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Ricardo Amado Armisen Yañez

Associate Professor

Universidad del Desarrollo

Santiago, Chile

Líneas de Investigación


Cancer functional genomics; applied genomics; bioinformatics; RNA biology

Educación

  •  Biomedical Sciences, UNIVERSIDAD DE CHILE. Chile, 2002
  •  Medical Surgeon, UNIVERSIDAD DE CHILE. Chile, 1996

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2006 - 2015

  •   Adjourn Professor Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2015 - A la fecha

  •   Associate Professor Full Time

    Universidad del Desarrollo

    Medicina

    Santiago, Chile

    2019 - A la fecha

  •   Head of Research Full Time

    LABORATORIO PFIZER DE CHILE S.A.

    CORFO Center of Excellence in Precision Medicine Pfizer

    Santiago, Chile

    2015 - 2019

Experiencia Profesional

  •   Associate Professor Full Time

    Universida del Desarrollo

    Santiago, Chile

    2020 - A la fecha

Formación de Capital Humano


Postdoctoral

1. Solange Rivas (2020-2023). "Uncovering novel driver mutations in non-small cell lung cancer from Chile, Brazil and Perú patients". Universidad del Desarrollo.

2.. Cesar Echeverria (2016) . "Lipopolysaccharide induces epithelial- mesenchymal transition of the bladder urothelium”. Universidad de Chile.

Graduate

1. Fernanda Morales (2020). Doctoral Program in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Thesis title: "Role of ADAR1 in the progression of breast cancer through the regulation of the Wnt / ?-catenin signaling pathway". Thesis Director. Finished.

2. Pamela Rojas from Santiago (2020). PhD Program in Cellular and Molecular Biology, Pontificia Universidad Católica de Chile. Thesis title: "Role of ADAR1-induced changes of long non-coding RNAs in the breast cancer cell line MDA-MB-436". Thesis Director. Finished.

3. Valentina Garate (2018). Master of Science Program, Faculty of Sciences, University of Chile. Thesis title: "Validation and evaluation of algorithms for the detection of INDELS in the MICA gene in Gastric Cancer". Thesis Director. Finished.

4. Eduardo Sagredo (2018). Doctoral Program in Biomedical Sciences, Faculty of Medicine, University of Chile. Thesis title: "Role of the ADAR1 enzyme in the response to DNA damage and cell cycle checkpoints in mammary adenocarcinoma". Thesis Director. Finished.

5. Jalaj Jain (2017). Doctorate Program in Applied Sciences, Universidad de Talca. Thesis title: “Studies on plasma focus devices and characterization of pulsed neutron and x-ray emission: Applied to cancer cells. Co-director of Thesis. Finished.

6. Marcela Morales (2016). Magister Program in Immunology, Faculty of Medicine, University of Chile. Thesis title: "Determination of genetic variations in the promoter of the ligand ULBP4 / RAET1E, which allow explaining its expression after stimulation by Helicobacter pylori, in gastric adenocarcinoma". Co-director. Finished.

7. Claudio Capelli (2016). Doctoral Program in Biomedical Sciences, Faculty of Medicine, University of Chile. Thesis title: "Maintenance of epigenetic information during mitosis by the co-repressor Ski". Co-director of Thesis. Finished.

8. Alfredo Sagredo Campos (2015). Doctoral Program in Biomedical Sciences, Faculty of Medicine, University of Chile. Thesis title: "The TRPM4 channel promotes cell proliferation and migration through the negative regulation of GSK-3? kinase and consequent increase in the activity of the ?-catenin oncogene". Thesis Director. Finished.

9. Pablo Báez Benavidez (2013). Master's Program in Medical and Biological Sciences, Genetics mention, Faculty of Medicine, University of Chile. Thesis title: "Role of the TRPM4 ion channel in the development of prostate cancer in a transgenic murine model". Thesis Director. Finished.

Undergraduate

1. Valentina Garate (2016). School of Biotechnology, Faculty of Sciences, University of Chile. Professional thesis to qualify for the title of Engineer in Molecular Biotechnology. Thesis title: Analysis of genetic polymorphisms of NKG2D ligands in Chilean patients with gastric cancer. Thesis Director. Finished.

2. Bárbara Avello (2014). School of Medical Technology, Faculty of Medicine, University of Chile. Professional thesis to qualify for the title of Medical Technologist with a mention in Clinical Bioanalysis, Hematology and Blood Bank. Thesis title: "Generation of a protocol to evaluate the clinical relevance of somatic and germline mutations detected by high-depth directed sequencing in 25 patients with breast cancer". Thesis Director. Finished.

3. Carolina Luco (2013). School of Medical Technology, Faculty of Medicine, University of Chile. Professional thesis to qualify for the title of Medical Technologist with a mention in Clinical Bioanalysis, Hematology and Blood Bank. Thesis title: "Determination of the proliferative change in the PC-3 cell line and its effect on the cell cycle according to the differential activity of the TRPM4 channel". Thesis Director. Finished.


Difusión y Transferencia


CONFERENCES and SEMINARS

1. Conference "Precision Medicine and its role in the therapeutic future of patients in Chile"
PLACE: 2020 Pharmaceutical Week of the Santiago Regional College of Pharmaceutical and Biochemical Chemists of Chile.
DATE: December 2, 2020

2. Conference "Precision Medicine in Lung Cancer"
PLACE: Oncosummit Chile 2020
DATE: November 19, 2020

3. Conference "Access to existing data in research perspective - 2 points of view / case studies: EU and LAC."
PLACE: EULAC-PerMed Virtual Workshop on Ethical, Legal and Social Aspects (ELSA) in Personalized Medicine
DATE: November 18, 2020

4. Conference "Molecular characterization of actionable somatic mutations in Chilean patients with NSCLC"
PLACE: Fourth Latin American Symposium on Thoracic Oncology (SILOT IV), Chile.
DATE: November 5, 6 and 13, 2020

5. Conference "Cancer functional genomics"
VENUE: ACCDIS Cancer Symposium, Santiago, Chile.
DATE: November 3, 2020.

6. Conference “Research made in Chile, what do we have to show? NGS Project "
PLACE: Fourth Latin American Symposium on Thoracic Oncology (SILOT IV), Chile.
DATE: November 5, 6 and 13, 2020

7. Conference "Challenges in Implementing Genomic Medicine in Latin America"
VENUE: 5th G2MC International VIRTUAL Conference Genomic Medicine Implementation in Low Resources Settings
DATE: May 6-8, 2020.

8. Conference "Personalized Medicine Situation in Latin America and the Caribbean: Chile"
PLACE: BUILDING BRIDGES IN PERSONALIZED MEDICINE BETWEEN LATIN AMERICA-CARIBBEAN AND EUROPE, Montevideo, Uruguay.
DATE: December 11-12, 2019.

9. Conference "Edition A> I of RNA in the progression of breast cancer"
PLACE: Doctoral Program in Molecular Biosciences, Andres Bello University, Santiago, Chile.
DATE: December 2, 2019.

10. Conference "Mutational tumor burden and biomarkers of resistance in Lung Cancer"
PLACE: IV Chilean Congress of Medical Oncology, Hotel Santa Cruz Plaza, Santa Cruz, Chile.
DATE: August 21-23, 2019.

11. Seminar "RNA Edition in the progression of breast cancer"
PLACE: Institute of Sciences and Innovation in Medicine, Faculty of German Clinical Medicine, Universidad del Desarrollo, Santiago, Chile.
DATE: July 31, 2019.

12. Conference “Understanding ADAR’s role in shaping the (cancer) transcriptome”.
VENUE: Pfizer Omics Workshop 2018, Target Sciences & Technologies, Cambridge, USA.
DATE: May 18th & 19th 2019.

13. Seminar "Genomics of Lung Cancer in Latin America".
PLACE: Seminars Department of Pathology, Clínica Alemana de Santiago, Chile.
DATE: September 25, 2018.

14. Conference "Genomics of Lung Cancer".
PLACE: Conference of the Respiratory Center and Thoracic Surgery, Las Condes Clinic, Santiago, Chile.
DATE: August 3, 2018.

15. Conference “A-to-I UTR editing by ADAR1 in breast cancer progression”.
VENUE: Pfizer Omics Workshop 2018, Target Sciences & Technologies, Cambridge, USA.
DATE: May 14th & 15th 2018.

16. Conference "Personalized medicine in breast cancer: The role of next generation sequencing".
PLACE: XI Santiago International Breast Cancer Symposium, Clínica Las Condes, Santiago, Chile.
DATE: April 16-18, 2018.

17. Conference "Collaboration in cancer research: External vision".
PLACE: 1st UC Oncology Research Conference 2017, Faculty of Medicine, Pontificia Universidad Catolica. Santiago, Chile.
DATE: December 15 and 16, 2017.

18. Conference “Precision Medicine in Latin America: CEMP and lung cancer genomics”.
PLACE: Workshop on Bioinformatics and Biostatistics in Genomics. Faculty of Mathematics, Astronomy, Physics and Computing. University City. National University of Cordoba. Cordoba Argentina.
DATE: December 4, 5 and 6, 2017.

19. Conference “Next generation sequencing, CEMP data”.
PLACE: Third Latin American Symposium on Thoracic Oncology (SILOT III), Iquique, Chile.
DATE: November 23 to 25, 2017.

20. Talk "Role of RNA editing in the progression of breast cancer".
PLACE: Cycle of talks "Genetics, Genomics and Evolution". Human Genetics Program, ICBM, Faculty of Medicine, U. de Chile, Santiago, Chile.
DATE: November 18, 2017.

21. Conversation "Bioinformatics applied to the study of cancer"
PLACE: Directorate of Technology Transfer, University of Talca, Talca, Chile.
DATE: November 17, 2017.

22. Conference “Molecular Epidemiology of Non-Small Cell Lung Cancer in Chile”.
PLACE: 1st Metting “Cell Differentiation, Signaling and Therapy”. Integrative Center for Applied Chemistry and Biology, Bernardo O'Higgins University, Santiago, Chile.
DATE: November 15, 2017.

23. Conference "New technologies in the identification of mutations".
PLACE: 1st International Course on Genetics in Breast and Ovarian Cancer. Controversies and challenges. Las Condes Clinic, Santiago, Chile.
DATE: 12 of October 13, 2017.

24. Conference "Molecular Epidemiology of Non-Small Cell Lung Cancer in Chile".
PLACE: III Chilean Congress of Oncology: Advances in Medical Oncology and Oncological Care, Chilean Society of Medical Oncology. Santa Cruz, Chile.
DATE: August 24-26, 2017.

25. Inaugural Conference "Precision Medicine and Genomics of Lung Cancer in Chile".
PLACE: Inauguration of the Molecular Pathology Laboratory, Christus Muguerza Hospital, Monterrey, Mexico.
DATE: June 22, 2017.

26. Seminar "Precision Medicine and Genomics of Lung Cancer in Chile".
PLACE: University Hospital of the Autonomous University of Nuevo León, Monterrey, Mexico.
DATE: June 21, 2017.

27. Conference “Precision Medicine in Latin America: CEMP and lung cancer genomics”.
VENUE: Pfizer Omics Workshop 2017, Cambridge, USA.
DATE: May 15, 2017.

28. Inaugural Conference "Edition of RNA in progression of breast cancer".
PLACE: Inauguration of the academic year of the Integrative Genomics Doctorate Program, Universidad Mayor, Santiago, Chile.
DATE: March 27, 2017.

29. Conference “New Frontiers of Health: Human development and major diseases”.
PLACE: Congress of the Future 2017. Senate of Chile, Santiago, Chile.
DATE: January 9-14, 2017

30. Conference “Lung cancer genomics in Chile”.
PLACE: International Symposium in Cancer Genomics and Bioinformatics, Faculty of Medicine, University of Chile. Santiago, Chile.
DATE: January 16, 2017.

31. Seminar "RNA edition in the progression of breast cancer".
PLACE: Seminars of the Department of Biology of the Faculty of Sciences of the University of Chile, Santiago, Chile.
DATE: June 2016.

32. Conference “Challenges in research for the development of Biotechnology in Chile, opportunities and national and international context”.
PLACE: Launch of the Health Technology Nucleus, Universidad San Sebastian, Santiago, Chile.
DATE: May 2016.

33. Inaugural Conference "Precision Medicine in Oncology today".
PLACE: Southern Oncology Society Congress, Villarrica, Chile.
DATE: October 2015.

34. Conference “Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA repair”.
PLACE: Center for Genetics and Genomics, Faculty of German Clinical Medicine, Universidad del Desarrollo, Santiago, Chile.
DATE: September 2015.

35. Conference “Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA repair”.
PLACE: Symposium “When Biology Meets Computers: Oncodomains, Microbiomes and Allosteric Networks”. International Society of Computational Biology (ISCB) & XXXVIII Annual Meeting of the Society for Biochemistry and Molecular Biology of Chile, Puerto Varas, Chile.
DATE: September 2015.

36. Conference "Genomics of cancer in Chile".
PLACE: XLVII Annual Meeting of the Chilean Genetics Society, Puerto Varas, Chile.
DATE: November 2014.

37. Conference "New molecular discoveries in Breast Cancer".
PLACE: First Latin American Congress of Molecular Oncology, Santiago, Chile.
DATE: May 2014

38. Conference "Personalized Medicine".
PLACE: 2nd Meeting of Basic Clinical Research. Biomedical Neuroscience Institute. Faculty of Medicine, U. de Chile, Santiago, Chile.
DATE: November 2013.

39. Conference "Incorporation of ultra-deep gene sequencing in the care of cancer patients".
PLACE: Cycle of Conferences in Oncology 2013, Center for Translational Research in Oncology (CITO), Pontificia Universidad Católica de Chile. Santiago, Chile.
DATE: August 2013.

40. Conference "Genome Study and Computer Integration".
PLACE: 1st Chilean Congress of Medical Oncology. Chilean Society of Medical Oncology, Santa Cruz, Chile.
DATE: August 2013.

41. Conference "Molecular diagnosis in the clinical laboratory: Molecular biology and cancer".
PLACE: XVII Chilean Congress of Clinical Chemistry, Extension Center of the Catholic University, Santiago, Chile.
DATE: May 17, 2012.

42. Conference "Personalized therapy, medicine of tomorrow".
PLACE: I Training Course in Oncology, Scientific Academy of Medical Students, Faculty of Medicine, U of Chile. Santiago, Chile.
DATE: May 3-5, 2012.

43. Conference “University of Chile Cancer Network”.
PLACE: Joint Symposium on Current Health Research in the Faculties of Medicine of the University of Sydney and the University of Chile, Facultad de Medicina, U de Chile. Santiago, Chile.
DATE: September 13, 2012.

44. Conference “Capacities and infrastructure needed for Translational Research in Cancer”.
PLACE: Workshop on "European Collaboration in the Development of Translational Research on Cancer in Chile". Institute of Biomedical Sciences, Faculty of Medicine, U. de Chile. Santiago, Chile.
DATE: January 19 and 20, 2011.

45. Conference “Cancer Center of the Faculty of Medicine: A strategy of Translational Medicine ”.
PLACE: Workshop on Cancer Research and Treatment, Institute of Biomedical Sciences / Moores Cancer Center, Faculty of Medicine, U. de Chile. Santiago, Chile.
DATE: November 28 - 30, 2011.

46. Conference “Role of TRPM4 in the development of prostate cancer”.
PLACE: Department of Internal Medicine, Clinical Hospital of the University of Chile, University of Chile. Santiago, Chile.
DATE: November 2010.

47. Lecture "Participation of TRPM4 in the development of prostate cancer".
PLACE: "First Conference on Cancer Research", Institute of Biomedical Sciences, Faculty of Medicine, University of Chile. Santiago, Chile.
DATE: July 16, 2011.

48. Conference "Mechanisms of subcellular localization of CAMKII in neurons".
PLACE: Center for Molecular Studies of the Cell, Faculty of Medicine, University of Chile. Santiago, Chile.
DATE: July 20, 2006.


Premios y Distinciones

  •   Fellowship for PhD studies, Fundación Guillermo Puelma, Chile.

    UNIVERSIDAD DE CHILE

    Chile, 1995

    Fellowship for PhD studies, Fundación Guillermo Puelma, Facultad de Medicina, Universidad de Chile, Chile.

  •   Fellowship for PhD studies, National Council of Science and Technologies, CONICYT.

    CONICYT

    Chile, 1996

    Fellowship for PhD studies, National Council of Science and Technologies, CONICYT, Chile.

  •   Development Travelling Fellowship Award, The Company of Biologist Ltd., Cambridge, United Kingdom.

    The Company of Biologist Ltd.

    Reino Unido, 1998

    Development Travelling Fellowship Award, The Company of Biologist Ltd., Cambridge, United Kingdom.

  •   Travelling Fellowship Award, Fundación de Estudios Biomédicos Avanzados, Chile.

    Fundación de Estudios Biomédicos Avanzados

    Chile, 1999

    Travelling Fellowship Award, Fundación de Estudios Biomédicos Avanzados, Chile.

  •   Howard Hughes Medical Institute Post-doctoral fellowship

    Howard Hughes Medical Institute

    Estados Unidos, 2002

    Howard Hughes Medical Institute Post-doctoral fellowship, USA.

  •   Award 2nd place Best Scientific Work. 9th International Congress of Phlebology, Bolonia, Italy.

    International Congress of Phlebology

    Italia, 2008

    Award 2nd place Best Scientific Work. 9th International Congress of Phlebology, Bolonia, Italy.

  •   Award 2nd place Best Basic Science work. XXVII Congreso Chileno de Nefrología, Coquimbo, Chile.

    XXVII Congreso Chileno de Nefrología

    Chile, 2010

    Award 2nd place Best Basic Science work. XXVII Congreso Chileno de Nefrología, Coquimbo, Chile.

  •   Award 1st place Best Basic Science work. XXVIII Congreso Conjunto de Las Sociedades Chilenas de Nefrología, Hipertensión y Trasplante, Coquimbo, Chile.

    XXVIII Congreso Conjunto de Las Sociedades Chilenas de Nefrología, Hipertensión y Trasplante

    Chile, 2011

    Award 1st place Best Basic Science work. XXVIII Congreso Conjunto de Las Sociedades Chilenas de Nefrología, Hipertensión y Trasplante, Coquimbo, Chile.

  •   Facultad de Medicina Medal Award for Excellence in Research, University of Chile.

    UNIVERSIDAD DE CHILE

    Chile, 2012

    Facultad de Medicina Medal Award for Excellence in Research, University of Chile.

  •   Facultad de Medicina Medal Award for Excellence in Research, University of Chile.

    UNIVERSIDAD DE CHILE

    Chile, 2013

    Facultad de Medicina Medal Award for Excellence in Research, University of Chile.

  •   Best Poster Award. 8th International Conference on the Frontier of Plasma Physics and Technology (FPPT-8). Viña del Mar, Chile.

    8th International Conference on the Frontier of Plasma Physics and Technology (FPPT-8)

    Chile, 2017

    Best Poster Award. 8th International Conference on the Frontier of Plasma Physics and Technology (FPPT-8). Viña del Mar, Chile.

  •   Gustavo Hoecker Award for the best free communication in oral format

    SOCIEDAD DE GENETICA DE CHILE

    Chile, 2018

    Alteration of pericentromeric heterochromatin leads to defective centromere formation, chromosomal segregation errors and aneuploidy. AUTHORS: Pola V, Sagredo EA, Cappelli C, Inostroza V, Armisén R, Marcelain K.

  •   Rene Cortázar Award for the best free communication in panel format

    SOCIEDAD DE GENETICA DE CHILE

    Chile, 2020

    LIII Annual Meeting of the Chilean Genetics Society, 2020, Chile. Low expression of immune-related lncRNA LINC00944 indicates poor outcomes in breast cancer. AUTHORS: Pamela Rojas de Santiago, Alejandro Blanco, Fernanda Morales, Eduardo Sagredo, Katherine Marcelain, Olivier Harismendy, Marcela Sjoberg & Ricardo Armisén. DATE: November 24-27, 2020.


 

Article (40)

Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis
A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response
Ski Is Required for Tri-Methylation of H3K9 in Major Satellite and for Repression of Pericentromeric Genes: Mmp3, Mmp10 and Mmp13, in Mouse Fibroblasts
High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric Cancer Patients: Results of the FORCE1 Study
TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines
ADAR1-mediated RNA-editing of 3 UTRs in breast cancer
Chilean Gastric Cancer Task Force A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ionizing radiation in DLD-1 cells
TRPM4 regulates Akt/GSK3-beta activity and enhances beta-catenin signaling and cell proliferation in prostate cancer cells
Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca2+ and Na+ Ions and Oxidative Stress with the Participation of PKC/NOX2 and PI3K/Akt Pathways
ALS-linked protein disulfide isomerase variants cause motor dysfunction
Characterization of x-rays pulses from a hundred joules plasma focus to study its effects on cancer cells.
Development of plasma needle to be used for biomedical applications
Immune DNA signature of T-cell infiltration in breast tumor exomes
The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release
The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A
Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability
Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway
Endotoxin Induces Fibrosis in Vascular Endothelial Cells through a Mechanism Dependent on Transient Receptor Protein Melastatin 7 Activity
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1 alpha
Chromosomal Instability in Mouse Embryonic Fibroblasts Null for the Transcriptional Co-Repressor Ski
TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis
CK2 functionally interacts with AKT/PKB to promote the beta-catenin-dependent expression of survivin and enhance cell survival
Identification of Ski as a target for Aurora A kinase
Increased Expression of the Transient Receptor Potential Melastatin 7 Channel Is Critically Involved in Lipopolysaccharide-Induced Reactive Oxygen Species-Mediated Neuronal Death
L-type calcium channel ? subunit modulates angiotensin II responses in cardiomyocytes
Phosphorylation of AKT/PKB by CK2 Is Necessary for the AKT-Dependent Up-Regulation of beta-Catenin Transcriptional Activity
Protein Kinase CK2 Promotes Cancer Cell Viability Via Up-Regulation of Cyclooxygenase-2 Expression and Enhanced Prostaglandin E2 Production
Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death
TRPM4 Enhances Cell Proliferation Through Up-Regulation of the beta-Catenin Signaling Pathway
Hydrogen Peroxide Removes TRPM4 Current Desensitization Conferring Increased Vulnerability to Necrotic Cell Death
Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress
Endovenous laser and echo-guided foam ablation in great saphenous vein reflux: one-year follow-up results
Activation of H2O2-induced VSOR CI(-)currents in HTC cells require phospholipase C gamma 1 phosphorylation and Ca2+ mobilisation
Tracking Tagged Molecules in Single Neurons in Intact Zebrafish
Developmental regulation of the expression of sodium currents in Xenopus primary neurons
A mutation in serca underlies motility dysfunction in accordion zebrafish
Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus
Modal gating in neuronal and skeletal muscle ryanodine-sensitive Ca2+ release channels

Abstract (7)

Preliminary assessment of a targeted break-point NGS assay for ALK gene fusion detection in lung adenocarcinoma samples from Chilean patients
Protein disulfide isomerase gene variants are associated with amyotrophic lateral sclerosis
The transcriptional co-repressor Ski localizes in the pericentromeric region of mitotic chromosomes, regulating the expression of targeted genes at the early G1 phase of the cell cycle
The TRPM4 channel regulates the Epithelial-Mesenchymal transition in prostate cancer cells
Vascular endothelial fibrosis induced by endotoxin: characteristics, mechanism and therapeutic perspectives
Protein kinase CK2 enhances colorectal cancer malignancy by upregulating the expression of cyclooxygenase-2 through the canonical Wnt signaling pathway
Protein kinase CK2 regulates beta-catenin association to E-cadherin and hence viability and invasion of colorectal cancer cells

Proyecto (19)

"Uncovering novel driver mutations in non-small cell lung cancer from Chile, Brazil and Perú patients"
ADAR promotes breast cancer progression through the regulation of cell cycle and DNA repair related genes
Center for Excellence in Precision Medicine, Pfizer Chile
Role of Ski/Smad4 complex on the establishment of epigenetic modifications of pericentromeric chromatin required for proper chromosome segregation
Biobanco Facultad de Medicina-HCUCH: Alianza estratégica entre la Facultad de Medicina - Hospital Clínico
BioMed-HPC: Red de biología y medicina computacional de alto rendimiento
Instalación de una plataforma de genómica multipropósito en la Universidad de Chile: Illumina NextSeq 550
Sistema de Almacenamiento y Servicios Informáticos Biomédicos Avanzados (SASIBA Data Center)
Training Chilean Bioinformatics Researchers in the Cancer Genomics field
Incorporación de la secuenciación de última generación en el cuidado de los pacientes con cáncer
Lipopolysaccharide induces epithelial-mesenchymal transition of the bladder urothelium
Plasma Physics, Pulsed Power and Cell Biology for Energy, Life and Environment
Molecular Profiling of Stage II and III Breast Cancer in Latin American Women Receiving Standard of Care Treatment
Protein kinase CK2 promotes colon cancer metastasis by increasing the expression of Endothelin-Converting Enzyme-1 isoform c (ECE-1c)
Red U-Cáncer, una plataforma en línea de investigación básico-clínico de cáncer en Chile
Ski-containing transcriptional co-repressor complexes on mitotic chromosomes repress the expression of selected target genes at early G1
The Transient Receptor Potential Melastatin 4 (TRPM4) channel stabilizes b-catenin and therefore enhances cell proliferation through a calcium-dependent negative regulation of GSK-3b activity
U-CANCER: Red de Medicina Traslacional en Cáncer
Centro de Estudios Moleculares de la Célula

Review (1)

Cell death by necrosis, a regulated way to go
74
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

14
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

13
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

11
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

8
Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

7
César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

7
Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

5
Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

5
Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

5
Julio Tapia

Profesor Asociado

Oncologia Basico Clinica

Universidad de Chile

Santiago, Chile

5
Ignacio Niechi

Profesor Adjunto

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

3
José Moreno

Jefe de Departamento

Ciencias Nucleares

COMISIÓN CHILENA DE ENERGÍA NUCLEAR

Santiago, Chile

3
Alfredo Sagredo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

3
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

3
Patricio Olguín

Assistant Professor

Facultad de Medicina, ICBM, Departamento de Neurociencia

Universidad de Chile

Santiago, Chile

2
Francisco Acevedo

Medico Oncologo

Hemato Oncologia

Pontificia Universidad Católica de Chile

Santiago, Chile

2
María Maturana

Bioquimico

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Miguel Cordova

Estudiando de Doctorado

Departamento de Posgrado

Universidad de Chile

Santiago, Chile

2
Edio Maldonado

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

2
Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Cristina Fernandez

anatomia patologica

anatomia patologica

HOSPITAL CLINICO DE LA UNIVERSIDAD DE CHILE

santiago, Chile

2
Marcelo Garrido

Director

CENTRO DEL CÁNCER, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ignacio Retamal

Docente

Universidad de Los Andes

Santiago, Chile

2
Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Cesar Sanchez

Profesor asistente

Hematologia-oncologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

santiago, Chile

2
FERNANDO CROVARI

Jefe Departamento

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

2
Leopoldo Soto

Head of the Plasma Physics and Nuclear Fusion Laboratory

Thermonuclear Plasma Department

Comisión Chilena de Energia Nuclear

Santiago, Chile

2
Pablo Olivero

Profesor Adjunto

Patologia y Fisiologia

Universidad de Valparaiso

Viña del Mar, Chile

2
Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

2
Solange Rivas

Postdoctoral Research Assistant

Oncología básico-clínico

Universidad de Chile

Santiago, Chile

2
Biswajit Bora

Investigador

Departamento de Ciencias Nucleares

comision chilena de energia nuclear

Santiago, Chile

2
Gonzalo Avaria

Investigador

Ciencias Nucleares

COMISIÓN CHILENA DE ENERGÍA NUCLEAR

Santiago, Chile

2
Claudio Cappelli

Technical Laboratory Manager

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

2
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Gino Nardocci

Investigador

Universidad de Los Andes

Santiago, Chile

1
Rodrigo Ramírez

Consultor

Asesorias CUBO

Santiago, Chile

1
Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Valentina Valenzuela

Investigador adjunto

Universidad de Concepcion

Concepción, Chile

1
Hery Urra

Postdoctorado

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Maria Lisbona

Postdoctorado

Biología

Universidad de Chile

Santiago, Chile

1
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

1
Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pablo Báez

Investigador Postdoctoral

Centro de Informática Médica y Telemedicina

Universidad de Chile

Santiago, Chile

1
Ulises Urzúa

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Manuel Espinoza

Profesor Asociado

Salud Pública

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

1
María Rodríguez

Profesora Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Rodrigo Arancibia

PUCV

Valparaiso, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

1
Erica Koch

Oncólogo Médico

Red de Salud UC Christus

Santiago, Chile

1
Alvaro Becerra

Coordinador Academico

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

1
Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

1
Daniel Henriquez

Director Ciencia Transversal

Fundación Centro MERI

Santiago, Chile

1
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

1
Viviana Pérez

Investigador Postdoctoral

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Jorge Ojeda

Académico investigador

Ciencias Básicas y Morfología

Universidad Católica de la Santisima Concepción

Concepción, Chile

1
Karina Palma

Postdoctorado

Instituto de Neurociencia Biomédica BNI

Universidad de Chile

Santiago, Chile

1
Marcia Manterola

Profesor Asistente

Genetica Humana Block C

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Bettina Müller

Jefe subrogante

Oncología Médica

Instituto Nacional del Cáncer

Santiago, Chile

1
Karen Castillo

Investigadora

Laboratorio de Sensores Moleculares, Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso

Valparaiso, Chile

1
Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
ALEJANDRO CORVALAN

Associate Professor

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Pablo Rozas

Asistente de Investigación

Instituto de Neurociencia Biomédica

Universidad de Chile

Santiago, Chile

1
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Paulina Villar

Tesista doctorado en bioquímica

Bioquímica

Universidad de Chile

Santiago, Chile