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Inmaculada Vaca Cerezo

Associate Professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Natural Product Chemistry; Microbiology Chemistry, Fungal secondary metabolism; Biotechnology; Molecular genetic of filamentous fungi

Chemist, Universidad de Valladolid. España, 2000
Biotechnology, Universidad de Leon. España, 2008

Assistant Professor Full Time

Universidad de Chile

Faculty of Sciences

Santiago, Chile

2009 - 2019
Associate Professor Full Time

UNIVERSIDAD DE CHILE

Faculty of Sciences

Santiago, Chile

2019 - A la fecha
Ayudante Part Time

Universidad de Leon

Faculty of Sciences

León, España

2017 - 2018

Academic Full Time

University of Chile

Santiago, Chile

2009 - A la fecha

Marlene Henríquez Urrutia (2015). Master's Thesis in Biological Sciences, Universidad de Chile. "Detection and characterization of the secondary metabolites of Penicillium roqueforti associated with the expression of a polyketide synthase".

Mauricio Jose Rozas Painemilla (2019). Seminar Title, Environmental Chemistry. "Identification of secondary metabolites with biological activity biosynthesized by the Antarctic fungal strain Pseudogymnoascus sp. 071209-E2-C3-CA "

Felipe Andrés Vega Silva (2016). Seminar Title, Engineering in Molecular Biotechnology, University of Chile. "Development of molecular tools for the study of the biosynthetic clusters of PKS and NRPS in the Antarctic fungus Pseudogymnoascus sp. 131209-E2A-C5II-EB"

Karen Alejandra Toro Tasso (2015). Seminar Title, Degree in Chemistry, University of Chile. "Isolation and identification of secondary metabolites produced by the Antarctic strain Trichocladium sp."

Marcelo Flores Catalán (2014). Seminar Title, Degree in Chemistry, University of Chile. "Analysis of the ability to produce bioactive compounds of two Antarctic fungal strains _Geomyces sp."

Marlene Henríquez Urrutia (2013). Seminar Title, Engineering in Molecular Biotechnology, University of Chile. " Fungal biodiversity associated with Antarctic marine sponges and their potential as producers of bioactive secondary metabolites"

Luis Ignacio Figueroa Gómez (2013). Undergraduate thesis, Biochemistry, University of Chile. "Purification of bioactive secondary metabolites of filamentous fungi isolated from Antarctic marine sponges."

Ivanna Araya Hormazabal (2013). Seminar Title, Degree in Chemistry, University of Chile. "Purification and characterization of secondary metabolites from the Antarctic strain Penicillium sp. 071209-E4-C5 "

Francisco Salgado (2013). Seminar Title, Degree in Chemistry, University of Chile. "Biotransformation of muelin-oic acid 11,13-dien-20-acid with different strains of Penicillium roqueforti."

Best Poster

Federation of European Microbiologist

Alemania, 2013

Award to the Best Poster- 5th Congress of European Microbiologists 2013.


Penicillium chrysogenum, a Vintage Model with a Cutting-Edge Profile in Biotechnology Fierro, F.; Vaca, I.; Castillo, N.I.; García-Rico, R.O.; Chávez, R. Article Microorganisms (2022)
IMA genome-F14 Draft genome sequences of Penicillium roqueforti, Fusarium sororula, Chrysoporthe puriensis, and Chalaropsis populi van der Nest, Magriet A.; Chavez, Renato; De Vos, Lieschen; Duong, Tuan A.; Gil-Duran, Carlos; Ferreira, Maria Alves; Lane, Frances A.; Levican, Gloria; Santana, Quentin C.; Steenkamp, Emma T.; Suzuki, Hiroyuki; Tello, Mario; Rakoma, Jostina R.; Vaca, Inmaculada; Valdes, Natalia; Wilken, P. Markus; Wingfield, Michael J.; Wingfield, Brenda D. Article ISI IMA FUNGUS (2021)
Fungal Planet Description Sheets: 951-1041 Crous P.W.; Wingfield M.J.; Lombard L.; Roets F.; Swart W.J.; Alvarado P.; Carnegie A.J.; Moreno G.; Luangsa-Ard J.; Thangavel R.; Alexandrova A.V.; Baseia I.G.; Bellanger J.-M.; Bessette A.E.; Bessette A.R.; De la Pena-Lastra S.; Garcia D.; Gene J.; Pham T.H.G.; Heykoop M.; Malysheva E.; Malysheva V.; Martin M.P.; Morozova O.V.; Noisripoom W.; Overton B.E.; Rea A.E.; Sewall B.J.; Smith M.E.; Smyth C.W.; Tasanathai K.; Visagie C.M.; Adamcik S.; Alves A.; Andrade J.P.; Aninat M.J.; Araujo R.V.B.; Bordallo J.J.; Boufleur T.; Baroncelli R.; Barreto R.W.; Bolin J.; Cabero J.; Cabon M.; Cafa G.; Caffot M.L.H.; Cai L.; Carlavilla J.R.; Chavez R.; de Castro R.R.L.; Delgat L.; Deschuyteneer D.; Dios M.M.; Dominguez L.S.; Evans H.C.; Eyssartier G.; Ferreira B.W.; Figueiredo C.N.; Liu F.; Fournier J.; Galli-Terasawa L.V.; Gil-Duran C.; Glienke C.; Goncalves M.F.M.; Gryta H.; Guarro J.; Himaman W.; Hywel-Jones N.; Iturrieta-Gonzalez I.; Ivanushkina N.E.; Jargeat P.; Khalid A.N.; Khan J.; Kiran M.; Kiss L.; Kochkina G.A.; Kolarik M.; Kubatova A.; Lodge D.J.; Loizides M.; Luque D.; Manjon J.L.; Marbach P.A.S.; Massola N.S.; Jr.; Mata M.; Miller A.N.; Mongkolsamrit S.; Moreau P.-A.; Morte A.; Mujic A.; Navarro-Rodenas A.; Nemeth M.Z.; Nobrega T.F.; Novakova A.; Olariaga I.; Ozerskaya S.M.; Palma M.A.; Petters-Vandresen D.A.L.; Piontelli E.; Popov E.S.; Rodriguez A.; Requejo O.; Rodrigues A.C.M.; Rong I.H.; Roux J.; Seifert K.A.; Silva B.D.B.; Sklenar F.; Smith J.A.; Sousa J.O.; Souza H.G.; De Souza J.T.; Svec K.; Tanchaud P.; Tanney J.B.; Terasawa F.; Thanakitpipattana D.; Torres-Garcia D.; Vaca I.; Vaghefi N.; van Iperen A.L.; Vasilenko O.V.; Verbeken A.; Yilmaz N.; Zamora J.C.; Zapata M.; Jurjevic Z.; Groenewald J.Z. Article ISI/WOS PERSOONIA (2019)
Genetic Transformation of the Filamentous Fungus Pseudogymnoascus verrucosus of Antarctic Origin DÃaz A.; Villanueva P.; Oliva V.; Gil-DurÃ¡n C.; Fierro F.; ChÃ¡vez R.; Vaca I. Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2019)
Cold-active pectinolytic activity produced by filamentous fungi associated with Antarctic marine sponges Poveda, G; Gil-Duran, C; Vaca I.; Levican, G; Chavez, R Article ISI SCIELO MICROORGANISMS (2018)
Heterologous expression, purification and characterization of a highly thermolabile endoxylanase from the Antarctic fungus Cladosporium sp. Gil-Durán, Carlos; Ravanal, María-Cristina; Ubilla, Pamela; Vaca, Inmaculada; Chávez, Renato Article ISI SCOPUS FUNGAL BIOLOGY (2018)
The developmental regulator Pcz1 affects the production of secondary metabolites in the filamentous fungus Penicillium roqueforti Rojas-Aedo, Juan F.; Gil-Durán, Carlos; Goity, Alejandra; Vaca, Inmaculada; Levicán, Gloria; Larrondo, Luis F.; Chávez, Renato Article ISI SCOPUS MICROBIOLOGICAL RESEARCH (2018)
Heterotrimeric G protein alpha subunit controls growth, stress response, extracellular protease activity and cyclopiazonic acid production in Penicillium camemberti García-Rico, Ramón. O; Gil-Durán, Carlos; Rojas-Aedo, Juan F.; Vaca, Inmaculada; Figueroa, Luis; Levicán, Gloria; Chávez, Renato Article Fungal Biology (2017)
Role of sfk1 Gene in the Filamentous Fungus Penicillium roqueforti Torrent, C; Gil-Duran, C; Rojas-Aedo, JF; Medina, E; Vaca, I; Castro, P; Garcia-Rico, RO; Cotoras, M; Mendoza, L; Levican, G; Chavez, R Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2017)
The biosynthetic gene cluster for andrastin A in Penicillium roqueforti Rojas-Aedo, Juan F.; Gil-Durán, Carlos; Del Cid, Abdiel; Valdés, Natalia; Álamos, Pamela; Vaca, Inmaculada; García-Rico, Ramón. O; Levicán, Gloria; Tello, Mario; Chávez, Renato Article Frontiers in Microbiology (2017)
The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti Rojas-Aedo J.F.; Gil-Duran C.; Del Cid A.; Valdes N.; Alamos P.; Vaca I.; Garcia-Rico R.O.; Levican G.; Tello M.; Chavez R. Article ISI/WOS FRONTIERS IN MICROBIOLOGY (2017)
The Polyphenol Altenusin Inhibits in Vitro Fibrillization of Tau and Reduces Induced Tau Pathology in Primary Neurons. Chua, Sook Wern; Cornejo, Alberto; van Eersel, Janet; Stevens, Claire H; Vaca, Inmaculada; Cueto, Mercedes; Kassiou, Michael; Gladbach, Amadeus; Macmillan, Alex; Lewis, Lev; Whan, Renee; Ittner, Lars M Article ACS Chemical Neuroscience (2017)
Identification and Functional Analysis of the Mycophenolic Acid Gene Cluster of Penicillium roqueforti Del Cid A.; Gil-Duran C.; Vaca I.; Rojas-Aedo J.F.; Garcia-Rico, R.O.; Levican G.; Chavez R. Article ISI/WOS PLOS ONE (2016)
Identification and functional analysis of the mycophenolic acid gene cluster of Penicillium roqueforti Del Cid, A., Gil-Durán, C., Vaca, I., Rojas-Aedo, J.F., García-Rico, R.O., Levicán, G. y Chávez, R. Article PLoS One (2016)
3-Nitroasterric Acid Derivatives from an Antarctic Sponge-Derived Pseudogymnoascus sp. Fungus Figueroa L; Jiménez C; Rodríguez J; Areche C; Chávez R; Henríquez M; de la Cruz M; Díaz C; Segade Y; Vaca I. Article JOURNAL OF NATURAL PRODUCTS (2015)
3-Nitroasterric Acid Derivatives from an Antarctic Sponge-Derived Pseudogymnoascus sp. Fungus Figueroa L.; Jiménez C.; Rodríguez J.; Areche C.; Chávez R.; Henríquez M.; de la Cruz M.; Díaz C.; Segade Y.; Vaca I. Article ISI/WOS JOURNAL OF NATURAL PRODUCTS (2015)
Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolites Chavez R.; Fierro F.; Garcia-Rico R.O.; Vaca I. Article ISI/WOS FRONTIERS IN MICROBIOLOGY (2015)
Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolites Chavez, Renato; Fierro, Francisco; Garcia-Rico, Ramón O.; Vaca, Inmaculada Article Frontiers in Microbiology (2015)
The pcz1 Gene, which Encodes a Zn(II)(2)Cys(6) Protein, Is Involved in the Control of Growth, Conidiation, and Conidial Germination in the Filamentous Fungus Penicillium roqueforti Gil-Duran C.; Rojas-Aedo J.F.; Medina E.; Vaca I.; Garcia-Rico, R.O.; Villagran S.; Levican G.; Chavez R. Article ISI/WOS PLOS ONE (2015)
The pcz1 gene, which encodes a Zn(II)2Cys6 protein, is involved in the control of growth, conidiation, and conidial germination in the filamentous fungus Penicillium roqueforti Gil-Durán C; Rojas-Aedo JF; Medina E; Vaca I; García-Rico RO; Villagrán S; Levicán G; Chávez R. Article PLoS One (2015)
Cold-Active Xylanase Produced by Fungi Associated with Antarctic Marine Sponges Del Cid, A., Ubilla, P., Ravanal, M.C., Medina, E., Vaca, I., Levicán, G., Eyzaguirre, J. y Chávez, R. Article ISI APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2014)
Diversity of cultivable fungi associated with Antarctic marine sponges and screening for their antimicrobial, antitumoral and antioxidant potential Henríquez M; Vergara K.; Norambuena J.; Beiza, A.; Maza, F.; Ubilla P.; Araya, I.; Chavez, R; San Martin, A; Darias J.; Darias, MJ; Vaca I. Article ISI WORLD JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY (2014)
Leucosporidium escuderoi f.a., sp nov., a basidiomycetous yeast associated with an Antarctic marine sponge Laich, F; Chavez, R; Vaca I. Article ISI SCOPUS ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2014)
Cultivable psychrotolerant yeasts associated with Antarctic marine sponges Vaca I.; Faúndez C.; Maza F.; Paillavil B.; Hernández V.; Acosta, F; Levicán G; Martínez C.; Chávez R. Article ISI/WOS (2013)
Rhodotorula portillonensis sp nov., a basidiomycetous yeast isolated from Antarctic shallow-water marine sediment Laich, F; Vaca I.; Chavez, R Article ISI SCOPUS International Journal of Systematic and Evolutionary Microbiology (2013)
Glucose-induced production of a Penicillium purpurogenum xylanase by Aspergillus nidulans Ravanal, M.C.; Espinosa, Y; Rosa L.; Vaca I.; Polanco, R.; Eyzaguirre, J; Levicán G; Chavez, R Article ISI SCOPUS Mycoscience (2012)
Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation Wu X.; Garcia-Estrada C.; Vaca I.; Martin J.-F. Article SCOPUS Biochimie (2012)
A preparative method for the purification of isopenicillin N from genetically blocked Acremonium chrysogenum strain TD189: studies on the degradation kinetics and storage conditions Vaca I.; Casqueiro J.; Ullan, RV; Rumbero A.; Chavez, R; Martin, JF Article ISI SCOPUS Journal of Antibiotics (2011)
Biotransformation of Stypotriol triacetate by Aspergillus niger Areche, C; Vaca I.; Labbé P.; Soto-Delgado, J; Astudillo, L; Silva M.; Rovirosa, J; San Martin, A Article ISI SCOPUS Journal of Molecular Structure (2011)
NEW BUTYROLACTONE FROM A MARINE-DERIVED FUNGUS ASPERGILLUS SP San Martin, A; Rovirosa, J; Vaca I.; Vergara K.; Acevedo L; Vina D.; Orallo F.; Chamy, MC Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2011)
Production of a heterologous recombinant protein using fragments of the glyceraldehyde-3-phosphate dehydrogenase promoter from Penicillium camemberti Espinosa, Y; Trebotich, J; Sepulveda, F; Cadena, J; Vargas-Straube, MJ; Vaca I.; Bull, P; Levicán G; Chavez, R Article ISI SCOPUS World Journal of Microbiology and Biotechnology (2011)
Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C Ullan R.V.; Teijeira F.; Vaca I.; Martin J.-F.; Guerra S.M. Article SCOPUS Biochemical Journal (2010)
Diterpenoids from Azorella madreporica and Their Antibacterial Activity Areche, C; Vaca I.; Loyola, LA; Bórquez J.; Rovirosa, J; San Martin, A Article ISI SCOPUS PLANTA MEDICA (2010)
Evaluation of properties of several cheese-ripening fungi for potential biotechnological applications Chavez, R; Roa A.; Navarrete, K; Trebotich, J; Espinosa, Y; Vaca I. Article ISI SCOPUS Mycoscience (2010)
Molecular characterization of a fungal gene paralogue of the penicillin penDE gene of Penicillium chrysogenum García-Estrada C., Vaca I., Ullán R.V., van den Berg M.A., Bovenberg R.A. & Marñnjltín J.F. Article BMC MICROBIOLOGY (2009)
Molecular characterization of the niaD and pyrG genes from Penicillium camemberti, and their use as transformation markers Navarrete, K; Roa A.; Vaca I.; Espinosa, Y; Navarro, C.; Chavez, R Article ISI SCOPUS CELLULAR & MOLECULAR BIOLOGY LETTERS (2009)
The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production Teijeira F., Ullán R.V., Guerra S.M., García-Estrada C., Vaca I. & Martín J.F. Article BIOCHEMICAL JOURNAL (2009)


GENOME MINING FOR NOVEL NATURAL PRODUCTS DISCOVERY FROM AN ANTARCTIC FUNGAL STRAIN FONDECYT (1150894) Proyecto 2015-2019 Inv. Responsable
Identification of new fungal species from Antarctic marine sponges Instituto Antártico Chileno (INACH) (RG_15-14) Proyecto 2014-2016 Inv. Responsable
Producción de pigmentos naturales con propiedades antioxidantes a partir de cepas antárticas del hongo filamentoso Epicoccum sp. FONDEF (VIU-FONDEF) Proyecto 2013-2014 Director(a)
SEARCH AND CHARACTERIZATION OF NEW GENES DOWNSTREAM FROM THE ALPHA SUBUNIT OF HETEROTRIMERIC G PROTEINS PUTATIVELY INVOLVED IN DEVELOPMENT, PHENOTYPE AND PRODUCTION OF SECONDARY METABOLITES IN PENICILLIUM ROQUEFORTI FONDECYT (1120833) Proyecto 2012-2016 Coinvestigador(a)
Búsqueda de actividades enzimáticas con potencial biotecnológico, en hongos filamentosos y levaduras aisladas desde esponjas marinas Antárticas de Bahía Fildes (isla Rey Jorge). Instituto Antartico Chileno (INACH) (INACH G_06-10) Proyecto 2010-2012 Coinvestigador(a)
Bioactive compounds obtained from new fungi isolated from Antarctic marine sponges FONDECYT (11090192) Proyecto 2009-2012 Inv. Responsable
Academia support of bioorganic chemistry area PAI (PDA 13) Proyecto 2007-2011 Coinvestigador(a)
Beta-lactam biosynthesis by Penicillium chrysogenum DSM Anti-Infectives B.V. (Proyecto Centro Tecnologico-Empresa) Proyecto 2004-2008 Investigador(a)

Inmaculada Vaca

Associate Professor

Chemistry Department

UNIVERSIDAD DE CHILE

Santiago, Chile

Renato Chavez

Full Professor

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Juana Rovirosa

Professor Ad. Honorem

Ciencias

Facultad de Ciencias y Recursos Naturales

Punta Arenas, Chile

Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

Gloria Levican

Académica Profesora Titular

Departamento de Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Carlos Gil

Docente Adjunto

Estudios interdisciplinarios

Universidad Mayor de Chile

Santiago de Chile, Chile

AURELIO SAN MARTIN

Profesor Asociado (media jornada)

de Ciencias y Recursos Naturales

FACULTAD DE CIENCIAS

Punta Arenas, Chile

Jovanka Trebotich

Coordinadora de Transferencia Tecnológica

Know Hub Chile

Santiago , Chile

Mario Silva

Emeritus Professor

Botany Department

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Luis Larrondo

Associate Professor

Genetica Molecular y Microbiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

Exequiel Medina

Researcher

BIología

Universidad de Chile

Santiago, Chile

Lorena Rosa

PhD

Departamento de Patología

Pontificia Universidad Católica de Chile

Santiago, Chile

Leonora Mendoza

Académico JC

Departamento de Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

KATHERINNE NAVARRETE

PhD student

King's College London

Chile

Rubén Polanco

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO (UNAB)

SANTIAGO, Chile

María Ravanal

Académico

Universidad Austral de Chile

Valdivia, Chile

María Vargas

Postdoctoral

Departamento de Química

Laboratorio de Microbiología Molecular y Biotecnología Ambiental

Valparaíso, Chile

Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Alejandra Goity

Investigador postdoctoral iBio

Genética Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

Mario Tello

Académico

Biología

Universidad de Santiago de Chile

Santiago, Chile

Javiera Norambuena

Post-Doctoral Associate

Biochemistry and Microbiology

Rutgers University

New Brunswick, Estados Unidos

Ivanna Araya

Researcher

Biomateriales y Materiales Renovables

Leitat Chile

Santiago, Chile

Inmaculada Vaca Cerezo

Líneas de Investigación

Educación

Chemist, Universidad de Valladolid. España, 2000

Biotechnology, Universidad de Leon. España, 2008

Experiencia Académica

Assistant Professor Full Time

Associate Professor Full Time

Ayudante Part Time

Experiencia Profesional

Academic Full Time

Formación de Capital Humano

Premios y Distinciones

Best Poster

Article (37)

Proyecto (8)

GENOME MINING FOR NOVEL NATURAL PRODUCTS DISCOVERY FROM AN ANTARCTIC FUNGAL STRAIN

Identification of new fungal species from Antarctic marine sponges

Producción de pigmentos naturales con propiedades antioxidantes a partir de cepas antárticas del hongo filamentoso Epicoccum sp.

SEARCH AND CHARACTERIZATION OF NEW GENES DOWNSTREAM FROM THE ALPHA SUBUNIT OF HETEROTRIMERIC G PROTEINS PUTATIVELY INVOLVED IN DEVELOPMENT, PHENOTYPE AND PRODUCTION OF SECONDARY METABOLITES IN PENICILLIUM ROQUEFORTI

Búsqueda de actividades enzimáticas con potencial biotecnológico, en hongos filamentosos y levaduras aisladas desde esponjas marinas Antárticas de Bahía Fildes (isla Rey Jorge).

Bioactive compounds obtained from new fungi isolated from Antarctic marine sponges

Academia support of bioorganic chemistry area

Beta-lactam biosynthesis by Penicillium chrysogenum