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Luciano Esteban Ferrada Cofré

Investigador

Universidad de Concepción

Concepcion, Chile

Líneas de Investigación


Necroptosis and Ferroptosis pathways in cancer. Non-apoptotic cell death

Educación

  •  Bioingeniero, UNIVERSIDAD DE CONCEPCION. Chile, 2014
  •  ciencias basicas, UNIVERSIDAD DE CONCEPCION. Chile, 2011
  •  Ciencias biológicas, Area biología celular y molecular, UNIVERSIDAD DE CONCEPCION. Chile, 2019

Experiencia Profesional

  •   Investigador Full Time

    Universidad de Concepción

    Concepcion, Chile

    2009 - 2018

  •   Investigador Asociado Full Time

    Centro de Microscopia Avanzada CMA BIOBIO

    Concepcion, Chile

    2018 - A la fecha

Premios y Distinciones

  •   Poster Presentation Award 2017

    international society of antioxidants in nutrition and health

    Francia, 2017

    Poster Presentation Award 2017 during the 19th international congress “paris redox” 2017. Held at University Pierre &Marie Curie, Paris, France on june 26th and 27th 2017. International society of antioxidants, ISANH.

  •   Expo posters alumnos y centros de investigacion I+D

    UNIVERSIDAD DE CONCEPCION

    Chile, 2016

    Expo posters alumnos y centros de investigacion I+D. Año 2016 Universidad de concepción. Por obtener mención honrosa con el poster: Oxidation of vitamin C induces neuronal death and alterations in distribution of GLUT1/SVCT2 and mitochondrial size, en el festival de la ciencia, organizado por la dirección de postgrado de la Univresidad de Concepción.

  •   CONCURSO DE INCENTIVO A ESTUDIANTES: PUBLICACIONES de 1er. AUTOR del PROYECTO MECESUP UCO 1311

    UNIVERSIDAD DE CONCEPCION

    Chile, 2015

    CONCURSO DE INCENTIVO A ESTUDIANTES: PUBLICACIONES de 1er. AUTOR del PROYECTO MECESUP UCO 1311. Año 2015 Universidad de concepción. Reconocimiento a publicación como primer autor en revista ISI, por el artículo Dehydroascorbic Acid Promotes Cell Death in Neurons Under Oxidative Stress: a Protective Role for Astrocytes

  •   Poster Followship

    COLD SPRING HARBOR LABORATORY

    China, 2018

    Cold Spring Harbor Poster followship in Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease, Suzhou, CHINA, November 26-30, 2018

  •   European Cell Death Organization Followship

    DRESDEN UNIVERSITY OF TECHNOLOGY

    Alemania, 2019

    Beca de asistencia al 27 European Cell Death Organization (ECDO) 2019, en Dresden, Alemania. Por mi trabajo ede excelencia en muerte celular como científico joven.


 

Article (12)

Hexose Transporters in Cancer: From Multifunctionality to Diagnosis and Therapy
Two Distinct Faces of Vitamin C: AA vs. DHA
Vitamin C deficient reduces proliferation in a human periventricular tumor stem cell-derived glioblastoma model
Vitamin C controls neuronal necroptosis under oxidative stress
Vitamin C Recycling Regulates Neurite Growth in Neurospheres Differentiated In Vitro
Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions
Metabolic control by dehydroascorbic acid: Questions and controversies in cancer cells
SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies
SVCT2 Is Expressed by Cerebellar Precursor Cells, Which Differentiate into Neurons in Response to Ascorbic Acid
Dehydroascorbic acid promotes cell death in neurons under oxidative stress=> a protective role for astrocyte
The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism
Vitamin C Transporters, Recycling and the Bystander Effect in the Nervous System=> SVCT2 versus Gluts

Abstract (1)

Dehydroascorbic acid promotes cell death in neurons under oxidative stress: a protective role for astrocytes

BookSection (1)

Vitamin C Transporter (SVCT2) Distribution in Developing and Adult Brains

ConferencePoster (8)

3D morphological characterization by confocal microscopy and super SIM resolution of the balloon-like morfology during neuronal necroptosis
Ferroptosis-resistant human glioblastoma cells are sensitized to ferroptosis by co-treatment with dehydroascorbic acid
Human glioblastoma cells are sensitized to ferroptosis by co-treatment with dehydroascorbic acid and Erastin.
Neuronal necroptosis is induced by vitamin C oxidation
Vitamin C sensitizes neural cancer cells to ferroptosis
Vitamin C and neuronal oxidative stress induce alterations in mitochondrial and cellular size, triggering neuronal death
Oxidation of vitamin C induces neuronal death and alterations in distribution of GLUT1/SVCT2 and mitochondrial size.
Oxidation of vitamin C by oxidative stress produces neuronal death and redistribution of transporters GLUT1 and SVCT2
19
Luciano Ferrada

Investigador

Biología celular

Universidad de Concepción

Concepcion, Chile

10
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

4
Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

3
Francisca Espinoza

Investigadora postdoctoral

Facultad de Medicina

Universidad Católica de la Santisima Concepción

Concepción, Chile

3
Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

2
María José Barahona

Investigador asociado

Universidad de Concepción

Concepción, Chile

2
Nery Jara

Profesor Asistente

Departamento de Farmacología

Universidad de Concepción

Concepción, Chile

2
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
KATHERINE FORMAN

Profesor Asociado

nutrition and dietetics

universidad de concepción

concepción, Chile

1
Pablo Torres

Profesor Asistente

Farmacia

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
Felipe Avila

Profesor Asistente

UNIVERSIDAD DE TALCA

Talca, Chile

1
Romina Bertinat

Technician

Farmacología

Universidad de Concepcion

Concepción, Chile