corticocortical Synapses onto Excitatory Layer 4 Neurons Schoonover, CE; Tapia, JC; Schilling, VC; Wimmer, V; Blazeski, R; Zhang, WY; Mason, CA; Bruno, RM Article ISI JOURNAL OF NEUROSCIENCE (2014)
Single-Cell Identity Generated by Combinatorial Homophilic Interactions between alpha, beta, and gamma Protocadherins Thu, CA; Chen, WV; Rubinstein, R; Chevee, M; Wolcott, HN; Felsovalyi, KO; Tapia, JC; Shapiro, L; Honig, B; Maniatis T. Article ISI CELL (2014)
Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles Via NGF/GDNF Signaling Shvartsman, Dmitry; Storrie-White, Hannah; Lee, Kangwon; Kearney, Cathal; Brudno, Yevgeny; Ho, Nhi; Cezar, Christine; McCann, Corey; Anderson, Erin; Koullias, John; Tapia, Juan Carlos; Vandenburgh, Herman; Lichtman, Jeff W; Mooney, David J Article Molecular Therapy (2014)
SVCT2 transporter expression is post-natally induced in cortical neurons and its function is regulated by its short isoform Salazar K1, Cerda G, Martínez F, Sarmiento JM, González C, Rodríguez F, García-Robles M, Tapia JC, Cifuentes M, Nualart F. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2014)
Intricate interplay between astrocytes and motor neurons in ALS Phatnani, HP; Guarnieri, P; Friedman, BA; Carrasco, MA; Muratet, M; O'Keeffe, S; Nwakeze, C; Pauli-Behn, F; Newberry, KM; Meadows, SK; Tapia, JC; Myers, RM; Maniatis T. Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions Samuel, Melanie A.; Valdez, Gregorio; Tapia, Juan C.; Lichtman, Jeff W.; Sanes, Joshua R. Article ISI PLOS ONE (2012)
Functional Significance of Isoform Diversification in the Protocadherin Gamma Gene Cluster Chen, Weisheng V.; Alvarez, Francisco J.; Lefebvre, Julie L.; Friedman, Brad; Nwakeze, Chiamaka; Geiman, Eric; Smith, Courtney; Thu, Chan Aye; Tapia, Juan Carlos; Tasic, Bosiljka; Sanes, Joshua R.; Maniatis, Tom Article Neuron (2012)
FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA Yamazaki, T.; Chen S.; Yu, Y; Yan, BA; Haertlein, TC; Carrasco, MA; Tapia, JC; Zhai, B; Das, R; Lalancette-Hebert, M; Sharma, A.; Chandran, S; Sullivan, G.; Nishimura, AL; Shaw, CE; Gygi, SP; Shneider, NA; Maniatis T.; Reed, R Article ISI CELL REPORTS (2012)
Glucose Transporter 1 and Monocarboxylate Transporters 1, 2, and 4 Localization within the Glial Cells of Shark Blood-Brain-Barriers Balmaceda-Aguilera, C; Cortes-Campos, C; Cifuentes M.; Peruzzo, B; Mack, L; Tapia, J.C.; Oyarce, K; García M.A.; Nualart, F. Article ISI SCOPUS PLOS ONE (2012)
High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy Tapia, JC; Kasthuri, N; Hayworth, KJ; Schalek, R; Lichtman, JW; Smith, SJ; Buchanan, J. Article ISI NATURE PROTOCOLS (2012)
Pervasive Synaptic Branch Removal in the Mammalian Neuromuscular System at Birth Tapia, JC; Wylie, JD; Kasthuri, N; Hayworth, KJ; Schalek, R; Berger, DR; Guatimosim C.; Seung, HS; Lichtman, JW Article ISI NEURON (2012)
Shared Resistance to Aging and ALS in Neuromuscular Junctions of Specific Muscles Valdez, Gregorio; Tapia, Juan C.; Lichtman, Jeff W.; Fox, Michael A.; Sanes, Joshua R.; Gillingwater, Thomas H. Article PLOS ONE (2012)
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology Nualart, Francisco; Salazar, Katterine; Oyarce, Karina; Cisternas, Pedro; Jara, Nery; Silva-Alvarez, Carmen; Pastor, Patricia; Martínez, Fernando; García, Andrea; García-Robles, María de los Ángeles; Tapia, Juan Carlos Article ISI SCIELO SCOPUS Biological Research (2012)
Delayed Synapse Elimination in Mouse Levator Palpebrae Superioris Muscle Fox, MA; Tapia, JC; Kasthuri, N; Lichtman, JW Article ISI JOURNAL OF COMPARATIVE NEUROLOGY (2011)
Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise Valdez, G; Tapia, JC; Kang H.; Clemenson, GD; Gage, FH; Lichtman, JW; Sanes, JR Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice Chiu, Isaac M.; Phatnani, Hemali; Kuligowski, Michael; Tapia, Juan C.; Carrasco, Monica A.; Zhang, Ming; Maniatis, Tom; Carroll, Michael C. Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The Interscutularis Muscle Connectome Lu, Ju; Tapia, Juan Carlos; White, Olivia L.; Lichtman, Jeff W. Article ISI PLOS BIOLOGY (2009)
Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo McCann, Corey M.; Tapia, Juan Carlos; Kim, Han; Coggan, Jay S.; Lichtman, Jeff W. Article ISI NATURE NEUROSCIENCE (2008)
Anti-homeostatic synaptic plasticity of glycine receptor function after chronic strychnine in developing cultured mouse spinal neurons Carrasco, MA; Castro, PA; Sepulveda, FJ; Cuevas, M; Tapia, JC; Izaurieta, P; van Zundert, B; Aguayo, LG Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2007)
Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons Carrasco, MA; Castro P.; Sepulveda, FJ; Tapia, JC; Gatica, K; Davis, MI; Aguayo, LG Article ISI SCOPUS NEUROSCIENCE (2007)
Changes on the properties of glycine receptors during neuronal development Aguayo, LG; van Zundert, B; Tapia, JC; Carrasco, MA; Alvarez, FJ Article ISI BRAIN RESEARCH REVIEWS (2004)
Developmental-dependent action of microtubule depolymerization on the function and structure of synaptic glycine receptor clusters in spinal neurons van Zundert, B; Alvarez, FJ; Tapia, JC; Yeh, HH; Diaz, E.; Aguayo, LG Article ISI SCOPUS Journal of Neurophysiology (2004)
Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice Ferguson, SM; Bazalakova, M; Savchenko V.; Tapia, JC; Wright, J; Blakely, RD Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Modulation of glycine-activated ion channel function by G-protein beta gamma subunits Yevenes, GE; Peoples, RW; Tapia, JC; Parodi, J; Soto, X; Olate, J; Aguayo, LG Article ISI NATURE NEUROSCIENCE (2003)
Early expression of glycine and GABA(A) receptors in developing spinal cord neurons. Effects on neurite outgrowth Tapia, JC; Mentis, GZ; Navarrete R.; Nualart, F.; Figueroa, E.; Sanchez A.; Aguayo, LG Article ISI SCOPUS NEUROSCIENCE (2001)
Elevated expression of glucose transporter-1 in hypothalamic ependymal cells not involved in the formation of the brain-cerebrospinal fluid barrier Garcia, MDA; Carrasco M.; Godoy A.; Reinicke K; Montecinos, VP; Aguayo, LG; Tapia, JC; Vera, JC; Nualart, F. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2001)
Neurite outgrowth in developing mouse spinal cord neurons is modulated by glycine receptors Tapia, JC; Cárdenas AM; Nualart, F.; Mentis, GZ; Navarrete R.; Aguayo, LG Article ISI SCOPUS NEUROREPORT (2000)


Characterisation of motoneurones and interneurones in mouse dissociated spinal cord cultures Roa, J; Aguayo, LG; Tapia, JC; Mentis, GZ; Diaz, E.; Moran, LB; Navarrete R. Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)


A semi-automatic tool for the connectivity tracking of neuronal processes acquired using electron microscopy Rodriguez, J. E.; Tapia, J.C.; Cardenas, G; Guevara, P ConferencePaper SCOPUS Proceedings - International Symposium on Biomedical Imaging (2015)


Functional Significance of Isoform Diversification in the Protocadherin Gamma Gene Cluster (vol 75, pg 402, 2012) Chen, WSV; Alvarez, FJ; Lefebvre, JL; Friedman, B; Nwakeze, C; Geiman, E; Smith C.; Thu, CA; Tapia, JC; Tasic, B; Sanes, JR; Maniatis T. Errata ISI NEURON (2012)