Man

Katterine Andrea Salazar Martinez

Associate Professor

University of Concepcion

Concepción, Chile

Líneas de Investigación


Neurosciences and cell biology, neuronal differentiation, ependymal cells differentiation, brain tumors, Ependymoma, vitamin C and glucose uptake, cilliogenesis

Educación

  •  Molecular and Cell Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2010
  •  Biochemistry, UNIVERSIDAD DE CONCEPCION. Chile, 2003
  •  Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 2003

Experiencia Académica

  •   Instructor Part Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Concepción, Chile

    2008 - 2010

  •   Assistant Professor Part Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Concepción, Chile

    2010 - 2013

  •   Post-Doc Part Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Chile

    2012 - 2013

  •   Assistant Professor Other

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Concepción, Chile

    2013 - 2014

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Concepcion, Chile

    2014 - 2018

  •   Associate Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Concepción, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Instructor Part Time

    Andres Bello University

    Chile

    2009 - 2010

  •   Academic collaborator Part Time

    University of Concepcion

    Concepcion, Chile

    2007 - Sin Información

  •   Academic Collaborator Part Time

    University of Concepcion

    Concepcion, Chile

    2008 - 2008

  •   Instructor Part Time

    University of Concepcion

    Concepcion, Chile

    2008 - 2012

  •   Assistant Professor Part Time

    University of Concepcion

    Concepcion, Chile

    2012 - 2013

  •   Assistant Professor Part Time

    University of Concepcion

    Concepcion, Chile

    2013 - 2015

  •   Assistant Professor Full Time

    University of Concepcion

    Concepcion, Chile

    2015 - 2018

  •   Associate professor Full Time

    University of Concepcion

    Concepción, Chile

    2018 - A la fecha

Formación de Capital Humano


Undergraduate Thesis:

1. Gustavo Cerda. "Lentiviral vectors to SVCT2 overexpression in neurons". Bioingeniering Thesis. Tutor: Dr. Francisco Nualart, Co-Tutor: Dr. Katterine Salazar 2013.

2. Francisca Espinoza. "Effect of Retinoic acid and ascorbic acid on the expression of neural stem cells SVCT2". Biochemistry Thesis. Tutor: Dr. Francisco Nualart, Co-Tutor: Dr. Katterine Salazar. 2015

3. Victor Baeza. "Characterization of the expression of IIIG9 in ependyml glial cells". Biochemistry Thesis. Tutor: Dr. Katterine Salazar, Co-tutor: Dr. Francisco Nualart. 2016

4. María José Oviedo Iturra. "Subcellular distribution analysis of PPP1 and IIIG9 during the differentiation and polarization of ependymal cells". Biochemistry Thesis. Tutor: Dr. Katterine Salazar, Co-tutor: Dr. Francisco Nualart. 2018.

5. Isabelle De Lima. "Analysis of proteins that interact with the IIIG9-PP1a complex in adherent junctions". Bioingeniering Thesis. Tutor: Dr. Katterine Salazar 2021.

Master Thesis:

1. Ana Belén Peterman. Title: "Study of the neuroactive effect of docosahexaenoic acid and S-allylcysteine ??in cultures of cortical neurons". Co-Tutor: Dr. Katterine Salazar 2020 (In progress).

PhD Thesis:

1. Victor Baeza. "Expression and function of IIIG9 in the differentiation and polarization of ependymal cells". PhD Thesis. Tutor: Dr. Katterine Salazar, Co-tutor: Dr. Francisco Nualart. 2017 (In progress)

2. Natalia Saldivia. "Vitamin C effect in the postnatal radial glial cells of normal and Slc23a+/- brains. PhD Thesis. Tutor: Dr. Francisco Nualart. Co-tutor: Dr. Katterine Salazar, 2017 (In progress)

3. María José Oviedo. Title: "Role of IIIG9 in the maintenance of adherent junctions and the polarity of normal ependymal cells and during their tumor transformation". In progress. Tutor: Dr. Katterine Salazar 2019 (In progress)


Difusión y Transferencia


2011 Seminar organizer: "Stem cells and induced pluripotent cells (iPS)", dictated by Dr. José Inzunza of the Karolinska Institute, Sweden. July 26, Concepción, Chile.
2012 Conference: "EFFECT OF VITAMIN C ON THE POSTNATAL DIFFERENTIATION OF CORTICAL NEURONS". Authors: Katterine Salazar, Francisco Nualart. Institute of Humanities of Concepcion. XVIII National Science and Technology Week organized by the EXPLORA-CONICYT program, in the activity "1000 CIENTIFICOS, 1000 AULAS". October 8, Concepción, Chile.
2013 Conference: "Use of panels to complement learning in freshmen Bioengineering students". III Teaching Conference, Faculty of Biological Sciences, University of Concepción. January 18, Concepción, Chile.
2013 Conference: Experimental design for RNA extraction in formalin-fixed samples embedded in paraffin (FFPE). Laser Microdissection Workshop of the Bío-Bío Advanced Microscopy Center, CMA BIO-BIO at the Agroindustry and Bioren Institute, UFRO, Temuco. May 30, Temuco, Chile.
2013 Conference: "Effect of vitamin C and its transporter SVCT2 on the postnatal differentiation of cortical neurons". Authors: Katterine Salazar, Francisco Nualart. Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, University of Malaga, July 18, Malaga, Spain.
2014 Conference: "Micro-dissection laser, coupling the histological study to the genomic analysis", Dr. Katterine Salazar. ROUND TABLE: "Neuroscience and applications in advanced microscopy: confocal spectrality, laser microdissection and superresolution (Center for Advanced Microscopy, CMA BIO BIO - University of Concepción)." XI Chilean Anatomy Conference, November 19-21, Temuco, Chile.
2015 Conference: "Laser microdissection: methodology and applications", Dr. Katterine Salazar. Biomedical Department, Faculty of Health Sciences, University of Antofagasta, Antofagasta, Chile, March 17.
2016 Conference: "Study of the expression and function in the brain of the ciliary protein IIIG9". Mini symposium, first international congress, Chilean Society of Experimental Biostructure, SOCHIBE. December 8
2017 Conference: "Study of the expression and function in the brain of the ciliary protein IIIG9". Lecture series: "Homeostasis of glucose, ciliogenesis and antioxidative defense". Department of Cellular Biology, Physiology and Genetics. University of Málaga, Spain. January 25.
2019 "An unexplored trip of the brain: proteins of unknown function". Authors: Katterine Salazar. Liceo de niñas de Concepcion. Brain Awarness Week of Concepcion. March 13, Concepción, Chile.
2019 Interview on the television program "The community of content" of the television channel TVU, to spread the celebration of Brain awarness week in conception and in the world. This interview was conducted in conjunction with the mayor of the commune of conception. March, 15th
2020 Conference: “Molecular mechanisms involved in cell polarization and adhesion. IIIG9 and its Biomedical implications ”. Sci Talks cycle 1. Ciencia Conecta UDEC/UBB/USS. 10 Septiembre.


Premios y Distinciones

  •   Southern Leaders

    DIARIO EL SUR

    Chile, 2010

    Recognition as one of the most outstanding young professionals in the Bio-Bio region

  •   ISN Travel Award to attend the 25th ISN APSN Joint Biennial Meeting organized in conjunction with ASN

    APSN-ASN

    Australia, 2015

    This awards consisted of a stipend ($3250) for travel costs

  •   Best Poster Presentation Award

    19th ISANH International Conference

    Francia, 2017

    Poster presentation: "Vitamin C and neuronal oxidative stress alter mitochondrial and cellular size, tiggering neuronal death"

  •   Best Image on Cellular Biology 2018

    Chilean Society for Cell Biology- XXXII Annual Meeting, October 22-26.

    Chile, 2018

    For many years, the SBCCH has rewarded the best photomicrographers who make important scientific contributions to cell biology in striking pictures.


 

Article (27)

Vitamin C deficient reduces proliferation in a human periventricular tumor stem cell-derived glioblastoma model
Vitamin C Recycling Regulates Neurite Growth in Neurospheres Differentiated In Vitro
Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice
Vitamin C controls neuronal necroptosis under oxidative stress
Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions
Brain Glucose-Sensing Mechanism and Energy Homeostasis
Metabolic control by dehydroascorbic acid: Questions and controversies in cancer cells.
Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells
SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies.
SVCT2 Is Expressed by Cerebellar Precursor Cells, Which Differentiate into Neurons in Response to Ascorbic Acid
Aging Selectively Modulates Vitamin C Transporter Expression Patterns in the Kidney.
Apical Polarization of SVCT2 in Apical Radial Glial Cells and Progenitors During Brain Development.
Cytoarchitecture, Proliferative Activity and Neuroblast Migration in the Subventricular Zone and Lateral Ventricle Extension of the Adult Guinea Pig Brain.
Dehydroascorbic Acid Promotes Cell Death in Neurons Under Oxidative Stress: a Protective Role for Astrocytes.
SVCT2 Overexpression in Neuroblastoma Cells Induces Cellular Branching that is Associated with ERK Signaling.
SVCT2 transporter expression is post-natally induced in cortical neurons and its function is regulated by its short isoform
The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism
Vitamin C transportres, Recycling and the Bystander Effect in the Nervous System: SVCT2 versus GLUTs
Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
Human choroid plexus papilloma cells efficiently transport glucose and vitamin C
SVCT2 vitamin C transporter expression in progenitor cells of the postnatal neurogenic niche
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology
Nutritional channels in breast cancer
The Na+-dependent l-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids
Differential distribution of the Sodium-vitamin C cotransporter-1 along the proximal tubule of the mouse and human kidney
Sodium vitamin C cotransporter SVCT2 is expressed in hypothalamic glial cells
Vitamin C uptake and recycling among normal and tumor cells from the central nervous system

BookReview (1)

Vitamin C transporter (SVCT2) distribution in developing and adult brain

ConferencePoster (38)

Molecular and cellular characterization of the late radial glia cells and the effect of vitamin C on its differentiation process.
Subcellular dynamics in cell-cell adhesion during ependymal cell specification and maturation from radial glia progenitors
Vitamin C controls neuronal necroptosis under oxidative Stress.
Cell adhesion protein analysis in polarized kidney and ependymal cells using super-resolution SIM.
Characterization of postnatal radial glia and correlation with vitamin C transporters, SVCT2
Novel IIIG9 localization in cell-cell adhesion complexes during embryonic and postnatal brain development
Transporter clustering analysis in the neuronal membranes using three dimensional structured illumination microscopy (3D-SIM)
Vitamin C índices glioblastoma invasiveness by increasing perivascular satellitosis and bystander effect
Effect of vitamin C recycling during neurospheres differentiation in vitro
Hyperglycemia modify the cell structure of GLUT2/GLUT6-positive tanycytes from the median eminence.
IIIG9: Analysis of its subcellular localization and the effect of its inhibition in ependymal cells.
Three dimensional structured illumination microscopy (3D-SIM) to evaluate SVCT2 clustering in the neuronal membrane.
Comparative analysis of vitamin C and vitamin A in stimulating neurite growth in neural progenitors
Spectral confocal microscopy and three dimensional structured illumination microscopy (3d-sim) to evaluate pre- and post-synaptic markers in cortical neurons over-expressing svct2.
The structure of GLUT2- and GLUT6-positive tanycytes is altered by acute hyperglycemia.
Vitamin C and neuronal oxidative stress induce alterations in mitochondrial and cellular size, triggering neuronal death
VITAMIN C TRANSPORTERS EXPRESSION AND DISTRIBUTION IN GLIOBLASTOMA CELLS
Oxidation of vitamin C induces neuronal death and alterations in distribution of GLUT1/SVCT2 and mitochondrial size
SVCT2 Overexpression in Neuroblastoma Cells Induces Cellular Branching that is Associated with ERK Signaling.
Ependymal cells differentiation and IIIG9 expression is a synchronous process.
Neurogenesis and lateral ventricular extensión in the adult guinea pig brain.
SIM Super-resolution microscopy to define the location and relationship of SVCT2 with synaptic proteins in cortical neurons.
Spectral-confocal and 3D-rendering analysis to define the glial cells distribution and SVCT2 transporter expression in the hypothalamus.
Structural changes induced for acute hyperglycemia in median eminence tanycytes and vasculature.
Vitamin C deficiency disrupts normal cellular composition within the subventricular zone neurogenic niche.
Glial cell distribution and SVCT2 transporter expression in different areas of the adult brain.
SVCT2 transporter expression is postnatally induced in cortical neurons and its function is regulated by hetero-oligomerization
Comparative analysis of GLUT1 and SVCT2 polarization in choroid plexus cells.
Super-resolution confocal analysis to define the localization and relation of SVCT2 with synaptic proteins in cortical neurons.
Superoxide-dependent uptake of vitamin C in human glioma cells.
Vitamin C deficiency disrupts normal cellular activity within the subventricular zone neurogenic niche.
Vitamin C recycling and the protective function of the astrocyte against neuronal death induced by oxidative stress and dehydroascorbic acid.
Superresolution confocal analysis to define the location and relationship of SVCT2 with synaptic proteins in cortical neurons.
SVCT2 y GLUT1 polarization and function in mouse and human choroid plexus cells..
SVCT lentiviral transduction effect on neuronal branching.
SVCT2 polarization and function of vitamin c in radial glial cells.
SVCT2 expression and polarization in radial glial cells.
SVCT2 lentiviral transduction effects in neuronal branching in vitro.

Proyecto (9)

IIIG9 EXPRESSION AND FUNCTION DURING THE DIFFERENTIATION AND POLARIZATION OF EPENDYMAL CELLS AND IN EPENDYMOMA PROGRESSION
VITAMIN C RECYCLING: FUNCTIONAL EFFECTS IN NEURONAL DIFFERENTIATION AND NECROPTOSIS INDUCTION
IIIG9 expression and function in normal ependymal cell differentiation and tumoral transformation
"Role of IIIG9 orphan gene during the normal ependymal differentiation and tumoral transformation". 2014-2015
Cellular Biology of vitamin C transporters in stem cells. 2010-2014
Cellular polarization and functional activity of the vitamin C transporter, SVCT2, during cerebral nervous system differentiation (pre- and post-natal) and glioblastoma progression. 2014-2018
Generating an interactive virtual classroom for bioengineering student of first year, strengthen learning Cell Biology and social commitment. 2012-2013
Research Center for the study of the nervous system: Cell Biology and Biomedical Application.
Vitamin C effect in the post-natal differentiation of cortical neurons. 2011-2012
80
Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

13
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

12
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

9
Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

8
Teresa Caprile

Associate profesor

DPTO. BIOLOGIA CELULAR,

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

6
Allisson Astuya

profesor asociado

Departamento de Oceanografia de la Universidad de Concepción

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

5
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

3
Luciano Ferrada

Investigador

Biología celular

Universidad de Concepción

Concepcion, Chile

3
Viviana Ulloa

Profesional Superior

Dirección de Estudios Estratégicos

Universidad de Concepción

Concepción, Chile

3
Carola Millan

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

2
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

2
Nery Jara

Profesor Asistente

Departamento de Farmacología

Universidad de Concepción

Concepción, Chile

2
Juan Tapia

Profesor

UNIVERSIDAD DE TALCA

Talca, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Pablo Torres

Profesor Asistente

Farmacia

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
María José Barahona

Investigador asociado

Universidad de Concepción

Concepción, Chile

1
Fredy Montoya

Upper extremity, In charge of shoulder and elbow surgery

- Hospital Traumatologico de Concepción

Concepción , Chile

1
Francisca Espinoza

Investigadora postdoctoral

Facultad de Medicina

Universidad Católica de la Santisima Concepción

Concepción, Chile