Man

ALEJANDRO HERNAN CORVALAN RODRIGUEZ

Associate Professor

Pontificia Universidad Catolica de Chile

Santiago, Chile

Líneas de Investigación


A full-time medical researcher at Pontificia Universidad Catolica de Chile, involved in translational cancer research at basic, clinical, and population levels. My research focused on cancer epigenetics, systems biology, and biomarker development.

Educación

  •  Medical Doctor, EDUCATIONAL COMMISION FOR FOREIGN MEDICAL GRADUATES. Estados Unidos, 1989
  •  Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 1985
  •  Cell Biology, UNIVERSIDAD DE CHILE. Chile, 2006

Experiencia Académica

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2003 - A la fecha

  •   Assistant Professor Full Time

    UNIV TEXAS M.D. ANDERSON CANCER CENTER

    Houston, TX, Estados Unidos

    2007 - 2009

Experiencia Profesional

  •   Director Molecular Biology Laboratory Part Time

    Clinica Las Condes

    Santiago, Chile

    1997 - 2003

  •   CSO Part Time

    Ilico Genetics

    Santiago, Chile

    2021 - A la fecha

Formación de Capital Humano


1. Ossandon F., Uso de Bioinformática como herramienta de análisis de datos en Cáncer Gástrico, in Carrera de Bioquimica, Escuela de Ciencias Quimicas y Farmaceuticas. 2006, Universidad de Chile, Santiago.
2. Alvarez H., Estudio multietnico de la patogenesis del cancer de vesicula biliar, in Programa Doctorado en Ciencias Medicas. 2008, Pontificia Universidad Catolica de Chile, Santiago.
3. Gonzalez P., Inactivación epigenética de genes supresores de tumores como potencial marcador de riesgo de diseminación en cáncer de mama, in Carrera de Bioquímica, Facultad de Ciencias Biológicas. 2009, Pontificia Universidad Catolica de Chile, Santiago.
4. Villarroel C., Reprimo en checkpoint g2/m y su posible rol como biomarcador en cancer gastrico., in Carrera de Bioquímica, Facultad de Ciencias Biológicas. 2009, Pontificia Universidad Catolica.de Chile, Santiago.
5. Buchegger K., Efecto de la modulacion de la expresion de Reprimo sobre el comportamiento celular tumoral in vitro en cancer de mama, in Programa Doctorado en Biología Molecular Aplicada. 2011, Universidad de la Frontera, Temuco.
6. Droguett R., Caracterización in silico de microARNs asociados al gen RPRM mediante herramienta bioinformática, in Escuela de Ingeniería en Bioinformática, Facultad de Ingeniería. 2011, Universidad de Talca, Talca.
7. Saavedra K., Reprimo como potencial Gen Supresor de Tumores en Cáncer Gástrico, evaluación in vitro, in Programa Doctorado en Biología Molecular Aplicada. 2011, Universidad de la Frontera, Temuco.
8. Sandoval A., Rol de miR-335 y miR-597 en la pérdida de función del gen Reprimo en un modelo in vitro de cáncer gástrico, in Programa Doctorado en Biología Molecular Aplicada. 2011, Universidad de la Frontera, Temuco.
9. Garcia B., El Aumento de la expresio n endo gena de Reprimo inducido por un factor de transcripcio n artificial modifica la capacidad tumorige nica de Ca ncer Ga strico in vitro e in vivo, in Programa Doctorado en Ciencias Medicas. 2012, Pontificia Universidad Catolica de Chile, Santiago.
10. Torres V., Regulación de la expresión del gen Reprimo por metilación y su posible rol como gen supresor tumoral en cáncer gástrico, in Carrera de Bioquímica, Escuela de Química. 2012, Pontificia Universidad Catolica de Valparaiso, Valparaiso.
11. Sanchez M., La inactivación del gen Reprimo por metilación de su región promotora es un evento preneoplásico y su detección cuantitativa en plasma permite la deteccion precoz de cáncer gástrico, in Carrera de Bioquímica, Escuela de Química. 2013, Pontificia Universidad Catolica Valparaiso, Valparaiso.
12. Fry, Jacqueline, Hipermetilación aberrante y pérdida de expresión de reprimo en lesiones precursoras de cáncer gástrico, Magíster/Master/DEA, 2015, Universidad Andres Bello, Santiago
13.Pino, Camila, Rol de DNp73 en el riesgo de progresión en lesiones precursoras de Carcinoma Gástrico, Licenciatura/Bachillerato/Bachelor, 2015, Universidad Andres Bello, Santiago
14. Cerda, Paulina, Regulación de Reprimo por Survivina, a través de p53 en Cáncer Gástrico, Magíster/Master/DEA, 2016, Universidad de Chile, Santiago
15. Parra, Nicole, Expresion de proteina RPRM y detection de Helicobater pylori por inmunohistoqumica en muestras de mucosa gastrica caracterizadas por el sistema OLGA y OLGIM, Licenciatura/Bachillerato/Bachelor, 2016, Universidad Andres Bello, Santiago
16. Aranda, Estrella; Ibanez, Natalia, Lesiones preneoplasicas de cancer gastrico albergan cambios de expresion de RPRM, Licenciatura/Bachillerato/Bachelor, 2018, Universidad Andres Bello, Santiago
17. Arriagada, Diego, Interacción funcional entre la oncoproteína EBNA-1 del Virus Epstein-Barr (VEB) y componentes del humo de cigarrillo en células epiteliales gástricas, Magíster/Master/DEA, 2018, Universidad Andres Bello, Santiago
18.Valdivia, Andres, Vasculogenic Mimicry, Programa Doctorado en Ciencias Biologicas, 2019, Pontificia Universidad Catolica de Chile, Santiago.
19. Alarcon, Maria Alejandra. Rol de Reprimo-like en cancer gastrico. Programa Doctorado en Ciencias Medicas. 2020, Pontificia Universidad Catolica de Chile, Santiago.
20. Wichmann, Ignacio. Identification of long noncoding RNAs in competing endogenous RNA networks throughout the gastric precancerous cascade. Programa Doctorado en Ciencias Medicas 2020, Pontificia Universidad Catolica de Chile, Santiago.


Difusión y Transferencia


PATENTS
1. Corvalán A.H., Método de detección precoz de cáncer gástrico que comprende detectar la presencia de marcadores específicos de cáncer gástrico en muestras de plasma. INAPI, Chile. WO 2011/035453 A2, PCT/CL2010/000041
2. Corvalán A.H.; Kogan, M.; Guzman, L.; Guerrero, A.; Marchant, MJ. “Método ultrasensible de detección de biomarcador de cáncer gástrico reprimo” INAPI-1649-2016
3. Corvalán A.H.; Maturana, MJ.; Santibanez, E. “Method and assay for the non-invasive detection of early gastric cancer by the combined use of methylated reprimo-cell free DNA and pepsinogens I/II. WO/2015/181804
4. Corvalán A.H.; Sandoval A. Método no invasivo de diagnóstico temprano de cáncer gástrico, usando como biomarcador los niveles de metilación de la secuencia de ADN del promotor del microRNA-335. INAPI-Chile
5. Corvalán A.H.; Alarcon, MA. Detección no-invasiva del cancer gastrico a traves de la deteccion en sangre de la metilacion de reprimo-like, PCT/CL2018/050047
6. Corvalán A.H.; Olivares W.; Santoro, P. KCNQ1OT1, un nuevo biomarcador en plasma para deteccion noinvasiva del Cáncer Gástrico (CG) PCT/CL2018/050126

CONFERENCES
1. VIII International Symposium on Helicobacter Pylori and Gastric Cancer, Pepsinogens and gastric atrophy in latin american populations, 2018, Brasil
2. VIII International Symposium on Helicobacter Pylori and Gastric Cancer,Reprimo-like a newly identified Reprimo paralogue gene, is downregulates by DNA methylation in early gastric cancer, 2018, Brasil
3. VIII International Symposium on Helicobacter Pylori and Gastric Cancer, Reprimo expression in gastric cancer and OLGA and OLGIM stages, 2018, Brasil
4. VIII International Symposium on Helicobacter Pylori and Gastric Cancer, A longitudinal study of cell-free DNA of reprimo methylated, pepsinogens and helicobacter pylori in plasma as a non-invasive risk-assessment for OLGA staging, 2018, Brasil
5. VIII International Symposium on Helicobacter Pylori and Gastric Cancer, Immunodetection of pepsinogens, gastrin-17 and helicobacter pylori for non-invasive diagnosis of high-risk atrophic gastritis in chile, 2018, Brasil
6. The International Society for Extracellular Vesicles, Role of microRNA-335-5p in gastric cancer derived extracellular, España, 2018
7.  Digestive Disease Week, Helicobacter pylori infection is associated with an increased expression of delta-NP73 in gastric tissue samples from asymptomatic donors, USA, 2018
8. The International Society for Extracellular Vesicles, A simple method to label vesicles for visualization and in vivo tracking, España, 2018
9. AACR annual meeting, The Chilean Gastric Cancer Task Force: An uptade of results, USA, 2018
10. Second AACR international conference translational cancer medicine. Cancer discoveries for clinical application, Molecular characterization of gastric adenocarcinoma tumors from chilean patients, Brasil, 2018
11. XXIX reunion anual sociedad de reproduccion y desarrollo, Vasculogenic mimicry: an alternative model of tumor irrigation in ovarian cancer, Chile, 2018
12. XXXII reunion anual sociedad de biologia celular, Reprimo (RPRM) is involved in epithelial-mesenchymal transition (EMT) in zebrafish embryos, Chile, 2018
13. XLI Reunión Anual de la Sociedad de Bioquímica y Biología Molecular, Gastric cancer derived extracellular vesicles loaded with microRNA-335-5p and their role in tumor development, Chile, 2018
14. XLI Reunión Anual de la Sociedad de Bioquímica y Biología Molecular, Exosomal miRNAs in Gastric Cancer. , Chile, 2018
15. 13th International Gastric Cancer Congress, Reprimo-Like: a potential tumor suppressor and biomarker in gastric cancer, Praga, 2019
16. 50 Digestive Disease Week, mir-597p is associated with tumor invasion and metastasis in gastric cancer, USA, 2019
17. 50 Digestive Disease Week, Reprimo-Like: a potential tumor supressor and biomarker in gastric cancer, USA, 2019
18. AACR annual meeting 2019, The chilean Gastric Cancer Task Force: Final Report, USA, 2019
19. AACR annual meeting 2019, Extracellular signaling linked to PI3K-AKT triggers the formation of vasculogenic mimicry in ovarian cancer, USA, 2019
20. XLII Reunión Anual de la Sociedad de Bioquímica y Biología Molecular, Reduced Angiotensin II Type 2 Receptor expression is associated with gastric
cancer progression and receptor activation reduces gastric cancer cell migration, Chile, 2019
21. AACR, Clinical, biological and translational significance of reprimo-like gene, an uncharacterized member of the reprimo gene family, Virtual annual meeting, 2020
22. AACR, An additive effect of ebv-miR-BART5-5p and hsa-miR18a-5p in the downregulation of CDH1 transcript in Epstein-Barr virus associated gastric cancer, Virtual annual meeting, 2020
23. AACR, Loss of expression of wild-type transcript of CDH1 gene is associated with overexpression of microRNA-20 in diffuse-type of gastric cancer, Virtual annual meeting, 2020
24. LIII Reunion Anual Sociedad Genética de Chile, Identificación de polimorfismos genéticos desde el genoma completo, asociados al patrón de crecimiento de la tasa de mortalidad por infección de Sars-Cov-2, entre diferentes poblaciones, Virtual annual meeting, 2020
25. Cancer Simposium, A clinical platform for cancer research, Virtual annual meeting, 2020
26. Cancer Simposium, Epigenomic landscapes in gastric cancer, Virtual annual meeting, 2020
27. Gastric Cancer Summit - Stanford University, 2020.

OUTREACH
1. II Simposio internacional de bioinformatica integrativa, Organizacion, Chile, 2018
2. IIInternational Symposium on Integrative Bioinformatics, Organizacion, Chile, 2019
3. Laboratorios Itinerantes, Llevar la ciencia a estudiantes de enseñanza básica, Chile, 2019
4. ¿Qué tan cerca está la ciencia de encontrar una cura para el cáncer?, Artículo en prensa, Chile, 2019
5. Encuentro Virtual ACCDiS, Organizacion, Chile, 2020
6. Oncologia Biomedica, Curso para alumons de Doctorado, Chile, 2020
7. Las listas de espera para endoscopia para detectar cáncer gástrico y lesiones precursoras o premalignas, Programa de Radio, Chile, 2020

NETWORK
1. Dr. Luis Carvajal, UC Davis, CA, USA
2. Dr. Wael-ElRifai, U de Miami, FL, USA
3. Dra. Constanza Camargo, NIH, MD, USA
4. Dr. Elmer Fernandez, U. Católica de Cordova, Cordoba, Argentina
5. Dra. Marcis Leja, U. Latvia, Latvia


Premios y Distinciones

  •   AVONNI en Salud

    FORO INNOVACION

    Chile, 2011

    2001 award for the discovery of a potential biomarker for early detection of gastric cancer in plasma.

  •   Premio Academia Medicina

    ACADEMIA CHILENA DE MEDICINA

    Chile, 2014

    Premio en reconocimiento a la trayectoria personal, y a la labor multidisciplinaria que realizada en Chile en Cancer Gastrico. Este premio fue compartido con la Dra. Catterina Ferreccio.

  •   Oncologo del Año

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2017

    Premio a la trayectoria, entregado por la Fundación Chilena para el Desarrollo de la Oncología, en conjunto con Comité Organizador del Congreso Latinoamericano de Oncología, SLAGO 2017, por la labor en el desarrollo de la oncología en Chile, contribuyendo al perfeccionamiento en investigación, docencia y en difusión del conocimiento científico”.


 

Article (95)

EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer
A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
Cohort Profile: The Maule Cohort (MAUCO)
Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer
Effects of preparation on catalytic, magnetic and hybrid micromotors on their functional features and application in gastric cancer biomarker detection
In vitro evaluation and molecular docking of QS-21 and quillaic acid from Quillaja saponaria Molina as gastric cancer agents
The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer
A Novel Role for Helicobacter pylori Gamma-Glutamyltranspeptidase in Regulating Autophagy and Bacterial Internalization in Human Gastric Cells
Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers
Fact or Fiction, It Is Time for a Verdict on Vasculogenic Mimicry?
Gold@Silica Nanoparticles Functionalized with Oligonucleotides: A Prominent Tool for the Detection of the Methylated Reprimo Gene in Gastric Cancer by Dynamic Light Scattering
High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric Cancer Patients: Results of the FORCE1 Study
Identification of c.1531C>T Pathogenic Variant in the CDH1 Gene as a Novel Germline Mutation of Hereditary Diffuse Gastric Cancer
Integrated Analysis of Mouse and Human Gastric Neoplasms Identifies Conserved microRNA Networks in Gastric Carcinogenesis
The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish
[Cardiotoxicity of anticancer therapies. Towards the implementation of cardio-oncology units].
Chilean Gastric Cancer Task Force=> A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients.
Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis?
Expression of RPRM/rprm in the Olfactory System of Embryonic Zebrafish (Danio rerio).
Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer.
Role of microRNAs and Exosomes in and Epstein-Barr Virus Associated Gastric Cancers
The Reprimo Gene Family=> A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties.
Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer.
Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer.
MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
Reprimo tissue-specific expression pattern is conserved between zebrafish and human.
Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer
The conundrum of the Epstein-Barr virus-associated gastric carcinoma in the Americas
Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells
Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival
Escaping Antiangiogenic Therapy=> Strategies Employed by Cancer Cells.
Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage.
Gastric Cancer=> Nanoparticles as Tools to Improve Treatment Efficacy.
Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer
Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line.
Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024.
Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system.
A snapshot of cancer in Chile: Analytical frameworks for developing a cancer policy
Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis.
Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer
Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer.
NonCoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers
Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer
Tobacco Smoke Activates Human Papillomavirus 16 p97 Promoter and Cooperates with High-Risk E6/E7 for Oxidative DNA Damage in Lung Cells
Improved survival of gastric cancer with tumor Epstein-Barr virus positivity: An international pooled analysis
A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients
Bases Epigenéticas del Cáncer Gástrico: Oportunidades para la búsqueda de nuevos biomarcadores
Class-Biased Electoral Participation: The Youth Vote in Chile
Functional Interaction between Human Papillomavirus Type 16 E6 and E7 Oncoproteins and Cigarette Smoke Components in Lung Epithelial Cells
Lynch syndrome: selection of families by microsatellite instability and immunohistochemistry
Merkel cell polyomavirus in non-small cell lung carcinomas from Chile
Síndrome de Lynch: selección de pacientes para el estudio genético mediante análisis de inestabilidad microsatelital e inmunohistoquímica
Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis
High-risk HPV infection after five years in a population-based cohort of Chilean women
Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile
Identification of the distinctive type i/XhoI+ strain of epstein-barr virus in gastric carcinoma in Peru
Factores de riesgo de alteraciones citológicas del cuello uterino en mujeres chilenas: Un estudio de casos y controles
Helicobacter pylori-Induced Loss of the Inhibitor-of-Apoptosis Protein Survivin Is Linked to Gastritis and Death of Human Gastric Cells
Human papillomavirus (HPV) genotypes in cervix uterine cancer patients in a public hospital and private clinic from Santiago, Chile
Overexpression of p73 as a Tissue Marker for High-Risk Gastritis
Recent patents of DNA methylation biomarkers in gastrointestinal oncology
Risk factors associated with abnormal cervical cytology among Chilean women: A case control study
Risk factors associated with abnormal cervical cytology among Chilean women: A case control study Factores de riesgo de alteraciones citológicas del cuello uterino en mujeres Chilenas: Un estudio de casos y controles
Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples
DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA 1 promoter region in early-onset gastric carcinogenesis
DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis
In Silico analysis of Gastric carcinoma Serial Analysis of Gene Expression libraries reveals different profiles associated with ethnicity
Mismatch repair expression in testicular cancer predicts recurrence and survival
Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors
Reprimo as a Potential Biomarker for Early Detection in Gastric Cancer
Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer
Analytical detection of immunoglobulin heavy chain gene rearrangements in gastric lymphoid infiltrates by peak area analysis of the melting curve in the LightCycler System
E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance
Epstein-Barr virus-associated primary lymphoepitheliomalike carcinoma of the esophagus
Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma
Gene expression profiles for therapeutic decisions in breast cancer
Gene expression profiles for therapeutic decisions in breast cancer Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama
Hierarchical clustering analysis to detect associations between clinical and pathological features of gastric tumors and hypermethylation of suppressor genes
High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
High frequency of p16 promoter methylation in non-small cell lung carcinomas from Chile
Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile
Nasal natural killer/T-cell lymphoma and its association with type i"/Xhol loss strain Epstein-Barr virus in Chile"
Association of a distinctive strain of Epstein-Barr virus with gastric cancer
Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile
Pathogenic role of PTEN tumor suppressor gene in ovarian cancer associated to endometriosis
Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus
Histology-specific gender, age and tumor-location distributions of Epstein-Barr virus-associated gastric carcinoma in Japan
Prognostic significance of Epstein-Barr virus involvement in gastric carcinoma in Japan
Epstein-Barr virus in gastric carcinoma is associated with location in the cardia and with a diffuse histology: A study in one area of Chile
Gastric permeability is not increased in children colonized by CagA-positive strains of Helicobacter pylori
Helicobacter pylori: análisis de cagA y genotipificación de vacA en Chile. Detección de una cepa s2/m1
Helicobacter pylori: cagA status and vacA genotyping in Chile. Detection of a s2/m1 strain
Helicobacter pylori: caga status and vaca genotyping in Chile. Detection of a s2/m1 strain [Helicobacter pylori: Análisis de caga y genotipificación de vaca en Chile. Detección de una cepa s2/m1]
Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer
Improved survival of gastric cancer with tumor Epstein-Barr virus positivity: An international pooled analysis.

Abstract (12)

Combined use of methylated reprimo cell-free DNA and pepsinogens for noninvasive detection of early gastric cancer
Could methylated reprimo cell-free DNA serve as a novel tumor marker to assess response in locally advanced gastric cancer treated with preoperative chemotherapy?
Identification of Emerging Micro RNA markers for Heart Failure Development Using a Bioinformatic Approach
Identification of novel upregulated microRNAs in the pathogenesis of gastric cancer by the use of open access databases and bioinformatics tools
HSP90 expression and antitumoral activity of geldanamycin and its analog 17-AAG in gallbladder cancer.
SCREENING AND TRIAGE TEST FOR EARLY DETECTION OF GASTRIC CANCER (STEAD-GC)
Screening and Triage Test for Early Detection of Gastric Cancer (STEAD-GC): A noninvasive trial for early detection of gastric cancer
A Multiple Testing Approach for Histological and Molecular Markers for Early Gastric Cancer
Inactivation of cell cycle regulatory genes in ovarian cancers
A new epithelial mapping system use cytology prep to detect gallbladder adenocarcinoma on the operative room
CpG island methylation profile in gastric carcinoma
Detection of oligoclonal immunoglobulins heavy chain gene rearrangement (IgH) by melting curve analysis in gastric lymphoid infiltrates.

EditorialMaterial (1)

Early Diagnosis of Hepatocellular Carcinoma by MicroRNAs: Shining a Light from the Genome's "Dark Matter"

Errata (1)

Author Correction: The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish (Scientific Reports, (2019), 9, 1, (7131), 10.1038/s41598-019-43436-8)

Proyecto (17)

The upregulation of long-noncoding RNA, a novel opportunity to address the complexities of the pathogenesis of gastric cancer
SCREENING OF GASTRIC CANCER VIA BREATH VOLATILE ORGANIC COMPUNDS BY HYBRID SENSING APROACH
EPIDEMIOLOGY AND RISK STRATIFICATION OF GASTRIC CANCER PRECURSOR LESIONS
ROLE OF MICRORNAS IN THE PATHOGENESIS OF GASTRIC CARCINOMA AND DEVELOPMENT OF NON-INVASIVE STRATEGIES FOR EARLY DETECTION
ADVANCED CENTER FOR CHRONIC DISEASES (ACCDiS)
PLATAFORMA TRANSVERSAL DE PIROSECUENCIACIÓN PARA EL ESTUDIO DE ALTERACIONES EPIGENÉTICAS Y POLIMORFISMOS
ROLE OF HPV-16 E6 AND E7 ONCOPROTEINS IN TOBACCO-SMOKE ASSOCIATED CARCINOGENESIS=> INTERACTION BETWEEN CIGARETTE SMOKE COMPONENTS (CSC) AND HPV16 E6/E7 ONCOPROTEINS IN ORAL AND BRONCHIAL EPITHELIAL CELLS AND CLINICAL SPECIMENS.
ROLE OF REPRIMO, A P53-DEPENDENT G2 ARREST MEDIATOR CANDIDATE, IN THE PATHOGENESIS OF HUMAN GASTRIC CARCINOMA
TEST DE TAMIZAJE PARA LA DETECCIÓN PRECOZ DE CÁNCER GÁSTRICO
EPIGENETIC BASES OF GASTRIC CARCINOMA PATHOGENESIS AND STRATEGIES FOR EARLY DETECTION
EPIGENETIC STATUS OF TUMOR SUPRESSOR GENES OF NON SMALL CELL LUNG CANCER (NSCLC) AND CORRELATION WITH MICRORNAS
EVALUATION AND CONTROL OF NEGLECTED MUCOSA ENTERIC INFECTIONS IN CHILDHOOD (CONTENT)
EVOLUCIÓN DE LA INFECCIÓN GENITAL POR VIRUS PAPILLOMA HUMANO (VPH) EN UNA COHORTE DE MUJERES CHILENAS ESTUDIADAS EL AÑO 2000
MARCADORES DE DETECCIÓN PRECOZ DE CÁNCER GÁSTRICO
PATRON DE METILACION DE GENES SUPRESORES DE TUMORES EN LA PATOGENESIS DEL CANCER GASTRICO DIFUSO
BUSQUEDA DE GENES PARTICIPANTES EN LA GENESIS Y EL DESARROLLO DE CANCER DE MAMA HEREDITARIO.
PATRON DE METILACIÓN DE GENES SUPRESORES DE TUMORES EN LA PATOGÉNESIS DEL CANCER GÁSTRICO DIFUSO

PuntoDeVista (1)

Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama

Review (3)

The Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas-Another Model of Disrupted Human-Pathogen Co-Evolution
Epigenetics in the pathogenesis and early detection of gastric cancer
Teneurin protein family: An emerging role in human tumorigenesis and drug resistance
106
ALEJANDRO CORVALAN

Associate Professor

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

17
Francisco Aguayo

Profesor Asociado

Departamento de Oncología Básico Clínica

Universidad de Chile

Santiago, Chile

8
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

7
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
María Maturana

Bioquimico

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

4
Leda Guzman

Profesor Adjunto

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

3
Ignacio Wichmann

Assitant Professor

Obstetrics

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
NATALIA LANDEROS

Postdoctoral Research Assistant

Hematología y Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
jose valbuena

Associate Professor

Anatomic Pathology

PONTIFICIA UNIVERSIDAD CATOLICA. FACULTAD DE MEDICINA/ESCUELA DE MEDICINA/ DEPARTAMENTO DE ANATOMÍA PATOLÓGICA

santiago, Chile

2
María Solís

Profesor Asistente

Instituto de Ciencias de la Salud

Universidad de O´Higgins

Rancagua, Chile

2
María Marchant

Profesor Postdoctoral

Química

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

2
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Yolanda Vargas

Profesor Asociado

Producción Vegetal

UNIVERSIDAD DE CONCEPCIÓN

Chillán, Chile

2
Marcelo Garrido

Director

CENTRO DEL CÁNCER, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Ignacio Retamal

Docente

Universidad de Los Andes

Santiago, Chile

2
Jaime Madariaga

ASSOCIATE PROFESSOR

MEDICAL SPECIALTIES

UNIVERSITY OF CONCEPCION

CONCEPCION, Chile

2
Bárbara Parra

Profesional de Laboratorio

BIOMEDICO Y NACIONAL DE REFERENCIA

INSTITUTO DE SALUD PUBLICA

Santiago, Chile

2
Wilda Olivares

Bioquímico-Asistente en investigación y Coordinadora de Proyectos de Investigación.

hematologia oncologia

Pontificia Universidad Católica de Chile

santiago, Chile

2
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

1
FERNANDO CROVARI

Jefe Departamento

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Cesar Sanchez

Profesor asistente

Hematologia-oncologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

santiago, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Erica Koch

Oncólogo Médico

Red de Salud UC Christus

Santiago, Chile

1
Jenny Ruedlinger

INVESTIGADOR POSTDOCTORAL EN PROYECTO MAUCO

SALUD PÚBLICA

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Paulina Orellana

Coordinadora traslacional

Universidad de Chile

Santiago, Chile

1
Miguel Cordova

Estudiando de Doctorado

Departamento de Posgrado

Universidad de Chile

Santiago, Chile

1
Vanessa Van De Wyngard

Investigadora

Escuela de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Daniela Báez

Investigador

Departamento de Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

1
Maria Cordero

Profesora asistente

Departamento de Física

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Francisco Acevedo

Medico Oncologo

Hemato Oncologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Aurora Molinari

Profesor Titular

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

VALPARAISO, Chile

1
Pablo Guzmán

Pathologist

Hospital Regional Dr. Hernán Henríquez Araven

Temuco, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
María Tarnok

Profesor Agregado

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Paula Díaz

-

-

-, Chile

1
Diego Carrillo

Asistente de investigación

Virologia

Universidad de Chile

Santiago, Chile

1
Juan Opazo

Profesor Titular

Instituto de Ciencias Ambientales y Evolutivas

Universidad Austral de Chile

Valdivia, Chile

1
German Reig

Investigador Principal

Centro integrativo de Biología y Química Aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

1
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paola Viviani

Profesor Asistente, categoría Ordinaria

Salud Pública

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
CLAUDIA BAMBS

PROFESORA ASOCIADA

SALUD PÚBLICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Laura Huidobro

Académico

Ciencias Preclínicas

Universidad Católica del Maule

Talca, Chile

1
Constanza Camargo

Investigador

Division of Cancer Epidemiology and Genetics

National Cancer Institute, USA

Rockville, Estados Unidos

1
Natalia Hassan

Coordinadora

Universidad Tecnológica Metropolitana

Santiago, Chile

1
Hugo Verdejo

Profesor Asistente

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
MARIA DURAN

Estudiante

Universidad Mcgill

Montreal, Canada

1
Pablo Letelier

Docente Planta Permanente (Instructor)

UNIVERSIDAD CATOLICA DE TEMUCO

temuco, Chile

1
Hery Urra

Postdoctorado

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Javier Morales

Profesor Asociado

Departamento de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago, Chile

1
Jaime Lopez

Asistente de Investigación

Anatomía Patologica

Universidad de La Frontera

Temuco, Chile

1
SERGIO BAEZ

SUBDIRECTOR MEDICO

CIRUGIA

HOSPITAL DR. SOTERO DEL RIO

SANTIAGO, Chile

1
Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Temuco, Chile

1
Kurt Buchegger

Investigador Postdoctoral

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

1
Ximena Aguilera

Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy

Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)

Universidad del Desarrollo

Santiago, Chile

1
paula margozzini

Académico investigador y profesor Asistente

Salud Pública

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gabriel Bastias

Profesor Asociado

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Enrique Castellón

Profesor Titular. Director

Oncología Básico-Clínica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Juan Araya

Pathologist

Anatomía Patológica

Hospital Dr. Hernan Henríquez Aravena

Temuco, Chile

1
Priscilla Brebi

Profesor Asociado

Departamento de Anatomía Patológica.

Universidad de La Frontera

Temuco, Chile

1
Carmen Ili

Investigador y Docente

Scientific and technological Bioresource Nucleus (BIOREN)

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Alejandro Maass

Director

Center for Mathematical Modeling

Universidad de Chile

Santiago, Chile

1
Carolina Alvarez

Profesor Asociado Planta Especial Docente

PONTIFICIA UNIVERSIDAD CATÓLICA CHILE

Santiago, Chile

1
Claudia Gonzalez

Associate Professor and Resarcher

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

1
SOLEDAD BOLLO

PROFESOR TITULAR

QUIMICA FARMACOLÓGICA Y TOXICOLÓGICA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jonas Chnaiderman

Profesor Asociado

Instituto de Ciencias Biomédicas

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Franz Villarroel

Jefe Laboratorio - PI

Unidades de Diagnóstico

Fundación Arturo López Pérez

Santiago, Chile

1
Alejandro Corvalan

Assistant Professor

Industrial Engineering

Universidad de Chile

Santiago, Chile

1
Aldo Gaggero

Académico. Profesor Asociado.

Virología

ICBM. FACULTAD DE MEDICINA. UNIVERSIDAD DE CHILE.

Santiago, Chile

1
Alvaro Muñoz

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Giuliano Bernal

Profesor Titular

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

1
Claudia Foerster

Assistant Professor

Institute of Agri-food, Animal and Environmental Sciences

Universidad de O'Higgins

San Fernando, Chile

1
Johanna Acevedo

Profesor asociado investigador

Instituto de Ciencias e Innovación en Medicina (ICIM)

Universidad del Desarrollo

Santiago, Chile

1
Denisse Bravo

Associate Professor

Pathology and Oral Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pilar Cárdenas

Asistente de investigación Fisiología y Bioquímica renal

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

1
Luigi Devoto

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Waldo Acevedo

Profesor Asociado

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile