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Charlotte Nicole Hill Machado

Postdoctoral Fellow

Boston Childrens Hospital, Harvard Medical School

Boston, Estados Unidos

T cell biology, T cell exhaustion, Treg destabilization, Metabolic adaptations of tissue T cells, Adoptive T cell therapy for cancer treatment, CART cell development, Cancer immunology and immunotherapy.

Biologo Mención Bioprocesos, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2016
Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2014
Fisiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2018
Inmunología, Biología del Cáncer, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile

Instructora Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biológicas

Chile

2019 - 2020
Ayudante Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

2011 - 2020
Postdoctoral Fellow Full Time

HARVARD UNIVERSITY

Estados Unidos

2021 - 2023
Teaching Assistant Other

HARVARD UNIVERSITY

Boston, Estados Unidos

2022 - 2023

Asistente de Investigación Full Time

Universidad de Los Andes

Chile

2016 - 2017
Biologo (Practicante en Diagnóstico Molecular) Part Time

Clinica Las Condes

Chile

2014 - 2015
Biologo Part Time

Selva Viva Spa

Chile

2015 - 2015
Profesora Ciencias Naturales y Biología Full Time

Colegio Altamira

Chile

2015 - 2015
Research Fellow Full Time

Boston Childrens Hospital

Boston, Estados Unidos

2021 - 2023

Faculty Academic Appointments:
2022 - 2023. Teaching Assitant, Harvard Medical School
2018 – 2020 Instructor, Pontificia Universidad Católica de Chile
2017- 2019 Teaching Assistant, Pontificia Universidad Católica de Chile
2016 – 2017 Research Assistant,Universidad de los Andes
2012 – 2014 Teaching Assistant, Pontificia Universidad Católica de Chile.

Mentored Trainees:
2016 Sebastián Venegas Eng, Universidad de Chile – Universidad de los Andes
2017 Elisa Cumsille BSc, Pontifica Universidad Católica de Chile
2017 Catalina Muñoz BSc, Pontifica Universidad Católica de Chile
2018 Camille Cabrollier BSc, Pontifica Universidad Católica de Chile
2020-21 Gabriela Maita BSc, Pontifica Universidad Católica de Chile
2020-21. Catalina Ascencio PhD(c), Pontificia Universidad Católica de Chile
2023 Yassine Al Fazaa, MS student (Intern), Boston Children’s Hospital

National and International Invited Teaching and Presentations:
2018-2021 “Cancer Immune Response”, Guest lecturer, Pontificia Universidad Católica de Chile
“Cancer Immunotherapy and Resistance Mechanisms”, Guest lecturer, Pontificia Universidad Católica de Chile

2020 “The Neurobiology of Love”, External evaluator, Universidad del Desarrollo.
2021 “Immunotherapy in Gastric Cancer”, Guest lecturer, Advances in Surgery Channel, Barcelona, Spain.
2021 “The Neurobiology of Love”, External evaluator, Universidad del Desarrollo.
2022 “Strategies to mitigate immune dysregulation mediated by Foxp3 deficiency”, Invited speaker, Universidad de los Andes, Santiago de Chile.
2023 ‘Strategies to mitigate immune dysregulation mediated by Foxp3 deficiency”, Leading Speaker, Immunology Division Seminar, Boston Children’s Hospital, Harvard Medical School,
Boston USA.

Mejor Ingreso a Programa de Doctorado 2017

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2017

Premio de Excelencia Académica a mejor ingreso al programa de doctorado.
AACR Associate Membership

Amercian Association for Cancer Research

Estados Unidos, 2018

Membresía de una de las sociedades científicas de investigación en cáncer más prestigiosa a nivel internacional.
FOCIS Membership

Federation Of Clinical Immunology

Chile, 2019

Graduate/Medical Student Membership
BECA REUNION ANUAL SBCCh 2019

Sociedad de Biología Celular Chilena

Chile, 2019

Beca SBCCh para asistir a congreso.
BECA REUNION ANUAL SBCCh 2018

Sociedad de Biología Celular Chilena

Chile, 2018

Beca de asistencia a congreso (presentación poster).
AAI membership

American Association of Immunology

Estados Unidos, 2022

AAI membership
Minority Scientist Travel Award

American Association of Immunology

Chile, 2023

Travel award to assist to Immunology 2023 meeting in Washington DC.


Differentially Expressed Genes and Signaling Pathways Potentially Involved in Primary Resistance to Chemo-Immunotherapy in Advanced-Stage Gastric Cancer Patients Pinto, Mauricio P.; Munoz-Medel, Matias; Retamal, Ignacio N.; Bravo, MariaLoreto; Latapiat, Veronica; Cordova-Delgado, Miguel; Hill, Charlotte N.; Fernandez, M. Fernanda; Sanchez, Carolina; Saez, Mauricio A.; Martin, Alberto J. M.; Morales-Pison, Sebastian; Fernandez-Ramires, Ricardo; Garcia-Bloj, Benjamin; Owen, Gareth, I; Garrido, Marcelo Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer Cordova-Delgado, Miguel; Loreto Bravo, Maria; Cumsille, Elisa; Hill, Charlotte N.; Munoz-Medel, Matias; Pinto, Mauricio P.; Retamal, Ignacio N.; Lavanderos, Maria A.; Francisco Miquel, Juan; Rodriguez-Fernandez, Maria; Liao, Yuwei; Li, Zhiguang; Corvalan, Alejandro H.; Armisen, Ricardo; Garrido, Marcelo; Quinones, Luis A.; Owen, Gareth, I Article ISI BMC CANCER (2021)
Role of microRNA Shuttled in Small Extracellular Vesicles Derived From Mesenchymal Stem/Stromal Cells for Osteoarticular Disease Treatment Lara-Barba, Eliana; Araya, Maria Jesus; Hill, Charlotte Nicole; Bustamante-Barrientos, Felipe A.; Ortloff, Alexander; Garcia, Cynthia; Galvez-Jiron, Felipe; Pradenas, Carolina; Luque-Campos, Noymar; Maita, Gabriela; Elizondo-Vega, Roberto; Djouad, Farida; Vega-Letter, Ana Maria; Luz-Crawford, Patricia Article ISI FRONTIERS IN IMMUNOLOGY (2021)
Deciphering the Role of the Coagulation Cascade and Autophagy in Cancer-Related Thrombosis and Metastasis Hill, Charlotte Nicole; Hernandez-Caceres, Maria Paz; Asencio, Catalina; Torres, Begona; Solis, Benjamin; Owen, Gareth I. Article ISI FRONTIERS IN ONCOLOGY (2020)
Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia Varas-Godoy, Manuel; Acuna-Gallardo, Stephanie; Venegas-Duarte, Sebastian; Hill, Charlotte; Caceres-Verschae, Albano; Realini, Ornella; Monteiro, Lara J.; Zavala, Gabriela; Khoury, Maroun; Romero, Roberto; Rice, Gregory; Illanes, Sebastian E. Article ISI SCOPUS STEM CELLS INTERNATIONAL (2019)
Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity Escobedo N; Contreras O.; Munoz, R.; Farias M.; Carrasco H.; Hill, C; Tran U; Pryor SE; Wessely O; Copp AJ; Larrain, J Article ISI SCOPUS Development (Cambridge) (2013)


Targeting glutamine metabolism mitigates Foxp3-deficiency mediated disease. Charlotte N. Hill; Yuelin Zhong; Louis Marie Charbonnier ConferencePaper (2023)
IL2 signaling and Foxp1 maintain Treg identity in the absence of Foxp3 Charlotte N. Hill; Yuelin Zhong; David Zemmour; Louis Marie Charbonnier ConferencePaper (2022)
IL2 signaling and Foxp1 expression maintain Treg identity in the absence of Foxp3 Charlotte N. Hill; Yuelin Zhong; David Zemmour; Louis Marie Charbonnier; American Association of Immunology ConferencePaper


Galectin 9 associates with PDL1 expression and promotes gastric cancer cell invasion Hill, Charlotte; Cabrolier, Camille; Cumsille, Elisa; Arce, Maximiliano; Bravo, María Loreto; Pinto, Mauricio; Garrido, Marcelo; Owen , Gareth ConferencePoster Presentación de Poster (2019)
Galectin 9 enhances gastric cancer cell invassion and associates with an immune suppressive microenvironment Hill, Charlotte; Cabrolier, Camille; Arce, Maximiliano; Garrido, Marcelo; Owen , Gareth ConferencePoster Presentación Oral (2019)
Galectin 9 expression correlates with PDL-1 checkpoint levels in gastric cancer Hill, Charlotte; Cabrolier, Camille; Cumsille, Elisa; Arce, Maximiliano; Garrido, Marcelo; Owen , Gareth ConferencePoster Presentación de Poster (2018)
Reprimo (RPRM) is involved in epithelial-mesenchymal transition (EMT) in zebrafish embryos Reyes, Cristian.; Hill, Charlotte; Figueroa, Ricardo; Arce, Maximiliano; Owen , Gareth; Amigo, Julio ConferencePoster Presentación de Poster (2018)
FIRST TRIMESTER GESTATION SCREENING BIOMARKERS OF PREECLAMPSIA IN ORAL FLUIDS. Chaparro, A.; Zuñiga, E; Albers, D; Hill, C; Varas-Godoy, M; Kusanovic J.P; Silva, K; Rice, GE; Illanes, SE ConferencePoster (2017)
Adición de ARN mensajero del Lactogeno Placentario humano como marcador de disfunción placentaria podría mejorar la predicción de preeclampsia durante el primer trimestre del embarazo Varas-Godoy, M; Monteiro L.; Correa P.; Monckeberg M.; Valenzuela, I.; Chaparro, A.; Hill, C; Palmeiro, Y.; Rice, GE; Illanes, SE ConferencePoster (2016)


Reprogramming of Regulatory T cells to Promote Immune Tolerance Louis-Marie Charbonnier; Chatila, Talal A. Proyecto (2020)
GASTRIC CANCER IMMUNE LANDSCAPE STUDY Bristol Myers Squibb (CA209-8F3) Proyecto 2018-2019 Tesista
Mechanisms of resistance to immunotherapy based on checkpoint inhibitors in metastasis gastric cancer FONDEF (1180173) Proyecto 2018-2020 Tesista
The extracellular matrix promotes the process of vasculogenic mimicry and thus delivers an advantage to ovarian cancer progression FONDEF (1180241) Proyecto 2018-2020 Tesista
Chilean Gastric Task Force (GCTF1) CITO UC (NCT03158571) Proyecto 2017-2018 Tesista
Interacción entre la coagulación y el sistema inmunológico en la progresión del cáncer. Instituto Milenio de Inmunología e Inmunoterapia (IMII P09/016-F) Proyecto 2016-2017 Tesista
Prediccion precoz de preeclampsia basada en la detección de biomarcadores en fluidos orales en pacientes embarazadas. MINEDUC-UANDES (UAN1301) Proyecto 2015-2016 Personal técnico y/o de apoyo
Immunomodulatory characteristics of endometrial mesenchymal stem cells and their role in the etiopathogenesis of preeclampsia. FONDECYT (1140119) Proyecto 2014-2017 Personal técnico y/o de apoyo
Modulation of the process of angiogenesis by coagulation factor X FONDECYT (1140970) Proyecto 2014-2018 Tesista
Function of Syndecan-4 and Beta-1 Integrin in Wnt signaling and early vertebrate development FONDEF (1100471) Proyecto 2010-2013 Personal técnico y/o de apoyo