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Jorge Andrés Soto Delgado

Profesor Asistente

Universidad Andrés Bello

Viña del Mar, Chile

Líneas de Investigación


Quimica Medicinal, Quimica Computacional, Diseño de Farmacos Asistido por Computador, Sintesis Organica

Educación

  •  Quimica , UNIVERSIDAD DE CHILE. Chile, 2006
  •  Quimica , UNIVERSIDAD DE CHILE. Chile, 2011

Experiencia Académica

  •   Post-Doctorado Other

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Quimica

    Santiago, Chile

    2012 - 2014

  •   Post-Doctorado Full Time

    NÚCLEO MILENIO CENTRO INTERDISCIPLINARIO DE LÍQUIDOS IÓNICOS - CILIS

    Santiago, Chile

    2011 - 2011

Experiencia Profesional

  •   Profesor Asistente Full Time

    Universidad Andres Bello

    Viña del Mar, Chile

    2014 - A la fecha

Formación de Capital Humano


- Claudio Aurelio Godoy Castillo, Memoria de Título para la obtención del título de Químico Farmacéutico (2020): Titulo: “Síntesis química y evaluación in vitro del efecto citotóxico de derivados 2-bencil-1,4-naftoquinona diseñados como inhibidores farmacológicos de la proteína chaperona Hsp90a”
- Nicolás Benjamín Bravo Acuña, Memoria de Título para la obtención del título de Ingeniero en Biotecnología (2020) “Estudio estructural y energético de la inhibición selectiva de Grp94. diseño racional de antitumorales contra cáncer de mama”
- Stefano Franco Simonetti Macaya Memoria de Título para la obtención del título de Ingeniero en Biotecnología (2020) “Síntesis y evaluación antitumoral de moléculas hibridas feniltiazolo-naftoquinona como inhibidores de hsp90”
- Jorge González Higueras, Programa Magister en Ciencias Mención Química, Universidad Técnica Federico Santa María. (2018) Titulo: “Estudio estructural de la interacción de inhibidores naftoquinonicos con HDAC6 y Hsp90, para el diseño de drogas multitarget.”



 

Article (31)

New benzimidazolequinones as trypanosomicidal agents
Identification of the naphthoquinone derivative inhibitors binding site in heat shock protein 90: an induced-fit docking, molecular dynamics and 3D-QSAR study
Experimental and Theoretical Approaches in the Study of Phenanthroline-Tetrahydroquinolines for Alzheimer's Disease
Ion-Ion Repulsions and Charge-Shielding Effects Dominate the Permeation Mechanism through the OmpF Porin Channel
State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures
Combined molecular modelling and 3D-QSAR study for understanding the inhibition of NQO1 by heterocyclic quinone derivatives
Influence of structural changes on photophysical properties of terpyridine derivates: Experimental studies and theoretical calculations
Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human 3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles
2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human beta(3)-Adrenergic Activity
Structural analysis and molecular docking of trypanocidal aryloxy-quinones in trypanothione and glutathione reductases: a comparison with biochemical data
Multiscale Treatment for the Molecular Mechanism of a Diels-Alder Reaction in Solution: A QM/MM-MD Study
Structural, electrochemical and theoretical study of a new chalcone derivative containing 3-thiophene rings
Examining the compatibility of collagen and a polythiophene derivative for the preparation of bioactive platforms
New aryloxy-quinone derivatives as potential antiChagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis
Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents
On the mechanism of biological activity of hydroquinone derivatives that inhibit tumor cell respiration. A theoretical study
Theoretical study on the molecular mechanism of the [5+2] vs. [4+2] cyclization mediated by Lewis acid in the quinone system
Bond Fukui Functions As Descriptor of the Electron Density Reorganization in pi Conjugated Systems
LOCATION, ORIENTATION AND DYNAMICS OF TWO MOLECULES WITH MITOCHONDRIAL ACTIVITY DISSOLVED IN ANIONIC LYOMESOPHASE: A ²H-NMR AND MD STUDY
On the Catalytic Effect of Water in the Intramolecular Diels-Alder Reaction of Quinone Systems: A Theoretical Study
STRUCTURAL REASSIGNMENT OF EPIERYTHRATIDINE, AN ALKALOID FROM Erythrinafusca, BASED ON NMR STUDIES AND COMPUTATIONAL METHODS
A DFT Study of the Regioselectivity in Intramolecular Diels-Alder Reactions with Formation of a Tricyclodecane Skeleton
Biotransformation of Stypotriol triacetate by Aspergillus niger
Invariance of electrophilicity of independent fragments. Application to intramolecular Diels-Alder reactions
Quantitative characterization of group electrophilicity and nucleophilicity for intramolecular Diels-Alder reactions
An unusual halogenated meroditerpenoid from Stypopodium flabelliforme: Studies by NMR spectroscopic and computational methods
Understanding the influence of Lewis acids in the regioselectivity of the Diels-Alder reactions of 2-methoxy-5-methyl-1,4-benzoquinone: A DFT study
Understanding the stereo- and regioselectivities of the polar Diels-Alder reactions between 2-acetyl-1,4-benzoquinone and methyl substituted 1,3-butadienes: a DFT study
Antioxidant properties and free radical-scavenging reactivity of a family of hydroxynaphthalenones and dihydroxyanthracenones
Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)-anthracenone derivatives on tumor cell respiration
Synthesis of 9-and 10-membered macrolactones by selective ozonolysis of 1,4-diazaphenanthrene derivatives

Proyecto (6)

Núcleo Interdisciplinario para desarrollo de Fármacos=> Diseño computacional, síntesis y evaluación biológica de antitumorales inhibidores de HSP90
Antioxidant Chilean Plants as possible gastroprotective agents
Diseño y Síntesis de Arilnaftoquinonas heterocíclicas con potencial actividad antitumoral
BENZIMIDAZOLEQUINONES AND BIOISOSTERES AS ANTI-CHAGASIC AGENT=> TRYPANOCIDAL EFFECT, SELECTIVITY AND 3D-QSAR STUDIES
DEVELOPMENT OF NEW MOLECULES HSP90 INHIBITORS=> COMPUTATIONAL DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION
THEORETICAL STUDY OF THE HETERO-DIELS-ALDER REACTIONS IN DIFFERENT REACTIONS MEDIA
31
Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

10
Renato Contreras

professor

Quimica

Universidad de Chile

Santiago, Chile

5
Ramiro Araya

UNIVERSIDAD DE CHILE, FAC. CIENCIAS QUÍMICAS Y FARMACÉUTICAS, DPTO. QUÍMICA ORGÁNICA Y FISICOQUÍMICA

Santiago, Chile

4
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

4
Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Juana Rovirosa

Professor Ad. Honorem

Ciencias

Facultad de Ciencias y Recursos Naturales

Punta Arenas, Chile

4
Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Inmaculada Vaca

Associate Professor

Chemistry Department

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

2
AURELIO SAN MARTIN

Profesor Asociado (media jornada)

de Ciencias y Recursos Naturales

FACULTAD DE CIENCIAS

Punta Arenas, Chile

2
Wilson Cardona

Chemistry Department Area Coordinator

Chemistry

Universidad Andrés Bello

Talcahuano, Chile

2
Mario Silva

Emeritus Professor

Botany Department

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
Cesar Morales

Associate Professor

Universidad Bernardo O'Higgins

Santiago, Chile

1
Jaime Pizarro

Postdoctorando

Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

1
José González

Director

Ciencias Físicas

Universidad Andres Bello

Santiago, Chile

1
Mauricio Cuellar

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Gonzalo Recabarren

Académico

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
YORLEY DUARTE

profesor Asistente

Universidad Andrés Bello

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

1
Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marco Mellado

Investigador

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Claudia López

Investigador Asociado

Food Science and Technology

The Ohio State University

Columbus, Estados Unidos

1
Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
ROBERTO LEON

Research Professor

Science of Engineering

Universidad Andres Bello

Viña del Mar, Chile

1
Jorge Rodriguez

Professor

Department of Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

La Florida, Chile

1
Dante Miranda

Director de Extensión

Bioquímica y Biología Molecular

Universidad de Chile, Faculatd de Ciencias Químicas y Farmacéuticas

Santiago, Chile