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Romina Victoria Sepúlveda Sepúlveda

Profesor Investigador

Universidad Andrés Bello

Santiago, Chile

Mis lineas de investigación estan dedicadas a resolver problemas biológicos con estrategias computacionales. Especificamente en el área de simulación molecular de complejos proteína-proteína y caracterización de membranas prebioticas.

Bioinformática, UNIVERSIDAD ANDRES BELLO. Chile, 2018

FONDECYT Postdoctorado Full Time

UNIVERSIDAD ANDRES BELLO

Ciencias Biologicas

Santiago, Chile

2020 - A la fecha

PostDoc FONDEF ID19I10160 Full Time

UNAB

Santiago, Chile

2020 - 2020
Senior Bioinformatician Full Time

uBiome

Santiago, Chile

2018 - 2019
Tesista doctoral Full Time

Universidad Andres Bello

Santiago, Chile

2013 - 2018


The Emergence of New Catalytic Abilities in an Endoxylanase from Family GH10 by Removing an Intrinsically Disordered Region Gil-Duran, Carlos; Sepulveda, Romina, V; Rojas, Maximiliano; Castro-Fernandez, Victor; Guixe, Victoria; Vaca, Inmaculada; Levican, Gloria; Gonzalez-Nilo, Fernando D.; Ravanal, Maria-Cristina; Chavez, Renato Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
A method for characterizing the thermal stability and antimicrobial binding to Lipopolysaccharides of Gram-negative isogenic mutant strains Navarro, Belen; Alarcon, Mackarenna; Osees, Maricarmen; Gomez-Alvear, Felipe; Sepulveda, Romina, V; Huerta, Jaime; Cecilia Opazo, Maria; Aguayo, Daniel Article ISI METHODSX (2021)
A rationally designed orthogonal synthetase for genetically encoded fluorescent amino acids Steinberg, Ximena; Galpin, Jason; Nasir, Gibran; Sepulveda, Romina, V; Ladron de Guevara, Ernesto; Gonzalez-Nilo, Fernando; Islas, Leon D.; Ahern, Christopher A.; Brauchi, Sebastian E. Article ISI HELIYON (2020)
Novel TRPV1 Channel Agonists With Faster and More Potent Analgesic Properties Than Capsaicin Duarte, Yorley; Caceres, Javier; Sepulveda, Romina V.; Arriagada, Diego; Olivares, Pedro; Diaz-Franulic, Ignacio; Stehberg, Jimmy; Gonzalez-Nilo, Fernando Article ISI FRONTIERS IN PHARMACOLOGY (2020)
The molecular nature of the 17 beta-Estradiol binding site in the voltage- and Ca2+-activated K+ (BK) channel beta 1 subunit Granados S.T.; Castillo K.; Bravo-Moraga F.; SepÃºlveda R.V.; Carrasquel-Ursulaez W.; Rojas M.; Carmona E.; Lorenzo-Ceballos Y.; GonzÃ¡lez-Nilo F.; GonzÃ¡lez C.; Latorre R.; Torres Y.P. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase Rubat, Sebastián; Varas, Ignacio; Sepúlveda, Romina; Almonacid, Daniel; González-Nilo, Fernando; Agosin, Eduardo Article ISI FEMS YEAST RESEARCH (2017)
MOLECULAR DETERMINANTS OF BK CHANNEL FUNCTIONAL DIVERSITY AND FUNCTIONING Latorre, Ramon; Castillo, Karen; Carrasquel-Ursulaez, Willy; Sepulveda, Romina V.; Gonzalez-Nilo, Fernando; González, Carlos; Alvarez, Osvaldo Article ISI SCOPUS PHYSIOLOGICAL REVIEWS (2017)
Structural determinants of 5 ',6 '-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel Berna-Erro, Alejandro; Izquierdo-Serra, Mercè; Sepúlveda, Romina V.; Rubio-Moscardo, Fanny; Doñate-Macián, Pau; Serra, Selma A.; Carrillo-Garcia, Julia; Perálvarez-Marín, Alex; González-Nilo, Fernando; Fernández-Fernández, José M.; Valverde, Miguel A. Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
?1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel Castillo J.P.; Sánchez-Rodríguez J.E.; Hyde H.C.; Zaelzer C.A.; Aguayo, D; Sepúlveda R.V.; Luk L.Y.P.; Kent S.B.H.; Gonzalez-Nilo, F. D.; Bezanilla, F; Latorre R. Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2016)
Structure-Driven Pharmacology of Transient Receptor Potential Channel Vanilloid 1 Diaz-Franulic, I.; Caceres-Molina, J.; Sepulveda, R. V.; Gonzalez-Nilo, F.; Latorre, R. Article ISI SCOPUS Molecular Pharmacology (2016)
Effects of the Accessory Subunit gamma 1 on the External Architecture of BK Channel Carrasquel-Ursulaez, Willy; Castillo, Juan P.; Lorenzo, Yenisleidy; Sepulveda, Romina; Aguayo, Daniel; Bezanilla, Francisco; Gonzalez-Nilo, Fernando D.; Latorre, Ramon Article ISI BIOPHYSICAL JOURNAL (2015)
Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel Carrasquel-Ursulaez, W; Contreras G.F.; Sepúlveda R.V.; Aguayo, D; Gonzalez-Nilo, F; González C; Latorre R. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2015)
Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels Garcia-Elias, A; Berna-Erro, A; Rubio-Moscardo, F; Pardo-Pastor, C; Mrkonjic, S; Sepulveda, RV; Vicente R.; Gonzalez-Nilo, F; Valverde, MA Article ISI SCOPUS Structure (2015)
Molecular Determinants of Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P-2) Binding to Transient Receptor Potential V1 (TRPV1) Channels Poblete, H.; Oyarzun, I; Olivero P.; Comer, J.; Zúñiga M; Sepúlveda R.V.; Baez-Nieto, D; Leon, C.G; Gonzalez-Nilo, F; Latorre R. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels Diaz-Franulic, I; Sepulveda, RV; Navarro-Quezada, N; Gonzalez-Nilo, F; Naranjo, D Article ISI SCOPUS Journal of General Physiology (2015)
Substitutions at F380 in S6 by Small Hydrophobic Amino Acids Makes the Opening Transition in BK Channels Rate Limiting Carrasquel-Ursulaez, Willy; Contreras, Gustavo F.; Sepulveda, Romina; Aguayo, Daniel; Gonzalez-Nilo, Fernando D.; Gonzalez, Carlos; Latorre, Ramon Article ISI BIOPHYSICAL JOURNAL (2014)
Turning a Small into Large Conductance K-Channel - How Far Can We Go? Diaz-Franulic, Ignacio; Navarro, Nieves; Gonzalez-Nilo, Fernando; Sepulveda, Romina V.; Naranjo, David Article ISI BIOPHYSICAL JOURNAL (2014)
K+ Conduction and Mg2+ Blockade in a Shaker Kv-Channel Single Point Mutant with an Unusually High Conductance Moscoso, C.; Vergara-Jaque, A; Marquez-Miranda, V; Sepúlveda R.V.; Valencia I.; Diaz-Franulic, I; Gonzalez-Nilo, F; Naranjo, D Article ISI SCOPUS Biophysical Journal (2012)


Thermal Diffusion Pathways of TRPV1 Gonzalez-Nilo, FD; Diaz-Franulic, I; Sepulveda, RV; Gomez-Becerra, FA; Mino-Galazi, G; Latorre, R Abstract ISI BIOPHYSICAL JOURNAL (2018)
17 beta-Estradiol Binds and Modulates BK Channel through its beta 1 Auxiliary Subunit Granados, ST; Bravo, F; Sepulveda, R; Gonzalez-Nilo, D; González, J; Latorre, R; Torres, Y Abstract ISI (2016)
Structural Characterization of Ligand-Specific Interactions in TRPV1 Channel: Gating Mechanism by Capsaicin and Capsazepine Gonzalez-Nilo, FD; Caceres-Molina, J; Bravo-Moraga, F; Sepulveda, R; Diaz-Franulic, I Abstract ISI (2016)
Rational discovery of new capsaicin analogues as TRPV1 activators Caceres J.; Sepulveda, R; Navas C.; Latorre R.; Gonzalez-Nilo, F Abstract ISI BMC BIOINFORMATICS (2015)