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Romina Victoria Sepúlveda Sepúlveda

Profesor Investigador

Universidad Andrés Bello

Santiago, Chile

Mis lineas de investigación estan dedicadas a resolver problemas biológicos con estrategias computacionales. Especificamente en el área de simulación molecular de complejos proteína-proteína y caracterización de membranas prebioticas.

Bioinformática, UNIVERSIDAD ANDRES BELLO. Chile, 2018

FONDECYT Postdoctorado Full Time

UNIVERSIDAD ANDRES BELLO

Ciencias Biologicas

Santiago, Chile

2020 - A la fecha

PostDoc FONDEF ID19I10160 Full Time

UNAB

Santiago, Chile

2020 - 2020
Senior Bioinformatician Full Time

uBiome

Santiago, Chile

2018 - 2019
Tesista doctoral Full Time

Universidad Andres Bello

Santiago, Chile

2013 - 2018


Insights into Early Steps of Decanoic Acid Self-Assemblies under Prebiotic Temperatures Using Molecular Dynamics Simulations Sepulveda, Romina V.; Sbarbaro, Christopher; Opazo, Ma Cecilia; Duarte, Yorley; Gonzalez-Nilo, Fernando; Aguayo, Daniel Article ISI MEMBRANES (2023)
The Emergence of New Catalytic Abilities in an Endoxylanase from Family GH10 by Removing an Intrinsically Disordered Region Gil-Duran, Carlos; Sepulveda, Romina, V; Rojas, Maximiliano; Castro-Fernandez, Victor; Guixe, Victoria; Vaca, Inmaculada; Levican, Gloria; Gonzalez-Nilo, Fernando D.; Ravanal, Maria-Cristina; Chavez, Renato Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
A method for characterizing the thermal stability and antimicrobial binding to Lipopolysaccharides of Gram-negative isogenic mutant strains Navarro, Belen; Alarcon, Mackarenna; Osees, Maricarmen; Gomez-Alvear, Felipe; Sepulveda, Romina, V; Huerta, Jaime; Cecilia Opazo, Maria; Aguayo, Daniel Article ISI METHODSX (2021)
A rationally designed orthogonal synthetase for genetically encoded fluorescent amino acids Steinberg, Ximena; Galpin, Jason; Nasir, Gibran; Sepulveda, Romina, V; Ladron de Guevara, Ernesto; Gonzalez-Nilo, Fernando; Islas, Leon D.; Ahern, Christopher A.; Brauchi, Sebastian E. Article ISI HELIYON (2020)
Novel TRPV1 Channel Agonists With Faster and More Potent Analgesic Properties Than Capsaicin Duarte, Yorley; Caceres, Javier; Sepulveda, Romina V.; Arriagada, Diego; Olivares, Pedro; Diaz-Franulic, Ignacio; Stehberg, Jimmy; Gonzalez-Nilo, Fernando Article ISI FRONTIERS IN PHARMACOLOGY (2020)
The molecular nature of the 17 beta-Estradiol binding site in the voltage- and Ca2+-activated K+ (BK) channel beta 1 subunit Granados S.T.; Castillo K.; Bravo-Moraga F.; SepÃºlveda R.V.; Carrasquel-Ursulaez W.; Rojas M.; Carmona E.; Lorenzo-Ceballos Y.; GonzÃ¡lez-Nilo F.; GonzÃ¡lez C.; Latorre R.; Torres Y.P. Article ISI SCOPUS Scientific Reports (2019)
Heterologous expression, purification and characterization of three novel esterases secreted by the lignocellulolytic fungus Penicillium purpurogenum when grown on sugar beet pulp Oleas, G; Callegari, E.; Sepúlveda R.V., and Eyzaguirre J. Article CARBOHYDRATE RESEARCH (2017)
Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase Rubat, Sebastián; Varas, Ignacio; Sepúlveda, Romina; Almonacid, Daniel; González-Nilo, Fernando; Agosin, Eduardo Article ISI FEMS YEAST RESEARCH (2017)
MOLECULAR DETERMINANTS OF BK CHANNEL FUNCTIONAL DIVERSITY AND FUNCTIONING Latorre, Ramon; Castillo, Karen; Carrasquel-Ursulaez, Willy; Sepulveda, Romina V.; Gonzalez-Nilo, Fernando; González, Carlos; Alvarez, Osvaldo Article ISI SCOPUS PHYSIOLOGICAL REVIEWS (2017)
Structural determinants of 5 ',6 '-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel Berna-Erro, Alejandro; Izquierdo-Serra, Mercè; Sepúlveda, Romina V.; Rubio-Moscardo, Fanny; Doñate-Macián, Pau; Serra, Selma A.; Carrillo-Garcia, Julia; Perálvarez-Marín, Alex; González-Nilo, Fernando; Fernández-Fernández, José M.; Valverde, Miguel A. Article ISI SCOPUS Scientific Reports (2017)
?1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel Castillo J.P.; Sánchez-Rodríguez J.E.; Hyde H.C.; Zaelzer C.A.; Aguayo, D; Sepúlveda R.V.; Luk L.Y.P.; Kent S.B.H.; Gonzalez-Nilo, F. D.; Bezanilla, F; Latorre R. Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2016)
Structure-Driven Pharmacology of Transient Receptor Potential Channel Vanilloid 1 Diaz-Franulic, I.; Caceres-Molina, J.; Sepulveda, R. V.; Gonzalez-Nilo, F.; Latorre, R. Article ISI SCOPUS Molecular Pharmacology (2016)
Effects of the Accessory Subunit gamma 1 on the External Architecture of BK Channel Carrasquel-Ursulaez, Willy; Castillo, Juan P.; Lorenzo, Yenisleidy; Sepulveda, Romina; Aguayo, Daniel; Bezanilla, Francisco; Gonzalez-Nilo, Fernando D.; Latorre, Ramon Article ISI BIOPHYSICAL JOURNAL (2015)
Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel Carrasquel-Ursulaez, W; Contreras G.F.; Sepúlveda R.V.; Aguayo, D; Gonzalez-Nilo, F; González C; Latorre R. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2015)
Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels Garcia-Elias, A; Berna-Erro, A; Rubio-Moscardo, F; Pardo-Pastor, C; Mrkonjic, S; Sepulveda, RV; Vicente R.; Gonzalez-Nilo, F; Valverde, MA Article ISI SCOPUS Structure (2015)
Molecular Determinants of Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P-2) Binding to Transient Receptor Potential V1 (TRPV1) Channels Poblete, H.; Oyarzun, I; Olivero P.; Comer, J.; Zúñiga M; Sepúlveda R.V.; Baez-Nieto, D; Leon, C.G; Gonzalez-Nilo, F; Latorre R. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels Diaz-Franulic, I; Sepulveda, RV; Navarro-Quezada, N; Gonzalez-Nilo, F; Naranjo, D Article ISI SCOPUS Journal of General Physiology (2015)
Substitutions at F380 in S6 by Small Hydrophobic Amino Acids Makes the Opening Transition in BK Channels Rate Limiting Carrasquel-Ursulaez, Willy; Contreras, Gustavo F.; Sepulveda, Romina; Aguayo, Daniel; Gonzalez-Nilo, Fernando D.; Gonzalez, Carlos; Latorre, Ramon Article ISI BIOPHYSICAL JOURNAL (2014)
Turning a Small into Large Conductance K-Channel - How Far Can We Go? Diaz-Franulic, Ignacio; Navarro, Nieves; Gonzalez-Nilo, Fernando; Sepulveda, Romina V.; Naranjo, David Article ISI BIOPHYSICAL JOURNAL (2014)
K+ Conduction and Mg2+ Blockade in a Shaker Kv-Channel Single Point Mutant with an Unusually High Conductance Moscoso, C.; Vergara-Jaque, A; Marquez-Miranda, V; Sepúlveda R.V.; Valencia I.; Diaz-Franulic, I; Gonzalez-Nilo, F; Naranjo, D Article ISI SCOPUS Biophysical Journal (2012)


Thermal Diffusion Pathways of TRPV1 Gonzalez-Nilo, FD; Diaz-Franulic, I; Sepulveda, RV; Gomez-Becerra, FA; Mino-Galazi, G; Latorre, R Abstract ISI BIOPHYSICAL JOURNAL (2018)
17 beta-Estradiol Binds and Modulates BK Channel through its beta 1 Auxiliary Subunit Granados, ST; Bravo, F; Sepulveda, R; Gonzalez-Nilo, D; González, J; Latorre, R; Torres, Y Abstract ISI (2016)
Structural Characterization of Ligand-Specific Interactions in TRPV1 Channel: Gating Mechanism by Capsaicin and Capsazepine Gonzalez-Nilo, FD; Caceres-Molina, J; Bravo-Moraga, F; Sepulveda, R; Diaz-Franulic, I Abstract ISI (2016)
Rational discovery of new capsaicin analogues as TRPV1 activators Caceres J.; sepulveda, r; Navas C.; Latorre R.; Gonzalez-Nilo, F Abstract ISI BMC BIOINFORMATICS (2015)