Man

CHRISTIAN MARCELO ESPINOSA BUSTOS

Profesor asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Líneas de Investigación


Química Medicinal Química Orgánica Síntesis de heterociclos

Educación

  •  Química, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2013
  •  Químico Farmacéutico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
  •  Química, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2013

Experiencia Académica

  •   Instructor Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Química

    Chile

    2014 - 2017

  •   Profesor asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Química y de Farmacia

    Chile

    2017 - A la fecha


 

Article (43)

3D-QSAR study for the development of chalcone-based inhibitors targeting ovarian cancer cells with experimental validation

Valenzuela-Valderrama, Manuel; Varas, Aranxa; Rubilar, Mariaignacia; Lorca, Marcos; Mella, Jaime; Espinosa-Bustos, Christian; Mellado, Marco; Echeverria, Javier

Article ISI
FRONTIERS IN PHARMACOLOGY  (2026)

3D-QSAR Design of New Bcr-Abl Inhibitors Based on Purine Scaffold and Cytotoxicity Studies on CML Cell Lines Sensitive and Resistant to Imatinib

Cabezas, David; Delgado, Thalia; Sepulveda, Guisselle; Krnavkova, Petra; Vojackova, Veronika; Krystof, Vladimir; Strnad, Miroslav; Silva, Nicolas Ignacio; Echeverria, Javier; Espinosa-Bustos, Christian; et al.

Article ISI
Pharmaceuticals  (2025)

An Efficient and Selective 7-(Diethylamino)quinolin-2(1H)-One-Chalcone Fluorescent Probe for Detecting Bisulfite in Wine Samples Using a Micellar Solution

Quintero, GE; Tiznado W.; Leyva-Parra L.; Espinoza, C.,; Sánchez-Velasco, O; Pérez, EG; Rojas-Romo C.; Espinosa-Bustos C.; Aliaga M.E.

Article ISI
ACS Omega  (2025)

Buddleja globosa Leaf Methanolic Extract Acts Against Trypanosoma cruzi Parasites by Inducing Mitochondrial Inner Membrane Hyperpolarization

Quintero-Pertuz H.; Valenzuela-Bass, V; Lapier M.; Ortega-Campos, J; Alfaro, S; von Poser, GL; Espinosa-Bustos C.; De Camargo A.C.; González-Herrera, F; Maya J.D.; et al.

Article ISI
Plants  (2025)

Experimental and In Silico Studies to Unravel the Antioxidant and Antibacterial Properties of Lichen Metabolites from <i>Pseudocyphellaria compar</i> and <i>Pseudocyphellaria nudata</i>

Cuellar, Mauricio A.; Mejia, Jessica; Quintero-Pertuz, Helena; Castro-Alvarez, Alejandro; Mellado, Marco; Vera-Quezada, Waleska; Montenegro, Gloria; Espinosa-Bustos, Christian; Bridi, Raquel; Salas, Cristian O.

Article ISI
ANTIOXIDANTS  (2025)

First in class pyrrolo[2,3-d]pyrimidine derivatives fused to fluorobenzylpiperidines as dual ligands of acetylcholinesterase and histamine H3 receptor

Añazco, T; Werner, T; Torres M.J.; Hornos-Carneiro, MF; Fernández J.; Zivkovic, A; Salas C.O.; Castro-Alvarez A.; Gutiérrez, M.; Stark H.; et al.

Article ISI
Archiv der Pharmazie  (2025)

Synthesis, antitumoral activity, and in silico studies on Smoothened receptor of new 2,6,9-trisubstituted purine derivatives

Espinosa-Bustos, Christian; Zarate, Ana-Maria; Castro-Alvarez, Alejandro; Guerrero, Simon; Kogan, Marcelo J.; Salas, Cristian O.

Article ISI
Journal of Molecular Structure  (2025)

First Report on Cationic Triphenylphosphonium Compounds as Mitochondriotropic H3R Ligands with Antioxidant Properties

Werner, Tobias; Anazco, Tito; Osses-Mendoza, Paula; Castro-Alvarez, Alejandro; SALAS-SANCHEZ, CRISTIAN OSVALDO; Bridi, Raquel; Stark, Holger; Espinosa-Bustos, Christian

Article ISI
 (2024)

Photoaged polystyrene nanoplastics exposure results in reproductive toxicity due to oxidative damage in Caenorhabditis elegans

Leon, RE; Salcedo, VAA; Miguel, FJNS; Tardio, CRAL; Briceño, AAT; Fouilloux, SFC; Barbosa, MD; Barros, CAS; Waldman, WR; Espinosa-Bustos C.; et al.

Article ISI
 (2024)

2,3-Diketopiperazine as potential scaffold to develop new anti-Chagasic agents

Osorio-Nieto, Urbano; Salas, Cristian O.; Mendez-Alvarez, Domingo; Rivera, Gildardo; Moreno-Rodriguez, Adriana; Perez-Cervera, Yobana; Castillo-Real, Lizet Monserrat; Espinosa-Bustos, Christian

Article ISI SCOPUS
Medicinal Chemistry Research  (2023)

Convergent synthesis, drug target prediction, and docking studies of new 2,6,9-trisubstituted purine derivatives

Villegas Á.; Satheeshkumar R.; Ballesteros-Casallas A.; Paulino M.; Castro A.; Espinosa-Bustos C.; Salas C.O.

Article ISI SCOPUS
JOURNAL OF HETEROCYCLIC CHEMISTRY  (2022)

Solvent-Free Synthesis of New Quinoline Derivatives via Eaton's Reagent Catalysed Friedlander Synthesis

Satheeshkumar, Rajendran; Rajendra Prasad, Karnam Jayarampillai; Wang W.L.; Wen-Long, Wang; Espinosa-Bustos, Christian; SALAS-SANCHEZ, CRISTIAN OSVALDO

Article ISI SCOPUS
CHEMISTRYSELECT  (2022)

Expanding the chemical space of aryloxy-naphthoquinones as potential anti-Chagasic agents: synthesis and trypanosomicidal activity

Becerra, Nohemi; Espinosa-Bustos, Christian; VAZQUEZ-CISNEROS, KARINA WENDOLINE; Rivera-Sanchez, Gildardo; Paulino Zunini, Margot; Nogueda-Torres, Benjamin; Chacon-Vargas, Karla F.; Castillo-Velazquez, Uziel; Rodríguez, Ana F.Elizondo; Elizondo Rodriguez, Ana F.; et al.

Article ISI SCOPUS
Medicinal Chemistry Research  (2021)

Hepatoprotective species from the Chilean medicinal flora: Junellia spathulata (Verbenaceae)

Bridi, Raquel; Lino von Poser, Gilsane; Andia, Marcelo E.; Oyarzun, Juan -Esteban; Vasquez Arias, Ariadsna Jael

Article ISI SCOPUS
Journal of Ethnopharmacology  (2021)

New 2,6,9-trisubstituted purine derivatives as Bcr-Abl and Btk inhibitors and as promising agents against leukemia

Bertrand J.; Dostálová H.; Krystof V.; Jorda R.; María Zarate A.; Salas, C. O.

Article ISI SCOPUS
Bioorganic Chemistry  (2020)

New aryloxy-quinone derivatives with promising activity on Trypanosoma cruzi

Cerecetto H.; Paulino M.; Vera B.; Zarate A.M.; Salas, C. O.

Article ISI SCOPUS
Archiv der Pharmazie  (2020)

Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

Salas, C. O.; Zarate A.M.; Kryštof V.; Hendrychová D.; Tapia R.A.

Article ISI SCOPUS
International journal of molecular sciences  (2020)

Unveiling interactions between DNA and cytotoxic 2-arylpiperidinyl-1,4-naphthoquinone derivatives: A combined electrochemical and computational study



Article ISI SCOPUS
Arabian Journal of Chemistry  (2020)

Nature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine H-3 receptor

Meza-Arriagada F.; Salas, C. O.

Article ISI SCOPUS
BIOORGANIC & MEDICINAL CHEMISTRY  (2019)

State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures

Mella, Jaime; Salas, Cristian O.

Article ISI SCOPUS
FUTURE MEDICINAL CHEMISTRY  (2019)

New lead elements for histamine H-3 receptor ligands in the pyrrolo[2,3-d] pyrimidine class

Frank A.; Stark H.

Article ISI SCOPUS
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  (2018)

Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3,6-disubstitued- 1,2,4,5-tetrazine derivatives as potential antitumor agents

Cañete-Molina, Alvaro; Gonzalez-Castro, Marcos

Article
Arabian Journal of Chemistry  (2017)

Enrofloxacin behavior in presence of soil extracted organic matter: An electrochemical approach

Peralta, Emilia

Article ISI SCOPUS
ELECTROCHIMICA ACTA  (2017)

Fluorescence properties of aurone derivatives: an experimental and theoretical study with some preliminary biological applications

Cortes-Arriagada, Diego; Soto-Arriaza, Marco A.; Robinson-Duggon, José

Article ISI SCOPUS
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES  (2017)

New imidoyl-indazole platinum (II) complexes as potential anticancer agents: Synthesis, evaluation of cytotoxicity, cell death and experimental-theoretical DNA interaction studies



Article ISI SCOPUS
JOURNAL OF INORGANIC BIOCHEMISTRY  (2017)

Synthesis, characterization, electropolymerization, and possible utilities of a new ruthenium-thiophene complex

Ramírez, AMR

Article ISI SCOPUS
JOURNAL OF APPLIED POLYMER SCIENCE  (2016)

Synthesis, characterization, electropolymerization, and possible utilities of a new ruthenium–thiophene complex

Ramírez, Andrés; Hernandez, Loreto

Article
JOURNAL OF APPLIED POLYMER SCIENCE  (2016)

Design, Synthesis, Biological Evaluation and Binding Mode Modeling of Benzimidazole Derivatives Targeting the Cannabinoid Receptor Type 1

Romero-Parra, Javier

Article
ARCHIV DER PHARMAZIE  (2015)

New aryloxy-quinone derivatives as potential anti- Chagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis

Varela, Javier; Birriel, Estefania; Paulino, Margot

Article
RSC ADVANCES  (2015)

New aryloxy-quinone derivatives as potential antiChagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis

Vazquez, K; Espinosa-Bustos C.; Soto-Delgado J.; Varela J.; Birriel, E; Segura R; Pizarro J.; Cerecetto H.; González, M; Paulino M.; et al.

Article ISI SCOPUS
RSC Advances  (2015)

Synthesis and electrochemical characterization of new ruthenium-terthiophene complexes

Gonzalez B; Del Valle M.A.; Diaz F.R.; Espinosa-Bustos C.; Ramirez, A; Hernandez, L. A.

Article ISI SCOPUS
POLYHEDRON  (2015)

Synthesis and electrochemical characterization of new ruthenium–terthiophene complexes

Ramírez, Andrés; Hernandez, Loreto

Article
POLYHEDRON  (2015)

Synthesis and Pharmacophore Modelling of 2,6,9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines

Calderon-Arancibia, Jeanette; Cañete-Molina, Alvaro; Paulino, Margot

Article
MOLECULES  (2015)

Synthesis, Biological Evaluation, and Molecular Simulation of Chalcones and Aurones as Selective MAO-B Inhibitors

Morales-Camilo, Nicoles; Reyes-Parada, Miguel; Caroli-Rezende, Marcos

Article
Chemical Biolgy and Drug Design  (2015)

2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities

Sieveking, Ivan; Estévez, Juan C.; Estevez, Ramon J.

Article ISI SCOPUS
 (2014)

Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents

Varela, Javier; Birriel, Estefania; Paulino, Margot

Article
Bioorganic and Medicinal Chemistry Letters  (2014)

Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles-A New Family of High Affinity CB1 Cannabinoid Ligands

Mella-Raipan, JA; Lagos C.F.; Recabarren-Gajardo G.; Espinosa-Bustos C.; Romero-Parra, J.; Pessoa-Mahana H.; ITURRIAGA-VÁSQUEZ P.; Pessoa-Mahana C.D.

Article ISI SCOPUS
MOLECULES  (2013)

Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands

Romero-Parra, Javier

Article
MOLECULES  (2013)

Evaluation of the Membrane Permeability (PAMPA and Skin) of Benzimidazoles with Potential Cannabinoid Activity and their Relation with the Biopharmaceutics Classification System (BCS)

Alvarez Figueroa MJ; Pessoa-Mahana C.D.; Palavecino-Gonzalez, ME; Mella-Raipan J.; Espinosa-Bustos C.; Lagos-Munoz, ME

Article ISI SCOPUS
AAPS PHARMSCITECH  (2011)

Synthesis, characterization, and electrochemical studies of new 5- and 6-nitro N-acyl-1H-indazoles

Recabarren-Gakardo, Gonzalo; Murueva, irina

Article
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY  (2011)

Synthesis, characterization, and electrochemical studies of new 5-and 6-nitro N-acyl-1H-indazoles

Recabarren-Gajardo G.; Gacitua M.; Murueva I.; romero, j; Espinosa-Bustos C.; Mella-Raipan J.; Pessoa-Mahana C.D.; Tapia R.

Article ISI SCOPUS
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY  (2011)

Synthesis of a Novel Series of 4-Arylpiperazinyl Derivatives Linked to a 2-(Pyridin-3-yl)-1H-benzimidazole as New Delavirdine Analogues



Article
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY  (2010)

Microwave-assisted synthesis and regioisomeric structural elucidation of novel benzimidazo[1,2d][1,4]benzodiazepinone derivatives

Canales-Pacheco, Jorge

Article
ARKIVOC  (2009)

1
Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Mario Aranda

Full Professor

Pharmacy

Pontificia Universidad Católica de Chile

Santiago, Chile

1
MONICA ANTILEN

Profesora Titular

quimica Inorganica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Aldo Escudey

Full Professor

Departamento de Química de los Materiales

UNIVERSIDAD DE SANTIAGO

Santiago, Chile

1
Rene Rojas

Professor

Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Pablo Jaque

Profesor Asociado

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

17
Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
RODRIGO SEGURA

Academico

DEPARTAMENTO DE QUIMICA DE LOS MATERIALES

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Javier Echeverría

Profesor Asociado e Investigador

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago de Chile, Chile

1
Manuel Gacitúa

Profesor asistente

Facultad de Ingeniería y Ciencias

Universidad Diego Portales

Santiago, Chile

2
Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

1
Denis Fuentealba

PROFESOR ASOCIADO

QUIMICA FISICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Raquel Bridi

Profesor Asociado

Departamento de Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

1
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marcelo Andia

Associate Professor

Radiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

3
Alan Cabrera

Profesor Asistente

Departamento de Química Inorganica

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Loreto Hernandez

profesor auxiliar

instituto de química y bioquímica

Universidad de Valparaíso

Valparaiso, Chile

2
Javier Romero

Profesor Asistente

Departamento de Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Diego Cortés

Profesor Titular

Instituto Universitario de Investigación y Desarrollo Universitario

Universidad Tecnológica Metropolitana

Santiago, Chile

43
CHRISTIAN ESPINOSA

Profesor asistente

Farmacia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Loreto Hernandez

postdoctorando

físico química

universidad de Valparaíso

Valparaiso, Chile

7
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Simon Guerrero

Académico Investigador

Facultad de Medicina

Universidad de Atacama

Copiapó, Chile

2
Andres Ramirez

Profesor Asosiado

Facultad de Ingenieria y Ciencia

Universidad de La Frontera

Temuco, Chile

1
Miguel Gómez

3
ANA ZÁRATE

investigadora

Químca-Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Alejandro Castro

Académico

Ciencias Preclínicas

Universidad de La Frontera

Temuco, Chile

1
Guido Mellado

profesor

ingenieria

Universidad Católica de Temuco

Temuco, Chile

2
Jaime Pizarro

Postdoctorando

Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

1
Alondra Villegas

Académica e Investigadora

Universidad Bernardo O'Higgins

Santiago, Chile

1
Sandra Arancibia

1
Jessica Mejía

PhD

Pontificia Universidad Católica de Chile

Santiago de Chile, Chile

1
David Cabezas

Investigador

Centro de Investigaciones Nucleares para Aplicaciones en Salud y Biomedicina

Comisión Chilena de Energía Nuclear

Santiago, Chile